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MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVP DGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNGGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQ RALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQR FDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0158c | ptbB | - | 100% (276) | phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0735 | - | 1e-76 | 55.31% (273) | protein tyrosine/serine phosphatase |
| M. tuberculosis H37Rv | Rv0153c | ptbB | 1e-154 | 99.64% (276) | phosphotyrosine protein phosphatase PTPB |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4591 | - | 6e-49 | 42.38% (269) | putative phosphotyrosine protein phosphatase |
| M. marinum M | MMAR_0373 | ptpB | 1e-118 | 78.47% (274) | phosphotyrosine protein phosphatase PtpB |
| M. avium 104 | MAV_5145 | - | 1e-116 | 76.45% (276) | phosphotyrosine protein phosphatase ptpb |
| M. smegmatis MC2 155 | MSMEG_0100 | - | 5e-79 | 56.67% (270) | phosphotyrosine protein phosphatase ptpb |
| M. thermoresistible (build 8) | TH_1776 | - | 4e-55 | 52.63% (209) | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB |
| M. ulcerans Agy99 | MUL_4739 | ptpB | 1e-117 | 77.74% (274) | phosphotyrosine protein phosphatase PtpB |
| M. vanbaalenii PYR-1 | Mvan_0115 | - | 4e-77 | 54.41% (272) | protein tyrosine/serine phosphatase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0158c|M.bovis_AF2122/97 ---------MAVR--ELPGAWNFRDV--ADTATALRPGRLFRSSELSRLD
Rv0153c|M.tuberculosis_H37Rv ---------MAVR--ELPGAWNFRDV--ADTATALRPGRLFRSSELSRLD
MMAR_0373|M.marinum_M ---------MAETGPELPGAWNFRDV--ADSTAALRPGRLFRSSELSGLD
MUL_4739|M.ulcerans_Agy99 ---------MAETGPELPGAWNFRDV--ADSTAALRPGRLFRSSELSGLD
MAV_5145|M.avium_104 ---------MPEALRELSGAWNFRDV--ADGAPMLRPGRLFRSGELSGLD
MSMEG_0100|M.smegmatis_MC2_155 ------MTGPDGTSLELGGAWNFRDV--AQETG-IRPGVLYRSSELSKLS
TH_1776|M.thermoresistible__bu --------------------------------------------------
Mflv_0735|M.gilvum_PYR-GCK ---------MPFSGRELSGAWNFRDV--SEPAG-IAPGHLFRSSELSKLD
Mvan_0115|M.vanbaalenii_PYR-1 ---------MAAAGDELSGAWNFRDV--SEQTG-VAPGRFFRASELSKLD
MAB_4591|M.abscessus_ATCC_1997 MTISSAESKASPADNPVEGIWNFRDVGGADSPVTIRPGVLFRSSELSGLT
Mb0158c|M.bovis_AF2122/97 DAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDD
Rv0153c|M.tuberculosis_H37Rv DAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDD
MMAR_0373|M.marinum_M DQGRAALRRFKITDVADLRSSREVARRGPGQVPAGVDVHLLPFPDLADDQ
MUL_4739|M.ulcerans_Agy99 DQGRAALRRFKITDVADLRSSREVARRGPGQVPAGVDVHLLPFPDLADDQ
MAV_5145|M.avium_104 DEGRATLRRLGITDVADLRAAREVARRGPGRVPDGVEVHLLPFPDLGEHE
MSMEG_0100|M.smegmatis_MC2_155 DDGRAVFKRLGITDVADLRSHQEVQRRGPGQVPDGVAVHLLPFHPDDTSG
TH_1776|M.thermoresistible__bu -------------------------------VPDDVVIHQLPFPDQSSVD
Mflv_0735|M.gilvum_PYR-GCK DDGRGALIGFGVTDVADLRTARELERHGPGRVPTEVEVHHLPFVETMAAD
Mvan_0115|M.vanbaalenii_PYR-1 DTGRAALKGLGVTDVADLRTSRELERHGPGLVPAGVEIHHLPFVETMAAD
MAB_4591|M.abscessus_ATCC_1997 PAGAQTLRAFGVTDLYDLRSPTEIARTGSDRVDGGIRVHEVPFATPAAGE
* : :* :**
Mb0158c|M.bovis_AF2122/97 A--DDSAPHETAFKRLLTNGGSNGESGESSQSINDAATRYMTDEYRQFPT
Rv0153c|M.tuberculosis_H37Rv A--DDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPT
MMAR_0373|M.marinum_M AGTDDNAPHETAFKRLLT----DGDAGESSEAIDQVAARYMADEYRQFPM
MUL_4739|M.ulcerans_Agy99 AGTDDNAPHETAFKGLLT----DGDAGESSEAIDQVAARYMADEYRQFPM
MAV_5145|M.avium_104 AGTDDQAPHEHAFQRLLT----GDGAEQSAESVDEAATRYMIDEYRQFPT
MSMEG_0100|M.smegmatis_MC2_155 Q----DAPHESTFQRVMS-------ESPDGEDVTESARRYMTEVYEEFPT
TH_1776|M.thermoresistible__bu G----EAPHESAFRRMMS-------EQPADGDVSAAARRYMTSAYKEFPT
Mflv_0735|M.gilvum_PYR-GCK G----ESPHEHAFQRMMT-------DKPDGEPIAEAAARYMSEEYGRIAT
Mvan_0115|M.vanbaalenii_PYR-1 G----ESPHEHAFQRMMT-------DKPDDEPVADAAARYMTEEYGRIAT
MAB_4591|M.abscessus_ATCC_1997 E----RAPHEIAYRQMMLES-----MTAGRGPDPASQVEFMLAEYRRFPE
:*** ::: :: .:* * .:.
Mb0158c|M.bovis_AF2122/97 RNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVI
Rv0153c|M.tuberculosis_H37Rv RNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVI
MMAR_0373|M.marinum_M RTGAQRAVHRVFTLLAAGRPVLTHCFAGKDRTGFVVATVLEAVGVDREVI
MUL_4739|M.ulcerans_Agy99 RTGAQRAVHRVFTLLAAGRPVLTHCFAGKDRTGFVVATVLEAVGVDREVI
MAV_5145|M.avium_104 RNGAQRALHRVISLLAAGRAVLTHCFAGKDRTGFVVATVLEAVGVDRDVI
MSMEG_0100|M.smegmatis_MC2_155 LPGAHNAVRQVVSLLAAGRPVIAHCFAGKDRTGFTVATVLDAAGVDRDDI
TH_1776|M.thermoresistible__bu LRGARRAVQQVVSLLIDGRPVIAHCFAGKDRTGFTVATVLAAAGVDRDAV
Mflv_0735|M.gilvum_PYR-GCK APLAQRAVHRVVTLLGSGRSVLAHCFAGKDRTGFTVAVVLEAAGVDRDAI
Mvan_0115|M.vanbaalenii_PYR-1 APFARRAVHRVVNLLGSERAVLAHCFAGKDRTGFTIAVVLEAAGVDRDAI
MAB_4591|M.abscessus_ATCC_1997 LPGTLVALKAVVDQLSSGATALVHCAAGKDRTGLLVGLLLSSVGVDYADI
: *:: *. * ..:.** *******: :. :* :.*:* :
Mb0158c|M.bovis_AF2122/97 VADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVR
Rv0153c|M.tuberculosis_H37Rv VADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVR
MMAR_0373|M.marinum_M LADYLRSNDAVPQLRDRISEMIRERTDVELTPEVVTFTKARLSDGVLGVR
MUL_4739|M.ulcerans_Agy99 LADYLRSNDAVPQLRDRVSEMIRERTDVELTPEVVTFTKARLSDGVLGVR
MAV_5145|M.avium_104 VADFLRSNDAAPALRAQISAMIAQRQDTELTPEVVTWTEARLSDGVLGVR
MSMEG_0100|M.smegmatis_MC2_155 FADFLRSNEAITPLRNRIMDSVRAR--SGDEPEIITFAEARLTDEVLGVR
TH_1776|M.thermoresistible__bu MADYLRSNDAVPQLRGRILSWIRDR--YADTPELETLAEARLTDAVLGVE
Mflv_0735|M.gilvum_PYR-GCK MADYLRSNEAVPQLRESILETIRVR--AAEAPEIMEFAEARLTDSVLGVR
Mvan_0115|M.vanbaalenii_PYR-1 MADYLRSNVAVPRLRESILATVRER--AVDAPEIMELAEARLTDAVLGVR
MAB_4591|M.abscessus_ATCC_1997 AADYLRSNAAIGAMRAHISAQMNAA-----EPELAQTMAAMLSDEVLGVR
**:**** : :* : : **: * *:* ****.
Mb0158c|M.bovis_AF2122/97 AEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
Rv0153c|M.tuberculosis_H37Rv AEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
MMAR_0373|M.marinum_M PEYLAAAWQTIDETFGSLDGYLADSGITEADRHQLRSALLG
MUL_4739|M.ulcerans_Agy99 PEYLAAAWQTIDETFGSLDGYLADSGITEADRHQLRSALLG
MAV_5145|M.avium_104 EEYLAAARQTIDEKFGSLQAYLRDAGVGEADVQRLRAALLA
MSMEG_0100|M.smegmatis_MC2_155 EEYLAAAWKRLEEAYGSLSGFMTAAGISPEELTALRDALR-
TH_1776|M.thermoresistible__bu EDYLAISWRTIDEEFGSLSNFLSAADVSADDVARLRDVLLG
Mflv_0735|M.gilvum_PYR-GCK EDYLDVARRTLEAEFGSLRDYLESAGVTDEDLARLRRVLHG
Mvan_0115|M.vanbaalenii_PYR-1 EEYLDSARRTIDDQFGSLTGYLESADVTDEDIRRLRKVLLG
MAB_4591|M.abscessus_ATCC_1997 EEYLDTGFRQVANVFGSPEAMLVAAGVDDDGLTALRAALT-
:** . : : :** : :.: :* .*