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MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLATTDRKLTPAWRTTIKRWFPGF MTFRFLECGLLTMVSNPLALRSDTDLERVLPVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLG FRPALGFSRVDTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPVLARLWRNVKT EAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAFFLNVWGADENYILLEWGIDRDFEHYRKANL YRAALMLSLKDAISRDKRRMEMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTL PDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYPRFTGPQRSTVKAAELGEIVL LGTNSYLGLATHPEVVEASAEATRRYGTGCSGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNL AAISALCESGDMIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGRRRIIVVDAVFSMEGT VADLATIAELADRHGCRVYVDESHALGVLGPDGRGASAALGVLARMDVVMGTFSKSFASVGGFIAGDRPV VDYIRHNGSGHVFSASLPPAAAAATHAALRVSRREPDRRARVLAAAEYMATGLARQGYQAEYHGTAIVPV ILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSGFRTSYLADHRQSDLDRALHVFAGLAEDLTPQGAA L
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0032 | bioF2 | - | 100% (771) | POSSIBLE 8-AMINO-7-OXONONANOATE SYNTHASE BIOF2 (AONS) (8-AMINO-7-KETOPELARGONATE SYNTHASE) (7-KETO-8-AMINO-PELARGONIC ACID SYNTHETASE) (7-KAP SYNTHETASE) (L-ALANINE--PIMELYL CoA LIGASE) |
| M. tuberculosis H37Rv | Rv1569 | bioF1 | 2e-54 | 39.17% (337) | 8-amino-7-oxononanoate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0033 | bioF2 | 0.0 | 100.00% (771) | 8-amino-7-oxononanoate synthase BioF2 |
| M. gilvum PYR-GCK | Mflv_3628 | - | 6e-59 | 38.38% (357) | 8-amino-7-oxononanoate synthase |
| M. leprae Br4923 | MLBr_01217 | bioF | 3e-51 | 35.85% (357) | 8-amino-7-oxononanoate synthase |
| M. abscessus ATCC 19977 | MAB_2687c | - | 4e-59 | 39.59% (341) | 8-amino-7-oxononanoate synthase |
| M. marinum M | MMAR_4971 | bioF2 | 3e-59 | 37.96% (353) | 8-amino-7-oxononanoate synthase BioF2 |
| M. avium 104 | MAV_3205 | bioF | 4e-51 | 35.62% (365) | 8-amino-7-oxononanoate synthase |
| M. smegmatis MC2 155 | MSMEG_3189 | bioF | 5e-54 | 37.57% (346) | 8-amino-7-oxononanoate synthase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4045 | bioF2 | 8e-59 | 37.68% (353) | 8-amino-7-oxononanoate synthase BioF2 |
| M. vanbaalenii PYR-1 | Mvan_2789 | - | 2e-53 | 36.41% (368) | 8-amino-7-oxononanoate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0032|M.tuberculosis_H37Rv MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLAT
Mb0033|M.bovis_AF2122/97 MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLAT
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
Rv0032|M.tuberculosis_H37Rv TDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVL
Mb0033|M.bovis_AF2122/97 TDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVL
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
Rv0032|M.tuberculosis_H37Rv PVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRV
Mb0033|M.bovis_AF2122/97 PVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRV
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
Rv0032|M.tuberculosis_H37Rv DTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPV
Mb0033|M.bovis_AF2122/97 DTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPV
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
Rv0032|M.tuberculosis_H37Rv LARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAF
Mb0033|M.bovis_AF2122/97 LARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAF
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
Rv0032|M.tuberculosis_H37Rv FLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRM
Mb0033|M.bovis_AF2122/97 FLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRM
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
Rv0032|M.tuberculosis_H37Rv EMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTL
Mb0033|M.bovis_AF2122/97 EMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTL
Mflv_3628|M.gilvum_PYR-GCK ----------------------------MTRAGLSPLAWLDEVETQR---
Mvan_2789|M.vanbaalenii_PYR-1 ----------------------------MTRVSLSPLAWLDEVETQR---
MSMEG_3189|M.smegmatis_MC2_155 ----------------------------MTRAGLSPLAWLADIEQRR---
MLBr_01217|M.leprae_Br4923 ---------------------------MKVPIETSPLAWLEAVEQQR---
MAV_3205|M.avium_104 ---------------------------MKAPIEVSPLAWLDAVEQQR---
MAB_2687c|M.abscessus_ATCC_199 ---------------------------MPVVEASSPLAWLGEVERQR---
MMAR_4971|M.marinum_M ---------------MLNTSRLNLHARVERDSRLAAFRHYGARMELP---
MUL_4045|M.ulcerans_Agy99 ---------------------------------MAAFRHYGARMELP---
:.:
Rv0032|M.tuberculosis_H37Rv PDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYP
Mb0033|M.bovis_AF2122/97 PDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYP
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4971|M.marinum_M ------------------------------------------------FF
MUL_4045|M.ulcerans_Agy99 ------------------------------------------------FF
Rv0032|M.tuberculosis_H37Rv RFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGC
Mb0033|M.bovis_AF2122/97 RFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGC
Mflv_3628|M.gilvum_PYR-GCK RAAGLRRSLRARPPVGTVLDLASNDYLGLSQHPRVIDGGVAALRTWGAGA
Mvan_2789|M.vanbaalenii_PYR-1 RAAGLRRTVRTRPPVGAELDLASNDYLGLSQHPRVIDGGVSALRTWGAGS
MSMEG_3189|M.smegmatis_MC2_155 RAEGLRRELRVRPPVAAELDLASNDYLGLSQHPDVLDGGVEALRTWGGGA
MLBr_01217|M.leprae_Br4923 RGAGLRRSLRPRSAVATELDLASNDYLGLSQHPDVIDGGVAALRVWGAGA
MAV_3205|M.avium_104 RAAGLRRSLRPRPPVATELDLASNDYLGLSQHPDVIDGGVAALRLWGAGA
MAB_2687c|M.abscessus_ATCC_199 EAAGLRRRLRTRSAAEPEIDLASNDYLGLSRHPQVIEAGVEALRIWGAGS
MMAR_4971|M.marinum_M RTVESAPGPTTVVEGQPRVMFASNNSLGLGGDPRLVEAANRATERYGPSC
MUL_4045|M.ulcerans_Agy99 RTVESAPGPTTVVEGQPRVMFASNNSLGLGGDPRLVEAANRATERYGPSC
. : :.:*. ***. .* :::.. * . :* ..
Rv0032|M.tuberculosis_H37Rv SGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESG
Mb0033|M.bovis_AF2122/97 SGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESG
Mflv_3628|M.gilvum_PYR-GCK TGSRLVTGNTELHEQFEDALASFVGADSALVFSSGYTANLGAVVALSGPG
Mvan_2789|M.vanbaalenii_PYR-1 TGSRLVTGNTELHEAFEDVLAAFVGAESALVFSSGYTANLGAVVALSGPG
MSMEG_3189|M.smegmatis_MC2_155 GGSRLVTGNTELHEAFEHQLASFLGAESALVFSSGYTANLGALVALSGPG
MLBr_01217|M.leprae_Br4923 TGSRLVTGDTILHHELECELAEFVGACVGLLFSSGYAANLGAVVGLSGPG
MAV_3205|M.avium_104 TGSRLVTGDTELHQQFESELADYVGAASGLLFSSGYAANLGAVVGLSGRG
MAB_2687c|M.abscessus_ATCC_199 TGSRLVTGNTELHEELEQELATFMGTESALVFSSGYTANLGAVVALSGPG
MMAR_4971|M.marinum_M AGAPPFCGTLQIKVELEELLADWYGTEAALVYNSGYLTNVGALTALLGVT
MUL_4045|M.ulcerans_Agy99 AGAPPFCGTLQIKVELEELLADWYGTEAALVYNSGYLTNVGALTALLGVT
*: . * :: :* ** : * .:: .:** :*:.*: .*
Rv0032|M.tuberculosis_H37Rv DMIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGR--RRI
Mb0033|M.bovis_AF2122/97 DMIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGR--RRI
Mflv_3628|M.gilvum_PYR-GCK SLLVSDAYTHASLVDACRLSRARVVVTPHNDVAAVARALATRDEE--RAV
Mvan_2789|M.vanbaalenii_PYR-1 SLLVSDANTHASLVDACRLSRARVVVTPHNDTAAVEQALATRSEA--RAV
MSMEG_3189|M.smegmatis_MC2_155 SLIVSDALSHASLVDACRLSRARVVVSPHRDVDAVDAALAARTEE--RAV
MLBr_01217|M.leprae_Br4923 SLIVSDAYSHASLVDACRLSRARVVVTPHCDVDAVDTALRSCHEE--RAV
MAV_3205|M.avium_104 ALVVSDAYSHASLVDACRLSRARVVVTPHRDVDAVLAALADRDEE--RAV
MAB_2687c|M.abscessus_ATCC_199 TLIVSDARTHASLIDACRLSRARVVVTPYRDTQAVAAALAQRPEE--RAL
MMAR_4971|M.marinum_M DLAFPDSEAHASIQDGIRLSGASSRFFAHNDLDALERNLIRTADRGGTKL
MUL_4045|M.ulcerans_Agy99 DLAFPDSEAHASIQDGIRLSGASSRFFAHNDLDALERNLIRTADRGGTKL
: . *: * *: *. *** * . : * : * :
Rv0032|M.tuberculosis_H37Rv IVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGPDGRGASA
Mb0033|M.bovis_AF2122/97 IVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGPDGRGASA
Mflv_3628|M.gilvum_PYR-GCK VVTDSVFSADGDLAPLRELHDACRRHGALMIVDEAHGLGVRGDRGRGLLD
Mvan_2789|M.vanbaalenii_PYR-1 VVTDSVFSADGDLAPLRALHTACRKHGALLIVDEAHGLGVRGDGGRGLLD
MSMEG_3189|M.smegmatis_MC2_155 VVTESVFSADGDLAPLRDLHAVCRRHGALLLVDEAHGLGVRGTRGQGLLH
MLBr_01217|M.leprae_Br4923 VVTESVFSADGVLAPVSELHDVCRRHGALLLVDEAHGLGVRG-GGRGLVY
MAV_3205|M.avium_104 VITESVFSTDGALAPLRELHEVCRRHRALLIVDEAHGLGVRG-GGRGLVF
MAB_2687c|M.abscessus_ATCC_199 VLTDAVFSADGALAPLAELYGVCRRHGAVLLVDEAHGLGVRGSGGRGLVA
MMAR_4971|M.marinum_M IVVDGLYSMQGDIAPMAGIAALASKYNVGLFVDEAHSVGVFGARRTGIAE
MUL_4045|M.ulcerans_Agy99 IVVDGLYSMQGDTAPMARIAALASKYNAGLFVDEAHSVGAFGSRRTGIAE
::.:.::* :* * : : . :: : ***:*.:*. * *
Rv0032|M.tuberculosis_H37Rv ALGVLARMDVVMG-TFSKSFASVGGFIAGDRPVVDYIRHNGSGHVFSASL
Mb0033|M.bovis_AF2122/97 ALGVLARMDVVMG-TFSKSFASVGGFIAGDRPVVDYIRHNGSGHVFSASL
Mflv_3628|M.gilvum_PYR-GCK EVGLAGAPDVVMTTTLSKALGSQGGVVLGPAAVRDHLIDAARPFIFDTGL
Mvan_2789|M.vanbaalenii_PYR-1 EVGLAGAPDLVMTTTLSKALGSQGGVVLGPAAVRAHLIDTARPFIFDTGL
