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MTLVAGVDSSTQSCKVVVCDSATGQVVRSASSPHPDGTEIHPDRWWEALQRTIEAVGGFDDVAAVSVGAQ QHGMICLDSAGQVVRDALLWNDTRSAEAAEQLVDELGGPAAWAERIGVVPVAAVTAAKLRWLADHEPVHA DATAAVCLPHDWLTWRLSGSTDIADLCTDRSDASGTGYYSAETDGYQYDLLALALRGRIPLAPRVLGPRE SAGATPHGAALGPGAGDNAAAALGLGAASGDCVVSLGTSGVVSAVGRAAPHDPEGIVAGFADATGHQLPL VCTLNGAPVLATVAEMLQVDFDEFDRLALSAPAGADGLVLVPYFAGERSPNLPQAAGALHGMTMRNLHPA NIARAAVEGLLSSMAFCIDKIGDQGVAAERIILVGGASRSEAVRRIAPAVLGATVYVPTPAEYVALGAAR QAAWVLSGQDTPPPWSVGEPARYDADATPQVLERYRAAAPLTLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5296 | - | - | 100% (464) | xylulokinase |
| M. vanbaalenii PYR-1 | Mvan_2625 | - | 9e-21 | 25.22% (464) | carbohydrate kinase, FGGY |
| M. vanbaalenii PYR-1 | Mvan_3929 | - | 2e-19 | 26.33% (490) | carbohydrate kinase, FGGY |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0750 | xylB | 7e-12 | 26.34% (486) | D-xylulose kinase XylB |
| M. gilvum PYR-GCK | Mflv_3774 | - | 8e-22 | 25.77% (454) | carbohydrate kinase, FGGY |
| M. tuberculosis H37Rv | Rv3696c | glpK | 3e-20 | 24.73% (457) | glycerol kinase |
| M. leprae Br4923 | MLBr_02314 | glpK | 1e-18 | 24.56% (456) | glycerol kinase |
| M. abscessus ATCC 19977 | MAB_0382 | glpK | 7e-21 | 25.44% (456) | glycerol kinase |
| M. marinum M | MMAR_0570 | - | 1e-165 | 62.99% (462) | carbohydrate kinase |
| M. avium 104 | MAV_0406 | glpK | 2e-19 | 23.66% (486) | glycerol kinase |
| M. smegmatis MC2 155 | MSMEG_3257 | xylB | 0.0 | 76.52% (460) | xylulokinase |
| M. thermoresistible (build 8) | TH_0046 | xylB | 1e-170 | 65.87% (463) | xylulokinase |
| M. ulcerans Agy99 | MUL_4281 | glpK | 7e-20 | 24.49% (494) | glycerol kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5296|M.vanbaalenii_PYR-1 -------------MTLVAGVDSSTQSCKVVVCDSATGQVVR-----SASS
MSMEG_3257|M.smegmatis_MC2_155 ----------------MAGIDSSTQSCKIVVCDADSGSVVR-----TASS
MMAR_0570|M.marinum_M -------------MTLVAGIDSSTQSCKVLVCDADTGEVAR-----RGQA
TH_0046|M.thermoresistible__bu -------------MTLVAGIDSSTQSCKVLICDADTGAVVR-----EGRA
Rv3696c|M.tuberculosis_H37Rv MSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHGAEVARHQLEHEQIL
MLBr_02314|M.leprae_Br4923 ---------MAEFAEFIAAIDQGTTSTRCVIFDHNGAEVARHQLEHEQIL
MUL_4281|M.ulcerans_Agy99 ---------MADSPDFVAAIDQGTTSTRCMIFDHQGAEIARHQLVHEQIL
