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VSGRELIVFGTASQVPTRHRNHNGYLLRWDDEGFLFDPGEGTQRQMLLAGVSPTAVTRMCITHLHGDHCL GVPGIIQRLSLDRVVRPVQAYYPASGREYFARLRHASVFHDVTDVREMPVDAEGAIADGPFGTLEARRLD HPVDAVGYRVVEPDGDRFVPELLAQFGVAGPEVGQLQRAGLLRRGTQTVRLSDVTRSRRGQRFAFVMDTR LCDGVYALADGADLLVIEATFLDSDADLAARYGHLTARQAAQVATECGVRRLVLTHFSQRYPDMRGHHDE ARAVFDGDLVLAEDLARVKMPPRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5799 | - | - | 100% (304) | ribonuclease Z |
| M. vanbaalenii PYR-1 | Mvan_3908 | - | 2e-13 | 24.53% (322) | ribonuclease Z |
| M. vanbaalenii PYR-1 | Mvan_4288 | - | 3e-10 | 25.08% (295) | beta-lactamase-like protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1374 | - | 4e-11 | 25.00% (292) | hypothetical protein Mb1374 |
| M. gilvum PYR-GCK | Mflv_2669 | - | 4e-13 | 25.71% (315) | ribonuclease Z |
| M. tuberculosis H37Rv | Rv1339 | - | 4e-11 | 25.00% (292) | hypothetical protein Rv1339 |
| M. leprae Br4923 | MLBr_01173 | - | 5e-12 | 26.98% (315) | hypothetical protein MLBr_01173 |
| M. abscessus ATCC 19977 | MAB_1483 | - | 7e-11 | 25.78% (287) | hypothetical protein MAB_1483 |
| M. marinum M | MMAR_4043 | - | 3e-10 | 26.51% (298) | metal-dependent hydrolase |
| M. avium 104 | MAV_1556 | - | 5e-12 | 26.96% (293) | metal-dependent hydrolase of the beta-lactamase superfamily |
| M. smegmatis MC2 155 | MSMEG_1776 | - | 1e-120 | 67.75% (307) | ribonuclease Z |
| M. thermoresistible (build 8) | TH_1057 | - | 1e-127 | 72.70% (304) | ribonuclease Z |
| M. ulcerans Agy99 | MUL_3909 | - | 2e-10 | 26.51% (298) | metal-dependent hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1776|M.smegmatis_MC2_155 --------------MSTRELVVLGTASQVPTRLRNHNGYLLRWDNEG-FL
TH_1057|M.thermoresistible__bu -------------MVSVRELIVLGTASQVPTRYRNHNGYFLRWDQEG-FL
Mvan_5799|M.vanbaalenii_PYR-1 --------------MSGRELIVFGTASQVPTRHRNHNGYLLRWDDEG-FL
MMAR_4043|M.marinum_M -----------------MRITVLGCSGSVVGPDSAASGYLLRAPDTPPIV
MUL_3909|M.ulcerans_Agy99 ---------------MSVRITVLGCSGSVVGPDSAASGYLLRAPDTPPIV
Mb1374|M.bovis_AF2122/97 MRRCIPHRCIGHGTVVSVRITVLGCSGSVVGPDSPASGYLLRAPHTPPLV
Rv1339|M.tuberculosis_H37Rv MRRCIPHRCIGHGTVVSVRITVLGCSGSVVGPDSPASGYLLRAPHTPPLV
MLBr_01173|M.leprae_Br4923 ---------------MTVRITVLGCSGSVVGPDSPASGYLLRAPDTPPLV
MAV_1556|M.avium_104 ---------------------MLGCSGSVVGPDSPASGYLLRAPDTPPLV
MAB_1483|M.abscessus_ATCC_1997 -----------------MRVTVLGCSGSVTGPDSPASGYLLTAPDAPPLV
Mflv_2669|M.gilvum_PYR-GCK ----------------MIEVTLLGTGSPIPDARRAGPSTLVRAGGQT-FL
::* .. : . :: ::
MSMEG_1776|M.smegmatis_MC2_155 FDPGEGTQRQMLLAGVSASSVTHLCLTHFHGDHCLGVPGIVQRMSLDHVA
TH_1057|M.thermoresistible__bu FDPGEGTQRQMLLAGVSAAGLTRLCLTHFHGDHCLGVPGVIQRLSLDRVA
Mvan_5799|M.vanbaalenii_PYR-1 FDPGEGTQRQMLLAGVSPTAVTRMCITHLHGDHCLGVPGIIQRLSLDRVV
MMAR_4043|M.marinum_M IDFGGGVLG--ALQRHLDPASVHVLLSHLHADHCLDMPGLFVWR-RYHPS
MUL_3909|M.ulcerans_Agy99 IDFGGGVVG--ALQRHLDPASVHVLLSHLHADHCLDMPGLFVWR-RYHPS
Mb1374|M.bovis_AF2122/97 IDFGGGVLG--ALQRHADPASVHVLLSHLHADHCLDLPGLFVWR-RYHPS
Rv1339|M.tuberculosis_H37Rv IDFGGGVLG--ALQRHADPASVHVLLSHLHADHCLDLPGLFVWR-RYHPS
MLBr_01173|M.leprae_Br4923 LDFGGGVLG--ALQRHADPGSVHVLLSHLHADHCLDMPGLFVWR-RYHPT
MAV_1556|M.avium_104 IDFGGGVLG--ALQRYADPSSVHVLLSHLHADHCLDLPGLFVWR-RYHPT
MAB_1483|M.abscessus_ATCC_1997 IDFGGGVLG--SLQRFADPGSVSVLLSHLHADHCLDLPGLFVWR-RYHPN
Mflv_2669|M.gilvum_PYR-GCK VDCGRGVLQRAAAVGVGANQISALLLTHLHSDHIADLGDVLITRWVSNFA
.* * *. : ::*:*.** .: .:. .
MSMEG_1776|M.smegmatis_MC2_155 HPVEAHYPASGQEFFTRLR----NAS-----AFHDTVDVR-----ENPVE
TH_1057|M.thermoresistible__bu HPVTAHYPRSGREYFARLR----HAC-----AFHEVADLR-----EEPVD
Mvan_5799|M.vanbaalenii_PYR-1 RPVQAYYPASGREYFARLR----HAS-----VFHDVTDVR-----EMPVD
MMAR_4043|M.marinum_M RPKGKALLYGPSDTWSRLG----AASSPFGGEIDDCSDIF-----DVRHW
MUL_3909|M.ulcerans_Agy99 RPKGKALLYGPSDTWSRLG----AASSPFGGEIDDCSDIF-----DVRHW
Mb1374|M.bovis_AF2122/97 RPSGKALLYGPSDTWSRLG----AASSPYGGEIDDCSDIF-----DVHHW
Rv1339|M.tuberculosis_H37Rv RPSGKALLYGPSDTWSRLG----AASSPYGGEIDDCSDIF-----DVHHW
MLBr_01173|M.leprae_Br4923 RPVGKALLYGPDDTWLRLG----AASSPYGGEIDDCSDIF-----DVRHW
MAV_1556|M.avium_104 RPLGKAMLYGPGDTWSRLG----AASSPYGGEIDDCSDIF-----DVRHW
MAB_1483|M.abscessus_ATCC_1997 PPKGKAIMYGPADTLVRVG----AASAEIGGEVDDFTDIF-----DVFPW
Mflv_2669|M.gilvum_PYR-GCK PDLPPLPIIGPPGTAEVVENMLKAFSFDIGYRIAHHDDLTTPPPVEVEEV
. : . . . *: :
MSMEG_1776|M.smegmatis_MC2_155 ADGPVAIGAFGTLEARRLDHS--VDSIGYRLTEPDSRRIRSDLLALYGIH
TH_1057|M.thermoresistible__bu SDGPVATGRFGTLEARRLDHS--IESIGYRLTEPDGRRFDARKLAEFGVH
Mvan_5799|M.vanbaalenii_PYR-1 AEGAIADGPFGTLEARRLDHP--VDAVGYRVVEPDGDRFVPELLAQFGVA
MMAR_4043|M.marinum_M VDGEPVTLGGVTVVPTVVAHP--TESYGMRFTDST---------------
MUL_3909|M.ulcerans_Agy99 VDGEPVTLGGVTVVPTVVAHP--TESYGMRFTDST---------------
Mb1374|M.bovis_AF2122/97 ADSEPVTLGALTIVPRLVAHP--TESFGLRITDPS---------------
Rv1339|M.tuberculosis_H37Rv ADSEPVTLGALTIVPRLVAHP--TESFGLRITDPS---------------
MLBr_01173|M.leprae_Br4923 VDGEPVPLGALMIMPRLVAHP--TESYGLRITDPS---------------
MAV_1556|M.avium_104 VDGEPVTIGGLTVTPRVVAHP--TESYGLRVTDHT---------------
MAB_1483|M.abscessus_ATCC_1997 ADGEPVQFGSLTVTPTRVAHP--PESYGLRIEDSS---------------
Mflv_2669|M.gilvum_PYR-GCK TDGVVWGRDEVSIRVGPTDHRPVTPTIGFRIEHHG---------------
:. : * : * *. .
MSMEG_1776|M.smegmatis_MC2_155 GPAVGELQREGTIRVGPDTEPEVVHLTQVSEPRPGQRFAFVMDTRLCDAV
TH_1057|M.thermoresistible__bu GPAVRRLQADGELVV----DGRLVRLSDVSEPRPGQRFAFVMDTRLCDAV
Mvan_5799|M.vanbaalenii_PYR-1 GPEVGQLQRAGLLRR----GTQTVRLSDVTRSRRGQRFAFVMDTRLCDGV
MMAR_4043|M.marinum_M ----------------------------------GASLAYSGDTGMCDQL
MUL_3909|M.ulcerans_Agy99 ----------------------------------GASLAYSGDTGMCDQL
Mb1374|M.bovis_AF2122/97 ----------------------------------GASLAYSGDTGICDQL
Rv1339|M.tuberculosis_H37Rv ----------------------------------GASLAYSGDTGICDQL
MLBr_01173|M.leprae_Br4923 ----------------------------------GASLVYSGDTGSCDQL
MAV_1556|M.avium_104 ----------------------------------GASFVYSGDTGACDQL
MAB_1483|M.abscessus_ATCC_1997 ----------------------------------GTVLAYSGDTGICDAV
Mflv_2669|M.gilvum_PYR-GCK -----------------------------------ASVVLAGDTVPCRGL
.. ** * :
MSMEG_1776|M.smegmatis_MC2_155 YALADGTDMLVIESTFLNEHAGLALKYG------HLTARQAARVAAECHV
TH_1057|M.thermoresistible__bu FDLADRADLLVIEATFLSADADLAREYG------HLTARQAAQVADRCGV
Mvan_5799|M.vanbaalenii_PYR-1 YALADGADLLVIEATFLDSDADLAARYG------HLTARQAAQVATECGV
MMAR_4043|M.marinum_M IELARGVDVFLCEASWTHSP-DRPPDL-------HLSGTEAGRAAARAGV
MUL_3909|M.ulcerans_Agy99 IELARGVDVFLCEASWTHSP-DRPPDL-------HLSGTEAGRAAARAGV
Mb1374|M.bovis_AF2122/97 VELARGVDVFLCEASWTHSP-KHPPDL-------HLSGTEAGMVAAQAGV
Rv1339|M.tuberculosis_H37Rv VELARGVDVFLCEASWTHSP-KHPPDL-------HLSGTEAGMVAAQAGV
MLBr_01173|M.leprae_Br4923 VELARGADVFLCEASWTHSP-DRPPNL-------HLSGTEAGRAAAQASV
MAV_1556|M.avium_104 VELARGADVFLCEASWTHSP-DRPPAL-------HLSGTEAGRAAAQAGV
MAB_1483|M.abscessus_ATCC_1997 VDLARGADVFLCEASWTHMPGHRPPDL-------HLSGTEAGQIATRAGV
Mflv_2669|M.gilvum_PYR-GCK DKLAAGAGALVHTVIRRDLIEALPMQRIRDICDYHSSVEQAAETATRAGV
** .. :: . * : :*. * .. *
MSMEG_1776|M.smegmatis_MC2_155 RKLVLTHFSQRYGDTQRHFEEAAEVYHG--ELVVADDLARIAVGHRSS--
TH_1057|M.thermoresistible__bu RRLVLTHFSQRYRDLSAFRDEAAEVFDG--DLVVAEDLARIPVPRRR---
Mvan_5799|M.vanbaalenii_PYR-1 RRLVLTHFSQRYPDMRGHHDEARAVFDG--DLVLAEDLARVKMPPRR---
MMAR_4043|M.marinum_M RELLLTHIPP-WTSREDVISEAKAEFDGPVHAVVCDETFEVSLG------
MUL_3909|M.ulcerans_Agy99 RELLLTHIPP-WTSREDVISEAKAEFDGPVHAVVCDETFEVSLG------
Mb1374|M.bovis_AF2122/97 RELLLTHIPP-WTSREDVISEAKAEFDGPVHAVVCDETFEVRRAG-----
Rv1339|M.tuberculosis_H37Rv RELLLTHIPP-WTSREDVISEAKAEFDGPVHAVVCDETFEVRRAG-----
MLBr_01173|M.leprae_Br4923 RELLLTHIPP-WTSREDVISEAKAEFDGPVHAVVSGETFDIQAPERV---
MAV_1556|M.avium_104 HELLLTHIPP-WTSREDVISEAKAEFDGPVHAVVCGETFDVRRSERV---
MAB_1483|M.abscessus_ATCC_1997 KELLLTHIPP-WTSREDVIAEAKSAFDGPVHAVVAGENIDL---------
Mflv_2669|M.gilvum_PYR-GCK GILILTHYVPTLQPGQEDDWRALAATRFDRQIEIGDDLHRVQVHPGVCAK
*:*** .* . : : :
MSMEG_1776|M.smegmatis_MC2_155 ---
TH_1057|M.thermoresistible__bu ---
Mvan_5799|M.vanbaalenii_PYR-1 ---
MMAR_4043|M.marinum_M ---
MUL_3909|M.ulcerans_Agy99 ---
Mb1374|M.bovis_AF2122/97 ---
Rv1339|M.tuberculosis_H37Rv ---
MLBr_01173|M.leprae_Br4923 ---
MAV_1556|M.avium_104 ---
MAB_1483|M.abscessus_ATCC_1997 ---
Mflv_2669|M.gilvum_PYR-GCK PAG