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PLSDGEVIAGYTIVRMLGSGGMGKVYLAKHPRLPRYDALKVLSTTVCADSEYRERFHREADIAATLWHPH IVAVHDRGEYEGRLWISMDHVEGTDAAWLLAERYPHGMPPALVIRIVTAVGEALDYAHQRGLLHRDVKPA NILIADPETENERIMLADFGIARRVGEVSTLTGTSMTVGTVAYSAPEQLTADEHIDGRADQYALAATAFQ LLTGSPPFQHSNPAIVISQHLTAQPPSISVHRPELSSLGMAFEKALAKSPADRFDRCVDFARALANRSGT ELPGSAFDPDATRHAAAPTGPRHAKTAAAPRSRRRVVLAGAGLVLALIAVAAAVFLARFERDVGRGEARA TASATASTAPTGSGSVTLPVVVVGADCATLGAAGVTEAGDPAYCARLASSGAPLWSLYPGEIPHPTGTSA PEGESQGPDTPVLVCMQQTGQSQVDCHDDILQENTDPGANDTQTPG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_5635 | - | - | 100% (467) | protein kinase |
M. vanbaalenii PYR-1 | Mvan_4693 | - | 7e-48 | 42.22% (270) | protein kinase |
M. vanbaalenii PYR-1 | Mvan_1066 | - | 2e-47 | 34.07% (405) | protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1775 | pknF | 1e-133 | 52.87% (488) | anchored-membrane serine/threonine-protein kinase PKNF |
M. gilvum PYR-GCK | Mflv_1172 | - | 0.0 | 76.76% (469) | protein kinase |
M. tuberculosis H37Rv | Rv1746 | pknF | 1e-133 | 52.87% (488) | anchored-membrane serine/threonine-protein kinase PKNF |
M. leprae Br4923 | MLBr_00016 | pknB | 5e-45 | 34.48% (377) | putative serine/threonine protein kinase |
M. abscessus ATCC 19977 | MAB_4435 | - | 8e-63 | 40.74% (378) | serine/threonine-protein kinase PknJ |
M. marinum M | MMAR_2606 | pknF_3 | 1e-133 | 53.31% (484) | anchored-membrane serine/threonine-protein kinase PknF_3 |
M. avium 104 | MAV_3145 | - | 1e-102 | 58.28% (338) | PknF protein |
M. smegmatis MC2 155 | MSMEG_3677 | - | 1e-138 | 52.71% (499) | serine/threonine protein kinase |
M. thermoresistible (build 8) | TH_1607 | pknI | 1e-92 | 73.57% (227) | PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE I |
M. ulcerans Agy99 | MUL_4471 | pknF | 1e-105 | 55.08% (374) | anchored-membrane serine/threonine-protein kinase PknF |
CLUSTAL 2.0.9 multiple sequence alignment Mb1775|M.bovis_AF2122/97 -------------------------------------------------- Rv1746|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2606|M.marinum_M -------------------------------------------------- MSMEG_3677|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5635|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1172|M.gilvum_PYR-GCK -------------------------------------------------- TH_1607|M.thermoresistible__bu -------------------------------------------------- MAV_3145|M.avium_104 MNEHKGTTRRIGAGRRLLSNPRQARAALRAGFQSLPGMPIGQLFRRIPPV MUL_4471|M.ulcerans_Agy99 -------------------------------------------------- MAB_4435|M.abscessus_ATCC_1997 -------------------------------------------------- MLBr_00016|M.leprae_Br4923 -------------------------------------------------- Mb1775|M.bovis_AF2122/97 ---------------------MPLAEGSTFAGFTIVRQLGSGGMGEVYLA Rv1746|M.tuberculosis_H37Rv ---------------------MPLAEGSTFAGFTIVRQLGSGGMGEVYLA MMAR_2606|M.marinum_M ---------------------MPLAAGSTFAGYTIVRQLGTGGMGEVYLA MSMEG_3677|M.smegmatis_MC2_155 ---------------------MPLAAGETFAGYNIIRLLGSGGMGEVYLA Mvan_5635|M.vanbaalenii_PYR-1 ---------------------MPLSDGEVIAGYTIVRMLGSGGMGKVYLA Mflv_1172|M.gilvum_PYR-GCK ---------------------MPLSAGEVISGYTISRMLGAGGMGEVYLA TH_1607|M.thermoresistible__bu ---------------------MPLADGQQFAEYTILRRLGAGGMGEVYLA MAV_3145|M.avium_104 DSRPHPEPAAAQGNSEPGGPRLTIGNGASFAGYTILRQLGAGGMAEVYLA MUL_4471|M.ulcerans_Agy99 ---------------------MPLPPGSAFAGYTIVGLLGSGAMGEVYLA MAB_4435|M.abscessus_ATCC_1997 -----MTSSDRSSPGPGGQQPGDLPPGTVVSGYQIERVLGRGGMGTVYLA MLBr_00016|M.leprae_Br4923 ----------------------MTTPPHLSDRYELGDILGFGGMSEVHLA : : ** *.*. *:** Mb1775|M.bovis_AF2122/97 RHPRLPRQDALKVLRADVSADGEYRARFNREADAAASLWHPHIVAVHDRG Rv1746|M.tuberculosis_H37Rv RHPRLPRQDALKVLRADVSADGEYRARFNREADAAASLWHPHIVAVHDRG MMAR_2606|M.marinum_M QHPRLPRQDALKVLRPEVSADHEYRQRFHREADAAAALWHPHIVAVHDRG MSMEG_3677|M.smegmatis_MC2_155 AHPRLPRQDALKVLPTSISADPEYRERFNREADVAAALWHPHIVEIHDRG Mvan_5635|M.vanbaalenii_PYR-1 KHPRLPRYDALKVLSTTVCADSEYRERFHREADIAATLWHPHIVAVHDRG Mflv_1172|M.gilvum_PYR-GCK KHPRLPRYDALKVLSASVSTDSEYRERFNREADIAASLWHPHIVQVHDRG TH_1607|M.thermoresistible__bu RHPRLPRNDALKVLSAEVSADDEYRRRFEQEADIAATLWHPHIVAVHDRG MAV_3145|M.avium_104 LHPRLPRRDVIKVLAEAVTVDPEFRERFNREADLAATLWHPHIVGVHDRG MUL_4471|M.ulcerans_Agy99 QHPRLPRRDALKVLPPDVSADTAFRERFQREADLAATLLHPHIVGVHDRG MAB_4435|M.abscessus_ATCC_1997 ANPNLQRSEALKILSAQSSRDPEFRARFMREASLAASLDHPNIVTVHNRG MLBr_00016|M.leprae_Br4923 RDIRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPSIVAVYDTG . .* * .:*:* * : ** :**. **:* ** ** ::: * Mb1775|M.bovis_AF2122/97 E-FDGQLWIDMDFVDGTDTVSLLRDRYPNG-MPGPEVTEIITAVAEALDY Rv1746|M.tuberculosis_H37Rv E-FDGQLWIDMDFVDGTDTVSLLRDRYPNG-MPGPEVTEIITAVAEALDY MMAR_2606|M.marinum_M E-TDGQLWIDMDYVDGTDAVTLLRDRYPNG-MPGSEVSEIITAVAEALDY MSMEG_3677|M.smegmatis_MC2_155 E-HDGQLWIAMDYVDGTDAARLLKEQYSGG-MPPHQVCEIVTAMAGALDY Mvan_5635|M.vanbaalenii_PYR-1 E-YEGRLWISMDHVEGTDAAWLLAERYPHG-MPPALVIRIVTAVGEALDY Mflv_1172|M.gilvum_PYR-GCK E-FEGRLWISMDHVEGTDAARLLAERYPDG-MPPALVARLVTAVGEALDY TH_1607|M.thermoresistible__bu E-YDGQLWIAMDHVDGTDVGRLLGEQYPNG-MPPDAVIRIITAVADALDH MAV_3145|M.avium_104 E-FNGHLWISMDYVEGTDASRLVKESYADG-MPLDEVSAIVQAVAGALDY MUL_4471|M.ulcerans_Agy99 E-FNGQLWISMDYIEGTDAAALIRSQYPAG-MPVAEVVAVVTAVAGALDY MAB_4435|M.abscessus_ATCC_1997 ETPEGDLWIAMQYVQGSDAH---SESASGR-MSLTRAVHIISEVAKALDY MLBr_00016|M.leprae_Br4923 EAETSAGPLPYIVMEYVDGATLRDIVHTDGPMPPQQAIEIVADACQALNF * . : :: * . *. . :: **:. Mb1775|M.bovis_AF2122/97 AHERRLLHRDVKPANILIANPDSPD--RRIMLADFGIAGWVDDPSGLTAT Rv1746|M.tuberculosis_H37Rv AHERRLLHRDVKPANILIANPDSPD--RRIMLADFGIAGWVDDPSGLTAT MMAR_2606|M.marinum_M AHDHKLLHRDVKPANILIAAPASQA--KRIMLADFGIAGWVGEASGLTAT MSMEG_3677|M.smegmatis_MC2_155 AHQRGLLHRDVKPANILLGHPGTDD--QRIMLADFGIARYADEASGLTAT Mvan_5635|M.vanbaalenii_PYR-1 AHQRGLLHRDVKPANILIADPETEN--ERIMLADFGIARRVGEVSTLTGT Mflv_1172|M.gilvum_PYR-GCK AHQRGLLHRDVKPANILIADPETEN--ERIMLADFGIARRVGEVSALTGT TH_1607|M.thermoresistible__bu AHSRNLLHRDVKPANILLAAGDGEQGAERVLLADFGIARWIDRSSGLTET MAV_3145|M.avium_104 AHARGLLHRDVKPANILLTHP-EAGE-RRILLADFGVARHLGDISGITET MUL_4471|M.ulcerans_Agy99 AHQRGLLHRDVKPANILLTGPDNAGG-PRIFLADFGIARQLDDISGITAT MAB_4435|M.abscessus_ATCC_1997 LHARGLVHRDVKPANILLSAGD-----RRIMLGDFGLTRALDDSNSVTSA MLBr_00016|M.leprae_Br4923 SHQNGIIHRDVKPANIMISATN------AVKVMDFGIARAIADSTSVTQT * . ::*********:: : : ***:: . :* : Mb1775|M.bovis_AF2122/97 NMTVGTVSYAAPEQLMGNE-LDGRADQYALAATAFHLLTGSPPFQHAN-P Rv1746|M.tuberculosis_H37Rv NMTVGTVSYAAPEQLMGNE-LDGRADQYALAATAFHLLTGSPPFQHAN-P MMAR_2606|M.marinum_M NMTVGTVSYAPPEQLMGHD-LDGKADQYALAATAYHLLTGSPPFQHSN-P MSMEG_3677|M.smegmatis_MC2_155 NMTVGTVTYAAPEQLLGNH-LDGRADQYALAATAYQLLTGRTPFEHSN-P Mvan_5635|M.vanbaalenii_PYR-1 SMTVGTVAYSAPEQLTADEHIDGRADQYALAATAFQLLTGSPPFQHSN-P Mflv_1172|M.gilvum_PYR-GCK NMTVGTVAYSAPEQLTADEAIDGRADQYALAATAFQLLTGKAPFQHSN-P TH_1607|M.thermoresistible__bu DMTVGTVAYAAPEQLRAAD-IDGRADQYALAATAFQLMTGAPPFQHSN-P MAV_3145|M.avium_104 NVAVGTVAYAAPEQLTGSP-IDGRADQYALAATAFHLLTGAPPFQHSN-P MUL_4471|M.ulcerans_Agy99 NLTVGTAAYAAPEQLTGAD-VDGRADQYALAATAFHLLTGAPPYQHAN-S MAB_4435|M.abscessus_ATCC_1997 GNVTATIAYAAPEILSGTA-VDGRADVYALGCTLFRMLTGQPPFGSGNSL MLBr_00016|M.leprae_Br4923 AAVIGTAQYLSPEQARGDS-VDARSDVYSLGCVLYEILTGEPPFIGDS-P . .* * .** . :*.::* *:*... :.::** .