MAV_0406|M.avium_104 ---------MAEFAEFIAAIDQGTTSTRCMIFDHQGAEVARHQLEHEQIL
MAB_0382|M.abscessus_ATCC_1997 ------------MADFVASIDQGTTSTRAMIFNHRGEEVGRHQLEHQQLL
Mb0750|M.bovis_AF2122/97 ----------MSRDDVTIGIDIGTTAVKAVAADDNGRVTARVRIGHQLAV
Mflv_3774|M.gilvum_PYR-GCK ------------MSRYTIGVDIGTTGTKTVLLDTTSGIVATASRETALHS
.:* .* . : : :
Mvan_5296|M.vanbaalenii_PYR-1 PHPDGTEIHPDRWWEALQRTIEAVG-----GFDDVAAVSVGAQQHGMICL
MSMEG_3257|M.smegmatis_MC2_155 PHPGGTEVDPGHWWDALQRTITAVG-----GLDDVEAVSVGAQQHGMVCL
MMAR_0570|M.marinum_M AHPDGTEIDPAAWESAARAAIAAAG-----GFDDVEAVAVGAQQHGMVCL
TH_0046|M.thermoresistible__bu AHPDGTEIDPAFWESAAHDAVRAAG-----GLDDVAAVAVGAQQHGMVCL
Rv3696c|M.tuberculosis_H37Rv PRAGWVEHNPVEIWERTASVLISVLNATNLSPKDIAALGITNQRETTLVW
MLBr_02314|M.leprae_Br4923 PRSGWVEHNPVEIWERTASVLMSVLNATNLSAKDIAALGITNQRETTLVW
MUL_4281|M.ulcerans_Agy99 PRAGWVEHNPVEIWERTASVLMSVLNATDLSPKNIAALGITNQRETTLVW
MAV_0406|M.avium_104 PRAGWVEHDPIEIWERTSSVLTSVLNRANLSAENLAALGITNQRETTLVW
MAB_0382|M.abscessus_ATCC_1997 PRAGWVEHNPVEIWERTWSVLATSLNVTGLSAGDLAAVGVTNQRETTLVW
Mb0750|M.bovis_AF2122/97 PAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAV
Mflv_3774|M.gilvum_PYR-GCK PAPGFAEADTTQWHANVIDSVREVLAHSGVAPDEIGALATSGMVPAVVPI
. .. * .. : *:.
Mvan_5296|M.vanbaalenii_PYR-1 D-SAGQVVRDALLWNDTRSAEAAEQLVDELGGPAAWAERIGVVPVAAVTA
MSMEG_3257|M.smegmatis_MC2_155 N-SSGQVVRDALLWNDTRSASSADDLVSELGGPDEWAKTVGVVPVAAITA
MMAR_0570|M.marinum_M D-MAGAVVRPALLWNDVRSADAALALIDELGGPRAWAQAVGLVPLAAVTV
TH_0046|M.thermoresistible__bu D-EAGKVVRDALLWNDVRSAGAAAALVDELGGPQAWAEAVGVVPLAAITV
Rv3696c|M.tuberculosis_H37Rv NRHTGRPYYNAIVWQDTRTDRIASALDRDGRG-NLIRRKAGLPPATYFSG
MLBr_02314|M.leprae_Br4923 NRNTGRPYCNAIVWQDTRTDRIAVALDRDGRG-EVIRRKAGLPPATYFSG
MUL_4281|M.ulcerans_Agy99 NKRTGRPYYNAIVWQDTRTDRIASALDRDGRG-DVIRRKAGLPPATYFSG
MAV_0406|M.avium_104 NRKTGRPYYNAIVWQDTRTDRIASALDRDGRG-QVIRRKAGLPPATYFSG
MAB_0382|M.abscessus_ATCC_1997 NRHTGRPYCNAIVWQDTRTDKIAAALDRDGRG-DIIRRKAGLPPATYFSG
Mb0750|M.bovis_AF2122/97 D-PAGRPITPGLLYGDARGRVPNASVAR-----------AQSVPSVGETA
Mflv_3774|M.gilvum_PYR-GCK D-DAGKPLRRAILQNDARAHREVDDLAGALAD-VDLVTLTGSALTQQSVA
: :* .:: *.* :
Mvan_5296|M.vanbaalenii_PYR-1 AKLRWLADHEP----VHADATAAVCLPHDWLTWRLSGSTDIADLCTDRSD
MSMEG_3257|M.smegmatis_MC2_155 TKLRWLADNEP----ENADATAAVCLPHDWLGWRLTGSNDLADLRTDRSD
