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VPHRIRRRPSRFRPVHARDLLAIGQQVSHPAMKARSRSGVGTATGKAIVLGEHLVVHGAAALAIPIPILV ETATAHRGPAPTPVRQPTVGSMGLDMASLISDFAERFDVPAAVASGVVVEVSHVVPCGRGLGSSAAVVRA VVLALADLFECEPSAAQVYELVQSRERTAHGTPSGVDAAATGADEPIVFHRGAVRPVSPAPVGVFVVADS GEISATKDSVAEVAAILTADRDGLARRDWLVEQLDALVGRAAIDMQQGDLTALGAAMARNHDLLRGLNLS TPRLEGLIEAANTSGAMGAKLTGSGRGGCALALARDWVHAQVIGEAMLKAGAVATWAVAVDSFAGRLTAS ASGREVAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3525 | erg12 | - | 100% (359) | mevalonate kinase, Erg12 |
| M. ulcerans Agy99 | MUL_0692 | galK | 9e-10 | 26.03% (315) | galactokinase |
| M. ulcerans Agy99 | MUL_3523 | - | 1e-09 | 25.29% (344) | phosphomevalonate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0636 | galK | 4e-11 | 27.25% (345) | galactokinase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0620 | galK | 5e-11 | 27.25% (345) | galactokinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4638 | - | 9e-16 | 27.86% (359) | galactokinase (GalK) |
| M. marinum M | MMAR_3217 | erg12 | 1e-172 | 94.85% (330) | mevalonate kinase, Erg12 |
| M. avium 104 | MAV_4564 | galK | 6e-13 | 27.33% (344) | galactokinase |
| M. smegmatis MC2 155 | MSMEG_3692 | galK | 2e-09 | 27.59% (232) | galactokinase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0636|M.bovis_AF2122/97 -------------------------MTVSYGAPGRVNLIGEHTDYNLGFA
Rv0620|M.tuberculosis_H37Rv -------------------------MTVSYGAPGRVNLIGEHTDYNLGFA
MAV_4564|M.avium_104 -------------------------MTVRYAAPGRINLIGEHTDYNLGFA
MSMEG_3692|M.smegmatis_MC2_155 -----------------------MGDTVTYAAPGRINLIGEHTDYNLGLA
MAB_4638|M.abscessus_ATCC_1997 -------------------------MTGTWSAPGRVNVIGEHTDYNGGLS
MUL_3525|M.ulcerans_Agy99 MVPHRIRRRPSRFRPVHARDLLAIGQQVSHPAMKARSRSGVGTATGKAIV
MMAR_3217|M.marinum_M ---------------------------MSHPAMKARSRSGVGTATGKAIV
* . * * . .:
Mb0636|M.bovis_AF2122/97 LPIALPRRTVVTFTPEHTGAITARSDRADGS-ARIPLDTTPG-QVTGWAA
Rv0620|M.tuberculosis_H37Rv LPIALPRRTVVTFTPEHTGAITARSDRADGS-ARIPLDTTPG-QVTGWAA
MAV_4564|M.avium_104 LPIALPQRTVASFTPADDDAITVVSDRADAP-VRIPIDTGPG-DVTGWAA
MSMEG_3692|M.smegmatis_MC2_155 LPIALPQRVVVRYQPDDSEAITVSSAQESGD-VVVPLDTTPG-DITGWAA
MAB_4638|M.abscessus_ATCC_1997 LPIAIPQHVDCTLTPRDDQTVRVTSQQHGRDWVEVPLDRLAHTDIVSWAR
MUL_3525|M.ulcerans_Agy99 LGEHLVVHGAAALAIPIPILVETATAHRGPAPTPVRQPTVGS-MGLDMAS
MMAR_3217|M.marinum_M LGEHLVVHGAAALAIPIPILVETATAHRGPSPTPVRQPTVGS-MGPDMAL
* : : : . : : . . : . *
Mb0636|M.bovis_AF2122/97 YAAGAIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAA
Rv0620|M.tuberculosis_H37Rv YAAGAIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAA
MAV_4564|M.avium_104 YPAGVMWALRTAGHPVPGGAMSITSDVPMGSGLSSSAALECAVLGAISSA
MSMEG_3692|M.smegmatis_MC2_155 YIAGVVWALRDRGHRVEGGRMSITSDVEMGSGLASSAALECAVLSAL--T
MAB_4638|M.abscessus_ATCC_1997 YPLGVVHEFVKRGNDIHGMDLRLDGDVPVGAGLSSSAAVECAVAAAIRDT
MUL_3525|M.ulcerans_Agy99 LISDFAERFDVPAAVASGVVVEVSHVVPCGRGLGSSAAVVRAVVLALADL
MMAR_3217|M.marinum_M LISDFAERFDVPAAVASGVVVEVSHVVPCGRGLGSSAAVVRAVVLALADL
. : . * : : * * **.****: ** *:
Mb0636|M.bovis_AF2122/97 TGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPKTALLIDFRDI
Rv0620|M.tuberculosis_H37Rv TGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPKTALLIDFRDI
MAV_4564|M.avium_104 AGIRIDATEQARLAQRAENEYVGAPTGLLDQLAALYGRPAAAVLIDFADL
MSMEG_3692|M.smegmatis_MC2_155 HGSDMDRVEQARIAQCAENVYVGAPTGLMDQLASLFGEPGRAMLIDFREL
MAB_4638|M.abscessus_ATCC_1997 FATELSDSELVDITHRAENDFVGAPTGLLDQSASILCTAGHALFLDAETG
MUL_3525|M.ulcerans_Agy99 FECEPSAAQVYELVQSRERTAHGTPSG-VDAAATGADEP-----IVFHRG
MMAR_3217|M.marinum_M FECEPSAAQVYQLVQSRERTAHGTPSG-VDAAATGADGP-----IVFCRG
. : :.: *. *:*:* :* *: . :
Mb0636|M.bovis_AF2122/97 TVRPVAFDPDACDVVLLLMDSRARHRHAGGEYALRRASCERAAADLGVSS
Rv0620|M.tuberculosis_H37Rv TVRPVAFDPDACDVVLLLMDSRARHCHAGGEYALRRASCERAAADLGVSS
MAV_4564|M.avium_104 AVTPVAFDPDAAGVALLLIDSRERHTHAGGDYAARRLSCERAAADLSASS
MSMEG_3692|M.smegmatis_MC2_155 SVHQVPFTPETAGLTLLVMNSRAPHRHAAGEYAARRASCERVAAALGVES
MAB_4638|M.abscessus_ATCC_1997 AHTQVPFDLAAAGLELVVIDTGTRHNHVTSEYATRRQQCQTAASLLEVHS
MUL_3525|M.ulcerans_Agy99 AVRPVSPAPVG---VFVVADS--------GEISATKDSVAEVAAILTAD-
MMAR_3217|M.marinum_M AVRPVSPAPVG---VFVVADS--------GEISATKDSVAEVAAILTAD-
: *. ::: :: .: : : . .*: * .
Mb0636|M.bovis_AF2122/97 LRAVQDRGLAALGAIADPIDARRARHVLTENQRVLDFAAALADS-DFTAA
Rv0620|M.tuberculosis_H37Rv LRAVQDRGLAALGAIADPIDARRARHVLTENQRVLDFAAALADS-DFTAA
MAV_4564|M.avium_104 LRAAADRGCTDLAAVRDPVDARRARHVLTENGRVIDCVAALNNS-DYTEA
MSMEG_3692|M.smegmatis_MC2_155 LREVQDRGLDALDAVTDDEDFRRARHILTENQRVLDVVAALEQS-DFATA
MAB_4638|M.abscessus_ATCC_1997 LSAVTDAG--VLDTVADPMLRARARHVVTENARVREVVAILQSGRDPRSI
MUL_3525|M.ulcerans_Agy99 ----------------RDGLARRDWLVEQLDALVGRAAIDMQQG-DLTAL
MMAR_3217|M.marinum_M ----------------RDGLARRDWLVEQLDALVACAAIDLQQG-NLSAL
* : : * . : .. :
Mb0636|M.bovis_AF2122/97 GQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAVIA
Rv0620|M.tuberculosis_H37Rv GQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAVIA
MAV_4564|M.avium_104 GRIFTASHASMRDDFGITTERIDLIADTALRAGALGARMTGGGFGGCVIA
MSMEG_3692|M.smegmatis_MC2_155 GEILTASHASMRDDFEITTAHIDLIADTAVRAGALGARLTGGGFGGCVIA
MAB_4638|M.abscessus_ATCC_1997 GPILTRGHGSLRDDFAVSTPQLDAAVEASCDSGAHGARMTGGGFGGSVIA
MUL_3525|M.ulcerans_Agy99 GAAMARNHDLLRG-LNLSTPRLEGLIEAANTSGAMGAKLTGSGRGGCALA
MMAR_3217|M.marinum_M GAAMARNHDLLRG-LNLSTPRLEGLIEAANTSGAMGAKLTGGGRGGCVLA
* :: .* :* : ::* ::: ::: :** **::**.* **..:*
Mb0636|M.bovis_AF2122/97 LVPADR-ARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECC----
Rv0620|M.tuberculosis_H37Rv LVPADR-ARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECR----
MAV_4564|M.avium_104 LAPVQR-AEAIGQAVRRAATQAGFAQPVVTRTRAAAGAGPCR----
MSMEG_3692|M.smegmatis_MC2_155 LVPEDL-ADSVAETVRSTVVAAGHPEPTISRAQAAPGAGIV-----
MAB_4638|M.abscessus_ATCC_1997 LAEADS-SARIGTAVAQHFSAQHWPIPQVFVVTPSDGARRIR----
MUL_3525|M.ulcerans_Agy99 LARDWVHAQVIGEAMLKAGAVATWAVAVDSFAGRLTASASGREVAP
MMAR_3217|M.marinum_M LARDWVQAQVIGEAMRKAGAVATWAVALDSFAGRLTAGASGREVGS
*. : :. :: . . ..