For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_1607 | pknI | - | 100% (233) | PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE I PKNI (PROTEIN KINASE I) (STPK I) (PHOSPHORYLASE B KINASE KINASE) (HYDROXYALKYL-PROTEIN KINASE) |
| M. thermoresistible (build 8) | TH_2931 | - | 6e-52 | 49.54% (216) | PUTATIVE methylmalonyl-CoA mutase large subunit |
| M. thermoresistible (build 8) | TH_2631 | - | 1e-39 | 41.74% (218) | PUTATIVE serine/threonine protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1775 | pknF | 3e-93 | 72.57% (226) | anchored-membrane serine/threonine-protein kinase PKNF |
| M. gilvum PYR-GCK | Mflv_1172 | - | 1e-90 | 71.81% (227) | protein kinase |
| M. tuberculosis H37Rv | Rv1746 | pknF | 3e-93 | 72.57% (226) | anchored-membrane serine/threonine-protein kinase PKNF |
| M. leprae Br4923 | MLBr_00016 | pknB | 7e-41 | 42.45% (212) | putative serine/threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_4435 | - | 2e-54 | 50.22% (223) | serine/threonine-protein kinase PknJ |
| M. marinum M | MMAR_2606 | pknF_3 | 2e-91 | 71.68% (226) | anchored-membrane serine/threonine-protein kinase PknF_3 |
| M. avium 104 | MAV_3145 | - | 2e-85 | 67.11% (225) | PknF protein |
| M. smegmatis MC2 155 | MSMEG_3677 | - | 5e-90 | 70.35% (226) | serine/threonine protein kinase |
| M. ulcerans Agy99 | MUL_4471 | pknF | 2e-85 | 66.96% (224) | anchored-membrane serine/threonine-protein kinase PknF |
| M. vanbaalenii PYR-1 | Mvan_5635 | - | 6e-93 | 73.57% (227) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1172|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5635|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1607|M.thermoresistible__bu --------------------------------------------------
Mb1775|M.bovis_AF2122/97 --------------------------------------------------
Rv1746|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2606|M.marinum_M --------------------------------------------------
MSMEG_3677|M.smegmatis_MC2_155 --------------------------------------------------
MAV_3145|M.avium_104 MNEHKGTTRRIGAGRRLLSNPRQARAALRAGFQSLPGMPIGQLFRRIPPV
MUL_4471|M.ulcerans_Agy99 --------------------------------------------------
MAB_4435|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00016|M.leprae_Br4923 --------------------------------------------------
Mflv_1172|M.gilvum_PYR-GCK ---------------------MPLSAGEVISGYTISRMLGAGGMGEVYLA
Mvan_5635|M.vanbaalenii_PYR-1 ---------------------MPLSDGEVIAGYTIVRMLGSGGMGKVYLA
TH_1607|M.thermoresistible__bu ---------------------MPLADGQQFAEYTILRRLGAGGMGEVYLA
Mb1775|M.bovis_AF2122/97 ---------------------MPLAEGSTFAGFTIVRQLGSGGMGEVYLA
Rv1746|M.tuberculosis_H37Rv ---------------------MPLAEGSTFAGFTIVRQLGSGGMGEVYLA
MMAR_2606|M.marinum_M ---------------------MPLAAGSTFAGYTIVRQLGTGGMGEVYLA
MSMEG_3677|M.smegmatis_MC2_155 ---------------------MPLAAGETFAGYNIIRLLGSGGMGEVYLA
MAV_3145|M.avium_104 DSRPHPEPAAAQGNSEPGGPRLTIGNGASFAGYTILRQLGAGGMAEVYLA
MUL_4471|M.ulcerans_Agy99 ---------------------MPLPPGSAFAGYTIVGLLGSGAMGEVYLA
MAB_4435|M.abscessus_ATCC_1997 -----MTSSDRSSPGPGGQQPGDLPPGTVVSGYQIERVLGRGGMGTVYLA
MLBr_00016|M.leprae_Br4923 ----------------------MTTPPHLSDRYELGDILGFGGMSEVHLA
: : ** *.*. *:**
Mflv_1172|M.gilvum_PYR-GCK KHPRLPRYDALKVLSASVSTDSEYRERFNREADIAASLWHPHIVQVHDRG
Mvan_5635|M.vanbaalenii_PYR-1 KHPRLPRYDALKVLSTTVCADSEYRERFHREADIAATLWHPHIVAVHDRG
TH_1607|M.thermoresistible__bu RHPRLPRNDALKVLSAEVSADDEYRRRFEQEADIAATLWHPHIVAVHDRG
Mb1775|M.bovis_AF2122/97 RHPRLPRQDALKVLRADVSADGEYRARFNREADAAASLWHPHIVAVHDRG
Rv1746|M.tuberculosis_H37Rv RHPRLPRQDALKVLRADVSADGEYRARFNREADAAASLWHPHIVAVHDRG
MMAR_2606|M.marinum_M QHPRLPRQDALKVLRPEVSADHEYRQRFHREADAAAALWHPHIVAVHDRG
MSMEG_3677|M.smegmatis_MC2_155 AHPRLPRQDALKVLPTSISADPEYRERFNREADVAAALWHPHIVEIHDRG
MAV_3145|M.avium_104 LHPRLPRRDVIKVLAEAVTVDPEFRERFNREADLAATLWHPHIVGVHDRG
MUL_4471|M.ulcerans_Agy99 QHPRLPRRDALKVLPPDVSADTAFRERFQREADLAATLLHPHIVGVHDRG
MAB_4435|M.abscessus_ATCC_1997 ANPNLQRSEALKILSAQSSRDPEFRARFMREASLAASLDHPNIVTVHNRG
MLBr_00016|M.leprae_Br4923 RDIRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPSIVAVYDTG
. .* * .:*:* * : ** :**. **:* ** ** ::: *
Mflv_1172|M.gilvum_PYR-GCK E-FEGRLWISMDHVEGTDAARLLAERYPDG-MPPALVARLVTAVGEALDY
Mvan_5635|M.vanbaalenii_PYR-1 E-YEGRLWISMDHVEGTDAAWLLAERYPHG-MPPALVIRIVTAVGEALDY
TH_1607|M.thermoresistible__bu E-YDGQLWIAMDHVDGTDVGRLLGEQYPNG-MPPDAVIRIITAVADALDH
Mb1775|M.bovis_AF2122/97 E-FDGQLWIDMDFVDGTDTVSLLRDRYPNG-MPGPEVTEIITAVAEALDY
Rv1746|M.tuberculosis_H37Rv E-FDGQLWIDMDFVDGTDTVSLLRDRYPNG-MPGPEVTEIITAVAEALDY
MMAR_2606|M.marinum_M E-TDGQLWIDMDYVDGTDAVTLLRDRYPNG-MPGSEVSEIITAVAEALDY
MSMEG_3677|M.smegmatis_MC2_155 E-HDGQLWIAMDYVDGTDAARLLKEQYSGG-MPPHQVCEIVTAMAGALDY
MAV_3145|M.avium_104 E-FNGHLWISMDYVEGTDASRLVKESYADG-MPLDEVSAIVQAVAGALDY
MUL_4471|M.ulcerans_Agy99 E-FNGQLWISMDYIEGTDAAALIRSQYPAG-MPVAEVVAVVTAVAGALDY
MAB_4435|M.abscessus_ATCC_1997 ETPEGDLWIAMQYVQGSDAH---SESASGR-MSLTRAVHIISEVAKALDY
MLBr_00016|M.leprae_Br4923 EAETSAGPLPYIVMEYVDGATLRDIVHTDGPMPPQQAIEIVADACQALNF
* . : :: * . *. . :: **:.
Mflv_1172|M.gilvum_PYR-GCK AHQRGLLHRDVKPANILIADPETEN--ERIMLADFGIARRVGEVSALTGT
Mvan_5635|M.vanbaalenii_PYR-1 AHQRGLLHRDVKPANILIADPETEN--ERIMLADFGIARRVGEVSTLTGT
TH_1607|M.thermoresistible__bu AHSRNLLHRDVKPANILLAAGDGEQGAERVLLADFGIARWIDRSSGLTET
Mb1775|M.bovis_AF2122/97 AHERRLLHRDVKPANILIANPDSPD--RRIMLADFGIAGWVDDPSGLTAT
Rv1746|M.tuberculosis_H37Rv AHERRLLHRDVKPANILIANPDSPD--RRIMLADFGIAGWVDDPSGLTAT
MMAR_2606|M.marinum_M AHDHKLLHRDVKPANILIAAPASQA--KRIMLADFGIAGWVGEASGLTAT
MSMEG_3677|M.smegmatis_MC2_155 AHQRGLLHRDVKPANILLGHPGTDD--QRIMLADFGIARYADEASGLTAT
MAV_3145|M.avium_104 AHARGLLHRDVKPANILLTHP-EAGE-RRILLADFGVARHLGDISGITET
MUL_4471|M.ulcerans_Agy99 AHQRGLLHRDVKPANILLTGPDNAGG-PRIFLADFGIARQLDDISGITAT
MAB_4435|M.abscessus_ATCC_1997 LHARGLVHRDVKPANILLSAGD-----RRIMLGDFGLTRALDDSNSVTSA
MLBr_00016|M.leprae_Br4923 SHQNGIIHRDVKPANIMISATN------AVKVMDFGIARAIADSTSVTQT
* . ::*********:: : : ***:: . :* :
Mflv_1172|M.gilvum_PYR-GCK NMTVGTVAYSAPEQLTADEAIDGRADQYALAATAFQLLTGKAPFQHSN-P
Mvan_5635|M.vanbaalenii_PYR-1 SMTVGTVAYSAPEQLTADEHIDGRADQYALAATAFQLLTGSPPFQHSN-P
TH_1607|M.thermoresistible__bu DMTVGTVAYAAPEQLRAAD-IDGRADQYALAATAFQLMTGAPPFQHSN-P
Mb1775|M.bovis_AF2122/97 NMTVGTVSYAAPEQLMGNE-LDGRADQYALAATAFHLLTGSPPFQHAN-P
Rv1746|M.tuberculosis_H37Rv NMTVGTVSYAAPEQLMGNE-LDGRADQYALAATAFHLLTGSPPFQHAN-P
MMAR_2606|M.marinum_M NMTVGTVSYAPPEQLMGHD-LDGKADQYALAATAYHLLTGSPPFQHSN-P
MSMEG_3677|M.smegmatis_MC2_155 NMTVGTVTYAAPEQLLGNH-LDGRADQYALAATAYQLLTGRTPFEHSN-P
MAV_3145|M.avium_104 NVAVGTVAYAAPEQLTGSP-IDGRADQYALAATAFHLLTGAPPFQHSN-P
MUL_4471|M.ulcerans_Agy99 NLTVGTAAYAAPEQLTGAD-VDGRADQYALAATAFHLLTGAPPYQHAN-S
MAB_4435|M.abscessus_ATCC_1997 GNVTATIAYAAPEILSGTA-VDGRADVYALGCTLFRMLTGQPPFGSGNSL
MLBr_00016|M.leprae_Br4923 AAVIGTAQYLSPEQARGDS-VDARSDVYSLGCVLYEILTGEPPFIGDS-P
. .* * .** . :*.::* *:*... :.::** .*: .
Mflv_1172|M.gilvum_PYR-GCK AIVISQHLTAQPPSIAVHRP-ELSGLGAAFQKALAKSPADRYDRCVDFAR
Mvan_5635|M.vanbaalenii_PYR-1 AIVISQHLTAQPPSISVHRP-ELSSLGMAFEKALAKSPADRFDRCVDFAR
TH_1607|M.thermoresistible__bu AXXXCGR-------------------------------------------
Mb1775|M.bovis_AF2122/97 AVVISQHLSASPPAIGDRVP-ELTPLDPVFAKALAKQPKDRYQRCVDFAR
Rv1746|M.tuberculosis_H37Rv AVVISQHLSASPPAIGDRVP-ELTPLDPVFAKALAKQPKDRYQRCVDFAR
MMAR_2606|M.marinum_M AVVISQHLSAAPPAIGQRLP-ALAELDPVFAKALAKDPKDRYQRCIDFAR
MSMEG_3677|M.smegmatis_MC2_155 AVVISQHLSAAPPAVGTHRP-DLATLDPVFAKALAKDPRDRYARCADFAR
MAV_3145|M.avium_104 IAVIGQHLHEDPPRLSDFRP-ELAALDEVFCQALAKVPEDRFDRCRAFAA
MUL_4471|M.ulcerans_Agy99 VAVISQHLTAPPPALGDRRS-ELAPLDRVFAAALAKQPNERYWRCADFAQ
MAB_4435|M.abscessus_ATCC_1997 PAIINAHLSAPPPRISQLAP-VPESWDALIAKAMAKTPADRYQSAGELAM
MLBr_00016|M.leprae_Br4923 VSVAYQHVREDPIPPSQRHEGISVDLDAVVLKALAKNPENRYQTAAEMRA
:
Mflv_1172|M.gilvum_PYR-GCK ALS-------------------------------------------NRST
Mvan_5635|M.vanbaalenii_PYR-1 ALA-------------------------------------------NRSG
TH_1607|M.thermoresistible__bu --------------------------------------------------
Mb1775|M.bovis_AF2122/97 ALG-------------------------------------------HRLG
Rv1746|M.tuberculosis_H37Rv ALG-------------------------------------------HRLG
MMAR_2606|M.marinum_M ALS-------------------------------------------HRLG
MSMEG_3677|M.smegmatis_MC2_155 ALR-------------------------------------------HRLG
MAV_3145|M.avium_104 AVSRECDGAAAIGPDARSRTVASPAHRRRGPGRVIAAVTHRFSPQTRWAA
MUL_4471|M.ulcerans_Agy99 ALS----------------QVASPQG-------AAAAVS----PSDPTLP
MAB_4435|M.abscessus_ATCC_1997 AAQQILTDP------------------------------------AQHRQ
MLBr_00016|M.leprae_Br4923 DLIR------------------------------------------VHSG
Mflv_1172|M.gilvum_PYR-GCK VTAAG---DPDATAHAP---------ATPTGPRHAKPAAPTAQASASRGR
Mvan_5635|M.vanbaalenii_PYR-1 TELPGSAFDPDATRHA----------AAPTGPRHAKTAAAPRSR---RRV
TH_1607|M.thermoresistible__bu --------------------------------------------------
Mb1775|M.bovis_AF2122/97 G--AGDPDDTRVSQPVA---------VAAP-AKRSLLRTAVIVPAVLAML
Rv1746|M.tuberculosis_H37Rv G--AGDPDDTRVSQPVA---------VAAP-AKRSLLRTAVIVPAVLAML
MMAR_2606|M.marinum_M G--VGDPDDTRISRPVA---------VAVPAAKKSLARASVIVPAVLAIL
MSMEG_3677|M.smegmatis_MC2_155 T--DADVADPDATRLAP---------VARHAAPHKRPKTAALIAGVLGVL
MAV_3145|M.avium_104 ALVCAVLVAVAATWSVLYSFQPGAPPANPALASKPSPPAAVAAPIAGGPV
MUL_4471|M.ulcerans_Agy99 VAICVPPEYAAATQAAPAPMP--WYPTAPAPARPRRQVRTIVVPVVVALL
MAB_4435|M.abscessus_ATCC_1997 TVTQPVPATTPAPIAAPEPVHAMAPLAMADTGQSMLKHKRIAAIIGVMVL
MLBr_00016|M.leprae_Br4923 QPPEAPKVLTDADRSCLLSSGAGNFGVPRTDALSRQSLDETESDGSIGRW
Mflv_1172|M.gilvum_PYR-GCK ILVGAAVVLAVVAV------------------------------------
Mvan_5635|M.vanbaalenii_PYR-1 VLAGAGLVLALIAV------------------------------------
TH_1607|M.thermoresistible__bu --------------------------------------------------
Mb1775|M.bovis_AF2122/97 LVMAVAVTVREFQR------------------------------------
Rv1746|M.tuberculosis_H37Rv LVMAVAVAVREFQR------------------------------------
MMAR_2606|M.marinum_M LVVAIAVALREFER------------------------------------
MSMEG_3677|M.smegmatis_MC2_155 LVAAIVVAAVEFRR------------------------------------
MAV_3145|M.avium_104 LNGTYKLDYDQTKRTTNGIGIRHDGAGTNWWAFRSACTSSGCAATGTRLD
MUL_4471|M.ulcerans_Agy99 LVSAVAFAVTQVLR------------------------------------
MAB_4435|M.abscessus_ATCC_1997 VVASSVVAVLIWPRADEG-----------------------------TDP
MLBr_00016|M.leprae_Br4923 VAVVAVLAVLTIAIVAAFNTFGGNTRDVQVPDVRGQVSADAISALQNRGF
Mflv_1172|M.gilvum_PYR-GCK -----------VAVVLLAVFEK----------------------DEIRSE
Mvan_5635|M.vanbaalenii_PYR-1 -----------AAAVFLARFER----------------------DVGRGE
TH_1607|M.thermoresistible__bu --------------------------------------------------
Mb1775|M.bovis_AF2122/97 -----------ADDERAAQPAR----------------------TRTTTS
Rv1746|M.tuberculosis_H37Rv -----------ADDERAAQPAR----------------------TRTTTS
MMAR_2606|M.marinum_M -----------ADDERVAPPAA----------------------TSSSRP
MSMEG_3677|M.smegmatis_MC2_155 -----------ADDERPVARAS----------------------GAATTT
MAV_3145|M.avium_104 DATHQAAGGPDGDQTDTLRFVGGYWQGAPEQQRVGCTRPGGPAGATQQET
MUL_4471|M.ulcerans_Agy99 ---------PDPRQTTAAPAEAPQWQPYVDH-------------AKQFAI
MAB_4435|M.abscessus_ATCC_1997 RTKASPSAAQVAPGASLAGQPNTVLDTLLPGQFDYPEGWEKNPSPTFRSG
MLBr_00016|M.leprae_Br4923 KTRTLQKPDSTIPPDHVISTEPGANASVGAG--DEITINVSTGPEQREVP
Mflv_1172|M.gilvum_PYR-GCK AR--------------------------------PTT-------------
Mvan_5635|M.vanbaalenii_PYR-1 AR--------------------------------ATASATASTAPTGSGS
TH_1607|M.thermoresistible__bu --------------------------------------------------
Mb1775|M.bovis_AF2122/97 AGTTTSVAPASTTRP------------------APTTPTTTGAADTATAS
Rv1746|M.tuberculosis_H37Rv AGTTTSVAPASTTRP------------------APTTPTTTGAADTATAS
MMAR_2606|M.marinum_M SPTAAKTSTTTATTT------------------APTSTSTSTAAATTESV
MSMEG_3677|M.smegmatis_MC2_155 SHTTTPVTTAPASPPPEVTDTVTITDTATDTAAVDTSTPATTTAATTAAA
MAV_3145|M.avium_104 IARSLAPQSDGTLRGTETETVLSNECGAQGAVVRVPVVATRVGDVPPGVT
MUL_4471|M.ulcerans_Agy99 SLTSVNPQT-------------------------IDADIQRILDGSTGAF
MAB_4435|M.abscessus_ATCC_1997 EFNPAVPPGSATNIGGTPVGCNTIDPAWALRAKGRETSTLYLRDRKKPER
MLBr_00016|M.leprae_Br4923 DVSSLNYTDAVKKLTSSGFKSFKQANSPSTPELLGKVIGTNPSANQTSAI