MMAR_0570|M.marinum_M AKLRWLADNEP----QHADRTAAVCLPHDWLTWRLRGDTDVATLTTDRSD
TH_0046|M.thermoresistible__bu AKLRWLADHEP----QHADRTAAVCLPHDWLTWRLRGSTDIAELTTDRSD
Rv3696c|M.tuberculosis_H37Rv GKLQWILENVDGVRAAAENGDALFGTPDTWVLWNLTGGPRGGVHVTDVTN
MLBr_02314|M.leprae_Br4923 GKLQWILENVDGVGAAAENGEALFGTPDTWLLWNLTGGPRGGVHVTDVTN
MUL_4281|M.ulcerans_Agy99 GKLQWILEDVDGVRAAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDVTN
MAV_0406|M.avium_104 AKLQWILDNVDGVREAAERGDALFGTADSWVLWQLTGGPRGGVHATDVTN
MAB_0382|M.abscessus_ATCC_1997 GKLQWILENVEGVRRDAENGDALFGTPDSWVIWNLTGGVRSGVHVTDVTN
Mb0750|M.bovis_AF2122/97 EFLRWTAGQAP--------DASGYWPAPAVANYALSG----EAVIDYATA
Mflv_3774|M.gilvum_PYR-GCK PTTVWLREHEP----EVYARTAHWVGSYDWVLSALGADVHVEQNWALESG
* . : . * . :
Mvan_5296|M.vanbaalenii_PYR-1 ASGTGYYSAETDGYQYDLLALALRGRIPL-------APRVLGPRESAGAT
MSMEG_3257|M.smegmatis_MC2_155 ASGTGYFSAETDSYRTDLLELAMRGRTPA-------LPTVLGPRDVAGRL
MMAR_0570|M.marinum_M ASGTGYYDAGSDRYRFDLLELAMHGRRPN-------LPRVLGP--SARAT
TH_0046|M.thermoresistible__bu ASGTGYYDASGDDYRLDLLELGLRGRRPH-------LPAVLGP--SDATR
Rv3696c|M.tuberculosis_H37Rv ASRTMLMDLETLDWDDELLSLFSIPRAMLPEIASSAPSEPYGVTLATGPV
MLBr_02314|M.leprae_Br4923 ASRTMLMDLEKLDWDDELLSFFSIPRAMLPAIASSSPLQPYGVTLADGPV
MUL_4281|M.ulcerans_Agy99 ASRTMLMNLETLDWDDELLSFFSIPRAMLPAIEPSSPLQPYGITQDTGPV
MAV_0406|M.avium_104 ASRTMLMDLETLDWDDELLSFFTIPRAMLPEIGPSSSPRPFGVTSDTGPA
MAB_0382|M.abscessus_ATCC_1997 ASRTMLMNLETLDWDDELLSFFSIPRQMLPPIKASSPVEPFGFTTQLGPL
Mb0750|M.bovis_AF2122/97 VTTLPLFDGTGWNATACADCGVTVDRMPR--------VETFGVG-VGQVR
Mflv_3774|M.gilvum_PYR-GCK LFSIVGDTADAVLGAAGLDPATLAPLRRP----GTRVGELSAAAADATGL
.
Mvan_5296|M.vanbaalenii_PYR-1 PHGAALGPGAGDNAAAALG-LGAASGDCVVSLGTSG-VVSAVGRAAPHDP
MSMEG_3257|M.smegmatis_MC2_155 PSGAILGPGAGDNAAAALG-LGAGPGDCIVSLGTSG-VVSAVGDAAPHDP
MMAR_0570|M.marinum_M RGSKTFGAGLGDNAAAALG-LGADEGDVMVSIGTSG-VVCAVAADPVRDE
TH_0046|M.thermoresistible__bu GGDRVFGAGLGDNAAAALG-LAAEPGDVIVSVGTSG-VVSAVATAPVRDG
Rv3696c|M.tuberculosis_H37Rv GGEVPITGVLGDQHAAMVGQVCLAPGEAKNTYGTGNFLLLNTGETIVRSN
MLBr_02314|M.leprae_Br4923 GGEVPITGVLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGEAIVRSG
MUL_4281|M.ulcerans_Agy99 GGEVPITGMLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGETIVRSS
MAV_0406|M.avium_104 GGRIPITAVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGESIVRSE
MAB_0382|M.abscessus_ATCC_1997 GGEVPIAGDLGDQQAAMVGQVCLNPGEAKNTYGTGNFLLLNTGEELVHSS
Mb0750|M.bovis_AF2122/97 GTGAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIVWTTISAARQVPG
Mflv_3774|M.gilvum_PYR-GCK RAGTPLVVGGADHVLSAYAAGVNGAGDALVKLGGAGDILVASDTEIVDER
: * *: * :
Mvan_5296|M.vanbaalenii_PYR-1 EGIVAGFADATGHQLPLVCTLN-GAPVLATVAEMLQVDFDEFDRLALSAP
MSMEG_3257|M.smegmatis_MC2_155 EGIVAGFADASGRQLPLVCTLN-GAPVLAATAAMLQVDFDEFDRLALSAP
MMAR_0570|M.marinum_M TGLVAGFADGTGRYLPLVCTLN-GARVLDAAAAMLRVDHDELSRLALSAP
TH_0046|M.thermoresistible__bu TGFVAGFADGTGRHLPLVCTLN-GARVLDAAAAMLQVDHAELSRLALSAP
Rv3696c|M.tuberculosis_H37Rv NGLLTTVCYQFGNAKPVYALEG-SIAVTGSAVQWLRDQLGIISGAAQSEA
MLBr_02314|M.leprae_Br4923 NGLLTTVCYQFGDAKPVYALEG-SIAVTGSAVQWLRDQLGIISGAAQSES
MUL_4281|M.ulcerans_Agy99 NGLLTTLCYQFGDAKPVYALEG-SIAVTGSAVQWLRDQLGIISGASQSEA
MAV_0406|M.avium_104 HGLLTTVCYQFGDAKPVYALEG-SIAVTGAAVQWLRDQLGIISGAAQSES
MAB_0382|M.abscessus_ATCC_1997 NGLLTTVCYQFGDNKPVYALEG-SIAVTGSAVQWLRDQLGIISGASQSED
Mb0750|M.bovis_AF2122/97 -------LWTIPHTAPGKSQIG-GASNAGGLFLNWVDRVIGPGDPALADP
Mflv_3774|M.gilvum_PYR-GCK -------LYLDAHPVPGRWLPNGCMATSGSLIRWFQTLIGGAELTELDDE
* .
Mvan_5296|M.vanbaalenii_PYR-1 AG-----ADGLVLVPYFAGERSPNL-PQAAGALHGMTMRNLHPANIARAA
MSMEG_3257|M.smegmatis_MC2_155 RG-----ADGLTLVPYLEGERSPNL-PRARGALHGVTTRNFSPANVARAG
MMAR_0570|M.marinum_M PG-----SAGLVLVPYLEGERTPNR-PKATGALHGLRLANATPAHLARAA
TH_0046|M.thermoresistible__bu PG-----SEGLVLVPYLEGERTPNR-PNASGALHGLRVSNATPANLARAA
Rv3696c|M.tuberculosis_H37Rv LARQVPDNGGMYFVPAFSGLFAPYWRSDARGAIVGLSRFNTN-AHLARAT
MLBr_02314|M.leprae_Br4923 LARQVVDNGGVYFVPAFSGLFSPYWRSDARGAIVGLSRFNTN-AHLARAT
MUL_4281|M.ulcerans_Agy99 LARQVSDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNNN-AHLARAT
MAV_0406|M.avium_104 LARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFDTN-AHLARAT
MAB_0382|M.abscessus_ATCC_1997 LARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTN-AHLARAT
Mb0750|M.bovis_AF2122/97 RR-------VPVWLPYIRGERTPFHEPDRRAVLDGVDLSQDA-ASVRRAA
Mflv_3774|M.gilvum_PYR-GCK AAQR--APGEILCLPYFLGEKSPVHDPDLRGVFAGMHLGHTR-ADMYRSV
:* : * :* . ..: *: . * : *:
Mvan_5296|M.vanbaalenii_PYR-1 VEGLLSSMAFCIDKIGDQ-GVAAERIILVGGASRSEAVRRIAPAVLGATV
MSMEG_3257|M.smegmatis_MC2_155 VEGLLASMAFCIDKIVSY-GVDIERIILVGGGARSEAVRRIAPAIWGRPV
