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VGPALRAVAVAGVLIVAGVSGGVAAVPALAQPTDTDGSGQTSDDPAGGGSEDAGGGGDTTDDPVDSGDPS EEPDEPEPSRESAPDQGGSGDYGGTDDPATESPAPTLRESPFENSITLPFIRLPSAGEIPMGSWPTVSTF YTTVEIPVPTLGEFLEALQIVPSPAPPPGPAIRTQEEAPVADATTGATGGGGGGSVAEPVIFRAPLVTVP RAGTVAGKPPRTLPGKPGAAAPNGVTAPGVAGVATPVIRGSVPSTPGVTALPPASPAGGQFVRLGGNPRG VTNPTLAEIAAVALPGLAGLIFLTFSGGVIGYRQANSTRFVRTAGAERFLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5736 | - | - | 100% (332) | hypothetical protein Mvan_5736 |
| M. vanbaalenii PYR-1 | Mvan_5676 | - | 4e-18 | 29.01% (355) | hypothetical protein Mvan_5676 |
| M. vanbaalenii PYR-1 | Mvan_4994 | - | 2e-08 | 24.46% (233) | hypothetical protein Mvan_4994 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2108 | - | 2e-06 | 25.30% (249) | hypothetical protein Mb2108 |
| M. gilvum PYR-GCK | Mflv_1086 | - | 3e-81 | 49.31% (363) | hypothetical protein Mflv_1086 |
| M. tuberculosis H37Rv | Rv2082 | - | 2e-06 | 25.30% (249) | hypothetical protein Rv2082 |
| M. leprae Br4923 | MLBr_01505 | - | 5e-06 | 28.08% (146) | hypothetical protein MLBr_01505 |
| M. abscessus ATCC 19977 | MAB_0112 | - | 4e-11 | 32.29% (192) | hypothetical protein MAB_0112 |
| M. marinum M | MMAR_3260 | sucB | 4e-09 | 29.27% (205) | pyruvate dehydrogenase (E2 component) SucB |
| M. avium 104 | MAV_2329 | - | 3e-08 | 31.53% (222) | hypothetical protein MAV_2329 |
| M. smegmatis MC2 155 | MSMEG_3244 | - | 1e-13 | 25.14% (346) | hypothetical protein MSMEG_3244 |
| M. thermoresistible (build 8) | TH_3373 | - | 2e-07 | 28.23% (209) | PUTATIVE hypothetical protein Mjls_1192 |
| M. ulcerans Agy99 | MUL_3575 | sucB | 2e-09 | 28.78% (205) | dihydrolipoamide acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5736|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1086|M.gilvum_PYR-GCK --------------------------------------------------
Mb2108|M.bovis_AF2122/97 MAGDLPPGRWSALLVGAWWPARPDAPMAGVTYWRKAAQLKRNEANDLRNE
Rv2082|M.tuberculosis_H37Rv MAGDLPPGRWSALLVGAWWPARPDAPMAGVTYWRKAAQLKRNEANDLRNE
MMAR_3260|M.marinum_M ------------MAFSVQMPALGESVTEGT-----VTRWLKQEGDTVEID
MUL_3575|M.ulcerans_Agy99 ------------MAFSVQMPALGESVTEGT-----VTRWLKQEGDTVEID
MAB_0112|M.abscessus_ATCC_1997 -----------------MLFAVGRHRANPSRRSQQLKRASARAAVVTVLS
MLBr_01505|M.leprae_Br4923 --------------------------------------------------
MSMEG_3244|M.smegmatis_MC2_155 --------------------MEITNPTLKVQCGPRPRSSGDPEERRDGRR
MAV_2329|M.avium_104 ----------------------MKAERETAKRRGGSDRRGARDGSARRGR
TH_3373|M.thermoresistible__bu -------------------------------------------MADFGRW
Mvan_5736|M.vanbaalenii_PYR-1 --------------------------------MVGPALRAVAVAGVLIVA
Mflv_1086|M.gilvum_PYR-GCK --------------------------------MNGPTQRTFAVAGVLALS
Mb2108|M.bovis_AF2122/97 RSLLAVNQGRTADDLLERYWRGEQRLATIAHQCEVKSDQSEQVADAVNYL
Rv2082|M.tuberculosis_H37Rv RSLLAVNQGRTADDLLERYWRGEQRLATIAHQCEVKSDQSEQVADAVNYL
MMAR_3260|M.marinum_M EPLVEVSTDKVDTEIPS-------PAAGVLTKIVAKEDDTVEVGGELAII
MUL_3575|M.ulcerans_Agy99 EPLVEVSTDKVDTEIPS-------PAAGVLTKIVAKEDDTVEVGGELAII
MAB_0112|M.abscessus_ATCC_1997 SGTLMGGFGVFAITTPAADAKPGGGSGNDHDHDHGLGGALHKLTGGLLGG
MLBr_01505|M.leprae_Br4923 --------------------------------------------------
MSMEG_3244|M.smegmatis_MC2_155 DPRRDGEHALSAGNPVGVVPRAGGHAVVERQFGHADRARTVAEDHSRSLC
MAV_2329|M.avium_104 RPAADAGAARRARGGPASAPTRESRAPKPGPQTSPVARPAERSARPKNTS
TH_3373|M.thermoresistible__bu NPNWNPDDGGQPSLQDIHRSEQFIEALSTGRPVYANDPGEDELAYLMAGW
Mvan_5736|M.vanbaalenii_PYR-1 ----GVSGG-VAAVPALAQP------TDTDGSGQTSD---DPAGGGSEDA
Mflv_1086|M.gilvum_PYR-GCK ----LVFGGTAVAAPVWADPGSETSGQDSGNTGSTADTGSEPSGSGSVET
Mb2108|M.bovis_AF2122/97 RDRLTEIAQSGNQQINQILAGKGPIEAKVAAVNAVIEQSNAMADHVGATA
Rv2082|M.tuberculosis_H37Rv RDRLTEIAQSGNQQINQILAGKGPIEAKVAAVNAVIEQSNAMADHVGATA
MMAR_3260|M.marinum_M GDAAESGGGDAPSQPEPEAEPAAAAQPEPEAEPEPQPEAKPQSGGSSAAG
MUL_3575|M.ulcerans_Agy99 GDAAESGGGDAPSQPEPEAEPAAAAQPEPEAEPEPQPEAKPQSGGSSTAG
MAB_0112|M.abscessus_ATCC_1997 GGGGNGGPGSGGARNAPSAPSFGKSLHGGSGSEGAAGGNGDSAKSDKDKD
MLBr_01505|M.leprae_Br4923 --------------------------------------------------
MSMEG_3244|M.smegmatis_MC2_155 PRCVPRSSISQHRRWRDVRPALRLRCASKPRRADHVAQWRLQVSVAGWRH
MAV_2329|M.avium_104 QAKARAKARKAKAPKVVRPRLTERLAARLAAIDLRPRTLASKVPFVVLVI
TH_3373|M.thermoresistible__bu RDRARNAPMRATITEQDAVAALQRGLPRPRGGAPRPGRRFSLTVVGSAAA
Mvan_5736|M.vanbaalenii_PYR-1 G--------------GGGDTTDDPVDSGDPSEEPDE-----PEPSRESAP
Mflv_1086|M.gilvum_PYR-GCK DPAETDPAETDPDETGSDETDPDETGGGVTDEEPDELPVRTPDDEERSDP
Mb2108|M.bovis_AF2122/97 MSNIIDATQRVFDETIGGDAHTWLRDHGVSLDAPARPRPVTAEDMTSMTA
Rv2082|M.tuberculosis_H37Rv MSNIIDATQRVFDETIGGDAHTWLRDHGVSLDTPARPRPVTAEDMTSMTA
MMAR_3260|M.marinum_M GDATPVLMPELGESVAEGTVTRWLKKVGDSVQVDEALVEVSTDKVDTEIP
MUL_3575|M.ulcerans_Agy99 GDVTPVLMPELGESVAEGTVTRWLKKVGDSVQVDEALVEVSTDKVDTEIP
MAB_0112|M.abscessus_ATCC_1997 KGPGASVPKPGSAGSTGKTADSAAGSAGSGTGTPGANSSAPGGSNGSSGG
MLBr_01505|M.leprae_Br4923 --------------------------------------------------
MSMEG_3244|M.smegmatis_MC2_155 RDPGGILSDERSWMRTTAISCAIACSAMVVGPGMAGTAVASADLFGVGGI
MAV_2329|M.avium_104 GALGVGLGLTLWLSTDSAERSYKLSHARERTRLLQQQKEALERDVREAEA
TH_3373|M.thermoresistible__bu AVICLGGFGALVAGAGPGDPLYGLRTMLFGDVVRDDPVVLAAQTQLAEVE
Mvan_5736|M.vanbaalenii_PYR-1 DQGG----------SGDYGGTDDPATESPAPTLRESPFEN-----SITLP
Mflv_1086|M.gilvum_PYR-GCK VPVR----------SGGSTARINGRYGPLAPGPQNSIYSN-----SIEIP
Mb2108|M.bovis_AF2122/97 NSPAGSPFGAAPSAPSHSTTTSGPPTAPTPTSPFGTAPMVLSSSSTSSGP
Rv2082|M.tuberculosis_H37Rv NSPAGSPFGAAPSAPSHSTTTSGPPTAPTPTSPFGTAPMVLSSSSTSSGP
MMAR_3260|M.marinum_M SPVAGVLLSIT--AEEDDVVQVGGELARIGSGSAAAAP-------PESKP
MUL_3575|M.ulcerans_Agy99 SPVAGVLLSIT--AEEDDVVQVGGELARIGSGSAAAAP-------PESKP
MAB_0112|M.abscessus_ATCC_1997 GIGGVGTTVGTTLPHSGGAAGVHTPTAEGAAATESSAGTGTHTEEHPSLK
MLBr_01505|M.leprae_Br4923 -------------------------MATIWTYLR----------------
MSMEG_3244|M.smegmatis_MC2_155 LDIFDHHKDQKKKKHSERGANVRGQQNGGSASQAGDRGSR-----RAPGF
MAV_2329|M.avium_104 APALAEAARKQGMIPTRDTAHLVQDPSGNWVVVGTPKPADG-----VPPP
TH_3373|M.thermoresistible__bu QLIAQG-------DWEAAQERLQAVTTTVATVGDETRKQE-----LVAEW
Mvan_5736|M.vanbaalenii_PYR-1 FIRLPSAGEIPMGSWPTVSTFYTTVEIPVPTLGEFLEALQIVPSPAPPP-
Mflv_1086|M.gilvum_PYR-GCK WFRLPAAGEIAPGSWPSAANFYGTLVVPVPSLSEYLRALRVAILPAPPPP
Mb2108|M.bovis_AF2122/97 PTAPTPTSPFGTAPMPPGPPPPGTVSPPLPPSAPAVGVGGPSVPAAGMPP
Rv2082|M.tuberculosis_H37Rv PTAPTPTSPFGTAPMPPGPPPPGTVSPPLPPSAPAVGVGGPSVPAAGMPP
MMAR_3260|M.marinum_M APAPEAAPETKAAPEPKAAPEPKPAPEPKAAPEPKPAPAATPQPAAAPAP
MUL_3575|M.ulcerans_Agy99 APAPEAAPETKAAPEPKAAPEPKAAPEPKAAPEPKPAPAATPQPAAAPAP
MAB_0112|M.abscessus_ATCC_1997 GALGSVAGALAPKTETATTPKTETATSPHTSTAPGATAETPTAGTTHPEH
MLBr_01505|M.leprae_Br4923 --ATAIVVGSSAALLTGGIAHADTAPAPAPAPAPAPALNIPQQLISSAAN
MSMEG_3244|M.smegmatis_MC2_155 GPGPRHAGPDRSGRPGAHRAPDRPGPAGNRQGQPSSADDRDDQQTGTARR
MAV_2329|M.avium_104 PLNSKLPDEAPQPPKPAPPAAEVPIRVELAPGGPVPARSGPEALLRAPDG
TH_3373|M.thermoresistible__bu QELSVKVESRNPDATVPPDAPPVTLPVIDPATSTEPTEPGTPSTEPAEPG
.
Mvan_5736|M.vanbaalenii_PYR-1 GPAIRTQEEAPVA-------------DATTGATGGG---GGGSVAEPVIF
Mflv_1086|M.gilvum_PYR-GCK GPAFRTQQEAPVA-------------DAFSGTTGGGDGSGGAAVSEPVVV
Mb2108|M.bovis_AF2122/97 AAAAATAPLSPQS----LGQSFTTGMTTGTPAAAGAQALSAGALHAATEP
Rv2082|M.tuberculosis_H37Rv AAAAATAPLSPQS----LGQSFTTGMTTGTPAAAGAQALSAGALHAATEP
MMAR_3260|M.marinum_M SAGDGTPYVTPLVR--KLAEENNIDLDSVTGTGVGGRIRKQDVLAAAEKK
MUL_3575|M.ulcerans_Agy99 SAGDGTPYVTPLVR--KLAEENNIDLDSVTGTGVGGRIRKQDVLAAAEKK
MAB_0112|M.abscessus_ATCC_1997 ESSAEEPKVPGVTVNMGGRTIIIWKKKPSTSTHTPGAGTGTNPGHESEGD
MLBr_01505|M.leprae_Br4923 APQILQNLATALG------------ATPPVTPSAPGISFPGLTPAAATVP
MSMEG_3244|M.smegmatis_MC2_155 SAQSVDVPESAITG--------ARITPPAVVAGGGGNGVSRVPTGGTTGR
MAV_2329|M.avium_104 ASTLGGQHLAPAVP---------------PVPGTPPGVPGGPVAAPPALP
TH_3373|M.thermoresistible__bu EPTEPGDPDMPVDG-----------TEPTSPGTEPTAGPDQPTVPPTVGP
. .
Mvan_5736|M.vanbaalenii_PYR-1 RAPLVTVPRAGTVAGK---------------PPRTLPGKPGAAAPNGVTA
Mflv_1086|M.gilvum_PYR-GCK RAPLVTVPRSTTVAGR---------------PTRIPTEATASGAAPAITQ
Mb2108|M.bovis_AF2122/97 LPPPAPPPTTPTVTTPTVATATTAGIP--HIPDSAPTPSPAPIAPPTTDN
Rv2082|M.tuberculosis_H37Rv LPPPAPPPTTPTVTTPTVATATTAGIP--HIPDSAPTPSPAPIAPPTTDN
MMAR_3260|M.marinum_M KERPEAKPAAAQASAP-----------------ASPSKAAAPAAAAALAH
MUL_3575|M.ulcerans_Agy99 KERPEAKPAAAQASAP-----------------ASPSKAAVPAAAAALAH
MAB_0112|M.abscessus_ATCC_1997 RDHVINLPGFPALGGATNPDAPFGGAAGTRTPGGNPSIHTGPVAPPTVPT
MLBr_01505|M.leprae_Br4923 TSSAATLPSLPGIMAP-----------------AISNTPTTPGLPASTPG
MSMEG_3244|M.smegmatis_MC2_155 APNLAPVPTAPSNRSIVIR--------------AQPPVASAPSVPAAPVA
MAV_2329|M.avium_104 GGPVAAVPPASP---------------------AMPTGPATGRPPGLTPG
TH_3373|M.thermoresistible__bu TSEPATSEPAMTAPTT-----------------TVPTSAPGSAVRTTTSA
.
Mvan_5736|M.vanbaalenii_PYR-1 PGVAGVATPVIRGSVPSTPGVTALPPASPAGGQFVRLGG-----------
Mflv_1086|M.gilvum_PYR-GCK PGVAGVRTPAIRGSVSSTPGAAVPLQTGPSAGQSARAGL-----------
Mb2108|M.bovis_AF2122/97 ASAMTPIAPMVANGPPASPAPPAAAPAGPLPAYGADLRPPVTTPPATPPT
Rv2082|M.tuberculosis_H37Rv ASAMTPIAPMVANGPPASPAPPAAAPAGPLPAYGADLRPPVTTPPATPPT
MMAR_3260|M.marinum_M LRGTKQKASRIRQITAIKTRESLQATAQLTQTHEVDMTR-----------
MUL_3575|M.ulcerans_Agy99 LRGTKQKASRIRQITAIKTRESLQATAQLTQTHEVDMTR-----------
MAB_0112|M.abscessus_ATCC_1997 PKAPAVAIATPPAPPVLAPLAPVVPPTPPVVTVKQAEGG-----------
MLBr_01505|M.leprae_Br4923 FPQARVDMPAMPFLPVSVPPQISLP-------------------------
MSMEG_3244|M.smegmatis_MC2_155 PVPVAVPPVPPVPVVVAPPGAPAGGGGAPGPSPATPSVP-----------
MAV_2329|M.avium_104 LPMPGLPMPAGPAVAPAPAEVSIPLGGLPVPAPGQLPAP-----------
TH_3373|M.thermoresistible__bu PTTATTTSGSTTAGPTAGGPTSSGPATGPTSVPREPGAG-----------
Mvan_5736|M.vanbaalenii_PYR-1 -------------------------NPRG-VTNPTLAEIAAVALPGLAGL
Mflv_1086|M.gilvum_PYR-GCK -------------------------FARGGSANATLAEIAAVALPGVAGL
Mb2108|M.bovis_AF2122/97 PTGPISGAAVTPSSPAAGGSLMSPVVNKSTAPATTQAQPSNPTPPLASAT
Rv2082|M.tuberculosis_H37Rv PTGPISGAAVTPSSPAAGGSLMSPVVNKSTAPATTQAQPSNPTPPLASAT
MMAR_3260|M.marinum_M ------------------------IVALRARAKGSFAEREGVNLTFLPFI
MUL_3575|M.ulcerans_Agy99 ------------------------IVALRARAKGSFAEREGVNLTFLPFI
MAB_0112|M.abscessus_ATCC_1997 ------------------------RGGDVVVTAGGTKQPEAVTKPIQQFV
MLBr_01505|M.leprae_Br4923 -------------------------GDLQALASSASAAAAPVAAPTLLSA
MSMEG_3244|M.smegmatis_MC2_155 ------------------------ALTPPAVTAPAPAGPPPNAVPASFRV
MAV_2329|M.avium_104 -------------------------LPPEVPVPVQLGRPGAAPQPVVPAA
TH_3373|M.thermoresistible__bu ------------------------AGTTEPTAPAARAGEDGVGGDGTVGG
Mvan_5736|M.vanbaalenii_PYR-1 IFLTFSGG------------------------------------------
Mflv_1086|M.gilvum_PYR-GCK LFLTVGGG------------------------------------------
Mb2108|M.bovis_AF2122/97 AAATTGAAAGDTSRRAAEQQRLRRILDTVARQEPGLSWAAGLRDNGQTTL
Rv2082|M.tuberculosis_H37Rv AAATTGAAAGDTSRRAAEQQRLRRILDTVARQEPGLSWAAGLRDNGQTTL
MMAR_3260|M.marinum_M ARAVIDALKIHPNINASYNEETKEITYYDAEHLG----------------
MUL_3575|M.ulcerans_Agy99 ARAVIDALKIHPNINASYNEETKEITYYDAEHLG----------------
MAB_0112|M.abscessus_ATCC_1997 AAETIAPRTGYTDYLRLTKTSEIAAVAIPGAAGIAMMTFVG---------
MLBr_01505|M.leprae_Br4923 LP------------------------------------------------
MSMEG_3244|M.smegmatis_MC2_155 GYADYLRTANNMDLLFAVLPGMAGLVLLTAAGG-----------------
MAV_2329|M.avium_104 PLPQPVNG------------------------------------------
TH_3373|M.thermoresistible__bu DGAFAEETVG----------------------------------------
Mvan_5736|M.vanbaalenii_PYR-1 -VIGYRQANSTRFVRTAGAERFLP--------------------------
Mflv_1086|M.gilvum_PYR-GCK -MIGYRQANSARFIRTAGAERFLA--------------------------
Mb2108|M.bovis_AF2122/97 LVTDLASGWIPPHIRLPAHITLLEPAPRRRHATVTDLLGTTTVAAAHHPH
Rv2082|M.tuberculosis_H37Rv LVTDLASGWIPPHIRLPAHITLLEPAPRRRHATVTDLLGTTTVAAAHHPH
MMAR_3260|M.marinum_M FAVDTDQGLLSPVIHNAGDLSLAG--LARAIADIAGRARSGNLKPDELSG
MUL_3575|M.ulcerans_Agy99 FAVDTDQGLLSPVIHNAGDLSLAG--LARAIADIAARARSGNLKPDELSG
MAB_0112|M.abscessus_ATCC_1997 AALGYRQAKAGHTVRASAAARFLE--------------------------
MLBr_01505|M.leprae_Br4923 --------------------------------------------------
MSMEG_3244|M.smegmatis_MC2_155 -AIGVRHARAAQAVPAPQIARFMA--------------------------
MAV_2329|M.avium_104 ------AQPGAAPVASPGAPR-----------------------------
TH_3373|M.thermoresistible__bu -EVPQLTATTTVVLPQSGAADAAGD-------------------------
Mvan_5736|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1086|M.gilvum_PYR-GCK --------------------------------------------------
Mb2108|M.bovis_AF2122/97 GYLSQPDPDTPALTGDRTARIAPTIDELGPTLVETVRRHDTLPRIAQAVV
Rv2082|M.tuberculosis_H37Rv GYLSQPDPDTPALTGDRTARIAPTIDELGPTLVETVRRHDTLPPIAQAVV
MMAR_3260|M.marinum_M GTFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPR----------VV
MUL_3575|M.ulcerans_Agy99 GTFTITNIGSQGALFDTPILVPPQAAMLGTGAIVKRPR----------VV
MAB_0112|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01505|M.leprae_Br4923 --------------------------------------------------
MSMEG_3244|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2329|M.avium_104 --------------------------------------------------
TH_3373|M.thermoresistible__bu --------------------------------------------------
Mvan_5736|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1086|M.gilvum_PYR-GCK --------------------------------------------------
Mb2108|M.bovis_AF2122/97 VAATRNYGVPDNETDLLHHKTTEIHQAVLTTYPNHDIATVVDWMLLAAIN
Rv2082|M.tuberculosis_H37Rv VAATRNYGVPDNETDLLHHKTTEIHQAVLTTYPNHDIATVVDWMLLAAIN
MMAR_3260|M.marinum_M VDDTGNESIGVRSVCYLP-----------LTYDHRLVDGADAGRFLTTIK
MUL_3575|M.ulcerans_Agy99 VDDTGNESIGVRSVCYLP-----------LTYDHRLVDGADAGRFLTTIK
MAB_0112|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01505|M.leprae_Br4923 --------------------------------------------------
MSMEG_3244|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2329|M.avium_104 --------------------------------------------------
TH_3373|M.thermoresistible__bu --------------------------------------------------
Mvan_5736|M.vanbaalenii_PYR-1 ---------------------------
Mflv_1086|M.gilvum_PYR-GCK ---------------------------
Mb2108|M.bovis_AF2122/97 ALIAGDQSGANYHLAWAIAAISTRRSR
Rv2082|M.tuberculosis_H37Rv ALIAGDQSGANYHLAWAIAAISTRRSR
MMAR_3260|M.marinum_M HRLEEGAFEADLGL-------------
MUL_3575|M.ulcerans_Agy99 HRLEKGAFEADLGL-------------
MAB_0112|M.abscessus_ATCC_1997 ---------------------------
MLBr_01505|M.leprae_Br4923 ---------------------------
MSMEG_3244|M.smegmatis_MC2_155 ---------------------------
MAV_2329|M.avium_104 ---------------------------
TH_3373|M.thermoresistible__bu ---------------------------