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GASSYVGRVGGLAVALGLGAVVFSGHGVASAAPDTESSAETSESVGSASTDDRGTVQPSTSSSAAGDHRS PDSSDDAQDASRAGSPDAETPETPQAKPAARSSSSRGRLEARASRLAEADPATATPGMSSPHQSIPSEVS SETAVASTAEVVPTPVPMVTVDVADGAPPGPSEDEPQTPDTPGAVWTLLAGAHRESVVKRQAVVLPGPVA VAEGPPSVQDDADSVSDTAVVDLPPMPVTEGSSFTVSTDFMEGFVADYLARGGDPTDNARFFFGDLAVAS LDALVNPNVQPEEARLLLGNLTASGYFGGLWLRDSLRDNATGADTPAPADDSRDERPLDEAATATLAPAA IAIRLFDALATFLNKAAAGKHPWVVRTVARIAVPVQLFLYGYNRGYLEFVLENPPPGVPSRKDSLTWAGF LDCNSTAFPLELATRYDSALDRLDAPATLRWGEMAVWTKFIEGAAGVGRSVWKVITGLTGGFSPTTYNAL VDLSSAFLMVTKAATLSSMLAYADRDVDLGRSSLRLQSGLWMWVGSYFAGLISAAPAGTMPEIVAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4994 | - | - | 100% (557) | hypothetical protein Mvan_4994 |
| M. vanbaalenii PYR-1 | Mvan_1041 | - | 2e-15 | 28.69% (237) | peptidase S15 |
| M. vanbaalenii PYR-1 | Mvan_5180 | - | 4e-15 | 31.55% (187) | hypothetical protein Mvan_5180 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2538 | - | 2e-15 | 28.74% (261) | peptidase S15 |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3723c | - | 8e-06 | 21.92% (219) | hypothetical protein MAB_3723c |
| M. marinum M | MMAR_3358 | - | 5e-06 | 24.42% (172) | hypothetical protein MMAR_3358 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1629 | - | 2e-07 | 23.14% (229) | hypothetical protein MSMEG_1629 |
| M. thermoresistible (build 8) | TH_2316 | - | 1e-07 | 29.28% (181) | conserved hypothetical protein |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4994|M.vanbaalenii_PYR-1 -----------MGASSYVGRVGGLAVALGLGAVVFSGHGVASAAPDTESS
Mflv_2538|M.gilvum_PYR-GCK -----------MNAASVIGRVGGLAVAFGVGTAVLGGNAVASAKPAADGS
MSMEG_1629|M.smegmatis_MC2_155 --MGSHRAATKAASTKYAGYVGGAAVALGVGAAIAVAGQGTAHADTDSGS
TH_2316|M.thermoresistible__bu -----------------VGRVGALAVALGVGVAVATGGTAVAWADSGSTA
MAB_3723c|M.abscessus_ATCC_199 ----------MADGRGWFPGQGGWQENEGPEDLAALRRTNRMIDAIAADL
MMAR_3358|M.marinum_M MAEGARPALGLSIGATNLAAVTADSAILRKPVLTLYRQRPPEIGLPSENP
.
Mvan_4994|M.vanbaalenii_PYR-1 ------AETSESVGSASTDDRGTVQPSTS-SSAAGDHRSPDSSDDAQDAS
Mflv_2538|M.gilvum_PYR-GCK DTRASVSQASETSGAADTSEPTTAADTDTRDSDIPADDAPDSDDDAADPD
MSMEG_1629|M.smegmatis_MC2_155 ---------AKTSSKESSKESSTAGSASRGSSGVNAGPKADTKTGSKAAG
TH_2316|M.thermoresistible__bu ---------SSSSSQDSSSKSNPAQTRSSAKSGIGSGAGSGPGSRLDRPA
MAB_3723c|M.abscessus_ATCC_199 P-----------VATSDSDEYAVAMMLAAWREDVGREPMP-----AKPTL
MMAR_3358|M.marinum_M RLDQSGLVISDFVDRVGDQIGIVAADGSVHRSEALVADALRALAYTATGG
. . . .
Mvan_4994|M.vanbaalenii_PYR-1 RAGSPDAETPETPQAKPAARSSSSRGRLEAR---ASRLAEADPATATPGM
Mflv_2538|M.gilvum_PYR-GCK GAAEPDREDADGDIGLPAANEDAGDAESDDRPATSSRKPDTSDGDASTQV
MSMEG_1629|M.smegmatis_MC2_155 KTERP-RPLSKVSAGVQKAADKAGKDIKKAVDTAAARAEKAAARTEKVGA
TH_2316|M.thermoresistible__bu SRAPLGGSGADSSATEQTGAVSSGTSAWRSAGMPAGTSLTGRLADSVRDA
MAB_3723c|M.abscessus_ATCC_199 GQARNALRDRGGRSRMLATTVGSAAAVTLLFGGFGAAVYQSHPGDALYGL
MMAR_3358|M.marinum_M HTLPASTAVAYPAHWTTSAVDALGAALGRVPEWSPAGQPLLLIPDAAAAL
. .
Mvan_4994|M.vanbaalenii_PYR-1 SSPHQSIP-------------------------------SEVSSETAVAS
Mflv_2538|M.gilvum_PYR-GCK TSPASATSPTSDDDAPAETPDDAGAAAPTTSPVRQEQAITWLSSPAAVAG
MSMEG_1629|M.smegmatis_MC2_155 HVSGQINS-------------------------------QINKAAAAVSK
TH_2316|M.thermoresistible__bu VKPWRPAT-------------------------------TRSTDPTPVET
MAB_3723c|M.abscessus_ATCC_199 RTSLFGAPP------------------------------AVRTDPVVLSA
MMAR_3358|M.marinum_M FAARANPG-------------------------------IPARGVVAVCD
. . :
Mvan_4994|M.vanbaalenii_PYR-1 TAEVVPTPVPMVTVDVADGAP--------PGPSEDEPQTPDTPGAVWTLL
Mflv_2538|M.gilvum_PYR-GCK RTGAAPTPAVTASASVASPLLTLVENLFSPFAGYSPDGLPSGSPLSWAMA
MSMEG_1629|M.smegmatis_MC2_155 SVTDSLKPVTGTVKPVTKDAL----------KDFEAEQIARLKEVFTPKE
TH_2316|M.thermoresistible__bu PAEANPEAQPDAHAGSPGESTAPETQPAPSSRGIRSMTAVLPDTESTNTE
MAB_3723c|M.abscessus_ATCC_199 QTELAQVEKLISQG------------------DWEEAQQQLGVAAARVNE
MMAR_3358|M.marinum_M FGGSGTSITLADASGEYQPLGATVRHPDFSGDLIDQSLLTYVMSEMPATG
Mvan_4994|M.vanbaalenii_PYR-1 AGAHRESVVKRQAVVLPGPVAVAEGPPSVQDDADSVSDTAVVDLPPMPV-
Mflv_2538|M.gilvum_PYR-GCK AAARREALVAGGPISVDPTLDFLDGVIYGSVGATDTNGRPLIYTLLDGP-
MSMEG_1629|M.smegmatis_MC2_155 AAAPNTEPEAGSALEKTTPTARATADTQVGAQADAPADPPWSPNPLRPD-
TH_2316|M.thermoresistible__bu STNTESTVQHDDSERRSSLRSTAASVPELSTPVRLADATAVRALAERLT-
MAB_3723c|M.abscessus_ATCC_199 VGDAQQKAELASRVQQAEVRIDAKDPQATVPPEMVTETPRIMLSPPSIA-
MMAR_3358|M.marinum_M SFDPSGTSAIGSLNRLRAECRQAKEQLSLSTVATLSDALPGVSGEVRLTR
Mvan_4994|M.vanbaalenii_PYR-1 -TEGSSFTVSTDFMEGFVADYLARGGDPTDN-------------------
Mflv_2538|M.gilvum_PYR-GCK -DQGGKITLNDDGTFSFLPDLSVVDSRGVENFTVMVSQTSVLMALLEQIP
MSMEG_1629|M.smegmatis_MC2_155 -DPDP--TDFPDAIMDLRDALLGASPEFLDP-------------------
TH_2316|M.thermoresistible__bu -ERRSVTLESVRAFTDVAATTALTSAASVAA-------------------
MAB_3723c|M.abscessus_ATCC_199 -PITSTTTTSTTSTTSASTTTSDSTSASTST-------------------
MMAR_3358|M.marinum_M NELDETIRDSLDGFARVVEHTLQRAGVPAAD-------------------
Mvan_4994|M.vanbaalenii_PYR-1 ------ARFFFGDLAVASLDALVNPNVQ-------------------PEE
Mflv_2538|M.gilvum_PYR-GCK IIGDFVQPLVIGLQQVPVLGALLQPIIGYRVITTIGVDVDELVPVGAPVA
MSMEG_1629|M.smegmatis_MC2_155 --------LVREATEQIYRGSQIVPWVN----------------------
TH_2316|M.thermoresistible__bu --------ATVEPVALITAAPEATPAVDAEQP-------------AAPRL
MAB_3723c|M.abscessus_ATCC_199 --------TETSGSASPSTSSSTSTSAT----------------------
MMAR_3358|M.marinum_M ---LVAIVTVGGGANIPSVTTTLSGRFG----------------VPVITA
.
Mvan_4994|M.vanbaalenii_PYR-1 ARLLLGNLTASGYFGG--LWLRDSLRDNATGADTP--APADDSRDERPLD
Mflv_2538|M.gilvum_PYR-GCK FTTMVTSFDGTQISTN--FFPASGLQFGETAPTVLNGPGLGSAGDIDPTS
MSMEG_1629|M.smegmatis_MC2_155 -----AVIPISKILPN--LAPALGDDD--------------AARDARQLI
TH_2316|M.thermoresistible__bu VTGLLAAVGLAPFTANSPLAPTQSTPLLALLGWARRETDRAYTQQARSLV
MAB_3723c|M.abscessus_ATCC_199 -----ASTSVTSVPTSTPTTVTITTTPPSSAATITSTPASATETTTAPSV
MMAR_3358|M.marinum_M PRPQLTAATGGALRAARGPGDSSATVLTSAAPMTQTAMAPLDPDVGAVAA
Mvan_4994|M.vanbaalenii_PYR-1 EAATATLAPAAIAIR-------LFDALATFLN-------------KAAAG
Mflv_2538|M.gilvum_PYR-GCK ETTVFDLVPGLVPLRDGGYNVVTWDPRGEFASGGVLQLDNPFFEGRDVQA
MSMEG_1629|M.smegmatis_MC2_155 ITELIKTTPPGSALYYG------YDIIADLIN------------------
TH_2316|M.thermoresistible__bu TARPAVVSTAAVVDPLPADLIGETERIGRITGPGITDGPNRLNIYGTDLG
MAB_3723c|M.abscessus_ATCC_199 STAPTTSVPGVTASTTVPPTASIVTVPTTPEG------------------
MMAR_3358|M.marinum_M ADAPVSALQPALAWSEADDQSRAMPVVGDDYSG-----------------
.
Mvan_4994|M.vanbaalenii_PYR-1 KHPWVVR-------------------------------------------
Mflv_2538|M.gilvum_PYR-GCK IISWVAGRPETELDAPGDPTMGMVGGSYGGGIQLVTAGIDDRVDAIVPVI
MSMEG_1629|M.smegmatis_MC2_155 --------------------------------------------------
TH_2316|M.thermoresistible__bu IMWDMGEWRGQR--------------------------------------
MAB_3723c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3358|M.marinum_M --------------------------------------------------
Mvan_4994|M.vanbaalenii_PYR-1 ---TVARIAVPVQLFLYGYN------------------------------
Mflv_2538|M.gilvum_PYR-GCK AWNSLTRALYPTKAFKTGWATLLGLDLLEAGARINSQIYPAIILGDLLGF
MSMEG_1629|M.smegmatis_MC2_155 --------------------------------------------------
TH_2316|M.thermoresistible__bu AVHVVFGDTFSGPNMSGDWISN--------------------------AI
MAB_3723c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3358|M.marinum_M --------------------------------------------------
Mvan_4994|M.vanbaalenii_PYR-1 -RGYLEFVLENPPPGVPSRKDSLTWAGFLDCNSTAFPLELATRYDSALDR
Mflv_2538|M.gilvum_PYR-GCK ITETQEAILESSGPTVLVSSITAPTLLIQGTADGLFTLAQAVANAMLLDA
MSMEG_1629|M.smegmatis_MC2_155 --------LETPAAELKYGAVATVWNILD-------PLQLVHNKDKAVGI
TH_2316|M.thermoresistible__bu MISTSRTLYENPAGFLEQTGPAFQFIPGGQLLSWFFPAEVTVIPTAGVHA
MAB_3723c|M.abscessus_ATCC_199 -----VTIVTTRPGVVNTPVITAPTTIEAPVPITRTPDNPAPAYQAPVNS
MMAR_3358|M.marinum_M ---ASGYTSARPQLTFEENARAEPAPKSVVIPWYRLPGVIIVATVVAVLL
. : . :
Mvan_4994|M.vanbaalenii_PYR-1 LDAPATLRWG----------------------EMAVWTKFIEGAAGVGR-
Mflv_2538|M.gilvum_PYR-GCK NGVPVEMIWACGGHGVCLDPLNPIQTPLLVNTTLDWLDRYVRGNELIPTG
MSMEG_1629|M.smegmatis_MC2_155 GSAAG---------------------------------------------
TH_2316|M.thermoresistible__bu NGTQYVNYMSVRQWGVPGSWTTNFSAISRYDQATDTWVTVPSSVRSAGWL
MAB_3723c|M.abscessus_ATCC_199 PGSGN---------------------------------------------
MMAR_3358|M.marinum_M VGAAVAIALSSGEQPATRSPEATTSPPTSAPAAVPPVTDAGTSAPAPSTQ
.
Mvan_4994|M.vanbaalenii_PYR-1 ----------------------------------SVWKVITGLTGGFSPT
Mflv_2538|M.gilvum_PYR-GCK PRFEWFDQTGAYHSSDLLPTEPDFYGDPIVTDSDGGFLPIIPILGGSGPQ
MSMEG_1629|M.smegmatis_MC2_155 --------------------------------------------------
TH_2316|M.thermoresistible__bu RSSTPYRAGDQNFQQMAYVLQPVDQVGEDGVRYVYAFGTPSGRQGSVHLS
MAB_3723c|M.abscessus_ATCC_199 ---------------------------------LHGYPGSGGNAGSGSDG
MMAR_3358|M.marinum_M PP------------------------------ASQEPAPPPTQQAPPPPS
Mvan_4994|M.vanbaalenii_PYR-1 TYNALVDLSSAFLMVTKAATLSSMLAYADRDVDLGRSSLRLQSGLWMWVG
Mflv_2538|M.gilvum_PYR-GCK TQSPTPLIVSPALASEASLALNLEIAAPAGTQIVGAPEITLTYSGLGTAT
MSMEG_1629|M.smegmatis_MC2_155 --------------------------------------------------
TH_2316|M.thermoresistible__bu RVPEEHITDVSKYEYWDGNAWVSSAAHAAPIIGESTRSAGLFGFIIDWAN
MAB_3723c|M.abscessus_ATCC_199 PSRHMPAMTSVPVAPANPGSGSANQGSGSGSHTDE---------------
MMAR_3358|M.marinum_M TEAPPPSTTQAPVTTQPPATTEAPPATTQPPVTTEAPPTTQAPATQQLPT
Mvan_4994|M.vanbaalenii_PYR-1 ------SYFAGLISAAPAGTMPEIVAS-----------------------
Mflv_2538|M.gilvum_PYR-GCK ------HIYGQLVDDATGLVLGNLVTPIPVTL--------NGRTQTVTID
MSMEG_1629|M.smegmatis_MC2_155 --------------------------------------------------
TH_2316|M.thermoresistible__bu DPNVFGGYLGGLFGAKTGGNVGEMSVQYNEYLGKYVILYGNGRTNNIEMR
MAB_3723c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3358|M.marinum_M PPPIPPIPQIPPIPQIPGIGFPQVPQVP--------------QIPQVPQV
Mvan_4994|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2538|M.gilvum_PYR-GCK LEQIAYTAVPGGTLTLQLAGFATPYLDLFQ----VGFIDVESVSLSLPTV
MSMEG_1629|M.smegmatis_MC2_155 --------------------------------------------------
TH_2316|M.thermoresistible__bu IADSPEGPWSDPIILATPQQYPGLYAPMIHPWSGTGYLLDENGDPDPESL
MAB_3723c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3358|M.marinum_M PGVPGFGQVIAPQVIAPQVIAPQAANGQ----------------------
Mvan_4994|M.vanbaalenii_PYR-1 -------------------------
Mflv_2538|M.gilvum_PYR-GCK AVGAGAGAAQAGVAVGSAAA-----
MSMEG_1629|M.smegmatis_MC2_155 -------------------------
TH_2316|M.thermoresistible__bu YWNMSMWGPYNVYLMQTDLSSLVEV
MAB_3723c|M.abscessus_ATCC_199 -------------------------
MMAR_3358|M.marinum_M -------------------------