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MTRPRIRARAPLRISFAGGGTDVPPFPTTEGGCVLSATIDRYAQGSLAPRTDRRVSIESVDFKTTHEMTL DSEILYDGSLDLIKAAVRRFGRDGTDGYDLVLRSSAPPGSGLGSSSTMMVALTGLLAEHYRVPMGEYETA QLACAIEREDLGIAGGMQDMYAATFGGFNFIEFTDRVIVNPLRIRDETAFELELSLLLCYTGITRDSARV IEDQTRRATTGSDDTLAGLRAQKELAVAMKAALLTGKLNDFGALLGEAWTEKKRMSPYITNERIDDLYEL ALKNGALGGKLTGAGGGGYILLFCDFAKKHRLIEALEGAGAAVTEFAFESKGLTTWQA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1118 | - | - | 100% (338) | D-glycero-D-manno-heptose 7-phosphate kinase |
| M. avium 104 | MAV_4564 | galK | 3e-11 | 24.19% (372) | galactokinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0119 | - | 7e-45 | 42.92% (240) | sugar kinase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0115 | hddA | 5e-58 | 39.64% (338) | D-alpha-D-heptose-7-phosphate kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4638 | - | 8e-08 | 22.29% (341) | galactokinase (GalK) |
| M. marinum M | MMAR_3217 | erg12 | 1e-07 | 29.60% (223) | mevalonate kinase, Erg12 |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3525 | erg12 | 2e-05 | 28.25% (223) | mevalonate kinase, Erg12 |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3217|M.marinum_M ---------------------------MSHPAMKARSRSGVGTATGKAIV
MUL_3525|M.ulcerans_Agy99 MVPHRIRRRPSRFRPVHARDLLAIGQQVSHPAMKARSRSGVGTATGKAIV
Mb0119|M.bovis_AF2122/97 --------------------------------------------------
Rv0115|M.tuberculosis_H37Rv -----------------------------MAILRGRAPLRLGLGGGGTDV
MAV_1118|M.avium_104 ---------------------------MTRPRIRARAPLRISFAGGGTDV
MAB_4638|M.abscessus_ATCC_1997 -------------------------------------MTGTWSAPGRVNV
MMAR_3217|M.marinum_M LGEHLVVHGAAALAIPIPILVETATAHRGPSPTPVRQPTVGSMGPDMALL
MUL_3525|M.ulcerans_Agy99 LGEHLVVHGAAALAIPIPILVETATAHRGPAPTPVRQPTVGSMGLDMASL
Mb0119|M.bovis_AF2122/97 -------------------MRSPFARR------TATEPARPRS---TIWR
Rv0115|M.tuberculosis_H37Rv E-PYSSQFGGRILSVTIDKYAYAFAERGTGDEIAFRSPDRDRAGQASIDD
MAV_1118|M.avium_104 P-PFPTTEGGCVLSATIDRYAQGSLAPRTDRRVSIESVDFKTTHEMTLDS
MAB_4638|M.abscessus_ATCC_1997 IGEHTDYNGGLSLPIAIPQHVDCTLTPRDDQTVRVTSQQHGRDWVEVPLD
.
MMAR_3217|M.marinum_M ISDFAERFDVP---AAVASGVVVE------------VSHVVPCGRGLGSS
MUL_3525|M.ulcerans_Agy99 ISDFAERFDVP---AAVASGVVVE------------VSHVVPCGRGLGSS
Mb0119|M.bovis_AF2122/97 LS--KKTLPLH---VAVYRRVIAEFNGGTPFPLQLATQVDAPPGSGLGSS
Rv0115|M.tuberculosis_H37Rv LASLEEDFPLH---VAVYRRVIAEFNGGTPFPLQLATQVDAPPGSGLGSS
MAV_1118|M.avium_104 EILYDGSLDLI---KAAVRRFGRDGTDG----YDLVLRSSAPPGSGLGSS
MAB_4638|M.abscessus_ATCC_1997 RLAHTDIVSWARYPLGVVHEFVKRGNDIHG--MDLRLDGDVPVGAGLSSS
. .. . .* * **.**
MMAR_3217|M.marinum_M AAVVRAVVLALADLFECEPSAAQVYQLVQSRERTAHGTPSGVDAAATGAD
MUL_3525|M.ulcerans_Agy99 AAVVRAVVLALADLFECEPSAAQVYELVQSRERTAHGTPSGVDAAATGAD
Mb0119|M.bovis_AF2122/97 SALVVAMLLTTCALIGSSPGPYELARLAWEIERVDLGMAGGWQDHYAAAF
Rv0115|M.tuberculosis_H37Rv SALVVAMLLTTCALIGSSPGPYELARLAWEIERVDLGMAGGWQDHYAAAF
MAV_1118|M.avium_104 STMMVALTGLLAEHYRVPMGEYETAQLACAIEREDLGIAGGMQDMYAATF
MAB_4638|M.abscessus_ATCC_1997 AAVECAVAAAIRDTFATELSDSELVDITHRAENDFVGAPTGLLDQSASIL
::: *: . : :. *. * . * :.
MMAR_3217|M.marinum_M G--PIVFCR------GAVRPVSPAPVGVFVVADSG---------EISATK
MUL_3525|M.ulcerans_Agy99 E--PIVFHR------GAVRPVSPAPVGVFVVADSG---------EISATK
Mb0119|M.bovis_AF2122/97 G--GFNFMESRPNGEVVVNPLRIRREVIAELEASL---------LLYFGG
Rv0115|M.tuberculosis_H37Rv G--GFNFMESRPNGEVVVNPLRIRREVIAELEASL---------LLYFGG
MAV_1118|M.avium_104 G--GFNFIEFTDR--VIVNPLRIRDETAFELELSL---------LLCYTG
MAB_4638|M.abscessus_ATCC_1997 CTAGHALFLDAETGAHTQVPFDLAAAGLELVVIDTGTRHNHVTSEYATRR
: *. : .
MMAR_3217|M.marinum_M DSVAEVAAILTADRDGLARRDWLVEQLDALVACAAID---LQQGNLSALG
MUL_3525|M.ulcerans_Agy99 DSVAEVAAILTADRDGLARRDWLVEQLDALVGRAAID---MQQGDLTALG
Mb0119|M.bovis_AF2122/97 VSRLSSEVIADQQRNVVERDADALAATHSICAEALEMKDLLVVGDIPGFA
Rv0115|M.tuberculosis_H37Rv VSRLSSEVIADQQRNVVERDADALAATHSICAEALEMKDLLVVGDIPGFA
MAV_1118|M.avium_104 ITRDSARVIEDQTRRATTGSDDTLAGLRAQKELAVAMKAALLTGKLNDFG
MAB_4638|M.abscessus_ATCC_1997 QQCQTAASLLEVHSLSAVTDAGVLDTVADPMLRARARHVVTENARVREVV
: : * . : .
MMAR_3217|M.marinum_M AAMARNHDLL------------RGLN--LSTPRLEGLIEAANTSGAMGAK
MUL_3525|M.ulcerans_Agy99 AAMARNHDLL------------RGLN--LSTPRLEGLIEAANTSGAMGAK
Mb0119|M.bovis_AF2122/97 DSLLRGWQAK------------KRTSTRISNPAIEHAYQVAQSSGMVAGK
Rv0115|M.tuberculosis_H37Rv DSLLRGWQAK------------KRTSTRISNPAIEHAYQVAQSSGMVAGK
MAV_1118|M.avium_104 ALLGEAWTEK------------KRMSPYITNERIDDLYELALKNGALGGK
MAB_4638|M.abscessus_ATCC_1997 AILQSGRDPRSIGPILTRGHGSLRDDFAVSTPQLDAAVEASCDSGAHGAR
: . ::. :: : : .* ..:
MMAR_3217|M.marinum_M LTGGGRGGCVLALARDWVQAQVIGEAMRKAGAVATWAVALDSFAGRLTAG
MUL_3525|M.ulcerans_Agy99 LTGSGRGGCALALARDWVHAQVIGEAMLKAGAVATWAVAVDSFAGRLTAS
Mb0119|M.bovis_AF2122/97 VSGAGGGGFLMMIVDPRRRIEVARSLERECGGSVAPCLFTKGGAVTWHIP
Rv0115|M.tuberculosis_H37Rv VSGAGGGGFLMMIVDPRRRIEVARSLERECGGSVAPCLFTKGGAVTWHIP
MAV_1118|M.avium_104 LTGAGGGGYILLFCDFAKKHRLIEALEG-AGAAVTEFAFESKGLTTWQA-
MAB_4638|M.abscessus_ATCC_1997 MTGGGFGGSVIALAEADSSARIGTAVAQHFSAQHWPIPQVFVVTPSDGAR
::*.* ** : : .: ..
MMAR_3217|M.marinum_M ASGREVGS----------------------------------
MUL_3525|M.ulcerans_Agy99 ASGREVAP----------------------------------
Mb0119|M.bovis_AF2122/97 ESTAPRK-----------------------------AWSC--
Rv0115|M.tuberculosis_H37Rv ESTAPVRRGVADAVASALGNAGILLCAGCVLATSHSTWRVPV
MAV_1118|M.avium_104 ------------------------------------------
MAB_4638|M.abscessus_ATCC_1997 RIR---------------------------------------