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SSVVCSHLSFSWPDDTPLFTDLSFTVGAGRTGLVAANGAGKSTLLRLIAGELTATTGAVTADGVVGYLPQ TLPLLDDRSVADVLGVAAVIDALNALAAGDPSAHHFAMIGDDWDVEERTRAQLDRLGLGHIGLDRSLRSL SGGEVVSLGLARELLRRPDVLLLDEPTNNLDADARHRLYDALDDFGGCLLVVSHDRVLLDRMDRIAELYR GQVRFYGGNFTAYQDAVTDAQRAAQDAVRSAEQLLRREKHQRQQARERADRRAGTAARTLGDAGLPKIVA GARKRRAQETAGRSDDVHASRVDDARSRLEDAERAVRDDDALVLELPGTLVPSARMVLRLNGIRVRRNGC DVLDGIDLTVRGPERIALTGPNGAGKTTLLRTLLGEIEPDAGAVEVADGRVAYLSQRLDLLDEDRSVAEN LAAFAPSLTVTRRRHLLAQFLFRGDAVERPVRVLSGGERLRATLACVLYAEPAPQLLLLDEPTNNLDLVS VGQLESALAAYRGAFIVVSHDASFLDAIGVDRVLRLADSTLAPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4514 | - | - | 100% (535) | ABC transporter-related protein |
| M. vanbaalenii PYR-1 | Mvan_5841 | - | 7e-60 | 34.38% (541) | ABC transporter-related protein |
| M. vanbaalenii PYR-1 | Mvan_2742 | - | 1e-55 | 33.27% (535) | ABC transporter-related protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1508 | - | 7e-59 | 35.13% (538) | macrolide ABC transporter ATP-binding protein |
| M. gilvum PYR-GCK | Mflv_2181 | - | 0.0 | 75.19% (536) | ABC transporter related |
| M. tuberculosis H37Rv | Rv1473 | - | 7e-59 | 35.13% (538) | macrolide ABC transporter ATP-binding protein |
| M. leprae Br4923 | MLBr_01816 | - | 3e-50 | 32.71% (538) | ABC transporter ATP-binding protein, possibly in EF-3 subfamily |
| M. abscessus ATCC 19977 | MAB_1846 | - | 1e-131 | 50.29% (525) | putative ABC transporter ATP-binding protein |
| M. marinum M | MMAR_2279 | - | 2e-59 | 34.95% (535) | ATP-binding protein ABC transporter |
| M. avium 104 | MAV_3306 | - | 1e-56 | 33.09% (541) | ABC transporter ATP-binding protein |
| M. smegmatis MC2 155 | MSMEG_5102 | - | 0.0 | 70.49% (532) | ABC transporter ATP-binding protein |
| M. thermoresistible (build 8) | TH_3711 | - | 0.0 | 68.74% (531) | PUTATIVE ABC transporter ATP-binding protein |
| M. ulcerans Agy99 | MUL_1481 | - | 1e-59 | 34.95% (535) | ATP-binding protein ABC transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2279|M.marinum_M -----------------------------MITATDLEVRAG--ARILLSP
MUL_1481|M.ulcerans_Agy99 -----------------------------MITATDVEVRAG--ARILLSP
MAV_3306|M.avium_104 -----------------------------MITATDLEVRAG--ARILLSP
MLBr_01816|M.leprae_Br4923 -----------------------------MITATDLEVRAG--ARILLSS
Mb1508|M.bovis_AF2122/97 -----------------------------MITATDLEVRAG--ARILLAP
Rv1473|M.tuberculosis_H37Rv -----------------------------MITATDLEVRAG--ARILLAP
Mvan_4514|M.vanbaalenii_PYR-1 ---------------------------MSSVVCSHLSFSW---PDDTPLF
Mflv_2181|M.gilvum_PYR-GCK MTPALPWNTCSRTEEPAPCPHLAESFRMPSITCTHLSYSFDAGPATAPLF
MSMEG_5102|M.smegmatis_MC2_155 ----------------------------MSVVCSNLSFSW---PDDTVLF
TH_3711|M.thermoresistible__bu ----------------------------MSIVFSDVSFAW---PDGTALF
MAB_1846|M.abscessus_ATCC_1997 --------------------------MSAVISCGALTYTH---PDGSVAL
: : .
