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TATLVAKNVAGGFAHRTLFEGVDLTVAPGDVVGVVGANGAGKSTLLRILAGELEPLDGSVAVAPADAFVG WLPQEHERVPGETVAAYVARRTGCAEATRAMDAAAATLDDAGNGADAYSAALDHWLATGAADLDERLPAV LADLGLDSDAVRPDSTPMTALSGGQAARVGLAALLLSRFDIVLLDEPTNDLDLDGLARLERFVSELRGGV VLVSHDREFLARTVTRVLELDLAQNTTTVFGGGYESYLEERAVNRRHRREQYEEFADKKADLVARARVQR EWSSQGTRNAIRKAPDNDKIRRRAATESSEKQAQKVRQMESRIARLEEVEEPRKEWTLQFTIGEAPRSSA VVATLDNAVVRQGDFVLGPVALQVDAGERIGITGPNGAGKSTLLRLLLGRLLPDEGRASMGASVEIGEID QARAYFTGPERLLDRFEQRVPEWPTADVRTLLAKFGLGADHVERAVDELSPGERTRAGLALLQACGTNVL VLDEPTNHLDLPAIEQLEQALESYDGALLLVTHDRRMLQNVRLDRSWRVENGQVTEL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5841 | - | - | 100% (548) | ABC transporter-related protein |
| M. vanbaalenii PYR-1 | Mvan_4514 | - | 7e-60 | 34.38% (541) | ABC transporter-related protein |
| M. vanbaalenii PYR-1 | Mvan_4070 | - | 1e-58 | 32.21% (534) | putative ABC transporter ATP-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1508 | - | 8e-58 | 33.14% (519) | macrolide ABC transporter ATP-binding protein |
| M. gilvum PYR-GCK | Mflv_0995 | - | 0.0 | 88.67% (547) | ABC transporter related |
| M. tuberculosis H37Rv | Rv1473 | - | 8e-58 | 33.14% (519) | macrolide ABC transporter ATP-binding protein |
| M. leprae Br4923 | MLBr_01816 | - | 2e-58 | 32.95% (522) | ABC transporter ATP-binding protein, possibly in EF-3 subfamily |
| M. abscessus ATCC 19977 | MAB_4781c | - | 0.0 | 85.12% (551) | ABC transporter ATP-binding protein |
| M. marinum M | MMAR_2279 | - | 1e-59 | 33.85% (520) | ATP-binding protein ABC transporter |
| M. avium 104 | MAV_3306 | - | 6e-60 | 33.08% (523) | ABC transporter ATP-binding protein |
| M. smegmatis MC2 155 | MSMEG_6748 | - | 0.0 | 86.44% (553) | ABC transporter ATPase |
| M. thermoresistible (build 8) | TH_3270 | - | 6e-61 | 33.27% (532) | PUTATIVE ABC transporter-related protein |
| M. ulcerans Agy99 | MUL_1481 | - | 3e-59 | 33.65% (520) | ATP-binding protein ABC transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2279|M.marinum_M ---MITATDLEVRAGARILLSPD-GPDLRVQPGDRIGLVGRNGAGKTTTL
MUL_1481|M.ulcerans_Agy99 ---MITATDVEVRAGARILLSPD-GPDLRVQPGDRIGLVGRNGAGKTTTL
MAV_3306|M.avium_104 ---MITATDLEVRAGARILLSPD-GPDLRVQPGDRIGLVGRNGAGKTTTL
Mb1508|M.bovis_AF2122/97 ---MITATDLEVRAGARILLAPD-GPDLRVQPGDRIGLVGRNGAGKTTTL
Rv1473|M.tuberculosis_H37Rv ---MITATDLEVRAGARILLAPD-GPDLRVQPGDRIGLVGRNGAGKTTTL
MLBr_01816|M.leprae_Br4923 ---MITATDLEVRAGARILLSSD-GPDLRVQPGDRIGLVGRNGAGKTTTL
TH_3270|M.thermoresistible__bu ---VITASGLEVRAGARTLLSLDDGQVLRVQPGDRIGLVGRNGAGKTTTL
Mvan_5841|M.vanbaalenii_PYR-1 ---MTATLVAKNVAGGFAHRTLFEGVDLTVAPGDVVGVVGANGAGKSTLL
Mflv_0995|M.gilvum_PYR-GCK ---MTATLVAKNVAGGFAHRTLFDGVDLTVAPGDVLGVVGVNGAGKSTLL
MSMEG_6748|M.smegmatis_MC2_155 MGTMTATLVAKNVAGGFAHRTLFEGLDLTVARGDVIGVVGANGAGKSTLL
MAB_4781c|M.abscessus_ATCC_199 ---MTATLVAKNLAGGFAHRTLFEGLDVTVAPGDVVGVVGANGAGKSTLL
: :: : **. : * : * ** :*:** *****:* *
MMAR_2279|M.marinum_M RILAGESEPYAGSVTRA---GEIGYLPQDPKEGDLEVLARDRVLSARGLD
MUL_1481|M.ulcerans_Agy99 RILAGESEPYAGSVTRA---GEIGYLPQDPKEGDLEVLARDRVLSARGLD
MAV_3306|M.avium_104 RILAGETEPYAGTIARS---GEIGYLPQDPKEGDLDVLARDRVLSARGLD
Mb1508|M.bovis_AF2122/97 RILAGEVEPYAGSVTRA---GEIGYLPQDPKVGDLDVLARDRVLSARGLD
Rv1473|M.tuberculosis_H37Rv RILAGEVEPYAGSVTRA---GEIGYLPQDPKVGDLDVLARDRVLSARGLD
MLBr_01816|M.leprae_Br4923 RILAGATEPYAGSVTWT---GEIGYLPQDPKVGNLDVLARDRVLSARGLD
TH_3270|M.thermoresistible__bu RILAGEGEPYAGTVTRT---GDIGYLPQDPKQGDLDVLARDRVLSARGLD
Mvan_5841|M.vanbaalenii_PYR-1 RILAGELEPLDGSVAVAPADAFVGWLPQEHERVPGETVAAYVARRTGCAE
Mflv_0995|M.gilvum_PYR-GCK RILARDLEPLEGTVSVAPADAFVGWLPQEHERVPGETVAAYIARRTGCAA
MSMEG_6748|M.smegmatis_MC2_155 RILAGDLDPLEGAVSVAPADAFVGWLPQEHERVPGETVAAYVARRAGCAD
MAB_4781c|M.abscessus_ATCC_199 RILAGDLQPLSGTVGVAPGDAFIGWLPQEHERIPGETVAAYIARRTGCIA
**** :* *:: : . :*:***: : :.:* . :
MMAR_2279|M.marinum_M VLLTDLEKQQALMAEVADDAARDRAIRRYGQLEERFVALGGYGAESEASR
MUL_1481|M.ulcerans_Agy99 VLLTDLEKQQALMAEVADDAARDRAIRRYGQLEERFVTLGGYGAESEASR
MAV_3306|M.avium_104 VLLTDLEKQQALMAEVADDDARDRAIRRYGQLEERFVALGGYGAESEASR
Mb1508|M.bovis_AF2122/97 VLLTDLEKQQALMAEVADEDERDRAIRRYGQLEERFVALGGYGAESEAGR
Rv1473|M.tuberculosis_H37Rv VLLTDLEKQQALMAEVADEDERDRAIRRYGQLEERFVALGGYGAESEAGR
MLBr_01816|M.leprae_Br4923 VLLTDLEKQQALMAEVADDDARDRAIRRYGQLEERFLALGGYSAESEAGR
TH_3270|M.thermoresistible__bu TLLAELEKQQVLMAEVVDDAARDRAVRRYGQLEERFAALGGYAAESEAGR
Mvan_5841|M.vanbaalenii_PYR-1 ATRAMDAAAATLDDAGNGAD-------AYSAALDHWLATGAADLDERLPA
Mflv_0995|M.gilvum_PYR-GCK ATLRMDAAAEELADSEQGAD-------AYSAALEHWLATGAADLDERMPA
MSMEG_6748|M.smegmatis_MC2_155 ATSAMEAAAAALADPTSNADPAVDPAEAYSAALDHWLATGAADLDERLPA
MAB_4781c|M.abscessus_ATCC_199 ATEAMESAAAALADQVQGRAD---LADEYSVAFDRWLACGAADLEDRVPA
. * . *. ::: : *. :..
MMAR_2279|M.marinum_M ICASLGLP---ERVLTQQLRTLSGGQRRRVELARILFAASD---TGAGSS
MUL_1481|M.ulcerans_Agy99 ICASLGLP---ERVLTQQLRTLSGGQRRRVELARILFAASD---TGAGSS
MAV_3306|M.avium_104 ICASLGLP---ERVLTQQLRTLSGGQRRRVELARILFAAAEGGATGSGSA
Mb1508|M.bovis_AF2122/97 ICASLGLP---ERVLTQRLRTLSGGQRRRVELARILFAASE---SGAGNS
Rv1473|M.tuberculosis_H37Rv ICASLGLP---ERVLTQRLRTLSGGQRRRVELARILFAASE---SGAGNS
MLBr_01816|M.leprae_Br4923 ICASLGLP---ERVLVQQLCTLSGGQRRRVELARILFAASRAGTGASGSG
TH_3270|M.thermoresistible__bu ICASLGLP---DRVLTQPLRTLSGGQRRRVELARILFAAADSG-SGGGAG
Mvan_5841|M.vanbaalenii_PYR-1 VLADLGLDSDAVRPDSTPMTALSGGQAARVGLAALLLSRFD---------
Mflv_0995|M.gilvum_PYR-GCK VLADLGLDSDAVRPESTMMTALSGGQAARVGLAALMLSRFD---------
MSMEG_6748|M.smegmatis_MC2_155 VLADLGLDTEMVRPDSTLMTALSGGQAARVGLAALLVSRFD---------
MAB_4781c|M.abscessus_ATCC_199 VLNDVGLGPDTVRPASTLMTSLSGGQAARVGLAALVLSRFD---------
: .:** * : :***** ** ** ::.:
MMAR_2279|M.marinum_M TVLLLDEPTNHLDADSVGWLRDFLRAHTGGLIIISHNVELLADVVNRVWF
MUL_1481|M.ulcerans_Agy99 TVLLLDEPTNHLDADSVGWLRDFLRAHTGGLIIISHNVELLADVVNRVWF
MAV_3306|M.avium_104 TTLLLDEPTNHLDADSIGWLRDFLRAHTGGLVIISHNVELLADVVNRVWF
Mb1508|M.bovis_AF2122/97 TTLLLDEPTNHLDADSLGWLRDFLRLHTGGLVVISHNVDLVADVVNKVWF
Rv1473|M.tuberculosis_H37Rv TTLLLDEPTNHLDADSLGWLRDFLRLHTGGLVVISHNVDLVADVVNKVWF
MLBr_01816|M.leprae_Br4923 TTLLLDEPTNHLDADSLGWLRDFLRSHTGGLVVISHNVELIAAVVNRVWF
TH_3270|M.thermoresistible__bu TTLLLDEPTNHLDADSIGWLRTFLQNHTGGLVIISHNVELLAEVVNRVWF
Mvan_5841|M.vanbaalenii_PYR-1 -IVLLDEPTNDLDLDGLARLERFVSELRGGVVLVSHDREFLARTVTRVLE
Mflv_0995|M.gilvum_PYR-GCK -IVLLDEPTNDLDLDGLDRLERLVRELRGGVVLVSHDREFLARSVTRVLE
MSMEG_6748|M.smegmatis_MC2_155 -IVLLDEPTNDLDLDGLDRLEAFVRDLRGGVVLVSHDREFLARSVTGVLE
MAB_4781c|M.abscessus_ATCC_199 -VVLLDEPTNDLDLDGLARLEDFVRDLRGGVVLVSHDREFLARSVTHVLE
:*******.** *.: *. :: **::::**: :::* *. *
MMAR_2279|M.marinum_M LDAVRGEVDVYNMGWHKYLDARATDEQRRR---------------RERAN
MUL_1481|M.ulcerans_Agy99 LDAVRGEVDVYNMGWHKYLDARATDEQRRR---------------RERAN
MAV_3306|M.avium_104 LDAVRGEVDVYNMSWQKYLDARATDEQRRR---------------RERAN
Mb1508|M.bovis_AF2122/97 LDAVRGQVDVYNMGWQRYVDARATDEQRRI---------------RERAN
Rv1473|M.tuberculosis_H37Rv LDAVRGQVDVYNMGWQRYVDARATDEQRRI---------------RERAN
MLBr_01816|M.leprae_Br4923 LDAVLGKVDVYNMGWYKYLDSRATDEQRRR---------------RERVN
TH_3270|M.thermoresistible__bu LDAVRGEVDIYNMGWHKYLDARATDEQRRR---------------RERAN
Mvan_5841|M.vanbaalenii_PYR-1 LDLAQNTTTVFGGGYESYLEERAVNRRHRREQYEEFADKKADLVARARVQ
Mflv_0995|M.gilvum_PYR-GCK LDLAQHTTTVFGGGYESYLEEREVNRRHRREQYEEFADRKADLVARARVQ
MSMEG_6748|M.smegmatis_MC2_155 LDLAQNTNTLYGGGYDSYLEEREVNRRHKREQYDEFAEKKADLVARARVQ
MAB_4781c|M.abscessus_ATCC_199 LDLAQNRTTVFGGGYESYLEERAVARRHRREQYEEFAEKKADLVARARIQ
** . ::. .: *:: * . .::: * * :
MMAR_2279|M.marinum_M AERKATALRTQAAKMG--------AKATKAVAAQNMLRRADRMMAALDEE
MUL_1481|M.ulcerans_Agy99 AERKATALRTQAAKMG--------AKATKAVAAQNMLRRADRMMAALDEE
MAV_3306|M.avium_104 AERKAAALRTQAAKLG--------AKATKAVAAQNMLRRADRMMAALDEE
Mb1508|M.bovis_AF2122/97 AERKAAALRAQAAKLG--------AKATKAVAAQNMLRRADRMMAALDEE
Rv1473|M.tuberculosis_H37Rv AERKAAALRAQAAKLG--------AKATKAVAAQNMLRRADRMMAALDEE
MLBr_01816|M.leprae_Br4923 AERKATALRTQAAKMG--------AKATKAVAAQNMLRRADRMMAALDEE
TH_3270|M.thermoresistible__bu AERKAAALRAQAAKMG--------AKATKAVAAQNMLRRAERMLAALDDA
Mvan_5841|M.vanbaalenii_PYR-1 REWSSQGTRNAIRKAPDNDKIRRRAATESSEKQAQKVRQMESRIARLEEV
Mflv_0995|M.gilvum_PYR-GCK REWSSQGVRNAIRKAPDNDKIRRRAASESSEKQAQKVRQMESRIARLEEV
MSMEG_6748|M.smegmatis_MC2_155 REWSSQGVRNAIRKAPDNDKIRRRAATESSEKQAQKVRQMESRIARLEEV
MAB_4781c|M.abscessus_ATCC_199 REWSSQGVRNAIRKAPDNDKIRRRAASESSEKQAQKVRQMESRIARLEEV
* .: . * * * : .: : :*: : :* *::
MMAR_2279|M.marinum_M RVADKVARIKFPTPAACGRVPLVVKGLSKTYGSLEVFTG-VDLAIDRGSR
MUL_1481|M.ulcerans_Agy99 RVADKVARIKFPTPAACGRVPLVVKGLSKTYGSLEVFTG-VDLAIDRGSR
MAV_3306|M.avium_104 RVADKVARIKFPTPAACGRTPLTATGLSKSYGSLEVFSG-VDLAIDRGSR
Mb1508|M.bovis_AF2122/97 RVADKVARIKFPTPAACGRTPLVANGLGKTYGSLEVFTG-VDLAIDRGSR
Rv1473|M.tuberculosis_H37Rv RVADKVARIKFPTPAACGRTPLVANGLGKTYGSLEVFTG-VDLAIDRGSR
MLBr_01816|M.leprae_Br4923 RVIEKVAQIKFPTPAACGRTPLVAKGLSKTYGSLEVFTG-VNLAIDRGSR
TH_3270|M.thermoresistible__bu PVADKVARIKFPTPAPCGRTPLVAKGLTKTYGSLEVFTG-VDLAIDRGSR
Mvan_5841|M.vanbaalenii_PYR-1 EEPRKEWTLQFTIGEAPRSSAVVATLDNAVVRQGDFVLGPVALQVDAGER
Mflv_0995|M.gilvum_PYR-GCK EEPRKEWQLQFTIGSAPRSSSVVATLDKAVVRLPDFVLGPVSLQVDAGER
MSMEG_6748|M.smegmatis_MC2_155 EEPRKEWVLQFSIGAAPRSSTVVATLDNAVVRQGNFVLGPVSLQVDAGER
MAB_4781c|M.abscessus_ATCC_199 VEPRKEWVLEFTIGAAPRSSAVVATLENAVVRQGEFVLGPVSLQVDAGER
* ::*. . .:... :.. * * * :* *.*
MMAR_2279|M.marinum_M VVVLGLNGAGKTTLLRLLAGVEHPDTGGLEPGHGLRIGYFAQEHDTLDND
MUL_1481|M.ulcerans_Agy99 VVVLGLNGAGKTTLLRLLAGVEHPDTGGLEPGHGLRIGYFAQEHDTLDND
MAV_3306|M.avium_104 VVVLGLNGAGKTTLLRLLAGAETPDTGRIEPGHGLRIGYFAQEHDTLDND
Mb1508|M.bovis_AF2122/97 VVILGLNGAGKTTLLRLLAGVEQPDTGVLEPGYGLRIGYFAQEHDTLDND
Rv1473|M.tuberculosis_H37Rv VVILGLNGAGKTTLLRLLAGVEQPDTGVLEPGYGLRIGYFAQEHDTLDND
MLBr_01816|M.leprae_Br4923 VVVLGLNGAGKTTLLRVLAGAEKPDVGRLEPGHGLRIGYFAQEHDTLDNE
TH_3270|M.thermoresistible__bu VVVLGLNGAGKTTLLRLLAGVETPDAGQIEPGHGLKIGYFAQEHDTLDDH
Mvan_5841|M.vanbaalenii_PYR-1 IGITGPNGAGKSTLLRLLLGRLLPDEGRASMGASVEIGEIDQARAYFTGP
Mflv_0995|M.gilvum_PYR-GCK IGITGPNGAGKSTLLRLLLGRCQPDDGRASLGANVAIGEIDQARAEFTGA
MSMEG_6748|M.smegmatis_MC2_155 IGITGPNGAGKSTLLRLLLGRQEPDEGRASLGASVAIGEIDQARALFTGT
MAB_4781c|M.abscessus_ATCC_199 IGITGPNGAGKSTLLRLLLGRQQPDEGRASLGANVAIGEIDQARADFTGT
: : * *****:****:* * ** * . * .: ** : * : : .
MMAR_2279|M.marinum_M ATVWENIRHAAPESGEQELRGLLGAFMFTGPQLDQPAGTLSGGEKTRLAL
MUL_1481|M.ulcerans_Agy99 ATVWENIRHAAPESGEQELRGLLGAFMFTGPQLDQPAGTLSGGEKTRLAL
MAV_3306|M.avium_104 ATVWQNIRHAAPDSGEQDLRGLLGAFMFSGPQLDQPAGTLSGGEKTRLAL
Mb1508|M.bovis_AF2122/97 ATVWENVRHAAPDAGEQDLRGLLGAFMFTGPQLEQPAGTLSGGEKTRLAL
Rv1473|M.tuberculosis_H37Rv ATVWENVRHAAPDAGEQDLRGLLGAFMFTGPQLEQPAGTLSGGEKTRLAL
MLBr_01816|M.leprae_Br4923 DTVWQNIRHTAPEFGEQDLRGLLGAFMFSGPQLDQLAGTLSGGEKTRLAL
TH_3270|M.thermoresistible__bu ATVWENIRHAAPDSGEQDLRGLLGAFMFSGPQLEQPAGTLSGGEKTRLAL
Mvan_5841|M.vanbaalenii_PYR-1 ERLLDRFEQRVPEWPTADVRTLLAKFGLGADHVERAVDELSPGERTRAGL
Mflv_0995|M.gilvum_PYR-GCK DRLVDRFEQRVPDWTTADVRTLLAKFGLTADHVERGIDELSPGERTRAGL
MSMEG_6748|M.smegmatis_MC2_155 ARLVDRFEEFLPTWTTADVRTLLAKFGLRADHVEREVGRLSPGERTRAGL
MAB_4781c|M.abscessus_ATCC_199 DRLVDRFEQRVPAWSTADARTLLAKFGLRADHVERTVDELSPGERTRAGL
: :.... * : * **. * : . :::: . ** **:** .*
MMAR_2279|M.marinum_M AGLVASTANVLLLDEPTNNLDPASREQVLDALRSYQGAVVLVTHDPGAAE
MUL_1481|M.ulcerans_Agy99 AGLVASTANVLLLDEPTNNLDPASREQVLDALRSYQGAVVLVTHDPGAAE
MAV_3306|M.avium_104 AGLVASTANVLLLDEPTNNLDPASREQVLDALRSYTGAVVLVTHDPGAAE
Mb1508|M.bovis_AF2122/97 AGLVASTANVLLLDEPTNNLDPASREQVLDALRSYRGAVVLVTHDPGAAA
Rv1473|M.tuberculosis_H37Rv AGLVASTANVLLLDEPTNNLDPASREQVLDALRSYRGAVVLVTHDPGAAA
MLBr_01816|M.leprae_Br4923 AGLVASTANVLLLDEPTNNLDPASRKQVLDALRNYQGAVVLVTHDPGAAK
TH_3270|M.thermoresistible__bu AGLVASAANVLLLDEPTNNLDPASREQVLDALRSYVGAVVLVTHDPGAAE
Mvan_5841|M.vanbaalenii_PYR-1 ALLQACGTNVLVLDEPTNHLDLPAIEQLEQALESYDGALLLVTHDRRMLQ
Mflv_0995|M.gilvum_PYR-GCK ALLQARGTNVLVLDEPTNHLDLPAIEQLEAALDTYDGALLLVTHDRRMLQ
MSMEG_6748|M.smegmatis_MC2_155 ALLQARGTNVLVLDEPTNHLDLPAIEQLEQALETYDGALLLVTHDRRMLQ
MAB_4781c|M.abscessus_ATCC_199 ALLQACGTNVLVLDEPTNHLDLAAIEQLEQALETYDGALLLVTHDRRMLQ
* * * :***:******:** .: :*: ** .* **::*****
MMAR_2279|M.marinum_M ALDPQRVVLLPDATEDYWSDEYRDLIELA
MUL_1481|M.ulcerans_Agy99 ALDPQRVVLLPDATEDYWSDEYRDLIELA
MAV_3306|M.avium_104 ALDPQRVVLLPDGTEDYWSDEYRDLIELA
Mb1508|M.bovis_AF2122/97 ALGPQRVVLLPDGTEDYWSDEYRDLIELA
Rv1473|M.tuberculosis_H37Rv ALGPQRVVLLPDGTEDYWSDEYRDLIELA
MLBr_01816|M.leprae_Br4923 ALDPQRVVLLPDGTEDYWSDEYRDLIELA
TH_3270|M.thermoresistible__bu ALDPQRVVLLPDGTEDFWSDEYRDLIELA
Mvan_5841|M.vanbaalenii_PYR-1 NVRLDRSWRVENGQVTEL-----------
Mflv_0995|M.gilvum_PYR-GCK NVRLDRYWRVDGGQVSETQR---------
MSMEG_6748|M.smegmatis_MC2_155 NVRLDRRWLVDGGRVTAV-----------
MAB_4781c|M.abscessus_ATCC_199 NVRLDRAWAVDNGCVTER-----------
: :* : ..