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TLVAGIDSSTQSCKVLVCDADTGEVARRGQAAHPDGTEIDPAAWESAARAAIAAAGGFDDVEAVAVGAQQ HGMVCLDMAGAVVRPALLWNDVRSADAALALIDELGGPRAWAQAVGLVPLAAVTVAKLRWLADNEPQHAD RTAAVCLPHDWLTWRLRGDTDVATLTTDRSDASGTGYYDAGSDRYRFDLLELAMHGRRPNLPRVLGPSAR ATRGSKTFGAGLGDNAAAALGLGADEGDVMVSIGTSGVVCAVAADPVRDETGLVAGFADGTGRYLPLVCT LNGARVLDAAAAMLRVDHDELSRLALSAPPGSAGLVLVPYLEGERTPNRPKATGALHGLRLANATPAHLA RAAVEGLLCALADGLAQLTEHGVVARRVLLIGGGARSQALREIAPLIFGVPVLVPDPAEYVALGAARQAA WALRGSTRPPSWQPPATDEYTGEPSPAVRQRYGQVRELTEGVASVPGPGETPPAPDTSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0570 | - | - | 100% (480) | carbohydrate kinase |
| M. marinum M | MMAR_1066 | xylB | 2e-18 | 28.22% (482) | D-xylulose-kinase (xylulokinase), XylB |
| M. marinum M | MMAR_5208 | glpK | 4e-18 | 26.35% (482) | glycerol kinase GlpK |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0750 | xylB | 1e-14 | 26.99% (478) | D-xylulose kinase XylB |
| M. gilvum PYR-GCK | Mflv_3774 | - | 1e-19 | 25.05% (491) | carbohydrate kinase, FGGY |
| M. tuberculosis H37Rv | Rv3696c | glpK | 4e-20 | 26.25% (461) | glycerol kinase |
| M. leprae Br4923 | MLBr_02314 | glpK | 2e-18 | 25.86% (464) | glycerol kinase |
| M. abscessus ATCC 19977 | MAB_0382 | glpK | 2e-17 | 24.75% (493) | glycerol kinase |
| M. avium 104 | MAV_0406 | glpK | 6e-21 | 27.72% (487) | glycerol kinase |
| M. smegmatis MC2 155 | MSMEG_3257 | xylB | 1e-163 | 62.91% (461) | xylulokinase |
| M. thermoresistible (build 8) | TH_0046 | xylB | 0.0 | 80.99% (463) | xylulokinase |
| M. ulcerans Agy99 | MUL_4281 | glpK | 3e-18 | 26.35% (482) | glycerol kinase |
| M. vanbaalenii PYR-1 | Mvan_5296 | - | 1e-165 | 62.99% (462) | xylulokinase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0570|M.marinum_M -------------MTLVAGIDSSTQSCKVLVCDADTGEVAR-----RGQA
TH_0046|M.thermoresistible__bu -------------MTLVAGIDSSTQSCKVLICDADTGAVVR-----EGRA
MSMEG_3257|M.smegmatis_MC2_155 ----------------MAGIDSSTQSCKIVVCDADSGSVVR-----TASS
Mvan_5296|M.vanbaalenii_PYR-1 -------------MTLVAGVDSSTQSCKVVVCDSATGQVVR-----SASS
Rv3696c|M.tuberculosis_H37Rv MSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHGAEVARHQLEHEQIL
MLBr_02314|M.leprae_Br4923 ---------MAEFAEFIAAIDQGTTSTRCVIFDHNGAEVARHQLEHEQIL
MUL_4281|M.ulcerans_Agy99 ---------MADSPDFVAAIDQGTTSTRCMIFDHQGAEIARHQLVHEQIL
