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AAFRHYGARMELPFFRTVESAPGPTTVVEGQPRVMFASNNSLGLGGDPRLVEAANRATERYGPSCAGAPP FCGTLQIKVELEELLADWYGTEAALVYNSGYLTNVGALTALLGVTDLAFPDSEAHASIQDGIRLSGASSR FFAHNDLDALERNLIRTADRGGTKLIVVDGLYSMQGDTAPMARIAALASKYNAGLFVDEAHSVGAFGSRR TGIAEEFGCAKHVDVLMGGMSKAIASTGGYIVGSQDLIDVLKLHSNAHIFTATAAPAALAASAAAIEIIR GPEGAQRAAAVLANAQALHDGLVAQGLQVRGGIVRADGSGAMAPHVSVWIGRESQAIAAWNRAFDDGVFC ALALPPAVGENEALMRCSVSAGHSTAQIERAVKVIAAAVLGARDK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4045 | bioF2 | - | 100% (396) | 8-amino-7-oxononanoate synthase BioF2 |
| M. ulcerans Agy99 | MUL_1560 | bioF1 | 1e-35 | 30.34% (356) | 8-amino-7-oxononanoate synthase |
| M. ulcerans Agy99 | MUL_1966 | bioF2_2 | 2e-35 | 29.17% (384) | 8-amino-7-oxononanoate synthase BioF2_2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0033 | bioF2 | 4e-59 | 37.68% (353) | 8-amino-7-oxononanoate synthase BioF2 |
| M. gilvum PYR-GCK | Mflv_3628 | - | 1e-38 | 32.26% (372) | 8-amino-7-oxononanoate synthase |
| M. tuberculosis H37Rv | Rv0032 | bioF2 | 4e-59 | 37.68% (353) | 8-amino-7-oxononanoate synthase BioF2 |
| M. leprae Br4923 | MLBr_01217 | bioF | 1e-32 | 30.62% (356) | 8-amino-7-oxononanoate synthase |
| M. abscessus ATCC 19977 | MAB_2687c | - | 8e-40 | 32.14% (364) | 8-amino-7-oxononanoate synthase |
| M. marinum M | MMAR_4971 | bioF2 | 0.0 | 97.98% (396) | 8-amino-7-oxononanoate synthase BioF2 |
| M. avium 104 | MAV_3205 | bioF | 7e-36 | 31.37% (357) | 8-amino-7-oxononanoate synthase |
| M. smegmatis MC2 155 | MSMEG_3189 | bioF | 5e-39 | 32.31% (359) | 8-amino-7-oxononanoate synthase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2789 | - | 4e-37 | 31.71% (350) | 8-amino-7-oxononanoate synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLAT
Rv0032|M.tuberculosis_H37Rv MPTGLGYDFLRPVEDSGINDLKHYYFMADLADGQPLGRANLYSVCFDLAT
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 TDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVL
Rv0032|M.tuberculosis_H37Rv TDRKLTPAWRTTIKRWFPGFMTFRFLECGLLTMVSNPLALRSDTDLERVL
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 PVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRV
Rv0032|M.tuberculosis_H37Rv PVLAGQMDQLAHDDGSDFLMIRDVDPEHYQRYLDILRPLGFRPALGFSRV
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 DTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPV
Rv0032|M.tuberculosis_H37Rv DTTISWSSVEEALGCLSHKRRLPLKTSLEFRERFGIEVEELDEYAEHAPV
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 LARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAF
Rv0032|M.tuberculosis_H37Rv LARLWRNVKTEAKDYQREDLNPEFFAACSRHLHGRSRLWLFRYQGTPIAF
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 FLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRM
Rv0032|M.tuberculosis_H37Rv FLNVWGADENYILLEWGIDRDFEHYRKANLYRAALMLSLKDAISRDKRRM
MUL_4045|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4971|M.marinum_M --------------------------------------------------
Mflv_3628|M.gilvum_PYR-GCK ----------------------------MTRAGLSPLAWLDEVETQR---
Mvan_2789|M.vanbaalenii_PYR-1 ----------------------------MTRVSLSPLAWLDEVETQR---
MSMEG_3189|M.smegmatis_MC2_155 ----------------------------MTRAGLSPLAWLADIEQRR---
MLBr_01217|M.leprae_Br4923 ---------------------------MKVPIETSPLAWLEAVEQQR---
MAV_3205|M.avium_104 ---------------------------MKAPIEVSPLAWLDAVEQQR---
MAB_2687c|M.abscessus_ATCC_199 ---------------------------MPVVEASSPLAWLGEVERQR---
Mb0033|M.bovis_AF2122/97 EMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTL
Rv0032|M.tuberculosis_H37Rv EMGITNYFTKLRIPGARVIPTIYFLRHSTDPVHTATLARMMMHNIQRPTL
MUL_4045|M.ulcerans_Agy99 ---------------------------------MAAFRHYGARMELP---
MMAR_4971|M.marinum_M ---------------MLNTSRLNLHARVERDSRLAAFRHYGARMELP---
:.:
Mflv_3628|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3189|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01217|M.leprae_Br4923 --------------------------------------------------
MAV_3205|M.avium_104 --------------------------------------------------
MAB_2687c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0033|M.bovis_AF2122/97 PDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYP
Rv0032|M.tuberculosis_H37Rv PDDMSEEFCRWEERIRLDQDGLPEHDIFRKIDRQHKYTGLKLGGVYGFYP
MUL_4045|M.ulcerans_Agy99 ------------------------------------------------FF
MMAR_4971|M.marinum_M ------------------------------------------------FF
Mflv_3628|M.gilvum_PYR-GCK RAAGLRRSLRARPPVGTVLDLASNDYLGLSQHPRVIDGGVAALRTWGAGA
Mvan_2789|M.vanbaalenii_PYR-1 RAAGLRRTVRTRPPVGAELDLASNDYLGLSQHPRVIDGGVSALRTWGAGS
MSMEG_3189|M.smegmatis_MC2_155 RAEGLRRELRVRPPVAAELDLASNDYLGLSQHPDVLDGGVEALRTWGGGA
MLBr_01217|M.leprae_Br4923 RGAGLRRSLRPRSAVATELDLASNDYLGLSQHPDVIDGGVAALRVWGAGA
MAV_3205|M.avium_104 RAAGLRRSLRPRPPVATELDLASNDYLGLSQHPDVIDGGVAALRLWGAGA
MAB_2687c|M.abscessus_ATCC_199 EAAGLRRRLRTRSAAEPEIDLASNDYLGLSRHPQVIEAGVEALRIWGAGS
Mb0033|M.bovis_AF2122/97 RFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGC
Rv0032|M.tuberculosis_H37Rv RFTGPQRSTVKAAELGEIVLLGTNSYLGLATHPEVVEASAEATRRYGTGC
MUL_4045|M.ulcerans_Agy99 RTVESAPGPTTVVEGQPRVMFASNNSLGLGGDPRLVEAANRATERYGPSC
MMAR_4971|M.marinum_M RTVESAPGPTTVVEGQPRVMFASNNSLGLGGDPRLVEAANRATERYGPSC
. : :.:*. ***. .* :::.. * . :* ..
Mflv_3628|M.gilvum_PYR-GCK TGSRLVTGNTELHEQFEDALASFVGADSALVFSSGYTANLGAVVALSGPG
Mvan_2789|M.vanbaalenii_PYR-1 TGSRLVTGNTELHEAFEDVLAAFVGAESALVFSSGYTANLGAVVALSGPG
MSMEG_3189|M.smegmatis_MC2_155 GGSRLVTGNTELHEAFEHQLASFLGAESALVFSSGYTANLGALVALSGPG
MLBr_01217|M.leprae_Br4923 TGSRLVTGDTILHHELECELAEFVGACVGLLFSSGYAANLGAVVGLSGPG
MAV_3205|M.avium_104 TGSRLVTGDTELHQQFESELADYVGAASGLLFSSGYAANLGAVVGLSGRG
MAB_2687c|M.abscessus_ATCC_199 TGSRLVTGNTELHEELEQELATFMGTESALVFSSGYTANLGAVVALSGPG
Mb0033|M.bovis_AF2122/97 SGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESG
Rv0032|M.tuberculosis_H37Rv SGSPLLNGTLDLHVSLEQELACFLGKPAAVLCSTGYQSNLAAISALCESG
MUL_4045|M.ulcerans_Agy99 AGAPPFCGTLQIKVELEELLADWYGTEAALVYNSGYLTNVGALTALLGVT
MMAR_4971|M.marinum_M AGAPPFCGTLQIKVELEELLADWYGTEAALVYNSGYLTNVGALTALLGVT
*: . * :: :* ** : * .:: .:** :*:.*: .*
Mflv_3628|M.gilvum_PYR-GCK SLLVSDAYTHASLVDACRLSRARVVVTPHNDVAAVARALATRDEE--RAV
Mvan_2789|M.vanbaalenii_PYR-1 SLLVSDANTHASLVDACRLSRARVVVTPHNDTAAVEQALATRSEA--RAV
MSMEG_3189|M.smegmatis_MC2_155 SLIVSDALSHASLVDACRLSRARVVVSPHRDVDAVDAALAARTEE--RAV
MLBr_01217|M.leprae_Br4923 SLIVSDAYSHASLVDACRLSRARVVVTPHCDVDAVDTALRSCHEE--RAV
MAV_3205|M.avium_104 ALVVSDAYSHASLVDACRLSRARVVVTPHRDVDAVLAALADRDEE--RAV
MAB_2687c|M.abscessus_ATCC_199 TLIVSDARTHASLIDACRLSRARVVVTPYRDTQAVAAALAQRPEE--RAL
Mb0033|M.bovis_AF2122/97 DMIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGR--RRI
Rv0032|M.tuberculosis_H37Rv DMIIQDALNHRSLFDAARLSGADFTLYRHNDMDHLARVLRRTEGR--RRI
MUL_4045|M.ulcerans_Agy99 DLAFPDSEAHASIQDGIRLSGASSRFFAHNDLDALERNLIRTADRGGTKL
MMAR_4971|M.marinum_M DLAFPDSEAHASIQDGIRLSGASSRFFAHNDLDALERNLIRTADRGGTKL
: . *: * *: *. *** * . : * : * :
Mflv_3628|M.gilvum_PYR-GCK VVTDSVFSADGDLAPLRELHDACRRHGALMIVDEAHGLGVRGDRGRGLLD
Mvan_2789|M.vanbaalenii_PYR-1 VVTDSVFSADGDLAPLRALHTACRKHGALLIVDEAHGLGVRGDGGRGLLD
MSMEG_3189|M.smegmatis_MC2_155 VVTESVFSADGDLAPLRDLHAVCRRHGALLLVDEAHGLGVRGTRGQGLLH
MLBr_01217|M.leprae_Br4923 VVTESVFSADGVLAPVSELHDVCRRHGALLLVDEAHGLGVRG-GGRGLVY
MAV_3205|M.avium_104 VITESVFSTDGALAPLRELHEVCRRHRALLIVDEAHGLGVRG-GGRGLVF
MAB_2687c|M.abscessus_ATCC_199 VLTDAVFSADGALAPLAELYGVCRRHGAVLLVDEAHGLGVRGSGGRGLVA
Mb0033|M.bovis_AF2122/97 IVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGPDGRGASA
Rv0032|M.tuberculosis_H37Rv IVVDAVFSMEGTVADLATIAELADRHGCRVYVDESHALGVLGPDGRGASA
MUL_4045|M.ulcerans_Agy99 IVVDGLYSMQGDTAPMARIAALASKYNAGLFVDEAHSVGAFGSRRTGIAE
MMAR_4971|M.marinum_M IVVDGLYSMQGDIAPMAGIAALASKYNVGLFVDEAHSVGVFGARRTGIAE
::.:.::* :* * : : . :: : ***:*.:*. * *
Mflv_3628|M.gilvum_PYR-GCK EVGLAGAPDVVMTTTLSKALGSQGGVVLGPAAVRDHLIDAARPFIFDTGL
Mvan_2789|M.vanbaalenii_PYR-1 EVGLAGAPDLVMTTTLSKALGSQGGVVLGPAAVRAHLIDTARPFIFDTGL
MSMEG_3189|M.smegmatis_MC2_155 EVGLAGAPDIVMTTTLSKALGSQGGAVLGPEAVRAHLIDTARSFIFDTGL
MLBr_01217|M.leprae_Br4923 EVGLAGAPDVVITTTMSKALGSQGGAVLGSSAVRAHLINTARPFIFDTGL
MAV_3205|M.avium_104 EAGLAGAPDVVMTTTLSKALGSQGGAVLGPAAVRAHLIDAARTFIFDTGL
MAB_2687c|M.abscessus_ATCC_199 EMNLAGRDDLVVTVTLSKALGSQGGAVLGSAAVRAHLIDAARPFIFDTGL
Mb0033|M.bovis_AF2122/97 ALGVLARMDVVMG-TFSKSFASVGGFIAGDRPVVDYIRHNGSGHVFSASL
Rv0032|M.tuberculosis_H37Rv ALGVLARMDVVMG-TFSKSFASVGGFIAGDRPVVDYIRHNGSGHVFSASL
MUL_4045|M.ulcerans_Agy99 EFGCAKHVDVLMG-GMSKAIASTGGYIVGSQDLIDVLKLHSNAHIFTATA
MMAR_4971|M.marinum_M EFGCAKDVDVLMG-GMSKAIASTGGYIVGSQDLIDVLKLHSNAHIFTATA
. *::: :**::.* ** : * : : . .:* :
Mflv_3628|M.gilvum_PYR-GCK APAAVGAAHAALQVLV--EEPWRAQRVLDHATTLAQICGVA---------
Mvan_2789|M.vanbaalenii_PYR-1 APAAVGAAFAALQVLI--DEPWRAQRVLDHAATLASICDVT---------
MSMEG_3189|M.smegmatis_MC2_155 APAAVGAASAALRVLD--AEPQRARAVLDRAAELATIAGVT---------
MLBr_01217|M.leprae_Br4923 APAAVGAARAALQILK--AETWRPEAVLQHARTLAKICDLS---------
MAV_3205|M.avium_104 APAAVGAARAALGVLR--AEPWRVGAVLRHAGVLAEVCRVR---------
MAB_2687c|M.abscessus_ATCC_199 APAAVGSALAALRLMI--DEPARIRAVLAHAAALGQWCGVP---------
Mb0033|M.bovis_AF2122/97 PPAAAAATHAALRVSR--REPDRRARVLAAAEYMATGLARQGYQA-----
Rv0032|M.tuberculosis_H37Rv PPAAAAATHAALRVSR--REPDRRARVLAAAEYMATGLARQGYQA-----
MUL_4045|M.ulcerans_Agy99 APAALAASAAAIEIIRGPEGAQRAAAVLANAQALHDGLVAQGLQVRGGIV
MMAR_4971|M.marinum_M APAALAASAAAIEIIRGPEGAQRAAAVLANAQALRDGLVAQGLQVRGGIV
.*** .:: **: : . * ** * :
Mflv_3628|M.gilvum_PYR-GCK ----DVPSSAVVSVILGEPEVALAAAMGCLERGVRVGCFRPPTVPAGTSR
Mvan_2789|M.vanbaalenii_PYR-1 ----EVPSSAVVSVILGEPEVAFAAAAACLDRGVRVGCFRPPTVPAGTSR
MSMEG_3189|M.smegmatis_MC2_155 ----EAPVSAVVSVILGDPEIAVGAAAACLDRGVRVGCFRPPTVPAGTSR
MLBr_01217|M.leprae_Br4923 ----ELPQSAVVSVVLGDPEVALAAAIACLDAGVRVGCFRPPTVPAGTSR
MAV_3205|M.avium_104 ----EVPQSAVVSVILGDPDVAVAAATACLDAGVRVGCFRPPTVPAGTSR
MAB_2687c|M.abscessus_ATCC_199 ----DKPESAVVPVVLGDPTVAFNAARSCLEQGVRVGCFRPPSVPEGQSL
Mb0033|M.bovis_AF2122/97 ----EYHGTAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSG
Rv0032|M.tuberculosis_H37Rv ----EYHGTAIVPVILGNPTVAHAGYLRLMRSGVYVNPVAPPAVPEERSG
MUL_4045|M.ulcerans_Agy99 RADGSGAMAPHVSVWIGRESQAIAAWNRAFDDGVFCALALPPAVGENEAL
MMAR_4971|M.marinum_M RADGSGAMAPHVSVWIGRESQAIAAWNRAFDDGVFCALALPPAVGENEAL
. :. *.* :* * . : ** **:* :
Mflv_3628|M.gilvum_PYR-GCK LRLTARASLSDDEMALAREVLTDVLSRA-------
Mvan_2789|M.vanbaalenii_PYR-1 LRLTARASLSEDEMTLARRVLTEVLSPR-------
MSMEG_3189|M.smegmatis_MC2_155 LRLAARASLTDDEMALARQVLTDVLATARA-----
MLBr_01217|M.leprae_Br4923 LRLTAHASLDSAKLEVARRVLTDVLGGCCVARR--
MAV_3205|M.avium_104 LRLTARASLDDAELEVARRVLTDVLAGLG------
MAB_2687c|M.abscessus_ATCC_199 LRLTARASLTEADMERVHEVLAGVLTLARR-----
Mb0033|M.bovis_AF2122/97 FRTSYLADHRQSDLDRALHVFAGLAEDLTPQGAAL
Rv0032|M.tuberculosis_H37Rv FRTSYLADHRQSDLDRALHVFAGLAEDLTPQGAAL
MUL_4045|M.ulcerans_Agy99 MRCSVSAGHSTAQIERAVKVIAAAVLGARDK----
MMAR_4971|M.marinum_M MRCSVSAGHSTAQIERAVEVIAAAVLGARDK----
:* : *. .: . .*::