For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MAILRGRAPLRLGLGGGGTDVEPYSSQFGGRILSVTIDKYAYAFAERGTGDEIAFRSPDRDRAGQASIDD LASLEEDFPLHVAVYRRVIAEFNGGTPFPLQLATQVDAPPGSGLGSSSALVVAMLLTTCALIGSSPGPYE LARLAWEIERVDLGMAGGWQDHYAAAFGGFNFMESRPNGEVVVNPLRIRREVIAELEASLLLYFGGVSRL SSEVIADQQRNVVERDADALAATHSICAEALEMKDLLVVGDIPGFADSLLRGWQAKKRTSTRISNPAIEH AYQVAQSSGMVAGKVSGAGGGGFLMMIVDPRRRIEVARSLERECGGSVAPCLFTKGGAVTWHIPESTAPV RRGVADAVASALGNAGILLCAGCVLATSHSTWRVPV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0115 | hddA | - | 100% (386) | POSSIBLE D-ALPHA-D-HEPTOSE-7-PHOSPHATE KINASE HDDA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0119 | - | 1e-154 | 98.55% (275) | sugar kinase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3217 | erg12 | 1e-07 | 25.55% (227) | mevalonate kinase, Erg12 |
| M. avium 104 | MAV_1118 | - | 6e-58 | 39.64% (338) | D-glycero-D-manno-heptose 7-phosphate kinase |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3525 | erg12 | 4e-07 | 26.26% (198) | mevalonate kinase, Erg12 |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0115|M.tuberculosis_H37Rv -----------------------------MAILRGRAPLRLGLGGGGTDV
Mb0119|M.bovis_AF2122/97 --------------------------------------------------
MAV_1118|M.avium_104 ---------------------------MTRPRIRARAPLRISFAGGGTDV
MMAR_3217|M.marinum_M ---------------------------MSHPAMKARSRSGVGTATGKAIV
MUL_3525|M.ulcerans_Agy99 MVPHRIRRRPSRFRPVHARDLLAIGQQVSHPAMKARSRSGVGTATGKAIV
Rv0115|M.tuberculosis_H37Rv E-PYSSQFGGRILSVTIDKYAY-AFAERGTGDEIAFRSPDRDRAGQASID
Mb0119|M.bovis_AF2122/97 -------------------MRS-PFARR------TATEPARPRS---TIW
MAV_1118|M.avium_104 P-PFPTTEGGCVLSATIDRYAQGSLAPR-TDRRVSIESVDFKTTHEMTLD
MMAR_3217|M.marinum_M LGEHLVVHGAAALAIPIPILVETATAHR---------GPSPTPVRQPTVG
MUL_3525|M.ulcerans_Agy99 LGEHLVVHGAAALAIPIPILVETATAHR---------GPAPTPVRQPTVG
. * * ::
Rv0115|M.tuberculosis_H37Rv DLASLEEDFPLHVAVYRRVIAEFNGGTPFPLQLATQVDAPPGSGLGSSSA
Mb0119|M.bovis_AF2122/97 RLS--KKTLPLHVAVYRRVIAEFNGGTPFPLQLATQVDAPPGSGLGSSSA
MAV_1118|M.avium_104 SEILYDGSLDLIKAAVRRFGRDGTDG----YDLVLRSSAPPGSGLGSSST
MMAR_3217|M.marinum_M SMGPDMALLISDFAERFDVPAAVASG----VVVEVSHVVPCGRGLGSSAA
MUL_3525|M.ulcerans_Agy99 SMGLDMASLISDFAERFDVPAAVASG----VVVEVSHVVPCGRGLGSSAA
: * . .* : .* * *****::
