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M. tuberculosis H37Rv Rv0153c (ptbB)

annotation: PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase)
coordinates: 181155 - 181985
length: 276

AVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPD
GIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQR
ALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRF
DTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv0153c ptbB - 100% (276) PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0158c ptbB 1e-154 99.64% (276) phosphotyrosine protein phosphatase PTPB
M. gilvum PYR-GCK Mflv_0735 - 3e-77 56.41% (273) protein tyrosine/serine phosphatase
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_4591 - 6e-49 42.38% (269) putative phosphotyrosine protein phosphatase
M. marinum M MMAR_0373 ptpB 1e-118 78.47% (274) phosphotyrosine protein phosphatase PtpB
M. avium 104 MAV_5145 - 1e-117 76.81% (276) phosphotyrosine protein phosphatase ptpb
M. smegmatis MC2 155 MSMEG_0100 - 5e-79 56.30% (270) phosphotyrosine protein phosphatase ptpb
M. thermoresistible (build 8) TH_1776 - 2e-55 52.63% (209) PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB
M. ulcerans Agy99 MUL_4739 ptpB 1e-117 77.74% (274) phosphotyrosine protein phosphatase PtpB
M. vanbaalenii PYR-1 Mvan_0115 - 3e-77 54.41% (272) protein tyrosine/serine phosphatase

CLUSTAL 2.0.9 multiple sequence alignment


Rv0153c|M.tuberculosis_H37Rv        ---------MAVR--ELPGAWNFRDV--ADTATALRPGRLFRSSELSRLD
Mb0158c|M.bovis_AF2122/97           ---------MAVR--ELPGAWNFRDV--ADTATALRPGRLFRSSELSRLD
MMAR_0373|M.marinum_M               ---------MAETGPELPGAWNFRDV--ADSTAALRPGRLFRSSELSGLD
MUL_4739|M.ulcerans_Agy99           ---------MAETGPELPGAWNFRDV--ADSTAALRPGRLFRSSELSGLD
MAV_5145|M.avium_104                ---------MPEALRELSGAWNFRDV--ADGAPMLRPGRLFRSGELSGLD
MSMEG_0100|M.smegmatis_MC2_155      ------MTGPDGTSLELGGAWNFRDV--AQETG-IRPGVLYRSSELSKLS
TH_1776|M.thermoresistible__bu      --------------------------------------------------
Mflv_0735|M.gilvum_PYR-GCK          ---------MPFSGRELSGAWNFRDV--SEPAG-IAPGHLFRSSELSKLD
Mvan_0115|M.vanbaalenii_PYR-1       ---------MAAAGDELSGAWNFRDV--SEQTG-VAPGRFFRASELSKLD
MAB_4591|M.abscessus_ATCC_1997      MTISSAESKASPADNPVEGIWNFRDVGGADSPVTIRPGVLFRSSELSGLT
                                                                                      

Rv0153c|M.tuberculosis_H37Rv        DAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDD
Mb0158c|M.bovis_AF2122/97           DAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDD
MMAR_0373|M.marinum_M               DQGRAALRRFKITDVADLRSSREVARRGPGQVPAGVDVHLLPFPDLADDQ
MUL_4739|M.ulcerans_Agy99           DQGRAALRRFKITDVADLRSSREVARRGPGQVPAGVDVHLLPFPDLADDQ
MAV_5145|M.avium_104                DEGRATLRRLGITDVADLRAAREVARRGPGRVPDGVEVHLLPFPDLGEHE
MSMEG_0100|M.smegmatis_MC2_155      DDGRAVFKRLGITDVADLRSHQEVQRRGPGQVPDGVAVHLLPFHPDDTSG
TH_1776|M.thermoresistible__bu      -------------------------------VPDDVVIHQLPFPDQSSVD
Mflv_0735|M.gilvum_PYR-GCK          DDGRGALIGFGVTDVADLRTARELERHGPGRVPTEVEVHHLPFVETMAAD
Mvan_0115|M.vanbaalenii_PYR-1       DTGRAALKGLGVTDVADLRTSRELERHGPGLVPAGVEIHHLPFVETMAAD
MAB_4591|M.abscessus_ATCC_1997      PAGAQTLRAFGVTDLYDLRSPTEIARTGSDRVDGGIRVHEVPFATPAAGE
                                                                   *   : :* :**       

Rv0153c|M.tuberculosis_H37Rv        A--DDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPT
Mb0158c|M.bovis_AF2122/97           A--DDSAPHETAFKRLLTNGGSNGESGESSQSINDAATRYMTDEYRQFPT
MMAR_0373|M.marinum_M               AGTDDNAPHETAFKRLLT----DGDAGESSEAIDQVAARYMADEYRQFPM
MUL_4739|M.ulcerans_Agy99           AGTDDNAPHETAFKGLLT----DGDAGESSEAIDQVAARYMADEYRQFPM
MAV_5145|M.avium_104                AGTDDQAPHEHAFQRLLT----GDGAEQSAESVDEAATRYMIDEYRQFPT
MSMEG_0100|M.smegmatis_MC2_155      Q----DAPHESTFQRVMS-------ESPDGEDVTESARRYMTEVYEEFPT
TH_1776|M.thermoresistible__bu      G----EAPHESAFRRMMS-------EQPADGDVSAAARRYMTSAYKEFPT
Mflv_0735|M.gilvum_PYR-GCK          G----ESPHEHAFQRMMT-------DKPDGEPIAEAAARYMSEEYGRIAT
Mvan_0115|M.vanbaalenii_PYR-1       G----ESPHEHAFQRMMT-------DKPDDEPVADAAARYMTEEYGRIAT
MAB_4591|M.abscessus_ATCC_1997      E----RAPHEIAYRQMMLES-----MTAGRGPDPASQVEFMLAEYRRFPE
                                          :*** ::: ::                     .:*   * .:. 

Rv0153c|M.tuberculosis_H37Rv        RNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVI
Mb0158c|M.bovis_AF2122/97           RNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVI
MMAR_0373|M.marinum_M               RTGAQRAVHRVFTLLAAGRPVLTHCFAGKDRTGFVVATVLEAVGVDREVI
MUL_4739|M.ulcerans_Agy99           RTGAQRAVHRVFTLLAAGRPVLTHCFAGKDRTGFVVATVLEAVGVDREVI
MAV_5145|M.avium_104                RNGAQRALHRVISLLAAGRAVLTHCFAGKDRTGFVVATVLEAVGVDRDVI
MSMEG_0100|M.smegmatis_MC2_155      LPGAHNAVRQVVSLLAAGRPVIAHCFAGKDRTGFTVATVLDAAGVDRDDI
TH_1776|M.thermoresistible__bu      LRGARRAVQQVVSLLIDGRPVIAHCFAGKDRTGFTVATVLAAAGVDRDAV
Mflv_0735|M.gilvum_PYR-GCK          APLAQRAVHRVVTLLGSGRSVLAHCFAGKDRTGFTVAVVLEAAGVDRDAI
Mvan_0115|M.vanbaalenii_PYR-1       APFARRAVHRVVNLLGSERAVLAHCFAGKDRTGFTIAVVLEAAGVDRDAI
MAB_4591|M.abscessus_ATCC_1997      LPGTLVALKAVVDQLSSGATALVHCAAGKDRTGLLVGLLLSSVGVDYADI
                                       :  *:: *.  *    ..:.** *******: :. :* :.*:*   :

Rv0153c|M.tuberculosis_H37Rv        VADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVR
Mb0158c|M.bovis_AF2122/97           VADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVR
MMAR_0373|M.marinum_M               LADYLRSNDAVPQLRDRISEMIRERTDVELTPEVVTFTKARLSDGVLGVR
MUL_4739|M.ulcerans_Agy99           LADYLRSNDAVPQLRDRVSEMIRERTDVELTPEVVTFTKARLSDGVLGVR
MAV_5145|M.avium_104                VADFLRSNDAAPALRAQISAMIAQRQDTELTPEVVTWTEARLSDGVLGVR
MSMEG_0100|M.smegmatis_MC2_155      FADFLRSNEAITPLRNRIMDSVRAR--SGDEPEIITFAEARLTDEVLGVR
TH_1776|M.thermoresistible__bu      MADYLRSNDAVPQLRGRILSWIRDR--YADTPELETLAEARLTDAVLGVE
Mflv_0735|M.gilvum_PYR-GCK          MADYLRSNEAVPQLRESILETIRVR--AAEAPEIMEFAEARLTDSVLGVR
Mvan_0115|M.vanbaalenii_PYR-1       MADYLRSNVAVPRLRESILATVRER--AVDAPEIMELAEARLTDAVLGVR
MAB_4591|M.abscessus_ATCC_1997      AADYLRSNAAIGAMRAHISAQMNAA-----EPELAQTMAAMLSDEVLGVR
                                     **:**** :   :*  :   :         **:     * *:* ****.

Rv0153c|M.tuberculosis_H37Rv        AEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
Mb0158c|M.bovis_AF2122/97           AEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
MMAR_0373|M.marinum_M               PEYLAAAWQTIDETFGSLDGYLADSGITEADRHQLRSALLG
MUL_4739|M.ulcerans_Agy99           PEYLAAAWQTIDETFGSLDGYLADSGITEADRHQLRSALLG
MAV_5145|M.avium_104                EEYLAAARQTIDEKFGSLQAYLRDAGVGEADVQRLRAALLA
MSMEG_0100|M.smegmatis_MC2_155      EEYLAAAWKRLEEAYGSLSGFMTAAGISPEELTALRDALR-
TH_1776|M.thermoresistible__bu      EDYLAISWRTIDEEFGSLSNFLSAADVSADDVARLRDVLLG
Mflv_0735|M.gilvum_PYR-GCK          EDYLDVARRTLEAEFGSLRDYLESAGVTDEDLARLRRVLHG
Mvan_0115|M.vanbaalenii_PYR-1       EEYLDSARRTIDDQFGSLTGYLESADVTDEDIRRLRKVLLG
MAB_4591|M.abscessus_ATCC_1997      EEYLDTGFRQVANVFGSPEAMLVAAGVDDDGLTALRAALT-
                                     :**  . : :   :**    :  :.:       :* .*

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv0153c	ptbB	-	100% (276)	PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase)