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ARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVASQLVIAALAHLDDDEPGGDLLA KLDAAVRAGNSAIAAQVEMEPDLEGMGTTLTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQT LVDEGRITPEEAHSHPQRSLIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDETILEALQIPEV AESAHRLIELALRGGGPDNVTVVVADVVDYDYGQTQPILAGAVSGDDDQLTLPNTAAGRASAISQRKEIV KRVPPQADTFSRPRWSGRRLAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQGSLLGMSL HQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPERAQVRAGLPAGTLDDAIGQLRELAANSLL PPCPAPRATSPPGRPAPPTTSETTEPNVTSSPASPSPTTSAPAPTGTTPAIPTSASPAAPASPPTPWPVT SSPTMAALPPPPPQPGIDCRAAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0018c | ppp | - | 100% (514) | POSSIBLE SERINE/THREONINE PHOSPHATASE PPP |
| M. tuberculosis H37Rv | Rv2264c | - | 6e-12 | 35.00% (140) | hypothetical protein Rv2264c |
| M. tuberculosis H37Rv | Rv3876 | - | 1e-08 | 34.48% (87) | hypothetical protein Rv3876 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0018c | ppp | 0.0 | 99.42% (514) | serine/threonine phosphatase |
| M. gilvum PYR-GCK | Mflv_0808 | - | 0.0 | 72.31% (520) | protein phosphatase 2C domain-containing protein |
| M. leprae Br4923 | MLBr_00020 | - | 0.0 | 76.41% (513) | hypothetical protein MLBr_00020 |
| M. abscessus ATCC 19977 | MAB_0037c | - | 1e-175 | 63.32% (518) | serine/threonine phosphatase Ppp |
| M. marinum M | MMAR_0020 | pstP | 0.0 | 84.04% (520) | serine/threonine phosphatase PstP |
| M. avium 104 | MAV_0022 | - | 0.0 | 77.10% (511) | protein phosphatase 2C |
| M. smegmatis MC2 155 | MSMEG_0033 | - | 0.0 | 71.40% (521) | protein phosphatase 2C |
| M. thermoresistible (build 8) | TH_0188 | - | 3e-07 | 36.79% (106) | serine/threonine-protein kinase PknD |
| M. ulcerans Agy99 | MUL_0022 | pstP | 0.0 | 83.85% (520) | serine/threonine phosphatase PstP |
| M. vanbaalenii PYR-1 | Mvan_0027 | - | 0.0 | 71.95% (517) | protein phosphatase 2C domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0808|M.gilvum_PYR-GCK ---MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVAS
Mvan_0027|M.vanbaalenii_PYR-1 ---MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVAS
MSMEG_0033|M.smegmatis_MC2_155 ---MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVAS
Rv0018c|M.tuberculosis_H37Rv MARVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVAS
Mb0018c|M.bovis_AF2122/97 MALVTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVAS
MMAR_0020|M.marinum_M ---MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVAS
MUL_0022|M.ulcerans_Agy99 ---MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVAS
MLBr_00020|M.leprae_Br4923 ---MTLVLRYAARSDRGLVRANNEDSVYAGARLLALADGMGGHAAGEVAS
MAV_0022|M.avium_104 ---MTLVLRYAARSDRGLVRSNNEDSVYAGARLLALADGMGGHAAGEVAS
MAB_0037c|M.abscessus_ATCC_199 ---MTLVLRYAARSDRGLVRSNNEDSVYAGARLLALADGMGGHAAGEVAS
TH_0188|M.thermoresistible__bu --------------------------------------------------
Mflv_0808|M.gilvum_PYR-GCK QLVIAALAHLDDDEPGGDLLSKLDSAVREGNNAIASHVEADPELEGMGTT
Mvan_0027|M.vanbaalenii_PYR-1 QLVIAALAHLDDDEPGGDLLSKLDSAVREGNSAIAAHVEADPELDGMGTT
MSMEG_0033|M.smegmatis_MC2_155 QLVIAALAHLDDDEPGGDLLSKLHQAVAEGNAAIAAHVEADPELDGMGTT
Rv0018c|M.tuberculosis_H37Rv QLVIAALAHLDDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTT
Mb0018c|M.bovis_AF2122/97 QLVIAALAHLDDDEPGGDLLAKLDAAVRAGNSAIAAQVEMEPDLEGMGTT
MMAR_0020|M.marinum_M QLVIAALAHLDDDEPGGDLLAKLDAAVRSGNSAIAAQVEMEPELEGMGTT
MUL_0022|M.ulcerans_Agy99 QLVIAALAHLDDDEPGGDLLAKLDAAVRSGNSAIAAQVEMEPELEGMGTT
MLBr_00020|M.leprae_Br4923 QLVIAALAHLDDDEPGGDLLGKLETAVRAGNLAIAAQVEMEPDFEGMGTT
MAV_0022|M.avium_104 QLVIAALAHLDDDEPGGDLLAKLDEAVRAGNAAIAAQVEAEPELEGMGTT
MAB_0037c|M.abscessus_ATCC_199 QLVIAALAPLDDDEPGGDLLDALADAVHAGNGAIADHVRAEPELDGMGTT
TH_0188|M.thermoresistible__bu -----------------------------------VVVAAVIVLFGVAAG
* : *:.:
Mflv_0808|M.gilvum_PYR-GCK LTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITA
Mvan_0027|M.vanbaalenii_PYR-1 LTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITA
MSMEG_0033|M.smegmatis_MC2_155 LTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITA
Rv0018c|M.tuberculosis_H37Rv LTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITP
Mb0018c|M.bovis_AF2122/97 LTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITP
MMAR_0020|M.marinum_M LTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITA
MUL_0022|M.ulcerans_Agy99 LTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITA
MLBr_00020|M.leprae_Br4923 LTAILFAGNRLGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITA
MAV_0022|M.avium_104 LTAILFAGDRIGLVHIGDSRGYLLRDGELTQITKDDTFVQTLVDEGRITR
MAB_0037c|M.abscessus_ATCC_199 LTAFLFAGKRLGMVHIGDSRAYLMRDGELTQISKDDTFVQTLVDEGRITP
TH_0188|M.thermoresistible__bu LAAVLVSD----------------RDGPAPSSQLAVPPAQTTEPTG--TT
*:*.*.:. *** .. . .** * *
Mflv_0808|M.gilvum_PYR-GCK EEAHSHPQRSLIMRALTGHEVEPTLIMREARAGDRYLLCSDGLSDPVSQD
Mvan_0027|M.vanbaalenii_PYR-1 EEAHSHPQRSLIMRALTGHEVEPTLIMREARAGDRYLLCSDGLSDPVSHD
MSMEG_0033|M.smegmatis_MC2_155 EEAHSHPQRSLIMRALTGHEVEPTLIMREAKAGDRYLLCSDGLSDPVSQE
Rv0018c|M.tuberculosis_H37Rv EEAHSHPQRSLIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDE
Mb0018c|M.bovis_AF2122/97 EEAHSHPQRSLIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDE
MMAR_0020|M.marinum_M EEAHSHPQRSLIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDE
MUL_0022|M.ulcerans_Agy99 EEAHSHPQRSLIMRALTGHEVEPTLTIREARAGDRYLLCSDGLSDPVSDE
MLBr_00020|M.leprae_Br4923 EEAHSHPQRSLIMRALTGHEVDPTLTMREARAGDRYLLCSDGLSDPVSDE
MAV_0022|M.avium_104 EEAHSHPQRSLIMRALTGHEVEPTLTMREARAGDRYLLCSDGLSDPVSDE
MAB_0037c|M.abscessus_ATCC_199 EQAHNHPQRSLIMRALTGAPVEPTLIMREAHAGDRYLLCSDGLSDPVSHE
TH_0188|M.thermoresistible__bu AAPTTGPTRSSTPTTPTTRTTPTTTTSPERTS-------------PVPSA
. . * ** : * . .* * : **.
Mflv_0808|M.gilvum_PYR-GCK TIAEALQIDDVTESADRLIELALRGGGPDNVTVVVADVVDYDYGQTQPIL
Mvan_0027|M.vanbaalenii_PYR-1 TIAEALQIEDVAESADRLIELALRGGGPDNVTVVVADVVDYDYGQTQPIL
MSMEG_0033|M.smegmatis_MC2_155 TIKEALQIEDVAESADRLIELALRGGGPDNVTVVVADVVDYDYGQTQPIL
Rv0018c|M.tuberculosis_H37Rv TILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVDYDYGQTQPIL
Mb0018c|M.bovis_AF2122/97 TILEALQIPEVAESAHRLIELALRGGGPDNVTVVVADVVDYDYGQTQPIL
MMAR_0020|M.marinum_M TIHEALQIPDVAESAYRLIELALRGGGPDNVTVVVADVVDYEYGQTQPIL
MUL_0022|M.ulcerans_Agy99 TIHEALQIPDVAESAYRLIELALRGGGPDNVTVVVADVVDYEYGQTQPIL
MLBr_00020|M.leprae_Br4923 TILEALQIPDVAESAYRLIELALRGGGPDNVTVVVADVIDYDYGQTQPIL
MAV_0022|M.avium_104 TILEALQIPDVAEAAYRLIELALRGGGPDNVTVVVADVVDYDYGQTQPIL
MAB_0037c|M.abscessus_ATCC_199 TIAEALEIPDVSAAADRLIELALRSGGPDNVTVVVADVVELDYGQTRPIV
TH_0188|M.thermoresistible__bu SPATPPATPPTSPTSP----------------------------VASPVT
: . .: :: : *:
Mflv_0808|M.gilvum_PYR-GCK AGAVSGDD-DQSAPPNTAAGRASAFNPKRNAAKRVVPQPE------EPPP
Mvan_0027|M.vanbaalenii_PYR-1 AGAVSGDD-DQSDPPNTAAGRASAFNPKRNAAKRVVPQPE------EPPP
MSMEG_0033|M.smegmatis_MC2_155 AGAVSGDD-DQTAPPDTAAGRASAFNPRRNEPKRVIPQPA------EPAR
Rv0018c|M.tuberculosis_H37Rv AGAVSGDD-DQLTLPNTAAGRASAISQRKEIVKRVPPQAD------TFSR
Mb0018c|M.bovis_AF2122/97 AGAVSGDD-DQLTLPNTAAGRASAISQRKEIVKRVPPQAD------TFSR
MMAR_0020|M.marinum_M AGAVSGDD-DQLTLPNTAAGRASAITARKEAVKRVPPQVE------TVHR
MUL_0022|M.ulcerans_Agy99 AGAVSGDD-DQLTLPNTAAGRASAITARKEAVKRVPPQVE------TVHR
MLBr_00020|M.leprae_Br4923 AGAVSGEESQQMALPNTAASRASAIVPRKEIAKSMAPQVD------KVHQ
MAV_0022|M.avium_104 AGAVSGDE-DQLTLPNTSAGRASAIRPRDESAKRVAPQPE------TPSR
MAB_0037c|M.abscessus_ATCC_199 AGAVSTDADTDTPPPNTAAGRAAAIQRALKEPEPAEDESDSETTDSENSK
TH_0188|M.thermoresistible__bu PAAVPGAD------RQGFIGHAARCDSGSTPAAMVRTDNS----------
..**. : .:*: :
Mflv_0808|M.gilvum_PYR-GCK RPRSRRRPIIAATVLVLVVLAGLAVGREIVRNNYYVSENDGTVSIMRGVQ
Mvan_0027|M.vanbaalenii_PYR-1 RPHSRRRMIIAAAVLVLVVLTGLAVGREIVRNNYYVSEHNGTVSIMRGVQ
MSMEG_0033|M.smegmatis_MC2_155 KPRSRRRMIIAAVLVVLVVVAGLAIGREILRNNYYVAEHDGTVSIMRGVQ
Rv0018c|M.tuberculosis_H37Rv PRWSGRRLAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQ
Mb0018c|M.bovis_AF2122/97 PRWSGRRLAFVVALVTVLMTAGLLIGRAIIRSNYYVADYAGSVSIMRGIQ
MMAR_0020|M.marinum_M PRWSWRRMALVATLVVLLVVAGLFISRAVIRNNYYVAEFNGTVSIMRGIQ
MUL_0022|M.ulcerans_Agy99 PRWSWRRMALVAELVVLLVVAGLFISRAVIRNNYYVAEFDGTVSIMRGIQ
MLBr_00020|M.leprae_Br4923 QRWSQRQTGITLTLLVLLVLAGVAIGRWVIRDNYYIAEYSGKVSIVRGIQ
MAV_0022|M.avium_104 PRWSRRRLFIVIALAVMLVLAGLTVGWWVIQRNYYVAEYNGRISIVRGIQ
MAB_0037c|M.abscessus_ATCC_199 PKKRRLRWLIAAVLVVLIALAGLAIARRVVLNNYYVSAHEGNVSIMQGVQ
TH_0188|M.thermoresistible__bu ----------------------LAVVCETRSGDYYYR-------------
: : :**
Mflv_0808|M.gilvum_PYR-GCK GSFLGVSLQEPYLLGCLNNRNELSLISADQSGEPRDCRLLGVDDMRPSER
Mvan_0027|M.vanbaalenii_PYR-1 GSFLGVSLQEPYLLGCLNARNELSLISAGQSQDSLDCRLLGVGDMRPSER
MSMEG_0033|M.smegmatis_MC2_155 GSFLGISLQEPYRLGCLNARNELSLIGANENRDNLGCRLMAVNDMRPSER
Rv0018c|M.tuberculosis_H37Rv GSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPER
Mb0018c|M.bovis_AF2122/97 GSLLGMSLHQPYLMGCLSPRNELSQISYGQSGGPLDCHLMKLEDLRPPER
MMAR_0020|M.marinum_M GSFLGMSLHEPYLMGCLNARNELSQISYQQSGEHLDCNLMKLDDLRPPER
MUL_0022|M.ulcerans_Agy99 GSFLGMSLHEPYLMGCLNARNELSQISYQQSGEHLDCNLMKLDDLRPPER
MLBr_00020|M.leprae_Br4923 GSLLGMPLHEPYLVGCLNTRNELSLISYGQSGGHLNCQVMTLRDLRPSGG
MAV_0022|M.avium_104 GSLLGVPLQQPYLVGCLNARNELSLISYGQSGGS-NCQLMTLQDLRRPGQ
MAB_0037c|M.abscessus_ATCC_199 GSLLGYRLQRPDLVGCLDSRGDMSLVSYGEAASNLSCKYLKVSDLRPSER
TH_0188|M.thermoresistible__bu ----GERLSDG--------------------------ASIELRNARPAGD
* * : : : * .
Mflv_0808|M.gilvum_PYR-GCK AQVIAGLPSGSLDQAIGQIEELSRSSVLPVCATHTTPTPSPRPAPSPG-A
Mvan_0027|M.vanbaalenii_PYR-1 AQVIAGLPSGSLDEAIGQIEELARSSVLPVCAPPAPPSTTRPPAPSPRPA
MSMEG_0033|M.smegmatis_MC2_155 AQVVAGLPGGTLDEAFAQIGELARSSLLPVCAPPRPTTTTRAPAPPPAPP
Rv0018c|M.tuberculosis_H37Rv AQVRAGLPAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSE
Mb0018c|M.bovis_AF2122/97 AQVRAGLPAGTLDDAIGQLRELAANSLLPPCPAPRATSPPGRPAPPTTSE
MMAR_0020|M.marinum_M AQVQAGLPAGSLDNAIGQLRELAANSLLPPCPAPRATSPPESSAPSTASE
MUL_0022|M.ulcerans_Agy99 AQVQAGLPAGSLDNAIGQLRELAANSLLPPCPAPRATSPPEPSAPSTASE
MLBr_00020|M.leprae_Br4923 AQVQAGLPGGNLDQAESQLRKLLADSLLPTCPPPRATSPPGPFTMPTDSG
MAV_0022|M.avium_104 VQVQTGLPGGSLDQAESQLRQLLAEYLLPLCPPPRATSPPG--AQATRSP
MAB_0037c|M.abscessus_ATCC_199 QQVETGLPGGTLDEAIGQLRQLSKN-ALPPCPPPAPKTPPP-PAPTAAGR
TH_0188|M.thermoresistible__bu GFDAVNPADGTRYEVRPDRLTIISNGRIDANEPVQQYAGR----------
.. . *. :. : : . : . :
Mflv_0808|M.gilvum_PYR-GCK SLPRPAPPASTPTTTPPESPAASPDPRTGTPAPVPPRTSSAPSPSGS--A
Mvan_0027|M.vanbaalenii_PYR-1 PAPTSTAPQTTGPSTTPRASGPAPAPETPRTVTTTAPSPASPAPVPP--A
MSMEG_0033|M.smegmatis_MC2_155 SSPAPGASG-RGAGESPVPPSPSP---TTTAAPAPSGAPGSPNPPPP--A
Rv0018c|M.tuberculosis_H37Rv TT-EPNVTSSPAS-----PSPTTSAPAPTGTTPAIPTSASPAAPASP--P
Mb0018c|M.bovis_AF2122/97 TT-EPNVTSSPAA-----PSPTTSASAPTGTTPAIPTSASPAAPASP--P
MMAR_0020|M.marinum_M TPGQPSVTSSPASTTPPTPSASTTPTTTSGSTAATSTPPTGTSPAAPTSP
MUL_0022|M.ulcerans_Agy99 TPGQPSVTSSPASTTTPTPSASTTPTTTSGSTAATSTPPAGTSPAAPTSP
MLBr_00020|M.leprae_Br4923 TP-QPTNTASPTST---TPPTITSSSGTAPTNISPTSSPASTAPTTP---
MAV_0022|M.avium_104 VP-ETGGPASP-------APPTTSASPTPSTNATPG--PASSSPAGP---
MAB_0037c|M.abscessus_ATCC_199 TP-----------------TTTSGTPTTTPSKPSPTTSAGPGASTTP---
TH_0188|M.thermoresistible__bu --------------------------------------------------
Mflv_0808|M.gilvum_PYR-GCK PPPPPSPSPTVTALPPPPPEPGTNCREVS
Mvan_0027|M.vanbaalenii_PYR-1 SPTPPPPPPTVTALPPPPPEPGTNCREVS
MSMEG_0033|M.smegmatis_MC2_155 SPSP-TPSPTVTALPPPPPQPGTNCRAVS
Rv0018c|M.tuberculosis_H37Rv TPWPVTSSPTMAALPPPPPQPGIDCRAAA
Mb0018c|M.bovis_AF2122/97 TPWPVTSSPTMAALPPPPPQPGIDCRAAA
MMAR_0020|M.marinum_M TPTLTTSSPNVTALPPPPPQPGIDCRAVA
MUL_0022|M.ulcerans_Agy99 TPTSTTSSPNVTALPPPPPQPGIDCRAVA
MLBr_00020|M.leprae_Br4923 ----VGTSQTVTILPPPPPQPGIDCRAVA
MAV_0022|M.avium_104 ----TTTSQTLTALPGPPLQPGIDCRTVA
MAB_0037c|M.abscessus_ATCC_199 ---TTTSTPAPAPLPAPPQEPGVTCRTVS
TH_0188|M.thermoresistible__bu -----------------------------