Rv0115|M.tuberculosis_H37Rv LVVAMLLTTCALIGSSPGPYELARLAWEIERVDLGMAGGWQDHYAAAFGG
Mb0119|M.bovis_AF2122/97 LVVAMLLTTCALIGSSPGPYELARLAWEIERVDLGMAGGWQDHYAAAFGG
MAV_1118|M.avium_104 MMVALTGLLAEHYRVPMGEYETAQLACAIEREDLGIAGGMQDMYAATFGG
MMAR_3217|M.marinum_M VVRAVVLALADLFECEPSAAQVYQLVQSRERTAHGTPSGVDAAATGADGP
MUL_3525|M.ulcerans_Agy99 VVRAVVLALADLFECEPSAAQVYELVQSRERTAHGTPSGVDAAATGADEP
:: *: . . : .*. ** * ..* : :.:
Rv0115|M.tuberculosis_H37Rv FNFMESRPNGEVVVNPLRIRREVIAELEASLLLYFGGVSRLSSEVIADQQ
Mb0119|M.bovis_AF2122/97 FNFMESRPNGEVVVNPLRIRREVIAELEASLLLYFGGVSRLSSEVIADQQ
MAV_1118|M.avium_104 FNFIEFTDR--VIVNPLRIRDETAFELELSLLLCYTGITRDSARVIEDQT
MMAR_3217|M.marinum_M IVFCR------GAVRPVSPAPVGVFVVADSGEISATKDSVAEVAAILTAD
MUL_3525|M.ulcerans_Agy99 IVFHR------GAVRPVSPAPVGVFVVADSGEISATKDSVAEVAAILTAD
: * . *.*: : * : : . .*
Rv0115|M.tuberculosis_H37Rv RNVVERDADALAATHSICAEALEMKDLLVVGDIPGFADSLLRGWQAKKRT
Mb0119|M.bovis_AF2122/97 RNVVERDADALAATHSICAEALEMKDLLVVGDIPGFADSLLRGWQAKKRT
MAV_1118|M.avium_104 RRATTGSDDTLAGLRAQKELAVAMKAALLTGKLNDFGALLGEAWTEKKRM
MMAR_3217|M.marinum_M RDGLARRDWLVEQLDALVACAAID---LQQGNLSALGAAMARNHDLLRGL
MUL_3525|M.ulcerans_Agy99 RDGLARRDWLVEQLDALVGRAAID---MQQGDLTALGAAMARNHDLLRGL
* : : * : *.: :. : . :
Rv0115|M.tuberculosis_H37Rv STRISNPAIEHAYQVAQSSGMVAGKVSGAGGGGFLMMIVDPRRRIEVARS
Mb0119|M.bovis_AF2122/97 STRISNPAIEHAYQVAQSSGMVAGKVSGAGGGGFLMMIVDPRRRIEVARS
MAV_1118|M.avium_104 SPYITNERIDDLYELALKNGALGGKLTGAGGGGYILLFCDFAKKHRLIEA
MMAR_3217|M.marinum_M N--LSTPRLEGLIEAANTSGAMGAKLTGGGRGGCVLALARDWVQAQVIGE
MUL_3525|M.ulcerans_Agy99 N--LSTPRLEGLIEAANTSGAMGAKLTGSGRGGCALALARDWVHAQVIGE
. ::. :: : * ..* :..*::*.* ** : : : .:
Rv0115|M.tuberculosis_H37Rv LERECGGSVAPCLFTKGGAVTWHIPESTAPVRRGVADAVASALGNAGILL
Mb0119|M.bovis_AF2122/97 LERECGGSVAPCLFTKGGAVTWHIPESTAPRK------------------
MAV_1118|M.avium_104 LEG-AGAAVTEFAFESKGLTTWQA--------------------------
MMAR_3217|M.marinum_M AMRKAGAVATWAVALDSFAGRLTAGASGREVGS-----------------
MUL_3525|M.ulcerans_Agy99 AMLKAGAVATWAVAVDSFAGRLTASASGREVAP-----------------
.*. .: .
Rv0115|M.tuberculosis_H37Rv CAGCVLATSHSTWRVPV
Mb0119|M.bovis_AF2122/97 -----------AWSC--
MAV_1118|M.avium_104 -----------------
MMAR_3217|M.marinum_M -----------------
MUL_3525|M.ulcerans_Agy99 -----------------