Mflv_1172|M.gilvum_PYR-GCK -AVPVVVVGADCATLGAAGITGDGKSAYCARLSSTGEPLWSLYDGEIPHP
Mvan_5635|M.vanbaalenii_PYR-1 VTLPVVVVGADCATLGAAGVTEAGDPAYCARLASSGAPLWSLYPGEIPHP
TH_1607|M.thermoresistible__bu --------------------------------------------------
Mb1775|M.bovis_AF2122/97 PTAAVVAIGALCFPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEDTVASP
Rv1746|M.tuberculosis_H37Rv PTAAVVAIGALCFPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEDTVASP
MMAR_2606|M.marinum_M TPAPAVVIGAMCSPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEGTVASP
MSMEG_3677|M.smegmatis_MC2_155 AAAQTAVIGASCSPVGATATTSDGSTAYCSTLATTGASIWSLTQGTIPSP
MAV_3145|M.avium_104 VADPASVINASPTATAPAPPVLGGLCSDVGKVAYDPTNNEQIVCEGSSWA
MUL_4471|M.ulcerans_Agy99 HSDFADKSAQFKQSIVDAGSATQGKATGAGLESISGTTAHVVVSVTSNIT
MAB_4435|M.abscessus_ATCC_1997 EILIRVVPAADALSTDGASDALKRCDAVAYIIPGSSTTWRCSFEFDEPNP
MLBr_00016|M.leprae_Br4923 TNVITIIVGSGPETKQIPDVTGQIVEIAQKNLNVYGFTKFSQASVDSPRP
Mflv_1172|M.gilvum_PYR-GCK SATPEP-GSAAPA----GAPVLVCVEQTGQSQADCHGDIQQENSDPTAND
Mvan_5635|M.vanbaalenii_PYR-1 TGTSAPEGESQGP----DTPVLVCMQQTGQSQVDCHDDILQENTDPGAND
TH_1607|M.thermoresistible__bu --------------------------------------------------
Mb1775|M.bovis_AF2122/97 TVTATADPTEAPLPIEQESPIRVCMQQTGQTRRECREEIRRSNGWP----
Rv1746|M.tuberculosis_H37Rv TVTATADPTEAPLPIEQESPIRVCMQQTGQTRRECREEIRRSNGWP----
MMAR_2606|M.marinum_M TVSATPDPTEPPLPIDQDSPIRICMQQTGQTRHECREDIRRSNGY-----
MSMEG_3677|M.smegmatis_MC2_155 TV--TPAATDEPLPFAEESPVRVCMQQTGMTRRECREAIRRSNGLP----
MAV_3145|M.avium_104 KAPITMGVHAAGSSCDRPGTSVFAMSTSSDGYLLQCDPVTRTWTRPAG--
MUL_4471|M.ulcerans_Agy99 KS---TGVQQE----PRQWRLRIQIEKIDDAYLASRVEFVT---------
MAB_4435|M.abscessus_ATCC_1997 VQNGQKELTTTESCYMFPSGANSIRQHVSFNVVRGLLVYILASGASNRND
MLBr_00016|M.leprae_Br4923 TGEVIGTNPPKDATVPVDSVIELQVSKGNQFVMPDLSGMFWADAEPRLRA
Mflv_1172|M.gilvum_PYR-GCK NQG-------------------------------------------
Mvan_5635|M.vanbaalenii_PYR-1 TQTPG-----------------------------------------
TH_1607|M.thermoresistible__bu ----------------------------------------------
Mb1775|M.bovis_AF2122/97 ----------------------------------------------
Rv1746|M.tuberculosis_H37Rv ----------------------------------------------
MMAR_2606|M.marinum_M ----------------------------------------------
MSMEG_3677|M.smegmatis_MC2_155 ----------------------------------------------
MAV_3145|M.avium_104 ----------------------------------------------
MUL_4471|M.ulcerans_Agy99 ----------------------------------------------
MAB_4435|M.abscessus_ATCC_1997 AAGSLSATALSFATTMKILRYGR-----------------------
MLBr_00016|M.leprae_Br4923 LGWTGVLDKGPDVDAGGSQHNRVAYQNPPAGAGVNRDGIITLKFGQ