MAV_0406|M.avium_104 ---------MAEFAEFIAAIDQGTTSTRCMIFDHQGAEVARHQLEHEQIL
MAB_0382|M.abscessus_ATCC_1997 ------------MADFVASIDQGTTSTRAMIFNHRGEEVGRHQLEHQQLL
Mb0750|M.bovis_AF2122/97 ----------MSRDDVTIGIDIGTTAVKAVAADDNGRVTARVRIGHQLAV
Mflv_3774|M.gilvum_PYR-GCK ------------MSRYTIGVDIGTTGTKTVLLDTTSGIVATASRETALHS
.:* .* . : : :
MMAR_0570|M.marinum_M AHPDGTEIDPAAWESAARAAIAAAG-----GFDDVEAVAVGAQQHGMVCL
TH_0046|M.thermoresistible__bu AHPDGTEIDPAFWESAAHDAVRAAG-----GLDDVAAVAVGAQQHGMVCL
MSMEG_3257|M.smegmatis_MC2_155 PHPGGTEVDPGHWWDALQRTITAVG-----GLDDVEAVSVGAQQHGMVCL
Mvan_5296|M.vanbaalenii_PYR-1 PHPDGTEIHPDRWWEALQRTIEAVG-----GFDDVAAVSVGAQQHGMICL
Rv3696c|M.tuberculosis_H37Rv PRAGWVEHNPVEIWERTASVLISVLNATNLSPKDIAALGITNQRETTLVW
MLBr_02314|M.leprae_Br4923 PRSGWVEHNPVEIWERTASVLMSVLNATNLSAKDIAALGITNQRETTLVW
MUL_4281|M.ulcerans_Agy99 PRAGWVEHNPVEIWERTASVLMSVLNATDLSPKNIAALGITNQRETTLVW
MAV_0406|M.avium_104 PRAGWVEHDPIEIWERTSSVLTSVLNRANLSAENLAALGITNQRETTLVW
MAB_0382|M.abscessus_ATCC_1997 PRAGWVEHNPVEIWERTWSVLATSLNVTGLSAGDLAAVGVTNQRETTLVW
Mb0750|M.bovis_AF2122/97 PAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAV
Mflv_3774|M.gilvum_PYR-GCK PAPGFAEADTTQWHANVIDSVREVLAHSGVAPDEIGALATSGMVPAVVPI
. .. * .. : *:.
MMAR_0570|M.marinum_M D-MAGAVVRPALLWNDVRSADAALALIDELGGPRAWAQAVGLVPLAAVTV
TH_0046|M.thermoresistible__bu D-EAGKVVRDALLWNDVRSAGAAAALVDELGGPQAWAEAVGVVPLAAITV
MSMEG_3257|M.smegmatis_MC2_155 N-SSGQVVRDALLWNDTRSASSADDLVSELGGPDEWAKTVGVVPVAAITA
Mvan_5296|M.vanbaalenii_PYR-1 D-SAGQVVRDALLWNDTRSAEAAEQLVDELGGPAAWAERIGVVPVAAVTA
Rv3696c|M.tuberculosis_H37Rv NRHTGRPYYNAIVWQDTRTDRIASALDRDGRG-NLIRRKAGLPPATYFSG
MLBr_02314|M.leprae_Br4923 NRNTGRPYCNAIVWQDTRTDRIAVALDRDGRG-EVIRRKAGLPPATYFSG
MUL_4281|M.ulcerans_Agy99 NKRTGRPYYNAIVWQDTRTDRIASALDRDGRG-DVIRRKAGLPPATYFSG
MAV_0406|M.avium_104 NRKTGRPYYNAIVWQDTRTDRIASALDRDGRG-QVIRRKAGLPPATYFSG
MAB_0382|M.abscessus_ATCC_1997 NRHTGRPYCNAIVWQDTRTDKIAAALDRDGRG-DIIRRKAGLPPATYFSG
Mb0750|M.bovis_AF2122/97 D-PAGRPITPGLLYGDARGRVPNASVAR-----------AQSVPSVGETA
Mflv_3774|M.gilvum_PYR-GCK D-DAGKPLRRAILQNDARAHREVDDLAGALAD-VDLVTLTGSALTQQSVA
: :* .:: *.* :
MMAR_0570|M.marinum_M AKLRWLADNEP----QHADRTAAVCLPHDWLTWRLRGDTDVATLTTDRSD
TH_0046|M.thermoresistible__bu AKLRWLADHEP----QHADRTAAVCLPHDWLTWRLRGSTDIAELTTDRSD
MSMEG_3257|M.smegmatis_MC2_155 TKLRWLADNEP----ENADATAAVCLPHDWLGWRLTGSNDLADLRTDRSD
Mvan_5296|M.vanbaalenii_PYR-1 AKLRWLADHEP----VHADATAAVCLPHDWLTWRLSGSTDIADLCTDRSD
Rv3696c|M.tuberculosis_H37Rv GKLQWILENVDGVRAAAENGDALFGTPDTWVLWNLTGGPRGGVHVTDVTN
MLBr_02314|M.leprae_Br4923 GKLQWILENVDGVGAAAENGEALFGTPDTWLLWNLTGGPRGGVHVTDVTN
MUL_4281|M.ulcerans_Agy99 GKLQWILEDVDGVRAAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDVTN
MAV_0406|M.avium_104 AKLQWILDNVDGVREAAERGDALFGTADSWVLWQLTGGPRGGVHATDVTN
MAB_0382|M.abscessus_ATCC_1997 GKLQWILENVEGVRRDAENGDALFGTPDSWVIWNLTGGVRSGVHVTDVTN
Mb0750|M.bovis_AF2122/97 EFLRWTAGQAP--------DASGYWPAPAVANYALSG----EAVIDYATA
Mflv_3774|M.gilvum_PYR-GCK PTTVWLREHEP----EVYARTAHWVGSYDWVLSALGADVHVEQNWALESG
* . : . * . :
MMAR_0570|M.marinum_M ASGTGYYDAGSDRYRFDLLELAMHGRRPN-------LPRVLGP--SARAT
TH_0046|M.thermoresistible__bu ASGTGYYDASGDDYRLDLLELGLRGRRPH-------LPAVLGP--SDATR
MSMEG_3257|M.smegmatis_MC2_155 ASGTGYFSAETDSYRTDLLELAMRGRTPA-------LPTVLGPRDVAGRL
Mvan_5296|M.vanbaalenii_PYR-1 ASGTGYYSAETDGYQYDLLALALRGRIPL-------APRVLGPRESAGAT
Rv3696c|M.tuberculosis_H37Rv ASRTMLMDLETLDWDDELLSLFSIPRAMLPEIASSAPSEPYGVTLATGPV
MLBr_02314|M.leprae_Br4923 ASRTMLMDLEKLDWDDELLSFFSIPRAMLPAIASSSPLQPYGVTLADGPV
MUL_4281|M.ulcerans_Agy99 ASRTMLMNLETLDWDDELLSFFSIPRAMLPAIEPSSPLQPYGITQDTGPV
MAV_0406|M.avium_104 ASRTMLMDLETLDWDDELLSFFTIPRAMLPEIGPSSSPRPFGVTSDTGPA
MAB_0382|M.abscessus_ATCC_1997 ASRTMLMNLETLDWDDELLSFFSIPRQMLPPIKASSPVEPFGFTTQLGPL
Mb0750|M.bovis_AF2122/97 VTTLPLFDGTGWNATACADCGVTVDRMPR--------VETFGVG-VGQVR
Mflv_3774|M.gilvum_PYR-GCK LFSIVGDTADAVLGAAGLDPATLAPLRRP----GTRVGELSAAAADATGL
.
MMAR_0570|M.marinum_M RGSKTFGAGLGDNAAAALG-LGADEGDVMVSIGTSG-VVCAVAADPVRDE
TH_0046|M.thermoresistible__bu GGDRVFGAGLGDNAAAALG-LAAEPGDVIVSVGTSG-VVSAVATAPVRDG
MSMEG_3257|M.smegmatis_MC2_155 PSGAILGPGAGDNAAAALG-LGAGPGDCIVSLGTSG-VVSAVGDAAPHDP
Mvan_5296|M.vanbaalenii_PYR-1 PHGAALGPGAGDNAAAALG-LGAASGDCVVSLGTSG-VVSAVGRAAPHDP
Rv3696c|M.tuberculosis_H37Rv GGEVPITGVLGDQHAAMVGQVCLAPGEAKNTYGTGNFLLLNTGETIVRSN
MLBr_02314|M.leprae_Br4923 GGEVPITGVLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGEAIVRSG
MUL_4281|M.ulcerans_Agy99 GGEVPITGMLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGETIVRSS
MAV_0406|M.avium_104 GGRIPITAVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGESIVRSE
MAB_0382|M.abscessus_ATCC_1997 GGEVPIAGDLGDQQAAMVGQVCLNPGEAKNTYGTGNFLLLNTGEELVHSS
Mb0750|M.bovis_AF2122/97 GTGAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIVWTTISAARQVPG
Mflv_3774|M.gilvum_PYR-GCK RAGTPLVVGGADHVLSAYAAGVNGAGDALVKLGGAGDILVASDTEIVDER
: * *: * :
MMAR_0570|M.marinum_M TGLVAGFADGTGRYLPLVCTLN-GARVLDAAAAMLRVDHDELSRLALSAP
TH_0046|M.thermoresistible__bu TGFVAGFADGTGRHLPLVCTLN-GARVLDAAAAMLQVDHAELSRLALSAP
MSMEG_3257|M.smegmatis_MC2_155 EGIVAGFADASGRQLPLVCTLN-GAPVLAATAAMLQVDFDEFDRLALSAP
Mvan_5296|M.vanbaalenii_PYR-1 EGIVAGFADATGHQLPLVCTLN-GAPVLATVAEMLQVDFDEFDRLALSAP
Rv3696c|M.tuberculosis_H37Rv NGLLTTVCYQFGNAKPVYALEG-SIAVTGSAVQWLRDQLGIISGAAQSEA
MLBr_02314|M.leprae_Br4923 NGLLTTVCYQFGDAKPVYALEG-SIAVTGSAVQWLRDQLGIISGAAQSES
MUL_4281|M.ulcerans_Agy99 NGLLTTLCYQFGDAKPVYALEG-SIAVTGSAVQWLRDQLGIISGASQSEA
MAV_0406|M.avium_104 HGLLTTVCYQFGDAKPVYALEG-SIAVTGAAVQWLRDQLGIISGAAQSES
MAB_0382|M.abscessus_ATCC_1997 NGLLTTVCYQFGDNKPVYALEG-SIAVTGSAVQWLRDQLGIISGASQSED
Mb0750|M.bovis_AF2122/97 -------LWTIPHTAPGKSQIG-GASNAGGLFLNWVDRVIGPGDPALADP
Mflv_3774|M.gilvum_PYR-GCK -------LYLDAHPVPGRWLPNGCMATSGSLIRWFQTLIGGAELTELDDE
* .
MMAR_0570|M.marinum_M PG-----SAGLVLVPYLEGERTPNR-PKATGALHGLRLANATPAHLARAA
TH_0046|M.thermoresistible__bu PG-----SEGLVLVPYLEGERTPNR-PNASGALHGLRVSNATPANLARAA
MSMEG_3257|M.smegmatis_MC2_155 RG-----ADGLTLVPYLEGERSPNL-PRARGALHGVTTRNFSPANVARAG
Mvan_5296|M.vanbaalenii_PYR-1 AG-----ADGLVLVPYFAGERSPNL-PQAAGALHGMTMRNLHPANIARAA
Rv3696c|M.tuberculosis_H37Rv LARQVPDNGGMYFVPAFSGLFAPYWRSDARGAIVGLSRFNTN-AHLARAT
MLBr_02314|M.leprae_Br4923 LARQVVDNGGVYFVPAFSGLFSPYWRSDARGAIVGLSRFNTN-AHLARAT
MUL_4281|M.ulcerans_Agy99 LARQVSDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNNN-AHLARAT
MAV_0406|M.avium_104 LARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFDTN-AHLARAT
MAB_0382|M.abscessus_ATCC_1997 LARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTN-AHLARAT
Mb0750|M.bovis_AF2122/97 RR-------VPVWLPYIRGERTPFHEPDRRAVLDGVDLSQDA-ASVRRAA
Mflv_3774|M.gilvum_PYR-GCK AAQR--APGEILCLPYFLGEKSPVHDPDLRGVFAGMHLGHTR-ADMYRSV
:* : * :* . ..: *: . * : *:
MMAR_0570|M.marinum_M VEGLLCALADGLAQLTEH-GVVARRVLLIGGGARSQALREIAPLIFGVPV
TH_0046|M.thermoresistible__bu VEGLLCALADGIAHLTGH-GIPLRRVLLIGGAARSEAVRAIAPQVFGVPV
MSMEG_3257|M.smegmatis_MC2_155 VEGLLASMAFCIDKIVSY-GVDIERIILVGGGARSEAVRRIAPAIWGRPV
Mvan_5296|M.vanbaalenii_PYR-1 VEGLLSSMAFCIDKIGDQ-GVAAERIILVGGASRSEAVRRIAPAVLGATV
Rv3696c|M.tuberculosis_H37Rv LEAICYQSRDVVDAMEADSGVRLQVLKVDGGITGNDLCMQIQADVLGVDV
MLBr_02314|M.leprae_Br4923 LEAICYQSRDVVDAMAADSGVRLDVLKVDGGITSNDLCMQIQADVLGVDV
MUL_4281|M.ulcerans_Agy99 LEAICYQSRDVVDAMEADSGVRLEVLKVDGGITSNDLCMQIQADVLGVDV
MAV_0406|M.avium_104 LEAICYQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQADVLGVDV
MAB_0382|M.abscessus_ATCC_1997 LEAICYQSREVVEAMEADSGVRMEVLKVDGGITANKLCMQIQADTLGVDV
Mb0750|M.bovis_AF2122/97 YEASGFVVR----QLIELSGAPVARIVAAGGGTRIQPWMQAIADATGRPV
Mflv_3774|M.gilvum_PYR-GCK LEAIAFGFRHHVDVFGEI-GIPFTRVMITNGGSRSTLWKQIHADVLGCEM
*. : * : .* : . * :
MMAR_0570|M.marinum_M LVPDPAEYVALGAARQAAWALRGSTRP----PSWQPPA--TDEYTGEPS-
TH_0046|M.thermoresistible__bu LVPDPAEYVALGAARQAAWALRGTPEP----PSWQPPR--TDRYEADPV-
MSMEG_3257|M.smegmatis_MC2_155 DVPPPGEYVALGAARQAAWALGQQDSP----PAWQVGS--TTTYTAEHA-
Mvan_5296|M.vanbaalenii_PYR-1 YVPTPAEYVALGAARQAAWVLSGQDTP----PPWSVGE--PARYDADAT-
Rv3696c|M.tuberculosis_H37Rv VRPVVAETTALGVAYAAGLAVGFWAAPSDLRANWREDKRWTPTWDDDER-
MLBr_02314|M.leprae_Br4923 VRSVVAETTALGSAYAAGLAVGFWAGPSDLRANWQEDKRWTPTWGEDQR-
MUL_4281|M.ulcerans_Agy99 VRPVVAETTALGAAYAAGLAVGFWADPSDLRANWQEDKRWTPQWTDDQR-
MAV_0406|M.avium_104 VRPVVAETTALGAAYAAGLAVGFWADPGELRANWREDKRWTPAWSDEQR-
MAB_0382|M.abscessus_ATCC_1997 VKPVVAETTALGAAYAAGLAVGFWKDADDLRRNWQEDERWSSSITDEKR-
Mb0750|M.bovis_AF2122/97 EVSRVAEGAALGAAFLGRLAAG-LESSIADAARWASTDR-IVEPSADWA-
Mflv_3774|M.gilvum_PYR-GCK NPVIGHPGASLGAAVIAAIGVGALDDWADADRFITLDAPYRPDPARRHAY
.:** * .
MMAR_0570|M.marinum_M PAVRQRYGQVRELTEGVASVPGPGETPPAPDTSR
TH_0046|M.thermoresistible__bu PAVRERYAEVRDLTEGVE----------------
MSMEG_3257|M.smegmatis_MC2_155 PQVLEQYLAAQPLTLGQ-----------------
Mvan_5296|M.vanbaalenii_PYR-1 PQVLERYRAAAPLTLR------------------
Rv3696c|M.tuberculosis_H37Rv AAGYAGWRKAVQRTLDWVDVS-------------
MLBr_02314|M.leprae_Br4923 AAAYAGWRKAVQRTLDWVDVS-------------
MUL_4281|M.ulcerans_Agy99 AAGYAGWRKAVQRTLDWVDVS-------------
MAV_0406|M.avium_104 AAGYAGWRKAVQRTLDWADVT-------------
MAB_0382|M.abscessus_ATCC_1997 AEGFAGWKKAVQRTLDGVDV--------------
Mb0750|M.bovis_AF2122/97 GPTKERYRRFLALSGSKLA---------------
Mflv_3774|M.gilvum_PYR-GCK DDAYQTWRELGAVMTPVSHKIARTTR--------
: