For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SHPAMKARSRSGVGTATGKAIVLGEHLVVHGAAALAIPIPILVETATAHRGPSPTPVRQPTVGSMGPDMA LLISDFAERFDVPAAVASGVVVEVSHVVPCGRGLGSSAAVVRAVVLALADLFECEPSAAQVYQLVQSRER TAHGTPSGVDAAATGADGPIVFCRGAVRPVSPAPVGVFVVADSGEISATKDSVAEVAAILTADRDGLARR DWLVEQLDALVACAAIDLQQGNLSALGAAMARNHDLLRGLNLSTPRLEGLIEAANTSGAMGAKLTGGGRG GCVLALARDWVQAQVIGEAMRKAGAVATWAVALDSFAGRLTAGASGREVGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3217 | erg12 | - | 100% (332) | mevalonate kinase, Erg12 |
| M. marinum M | MMAR_0941 | galK | 1e-08 | 27.13% (247) | galactokinase, GalK |
| M. marinum M | MMAR_3215 | - | 8e-08 | 24.71% (348) | phosphomevalonate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0636 | galK | 9e-11 | 28.63% (255) | galactokinase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0620 | galK | 9e-11 | 28.63% (255) | galactokinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4638 | - | 2e-16 | 27.59% (348) | galactokinase (GalK) |
| M. avium 104 | MAV_4564 | galK | 2e-14 | 27.78% (360) | galactokinase |
| M. smegmatis MC2 155 | MSMEG_3692 | galK | 1e-10 | 24.78% (343) | galactokinase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3525 | erg12 | 1e-173 | 94.85% (330) | mevalonate kinase, Erg12 |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0636|M.bovis_AF2122/97 -------------------------MTVSYGAPGRVNLIGEHTDYNLGFA
Rv0620|M.tuberculosis_H37Rv -------------------------MTVSYGAPGRVNLIGEHTDYNLGFA
MAV_4564|M.avium_104 -------------------------MTVRYAAPGRINLIGEHTDYNLGFA
MSMEG_3692|M.smegmatis_MC2_155 -----------------------MGDTVTYAAPGRINLIGEHTDYNLGLA
MAB_4638|M.abscessus_ATCC_1997 -------------------------MTGTWSAPGRVNVIGEHTDYNGGLS
MMAR_3217|M.marinum_M ---------------------------MSHPAMKARSRSGVGTATGKAIV
MUL_3525|M.ulcerans_Agy99 MVPHRIRRRPSRFRPVHARDLLAIGQQVSHPAMKARSRSGVGTATGKAIV
* . * * . .:
Mb0636|M.bovis_AF2122/97 LPIALPRRTVVTFTPEHTGAITARSDRADGS-ARIPLDTTPG-QVTGWAA
Rv0620|M.tuberculosis_H37Rv LPIALPRRTVVTFTPEHTGAITARSDRADGS-ARIPLDTTPG-QVTGWAA
MAV_4564|M.avium_104 LPIALPQRTVASFTPADDDAITVVSDRADAP-VRIPIDTGPG-DVTGWAA
MSMEG_3692|M.smegmatis_MC2_155 LPIALPQRVVVRYQPDDSEAITVSSAQESGD-VVVPLDTTPG-DITGWAA
MAB_4638|M.abscessus_ATCC_1997 LPIAIPQHVDCTLTPRDDQTVRVTSQQHGRDWVEVPLDRLAHTDIVSWAR
MMAR_3217|M.marinum_M LGEHLVVHGAAALAIPIPILVETATAHRGPSPTPVRQPTVGS-MGPDMAL
MUL_3525|M.ulcerans_Agy99 LGEHLVVHGAAALAIPIPILVETATAHRGPAPTPVRQPTVGS-MGLDMAS
* : : : . : : . . : . *
Mb0636|M.bovis_AF2122/97 YAAGAIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAA
Rv0620|M.tuberculosis_H37Rv YAAGAIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAA
MAV_4564|M.avium_104 YPAGVMWALRTAGHPVPGGAMSITSDVPMGSGLSSSAALECAVLGAISSA
MSMEG_3692|M.smegmatis_MC2_155 YIAGVVWALRDRGHRVEGGRMSITSDVEMGSGLASSAALECAVLSAL--T
MAB_4638|M.abscessus_ATCC_1997 YPLGVVHEFVKRGNDIHGMDLRLDGDVPVGAGLSSSAAVECAVAAAIRDT
MMAR_3217|M.marinum_M LISDFAERFDVPAAVASGVVVEVSHVVPCGRGLGSSAAVVRAVVLALADL
MUL_3525|M.ulcerans_Agy99 LISDFAERFDVPAAVASGVVVEVSHVVPCGRGLGSSAAVVRAVVLALADL
. : . * : : * * **.****: ** *:
Mb0636|M.bovis_AF2122/97 TGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPKTALLIDFRDI
Rv0620|M.tuberculosis_H37Rv TGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPKTALLIDFRDI
MAV_4564|M.avium_104 AGIRIDATEQARLAQRAENEYVGAPTGLLDQLAALYGRPAAAVLIDFADL
MSMEG_3692|M.smegmatis_MC2_155 HGSDMDRVEQARIAQCAENVYVGAPTGLMDQLASLFGEPGRAMLIDFREL
MAB_4638|M.abscessus_ATCC_1997 FATELSDSELVDITHRAENDFVGAPTGLLDQSASILCTAGHALFLDAETG
MMAR_3217|M.marinum_M FECEPSAAQVYQLVQSRERTAHGTPSG-VDAAATGADGP-----IVFCRG
MUL_3525|M.ulcerans_Agy99 FECEPSAAQVYELVQSRERTAHGTPSG-VDAAATGADEP-----IVFHRG
. : :.: *. *:*:* :* *: . :
Mb0636|M.bovis_AF2122/97 TVRPVAFDPDACDVVLLLMDSRARHRHAGGEYALRRASCERAAADLGVSS
Rv0620|M.tuberculosis_H37Rv TVRPVAFDPDACDVVLLLMDSRARHCHAGGEYALRRASCERAAADLGVSS
MAV_4564|M.avium_104 AVTPVAFDPDAAGVALLLIDSRERHTHAGGDYAARRLSCERAAADLSASS
MSMEG_3692|M.smegmatis_MC2_155 SVHQVPFTPETAGLTLLVMNSRAPHRHAAGEYAARRASCERVAAALGVES
MAB_4638|M.abscessus_ATCC_1997 AHTQVPFDLAAAGLELVVIDTGTRHNHVTSEYATRRQQCQTAASLLEVHS
MMAR_3217|M.marinum_M AVRPVSPAPVG---VFVVADS--------GEISATKDSVAEVAAILTAD-
MUL_3525|M.ulcerans_Agy99 AVRPVSPAPVG---VFVVADS--------GEISATKDSVAEVAAILTAD-
: *. ::: :: .: : : . .*: * .
Mb0636|M.bovis_AF2122/97 LRAVQDRGLAALGAIADPIDARRARHVLTENQRVLDFAAALADS-DFTAA
Rv0620|M.tuberculosis_H37Rv LRAVQDRGLAALGAIADPIDARRARHVLTENQRVLDFAAALADS-DFTAA
MAV_4564|M.avium_104 LRAAADRGCTDLAAVRDPVDARRARHVLTENGRVIDCVAALNNS-DYTEA
MSMEG_3692|M.smegmatis_MC2_155 LREVQDRGLDALDAVTDDEDFRRARHILTENQRVLDVVAALEQS-DFATA
MAB_4638|M.abscessus_ATCC_1997 LSAVTDAG--VLDTVADPMLRARARHVVTENARVREVVAILQSGRDPRSI
MMAR_3217|M.marinum_M ----------------RDGLARRDWLVEQLDALVACAAIDLQQG-NLSAL
MUL_3525|M.ulcerans_Agy99 ----------------RDGLARRDWLVEQLDALVGRAAIDMQQG-DLTAL
* : : * . : .. :
Mb0636|M.bovis_AF2122/97 GQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAVIA
Rv0620|M.tuberculosis_H37Rv GQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAVIA
MAV_4564|M.avium_104 GRIFTASHASMRDDFGITTERIDLIADTALRAGALGARMTGGGFGGCVIA
MSMEG_3692|M.smegmatis_MC2_155 GEILTASHASMRDDFEITTAHIDLIADTAVRAGALGARLTGGGFGGCVIA
MAB_4638|M.abscessus_ATCC_1997 GPILTRGHGSLRDDFAVSTPQLDAAVEASCDSGAHGARMTGGGFGGSVIA
MMAR_3217|M.marinum_M GAAMARNHDLLRG-LNLSTPRLEGLIEAANTSGAMGAKLTGGGRGGCVLA
MUL_3525|M.ulcerans_Agy99 GAAMARNHDLLRG-LNLSTPRLEGLIEAANTSGAMGAKLTGSGRGGCALA
* :: .* :* : ::* ::: ::: :** **::**.* **..:*
Mb0636|M.bovis_AF2122/97 LVPADR-ARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECC----
Rv0620|M.tuberculosis_H37Rv LVPADR-ARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECR----
MAV_4564|M.avium_104 LAPVQR-AEAIGQAVRRAATQAGFAQPVVTRTRAAAGAGPCR----
MSMEG_3692|M.smegmatis_MC2_155 LVPEDL-ADSVAETVRSTVVAAGHPEPTISRAQAAPGAGIV-----
MAB_4638|M.abscessus_ATCC_1997 LAEADS-SARIGTAVAQHFSAQHWPIPQVFVVTPSDGARRIR----
MMAR_3217|M.marinum_M LARDWVQAQVIGEAMRKAGAVATWAVALDSFAGRLTAGASGREVGS
MUL_3525|M.ulcerans_Agy99 LARDWVHAQVIGEAMLKAGAVATWAVAVDSFAGRLTASASGREVAP
*. : :. :: . . ..