MMAR_2279|M.marinum_M DGPDLRVQPGDRIGLVGRNGAGKTTTLRILAGESEPYAGSVTRAGEIGYL
MUL_1481|M.ulcerans_Agy99 DGPDLRVQPGDRIGLVGRNGAGKTTTLRILAGESEPYAGSVTRAGEIGYL
MAV_3306|M.avium_104 DGPDLRVQPGDRIGLVGRNGAGKTTTLRILAGETEPYAGTIARSGEIGYL
MLBr_01816|M.leprae_Br4923 DGPDLRVQPGDRIGLVGRNGAGKTTTLRILAGATEPYAGSVTWTGEIGYL
Mb1508|M.bovis_AF2122/97 DGPDLRVQPGDRIGLVGRNGAGKTTTLRILAGEVEPYAGSVTRAGEIGYL
Rv1473|M.tuberculosis_H37Rv DGPDLRVQPGDRIGLVGRNGAGKTTTLRILAGEVEPYAGSVTRAGEIGYL
Mvan_4514|M.vanbaalenii_PYR-1 TDLSFTVGAG-RTGLVAANGAGKSTLLRLIAGELTATTGAVTADGVVGYL
Mflv_2181|M.gilvum_PYR-GCK ADLTFSAGPG-RTGLVGSNGSGKSTLLRLIAGELSPTAGAVTVDGVIGHL
MSMEG_5102|M.smegmatis_MC2_155 SDLSFSLGPG-RTGLVAPNGAGKSTLLKLIAGEYRPTAGSVSVDGTVGYL
TH_3711|M.thermoresistible__bu TDLSFTIGPG-RTGLVAPNGAGKSTLLDLIAGARRPTSGSVTVDGTVGHL
MAB_1846|M.abscessus_ATCC_1997 DGLDMLVPAG-RSGLVGVNGSGKSTLLKLIAGELRPTSGMVHASGEIGYL
. : .* * ***. **:**:* * ::** . :* : * :*:*
MMAR_2279|M.marinum_M PQDPKEGDLEVLARDRVLSARGLDVLLTDLEKQQALMAEVADDAARDRAI
MUL_1481|M.ulcerans_Agy99 PQDPKEGDLEVLARDRVLSARGLDVLLTDLEKQQALMAEVADDAARDRAI
MAV_3306|M.avium_104 PQDPKEGDLDVLARDRVLSARGLDVLLTDLEKQQALMAEVADDDARDRAI
MLBr_01816|M.leprae_Br4923 PQDPKVGNLDVLARDRVLSARGLDVLLTDLEKQQALMAEVADDDARDRAI
Mb1508|M.bovis_AF2122/97 PQDPKVGDLDVLARDRVLSARGLDVLLTDLEKQQALMAEVADEDERDRAI
Rv1473|M.tuberculosis_H37Rv PQDPKVGDLDVLARDRVLSARGLDVLLTDLEKQQALMAEVADEDERDRAI
Mvan_4514|M.vanbaalenii_PYR-1 PQT-----LPLLDDRSVADVLGVAAVIDALN-------ALAAGDPSAHHF
Mflv_2181|M.gilvum_PYR-GCK PQT-----LPMRDDRRVAEVLGVAEAIDALN-------ALSDGDSRDTVF
MSMEG_5102|M.smegmatis_MC2_155 PQS-----LPFTGDLTVAAVLGIAPVLDALT-------ALAAGDASDDVF
TH_3711|M.thermoresistible__bu PQH-----LPFMPEATVGDVLGITPVLTALD-------ALAAGDASEAVF
MAB_1846|M.abscessus_ATCC_1997 PQD-----LTIRADQSVPDLLGLTPVLAAIE-------AIENGSTDQTDF
** * . * *: : : : :
MMAR_2279|M.marinum_M RRYGQLEERFVALGGYGAESEASRICASLGLPERVLTQQLRTLSGGQRRR
MUL_1481|M.ulcerans_Agy99 RRYGQLEERFVTLGGYGAESEASRICASLGLPERVLTQQLRTLSGGQRRR
MAV_3306|M.avium_104 RRYGQLEERFVALGGYGAESEASRICASLGLPERVLTQQLRTLSGGQRRR
MLBr_01816|M.leprae_Br4923 RRYGQLEERFLALGGYSAESEAGRICASLGLPERVLVQQLCTLSGGQRRR
Mb1508|M.bovis_AF2122/97 RRYGQLEERFVALGGYGAESEAGRICASLGLPERVLTQRLRTLSGGQRRR
Rv1473|M.tuberculosis_H37Rv RRYGQLEERFVALGGYGAESEAGRICASLGLPERVLTQRLRTLSGGQRRR
Mvan_4514|M.vanbaalenii_PYR-1 AMIG---------DDWDVEERTRAQLDRLGLGHIGLDRSLRSLSGGEVVS
Mflv_2181|M.gilvum_PYR-GCK AAIG---------DDWDVEERTRAQLDRLGLGHVALDRSLRSLSGGEVVT
MSMEG_5102|M.smegmatis_MC2_155 TTIG---------DDWDIEERSRAQLDRLGLDTVALDRRLDTLSGGEVVS
TH_3711|M.thermoresistible__bu AAIG---------DDWDVEERCRGMLDRLGLGEVAVDRRLGSLSGGEVVA
MAB_1846|M.abscessus_ATCC_1997 DTVG---------DDWDLAERVRAELDRLGLPAAVLDRSLGELSGGEVIR
* ..:. .. *** : : * ****:
MMAR_2279|M.marinum_M VELARILFAASD---TGAGSSTVLLLDEPTNHLDADSVGWLRDFLRAHTG
MUL_1481|M.ulcerans_Agy99 VELARILFAASD---TGAGSSTVLLLDEPTNHLDADSVGWLRDFLRAHTG
MAV_3306|M.avium_104 VELARILFAAAEGGATGSGSATTLLLDEPTNHLDADSIGWLRDFLRAHTG
MLBr_01816|M.leprae_Br4923 VELARILFAASRAGTGASGSGTTLLLDEPTNHLDADSLGWLRDFLRSHTG
Mb1508|M.bovis_AF2122/97 VELARILFAASE---SGAGNSTTLLLDEPTNHLDADSLGWLRDFLRLHTG
Rv1473|M.tuberculosis_H37Rv VELARILFAASE---SGAGNSTTLLLDEPTNHLDADSLGWLRDFLRLHTG
Mvan_4514|M.vanbaalenii_PYR-1 LGLARELLRRPD----------VLLLDEPTNNLDADARHRLYDALDDFGG
Mflv_2181|M.gilvum_PYR-GCK LGLARELLRRPD----------VLLLDEPTNNLDADARGKLCDALDDFTG
MSMEG_5102|M.smegmatis_MC2_155 LGLAAQLLKRPE----------VLMLDEPTNNLDSAARQRFYDALDGYSG
TH_3711|M.thermoresistible__bu VGLAAQLLRRPE----------VLLLDEPTNNLDADARRRLHAALDDYPG
MAB_1846|M.abscessus_ATCC_1997 LGLARLLLRRPD----------VLLLDEPTNNLDGESRRHLYDVVSAWQR
: ** *: . .*:******:**. : : :
MMAR_2279|M.marinum_M GLIIISHNVELLADVVNRVWFLDAVRGEVDVYNMGWHKYLDARATDE---
MUL_1481|M.ulcerans_Agy99 GLIIISHNVELLADVVNRVWFLDAVRGEVDVYNMGWHKYLDARATDE---
MAV_3306|M.avium_104 GLVIISHNVELLADVVNRVWFLDAVRGEVDVYNMSWQKYLDARATDE---
MLBr_01816|M.leprae_Br4923 GLVVISHNVELIAAVVNRVWFLDAVLGKVDVYNMGWYKYLDSRATDE---
Mb1508|M.bovis_AF2122/97 GLVVISHNVDLVADVVNKVWFLDAVRGQVDVYNMGWQRYVDARATDE---
Rv1473|M.tuberculosis_H37Rv GLVVISHNVDLVADVVNKVWFLDAVRGQVDVYNMGWQRYVDARATDE---
Mvan_4514|M.vanbaalenii_PYR-1 CLLVVSHDRVLLDRMDR---IAELYRGQVRFYGGNFTAYQDAVTDAQRAA
Mflv_2181|M.gilvum_PYR-GCK CLLLVSHDRMLLDRMDR---IAELDRGEVVLYGGNFTAYQGAVADAQRAA
MSMEG_5102|M.smegmatis_MC2_155 CLLVVSHDRALLDRMDQ---IAELYRGEVVFYGGNFTAYRETVEANQRAA
TH_3711|M.thermoresistible__bu TLLVVSHDRVLLDRMER---IAELYRGEMLFYGGNFTTYQRQLAADQQSA
MAB_1846|M.abscessus_ATCC_1997 TLLVVSHDRELLEHVER---IGDLRDGGVTWYGGGYSDYAAAVAAEQEAA
*:::**: *: : . : : * : *. .: * :
MMAR_2279|M.marinum_M -----------QRRRRERANAERKATALRTQAAKMGAKATKAVAAQNMLR
MUL_1481|M.ulcerans_Agy99 -----------QRRRRERANAERKATALRTQAAKMGAKATKAVAAQNMLR
MAV_3306|M.avium_104 -----------QRRRRERANAERKAAALRTQAAKLGAKATKAVAAQNMLR
MLBr_01816|M.leprae_Br4923 -----------QRRRRERVNAERKATALRTQAAKMGAKATKAVAAQNMLR
Mb1508|M.bovis_AF2122/97 -----------QRRIRERANAERKAAALRAQAAKLGAKATKAVAAQNMLR
Rv1473|M.tuberculosis_H37Rv -----------QRRIRERANAERKAAALRAQAAKLGAKATKAVAAQNMLR
Mvan_4514|M.vanbaalenii_PYR-1 QDAVRSAEQLLRREKHQRQQARERADRRAGTAARTLGDAGLPKIVAGARK
Mflv_2181|M.gilvum_PYR-GCK RDTVRNAEQTIKREQRQRQQARERADRRSGNAARTLKDAGLPKIVAGARK
MSMEG_5102|M.smegmatis_MC2_155 ESSIRNAEQQLKREKRQMQEARERAARRSSAAARNLKDAGLPKIVAGKLK
TH_3711|M.thermoresistible__bu RNDVRHAEQSLRREKRERQQARERAARRSGTAARTVKDAGLPRIVAGAMK
MAB_1846|M.abscessus_ATCC_1997 AQAISTAKAEVRRERRDLAEAERVIAQRRRYGAKMQANKREPKIVMGLRK
:*. :: :*.. .*: . . . . :
MMAR_2279|M.marinum_M RADRMMAALDE-------------------ERVADKVARIKFP-TPAACG
MUL_1481|M.ulcerans_Agy99 RADRMMAALDE-------------------ERVADKVARIKFP-TPAACG
MAV_3306|M.avium_104 RADRMMAALDE-------------------ERVADKVARIKFP-TPAACG
MLBr_01816|M.leprae_Br4923 RADRMMAALDE-------------------ERVIEKVAQIKFP-TPAACG
Mb1508|M.bovis_AF2122/97 RADRMMAALDE-------------------ERVADKVARIKFP-TPAACG
Rv1473|M.tuberculosis_H37Rv RADRMMAALDE-------------------ERVADKVARIKFP-TPAACG
Mvan_4514|M.vanbaalenii_PYR-1 RRAQETAGRSDDVHASRVDDARSRLEDAERAVRDDDALVLELPGTLVPSA
Mflv_2181|M.gilvum_PYR-GCK RRAQESAARADDVHARRIDEAKLRLVSAERAVRDDDELALQLPATTVAAG
MSMEG_5102|M.smegmatis_MC2_155 RDAQESAAKSDDVHAKRVDAARARLEDAERALRDDKVIVLDLPDTEVPAG
TH_3711|M.thermoresistible__bu RRAQESAGRTDEVRAARIAAGRARLEEAEKRLRDDDAMVLDLPDTTVPAG
MAB_1846|M.abscessus_ATCC_1997 RAAQESAAALKQTQTDRLDKARENLGEAQTRLRADRSIRIDLPGTEVPAG
* : *. . : :.:* * ....
MMAR_2279|M.marinum_M RVPLVVKGLSKTYGSLEVFT--GVDLAIDRGSRVVVLGLNGAGKTTLLRL
MUL_1481|M.ulcerans_Agy99 RVPLVVKGLSKTYGSLEVFT--GVDLAIDRGSRVVVLGLNGAGKTTLLRL
MAV_3306|M.avium_104 RTPLTATGLSKSYGSLEVFS--GVDLAIDRGSRVVVLGLNGAGKTTLLRL
MLBr_01816|M.leprae_Br4923 RTPLVAKGLSKTYGSLEVFT--GVNLAIDRGSRVVVLGLNGAGKTTLLRV
Mb1508|M.bovis_AF2122/97 RTPLVANGLGKTYGSLEVFT--GVDLAIDRGSRVVILGLNGAGKTTLLRL
Rv1473|M.tuberculosis_H37Rv RTPLVANGLGKTYGSLEVFT--GVDLAIDRGSRVVILGLNGAGKTTLLRL
Mvan_4514|M.vanbaalenii_PYR-1 RMVLRLNGIRVRRNGCDVLD--GIDLTVRGPERIALTGPNGAGKTTLLRT
Mflv_2181|M.gilvum_PYR-GCK RTVLQASALQVDRGGRTLLA--GVDLTIRGPERIALTGRNGAGKTTLLRT
MSMEG_5102|M.smegmatis_MC2_155 RTLFTGTGLQISRGGRNLFADNGIDVSIRGPERIALTGSNGAGKSTLLRI
TH_3711|M.thermoresistible__bu RTVFAGSGLTVGNVLR------GIDLTVRGPERIALTGANGVGKTTLLRV
MAB_1846|M.abscessus_ATCC_1997 RVVLTTEQLVLRHGVP-------AHLDLRGPQRVGLVGPNGSGKTTLLHT
* : : .: : .*: : * ** **:***:
MMAR_2279|M.marinum_M LAGVEHPDTGGLEPGHGLRIGYFAQEHDTLDNDATVWENIRHAAPESGEQ
MUL_1481|M.ulcerans_Agy99 LAGVEHPDTGGLEPGHGLRIGYFAQEHDTLDNDATVWENIRHAAPESGEQ
MAV_3306|M.avium_104 LAGAETPDTGRIEPGHGLRIGYFAQEHDTLDNDATVWQNIRHAAPDSGEQ
MLBr_01816|M.leprae_Br4923 LAGAEKPDVGRLEPGHGLRIGYFAQEHDTLDNEDTVWQNIRHTAPEFGEQ
Mb1508|M.bovis_AF2122/97 LAGVEQPDTGVLEPGYGLRIGYFAQEHDTLDNDATVWENVRHAAPDAGEQ
Rv1473|M.tuberculosis_H37Rv LAGVEQPDTGVLEPGYGLRIGYFAQEHDTLDNDATVWENVRHAAPDAGEQ
Mvan_4514|M.vanbaalenii_PYR-1 LLGEIEPDAGAVEVADGR-VAYLSQRLDLLDEDRSVAENLAAFAPSLTVT
Mflv_2181|M.gilvum_PYR-GCK LRGDVVPDAGTVQVADGR-VAYLSQRLDLLDDDRTLSDNLAMSAPTLSVT
MSMEG_5102|M.smegmatis_MC2_155 IDGQLKPDGGTCQQADGR-VAYLSQRLDLLDLDRSVAESLAASAPSLTHT
TH_3711|M.thermoresistible__bu IGGRLAPDAGTVTRADGR-IAYLSQRLDLLDPGQTVLDNLAEFAPTLSVT
MAB_1846|M.abscessus_ATCC_1997 IAGRIPAAEGSATVHVP--LGLLPQRLDLLDDSLSVADNVARRAPHADVN
: * . * :. :.*. * ** :: :.: **
MMAR_2279|M.marinum_M ELRGLLGAFMFTGPQLDQPAGTLSGGEKTRLALAGLVASTAN--VLLLDE
MUL_1481|M.ulcerans_Agy99 ELRGLLGAFMFTGPQLDQPAGTLSGGEKTRLALAGLVASTAN--VLLLDE
MAV_3306|M.avium_104 DLRGLLGAFMFSGPQLDQPAGTLSGGEKTRLALAGLVASTAN--VLLLDE
MLBr_01816|M.leprae_Br4923 DLRGLLGAFMFSGPQLDQLAGTLSGGEKTRLALAGLVASTAN--VLLLDE
Mb1508|M.bovis_AF2122/97 DLRGLLGAFMFTGPQLEQPAGTLSGGEKTRLALAGLVASTAN--VLLLDE
Rv1473|M.tuberculosis_H37Rv DLRGLLGAFMFTGPQLEQPAGTLSGGEKTRLALAGLVASTAN--VLLLDE
Mvan_4514|M.vanbaalenii_PYR-1 RRRHLLAQFLFRGDAVERPVRVLSGGERLRATLACVLYAEPAPQLLLLDE
Mflv_2181|M.gilvum_PYR-GCK RRRHLLAQFLFRGDAVDLPVRALSGGERLRATLACVLFSEPAPHLLLLDE
MSMEG_5102|M.smegmatis_MC2_155 RRMHLLAQFLFRGDRIHLPVGALSGGERLRATLACVLFAEPAPQLLLLDE
TH_3711|M.thermoresistible__bu GRRHLLARFLFDDKRIALPIRALSGGERLRATLACVLHAEPAPQLLLLDE
MAB_1846|M.abscessus_ATCC_1997 AVRARLARFLFRGNAADKLVGALSGGERFRATLAAVLLADPAPQLLLLDE
*. *:* . .*****: * :** :: : . :*****
MMAR_2279|M.marinum_M PTNNLDPASREQVLDALRSYQGAVVLVTHDPGAAEALDPQRVVLLPDATE
MUL_1481|M.ulcerans_Agy99 PTNNLDPASREQVLDALRSYQGAVVLVTHDPGAAEALDPQRVVLLPDATE
MAV_3306|M.avium_104 PTNNLDPASREQVLDALRSYTGAVVLVTHDPGAAEALDPQRVVLLPDGTE
MLBr_01816|M.leprae_Br4923 PTNNLDPASRKQVLDALRNYQGAVVLVTHDPGAAKALDPQRVVLLPDGTE
Mb1508|M.bovis_AF2122/97 PTNNLDPASREQVLDALRSYRGAVVLVTHDPGAAAALGPQRVVLLPDGTE
Rv1473|M.tuberculosis_H37Rv PTNNLDPASREQVLDALRSYRGAVVLVTHDPGAAAALGPQRVVLLPDGTE
Mvan_4514|M.vanbaalenii_PYR-1 PTNNLDLVSVGQLESALAAYRGAFIVVSHDASFLDAIGVDRVLRLADSTL
Mflv_2181|M.gilvum_PYR-GCK PTNNLDLAGIAQLESALVAYRGAFIVVSHDAPFLDAIAVDRVVHLAGGRL
MSMEG_5102|M.smegmatis_MC2_155 PTNNLDLVSVGQLESALNAYRGAFVVVSHDERFLDTIGIERRWHLEDGRL
TH_3711|M.thermoresistible__bu PTNNLDLTSIAQLESALIAYRGAFIVVSHDDRFVAAIGVNRRLRLSDGKL
MAB_1846|M.abscessus_ATCC_1997 PTNNLDFASYDALVSALAEYRGAVLVASHDLGFLEDIGAAQVDWRPDPVI
****** .. : .** * **.::.:** : : .
MMAR_2279|M.marinum_M DYWSDEYRDLIELA
MUL_1481|M.ulcerans_Agy99 DYWSDEYRDLIELA
MAV_3306|M.avium_104 DYWSDEYRDLIELA
MLBr_01816|M.leprae_Br4923 DYWSDEYRDLIELA
Mb1508|M.bovis_AF2122/97 DYWSDEYRDLIELA
Rv1473|M.tuberculosis_H37Rv DYWSDEYRDLIELA
Mvan_4514|M.vanbaalenii_PYR-1 APG-----------
Mflv_2181|M.gilvum_PYR-GCK AEV-----------
MSMEG_5102|M.smegmatis_MC2_155 RVTAAAG-------
TH_3711|M.thermoresistible__bu S-------------
MAB_1846|M.abscessus_ATCC_1997 G-------------