MSMEG_3189|M.smegmatis_MC2_155 EVGLAGAPDIVMTTTLSKALGSQGGAVLGPEAVRAHLIDTARSFIFDTGL
MLBr_01217|M.leprae_Br4923 EVGLAGAPDVVITTTMSKALGSQGGAVLGSSAVRAHLINTARPFIFDTGL
MAV_3205|M.avium_104 EAGLAGAPDVVMTTTLSKALGSQGGAVLGPAAVRAHLIDAARTFIFDTGL
MAB_2687c|M.abscessus_ATCC_199 EMNLAGRDDLVVTVTLSKALGSQGGAVLGSAAVRAHLIDAARPFIFDTGL
MMAR_4971|M.marinum_M EFGCAKDVDVLMG-GMSKAIASTGGYIVGSQDLIDVLKLHSNAHIFTATA
MUL_4045|M.ulcerans_Agy99 EFGCAKHVDVLMG-GMSKAIASTGGYIVGSQDLIDVLKLHSNAHIFTATA
. *::: :**::.* ** : * : : . .:* :
Rv0032|M.tuberculosis_H37Rv PPAAAAATHAALRVSR--REPDRRARVLAAAEYMATGLARQGYQA-----
Mb0033|M.bovis_AF2122/97 PPAAAAATHAALRVSR--REPDRRARVLAAAEYMATGLARQGYQA-----
Mflv_3628|M.gilvum_PYR-GCK APAAVGAAHAALQVLV--EEPWRAQRVLDHATTLAQICGVA---------
Mvan_2789|M.vanbaalenii_PYR-1 APAAVGAAFAALQVLI--DEPWRAQRVLDHAATLASICDVT---------
MSMEG_3189|M.smegmatis_MC2_155 APAAVGAASAALRVLD--AEPQRARAVLDRAAELATIAGVT---------
MLBr_01217|M.leprae_Br4923 APAAVGAARAALQILK--AETWRPEAVLQHARTLAKICDLS---------
MAV_3205|M.avium_104 APAAVGAARAALGVLR--AEPWRVGAVLRHAGVLAEVCRVR---------
MAB_2687c|M.abscessus_ATCC_199 APAAVGSALAALRLMI--DEPARIRAVLAHAAALGQWCGVP---------
MMAR_4971|M.marinum_M APAALAASAAAIEIIRGPEGAQRAAAVLANAQALRDGLVAQGLQVRGGIV
MUL_4045|M.ulcerans_Agy99 APAALAASAAAIEIIRGPEGAQRAAAVLANAQALHDGLVAQGLQVRGGIV
.*** .:: **: : . * ** * :
Rv0032|M.tuberculosis_H37Rv ----EYHGTAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSG
Mb0033|M.bovis_AF2122/97 ----EYHGTAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSG
Mflv_3628|M.gilvum_PYR-GCK ----DVPSSAVVSVILGEPEVALAAAMGCLERGVRVGCFRPPTVPAGTSR
Mvan_2789|M.vanbaalenii_PYR-1 ----EVPSSAVVSVILGEPEVAFAAAAACLDRGVRVGCFRPPTVPAGTSR
MSMEG_3189|M.smegmatis_MC2_155 ----EAPVSAVVSVILGDPEIAVGAAAACLDRGVRVGCFRPPTVPAGTSR
MLBr_01217|M.leprae_Br4923 ----ELPQSAVVSVVLGDPEVALAAAIACLDAGVRVGCFRPPTVPAGTSR
MAV_3205|M.avium_104 ----EVPQSAVVSVILGDPDVAVAAATACLDAGVRVGCFRPPTVPAGTSR
MAB_2687c|M.abscessus_ATCC_199 ----DKPESAVVPVVLGDPTVAFNAARSCLEQGVRVGCFRPPSVPEGQSL
MMAR_4971|M.marinum_M RADGSGAMAPHVSVWIGRESQAIAAWNRAFDDGVFCALALPPAVGENEAL
MUL_4045|M.ulcerans_Agy99 RADGSGAMAPHVSVWIGRESQAIAAWNRAFDDGVFCALALPPAVGENEAL
. :. *.* :* * . : ** **:* :
Rv0032|M.tuberculosis_H37Rv FRTSYLADHRQSDLDRALHVFAGLAEDLTPQGAAL
Mb0033|M.bovis_AF2122/97 FRTSYLADHRQSDLDRALHVFAGLAEDLTPQGAAL
Mflv_3628|M.gilvum_PYR-GCK LRLTARASLSDDEMALAREVLTDVLSRA-------
Mvan_2789|M.vanbaalenii_PYR-1 LRLTARASLSEDEMTLARRVLTEVLSPR-------
MSMEG_3189|M.smegmatis_MC2_155 LRLAARASLTDDEMALARQVLTDVLATARA-----
MLBr_01217|M.leprae_Br4923 LRLTAHASLDSAKLEVARRVLTDVLGGCCVARR--
MAV_3205|M.avium_104 LRLTARASLDDAELEVARRVLTDVLAGLG------
MAB_2687c|M.abscessus_ATCC_199 LRLTARASLTEADMERVHEVLAGVLTLARR-----
MMAR_4971|M.marinum_M MRCSVSAGHSTAQIERAVEVIAAAVLGARDK----
MUL_4045|M.ulcerans_Agy99 MRCSVSAGHSTAQIERAVKVIAAAVLGARDK----
:* : *. .: . .*::