*: . Mb1775|M.bovis_AF2122/97 AVVISQHLSASPPAIGDRVP-ELTPLDPVFAKALAKQPKDRYQRCVDFAR Rv1746|M.tuberculosis_H37Rv AVVISQHLSASPPAIGDRVP-ELTPLDPVFAKALAKQPKDRYQRCVDFAR MMAR_2606|M.marinum_M AVVISQHLSAAPPAIGQRLP-ALAELDPVFAKALAKDPKDRYQRCIDFAR MSMEG_3677|M.smegmatis_MC2_155 AVVISQHLSAAPPAVGTHRP-DLATLDPVFAKALAKDPRDRYARCADFAR Mvan_5635|M.vanbaalenii_PYR-1 AIVISQHLTAQPPSISVHRP-ELSSLGMAFEKALAKSPADRFDRCVDFAR Mflv_1172|M.gilvum_PYR-GCK AIVISQHLTAQPPSIAVHRP-ELSGLGAAFQKALAKSPADRYDRCVDFAR TH_1607|M.thermoresistible__bu AXXXCGR------------------------------------------- MAV_3145|M.avium_104 IAVIGQHLHEDPPRLSDFRP-ELAALDEVFCQALAKVPEDRFDRCRAFAA MUL_4471|M.ulcerans_Agy99 VAVISQHLTAPPPALGDRRS-ELAPLDRVFAAALAKQPNERYWRCADFAQ MAB_4435|M.abscessus_ATCC_1997 PAIINAHLSAPPPRISQLAP-VPESWDALIAKAMAKTPADRYQSAGELAM MLBr_00016|M.leprae_Br4923 VSVAYQHVREDPIPPSQRHEGISVDLDAVVLKALAKNPENRYQTAAEMRA : Mb1775|M.bovis_AF2122/97 ALG-------------------------------------------HRLG Rv1746|M.tuberculosis_H37Rv ALG-------------------------------------------HRLG MMAR_2606|M.marinum_M ALS-------------------------------------------HRLG MSMEG_3677|M.smegmatis_MC2_155 ALR-------------------------------------------HRLG Mvan_5635|M.vanbaalenii_PYR-1 ALA-------------------------------------------NRSG Mflv_1172|M.gilvum_PYR-GCK ALS-------------------------------------------NRST TH_1607|M.thermoresistible__bu -------------------------------------------------- MAV_3145|M.avium_104 AVSRECDGAAAIGPDARSRTVASPAHRRRGPGRVIAAVTHRFSPQTRWAA MUL_4471|M.ulcerans_Agy99 ALS----------------QVASPQG-------AAAAVS----PSDPTLP MAB_4435|M.abscessus_ATCC_1997 AAQQILTDP------------------------------------AQHRQ MLBr_00016|M.leprae_Br4923 DLIR------------------------------------------VHSG Mb1775|M.bovis_AF2122/97 G--AGDPDDTRVSQPVA---------VAAP-AKRSLLRTAVIVPAVLAML Rv1746|M.tuberculosis_H37Rv G--AGDPDDTRVSQPVA---------VAAP-AKRSLLRTAVIVPAVLAML MMAR_2606|M.marinum_M G--VGDPDDTRISRPVA---------VAVPAAKKSLARASVIVPAVLAIL MSMEG_3677|M.smegmatis_MC2_155 T--DADVADPDATRLAP---------VARHAAPHKRPKTAALIAGVLGVL Mvan_5635|M.vanbaalenii_PYR-1 TELPGSAFDPDATRHA----------AAPTGPRHAKTAAAPRSR---RRV Mflv_1172|M.gilvum_PYR-GCK VTAAG---DPDATAHAP---------ATPTGPRHAKPAAPTAQASASRGR TH_1607|M.thermoresistible__bu -------------------------------------------------- MAV_3145|M.avium_104 ALVCAVLVAVAATWSVLYSFQPGAPPANPALASKPSPPAAVAAPIAGGPV MUL_4471|M.ulcerans_Agy99 VAICVPPEYAAATQAAPAPMP--WYPTAPAPARPRRQVRTIVVPVVVALL MAB_4435|M.abscessus_ATCC_1997 TVTQPVPATTPAPIAAPEPVHAMAPLAMADTGQSMLKHKRIAAIIGVMVL MLBr_00016|M.leprae_Br4923 QPPEAPKVLTDADRSCLLSSGAGNFGVPRTDALSRQSLDETESDGSIGRW Mb1775|M.bovis_AF2122/97 LVMAVAVTVREFQR------------------------------------ Rv1746|M.tuberculosis_H37Rv LVMAVAVAVREFQR------------------------------------ MMAR_2606|M.marinum_M LVVAIAVALREFER------------------------------------ MSMEG_3677|M.smegmatis_MC2_155 LVAAIVVAAVEFRR------------------------------------ Mvan_5635|M.vanbaalenii_PYR-1 VLAGAGLVLALIAV------------------------------------ Mflv_1172|M.gilvum_PYR-GCK ILVGAAVVLAVVAV------------------------------------ TH_1607|M.thermoresistible__bu -------------------------------------------------- MAV_3145|M.avium_104 LNGTYKLDYDQTKRTTNGIGIRHDGAGTNWWAFRSACTSSGCAATGTRLD MUL_4471|M.ulcerans_Agy99 LVSAVAFAVTQVLR------------------------------------ MAB_4435|M.abscessus_ATCC_1997 VVASSVVAVLIWPRADEG-----------------------------TDP MLBr_00016|M.leprae_Br4923 VAVVAVLAVLTIAIVAAFNTFGGNTRDVQVPDVRGQVSADAISALQNRGF Mb1775|M.bovis_AF2122/97 -----------ADDERAAQPAR----------------------TRTTTS Rv1746|M.tuberculosis_H37Rv -----------ADDERAAQPAR----------------------TRTTTS MMAR_2606|M.marinum_M -----------ADDERVAPPAA----------------------TSSSRP MSMEG_3677|M.smegmatis_MC2_155 -----------ADDERPVARAS----------------------GAATTT Mvan_5635|M.vanbaalenii_PYR-1 -----------AAAVFLARFER----------------------DVGRGE Mflv_1172|M.gilvum_PYR-GCK -----------VAVVLLAVFEK----------------------DEIRSE TH_1607|M.thermoresistible__bu -------------------------------------------------- MAV_3145|M.avium_104 DATHQAAGGPDGDQTDTLRFVGGYWQGAPEQQRVGCTRPGGPAGATQQET MUL_4471|M.ulcerans_Agy99 ---------PDPRQTTAAPAEAPQWQPYVDH-------------AKQFAI MAB_4435|M.abscessus_ATCC_1997 RTKASPSAAQVAPGASLAGQPNTVLDTLLPGQFDYPEGWEKNPSPTFRSG MLBr_00016|M.leprae_Br4923 KTRTLQKPDSTIPPDHVISTEPGANASVGAG--DEITINVSTGPEQREVP Mb1775|M.bovis_AF2122/97 AGTTTSVAPASTTRP------------------APTTPTTTGAADTATAS Rv1746|M.tuberculosis_H37Rv AGTTTSVAPASTTRP------------------APTTPTTTGAADTATAS MMAR_2606|M.marinum_M SPTAAKTSTTTATTT------------------APTSTSTSTAAATTESV MSMEG_3677|M.smegmatis_MC2_155 SHTTTPVTTAPASPPPEVTDTVTITDTATDTAAVDTSTPATTTAATTAAA Mvan_5635|M.vanbaalenii_PYR-1 AR--------------------------------ATASATASTAPTGSGS Mflv_1172|M.gilvum_PYR-GCK AR--------------------------------PTT------------- TH_1607|M.thermoresistible__bu -------------------------------------------------- MAV_3145|M.avium_104 IARSLAPQSDGTLRGTETETVLSNECGAQGAVVRVPVVATRVGDVPPGVT MUL_4471|M.ulcerans_Agy99 SLTSVNPQT-------------------------IDADIQRILDGSTGAF MAB_4435|M.abscessus_ATCC_1997 EFNPAVPPGSATNIGGTPVGCNTIDPAWALRAKGRETSTLYLRDRKKPER MLBr_00016|M.leprae_Br4923 DVSSLNYTDAVKKLTSSGFKSFKQANSPSTPELLGKVIGTNPSANQTSAI Mb1775|M.bovis_AF2122/97 PTAAVVAIGALCFPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEDTVASP Rv1746|M.tuberculosis_H37Rv PTAAVVAIGALCFPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEDTVASP MMAR_2606|M.marinum_M TPAPAVVIGAMCSPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEGTVASP MSMEG_3677|M.smegmatis_MC2_155 AAAQTAVIGASCSPVGATATTSDGSTAYCSTLATTGASIWSLTQGTIPSP Mvan_5635|M.vanbaalenii_PYR-1 VTLPVVVVGADCATLGAAGVTEAGDPAYCARLASSGAPLWSLYPGEIPHP Mflv_1172|M.gilvum_PYR-GCK -AVPVVVVGADCATLGAAGITGDGKSAYCARLSSTGEPLWSLYDGEIPHP TH_1607|M.thermoresistible__bu -------------------------------------------------- MAV_3145|M.avium_104 VADPASVINASPTATAPAPPVLGGLCSDVGKVAYDPTNNEQIVCEGSSWA MUL_4471|M.ulcerans_Agy99 HSDFADKSAQFKQSIVDAGSATQGKATGAGLESISGTTAHVVVSVTSNIT MAB_4435|M.abscessus_ATCC_1997 EILIRVVPAADALSTDGASDALKRCDAVAYIIPGSSTTWRCSFEFDEPNP MLBr_00016|M.leprae_Br4923 TNVITIIVGSGPETKQIPDVTGQIVEIAQKNLNVYGFTKFSQASVDSPRP Mb1775|M.bovis_AF2122/97 TVTATADPTEAPLPIEQESPIRVCMQQTGQTRRECREEIRRSNGWP---- Rv1746|M.tuberculosis_H37Rv TVTATADPTEAPLPIEQESPIRVCMQQTGQTRRECREEIRRSNGWP---- MMAR_2606|M.marinum_M TVSATPDPTEPPLPIDQDSPIRICMQQTGQTRHECREDIRRSNGY----- MSMEG_3677|M.smegmatis_MC2_155 TV--TPAATDEPLPFAEESPVRVCMQQTGMTRRECREAIRRSNGLP---- Mvan_5635|M.vanbaalenii_PYR-1 TGTSAPEGESQGP----DTPVLVCMQQTGQSQVDCHDDILQENTDPGAND Mflv_1172|M.gilvum_PYR-GCK SATPEP-GSAAPA----GAPVLVCVEQTGQSQADCHGDIQQENSDPTAND TH_1607|M.thermoresistible__bu -------------------------------------------------- MAV_3145|M.avium_104 KAPITMGVHAAGSSCDRPGTSVFAMSTSSDGYLLQCDPVTRTWTRPAG-- MUL_4471|M.ulcerans_Agy99 KS---TGVQQE----PRQWRLRIQIEKIDDAYLASRVEFVT--------- MAB_4435|M.abscessus_ATCC_1997 VQNGQKELTTTESCYMFPSGANSIRQHVSFNVVRGLLVYILASGASNRND MLBr_00016|M.leprae_Br4923 TGEVIGTNPPKDATVPVDSVIELQVSKGNQFVMPDLSGMFWADAEPRLRA Mb1775|M.bovis_AF2122/97 ---------------------------------------------- Rv1746|M.tuberculosis_H37Rv ---------------------------------------------- MMAR_2606|M.marinum_M ---------------------------------------------- MSMEG_3677|M.smegmatis_MC2_155 ---------------------------------------------- Mvan_5635|M.vanbaalenii_PYR-1 TQTPG----------------------------------------- Mflv_1172|M.gilvum_PYR-GCK NQG------------------------------------------- TH_1607|M.thermoresistible__bu ---------------------------------------------- MAV_3145|M.avium_104 ---------------------------------------------- MUL_4471|M.ulcerans_Agy99 ---------------------------------------------- MAB_4435|M.abscessus_ATCC_1997 AAGSLSATALSFATTMKILRYGR----------------------- MLBr_00016|M.leprae_Br4923 LGWTGVLDKGPDVDAGGSQHNRVAYQNPPAGAGVNRDGIITLKFGQ