MMAR_0570|M.marinum_M VEGLLCALADGLAQLTEH-GVVARRVLLIGGGARSQALREIAPLIFGVPV
TH_0046|M.thermoresistible__bu VEGLLCALADGIAHLTGH-GIPLRRVLLIGGAARSEAVRAIAPQVFGVPV
Rv3696c|M.tuberculosis_H37Rv LEAICYQSRDVVDAMEADSGVRLQVLKVDGGITGNDLCMQIQADVLGVDV
MLBr_02314|M.leprae_Br4923 LEAICYQSRDVVDAMAADSGVRLDVLKVDGGITSNDLCMQIQADVLGVDV
MUL_4281|M.ulcerans_Agy99 LEAICYQSRDVVDAMEADSGVRLEVLKVDGGITSNDLCMQIQADVLGVDV
MAV_0406|M.avium_104 LEAICYQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQADVLGVDV
MAB_0382|M.abscessus_ATCC_1997 LEAICYQSREVVEAMEADSGVRMEVLKVDGGITANKLCMQIQADTLGVDV
Mb0750|M.bovis_AF2122/97 YEASGFVVR----QLIELSGAPVARIVAAGGGTRIQPWMQAIADATGRPV
Mflv_3774|M.gilvum_PYR-GCK LEAIAFGFRHHVDVFGEI-GIPFTRVMITNGGSRSTLWKQIHADVLGCEM
*. : * : .* : . * :
Mvan_5296|M.vanbaalenii_PYR-1 YVPTPAEYVALGAARQAAWVLSGQDTP----PPWSVGE--PARYDADAT-
MSMEG_3257|M.smegmatis_MC2_155 DVPPPGEYVALGAARQAAWALGQQDSP----PAWQVGS--TTTYTAEHA-
MMAR_0570|M.marinum_M LVPDPAEYVALGAARQAAWALRGSTRP----PSWQPPA--TDEYTGEPS-
TH_0046|M.thermoresistible__bu LVPDPAEYVALGAARQAAWALRGTPEP----PSWQPPR--TDRYEADPV-
Rv3696c|M.tuberculosis_H37Rv VRPVVAETTALGVAYAAGLAVGFWAAPSDLRANWREDKRWTPTWDDDER-
MLBr_02314|M.leprae_Br4923 VRSVVAETTALGSAYAAGLAVGFWAGPSDLRANWQEDKRWTPTWGEDQR-
MUL_4281|M.ulcerans_Agy99 VRPVVAETTALGAAYAAGLAVGFWADPSDLRANWQEDKRWTPQWTDDQR-
MAV_0406|M.avium_104 VRPVVAETTALGAAYAAGLAVGFWADPGELRANWREDKRWTPAWSDEQR-
MAB_0382|M.abscessus_ATCC_1997 VKPVVAETTALGAAYAAGLAVGFWKDADDLRRNWQEDERWSSSITDEKR-
Mb0750|M.bovis_AF2122/97 EVSRVAEGAALGAAFLGRLAAG-LESSIADAARWASTDR-IVEPSADWA-
Mflv_3774|M.gilvum_PYR-GCK NPVIGHPGASLGAAVIAAIGVGALDDWADADRFITLDAPYRPDPARRHAY
.:** * .
Mvan_5296|M.vanbaalenii_PYR-1 PQVLERYRAAAPLTLR------------------
MSMEG_3257|M.smegmatis_MC2_155 PQVLEQYLAAQPLTLGQ-----------------
MMAR_0570|M.marinum_M PAVRQRYGQVRELTEGVASVPGPGETPPAPDTSR
TH_0046|M.thermoresistible__bu PAVRERYAEVRDLTEGVE----------------
Rv3696c|M.tuberculosis_H37Rv AAGYAGWRKAVQRTLDWVDVS-------------
MLBr_02314|M.leprae_Br4923 AAAYAGWRKAVQRTLDWVDVS-------------
MUL_4281|M.ulcerans_Agy99 AAGYAGWRKAVQRTLDWVDVS-------------
MAV_0406|M.avium_104 AAGYAGWRKAVQRTLDWADVT-------------
MAB_0382|M.abscessus_ATCC_1997 AEGFAGWKKAVQRTLDGVDV--------------
Mb0750|M.bovis_AF2122/97 GPTKERYRRFLALSGSKLA---------------
Mflv_3774|M.gilvum_PYR-GCK DDAYQTWRELGAVMTPVSHKIARTTR--------
: