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MTVSQRSGIPPFYVMDVWLAAAERRRTHGDLVNLSAGQPSAGAPSAVRDAAVAALNRNDLGYTVALGIPE LRAAIAGSYTARHGLTVDPDDVVVTTGSSGGFLLTFLACFDPGDRVAIASPGYPCYRNILTALGCEVVEL PCGPKTRFQPTLQMLTELDPPVSGVIVASPANPSGTVIPPAELAAIATWCESSGVRLISDEVYHGLVYPG APATSCAWETSREAVVVNSFSKYFAMTGWRLGWLLVPDELKRAVDRLTGNFTICPPALPQIAAVSAFTPE SIAEAEALLHDYAANRTLLLDGLSALGIDRLAPTDGAFYVYADVSHLTTDSLAFCSKLLDDTGVAIAPGV DFDTVRGGAFVRLSFAGPASDLEEALRRIGAWLA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5290 | - | - | 100% (384) | aspartate aminotransferase |
| M. vanbaalenii PYR-1 | Mvan_5070 | - | 1e-32 | 31.40% (363) | aminotransferase |
| M. vanbaalenii PYR-1 | Mvan_4528 | - | 5e-20 | 26.54% (373) | N-succinyldiaminopimelate aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3595 | aspB | 0.0 | 80.31% (381) | aspartate aminotransferase |
| M. gilvum PYR-GCK | Mflv_1476 | - | 0.0 | 90.08% (383) | aspartate aminotransferase |
| M. tuberculosis H37Rv | Rv3565 | aspB | 0.0 | 80.31% (381) | aspartate aminotransferase |
| M. leprae Br4923 | MLBr_01794 | - | 2e-18 | 29.53% (359) | aminotransferase |
| M. abscessus ATCC 19977 | MAB_0685 | - | 1e-130 | 60.89% (381) | aspartate aminotransferase |
| M. marinum M | MMAR_5054 | aspB | 1e-179 | 78.22% (381) | aspartate aminotransferase AspB |
| M. avium 104 | MAV_0596 | - | 1e-178 | 77.95% (381) | aspartate aminotransferase |
| M. smegmatis MC2 155 | MSMEG_6017 | - | 1e-178 | 79.27% (381) | aspartate aminotransferase |
| M. thermoresistible (build 8) | TH_2065 | aspB | 0.0 | 82.06% (379) | POSSIBLE ASPARTATE AMINOTRANSFERASE ASPB (TRANSAMINASE A) |
| M. ulcerans Agy99 | MUL_4130 | aspB | 1e-176 | 77.43% (381) | aspartate aminotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5290|M.vanbaalenii_PYR-1 -----MTVSQRSGIPPFYVMDVWLAAAERRRTH-GDLVNLSAGQPSAGAP
Mflv_1476|M.gilvum_PYR-GCK -----MTPSQRSGIPPFYVMDVWLAAAERQRTH-GDLVNLSAGQPSAGAP
Mb3595|M.bovis_AF2122/97 ---MTDRVALRAGVPPFYVMDVWLAAAERQRTH-GDLVNLSAGQPSAGAP
Rv3565|M.tuberculosis_H37Rv ---MTDRVALRAGVPPFYVMDVWLAAAERQRTH-GDLVNLSAGQPSAGAP
MMAR_5054|M.marinum_M MNAVNTHIARRAGIPPFYVMDVWLAAAERQRTH-GDLVNLSAGQPSVGAP
MUL_4130|M.ulcerans_Agy99 MNAVNTHIARRAGIPPFYVMDVWLAAAERQRTH-GDLVNLSAGQPSVGAP
MAV_0596|M.avium_104 ---MTDRVSLRAGIPPFYVMDVWLAAAERQRSH-GDLVNLSAGQPSVGAP
MSMEG_6017|M.smegmatis_MC2_155 MGEMNDRVALRAGVPPFYVMDVWQAAAERQRTH-GDLVNLSAGQPSAGAP
TH_2065|M.thermoresistible__bu ---MNDRTALRAGIPPFYVMDVWLAAAERQRSH-GDLVNLSAGQPSAGAP
MAB_0685|M.abscessus_ATCC_1997 ----MVDLSRRSDVPPFYVMDVLAAAATRQRTH-GDMISLAAGQPSTGAP
MLBr_01794|M.leprae_Br4923 --------MTSNPLEQLTIEQLQCRTSMKWRAHPEDVLPLWVAEMDVLLA
: : : :: :: : *:* *:: * ..: .. .
Mvan_5290|M.vanbaalenii_PYR-1 SAVRDAAVAALNRNDLGYTVALGIPELRAAIAGSYTARHGLTVDPDDVVV
Mflv_1476|M.gilvum_PYR-GCK TAVRDAAVAALHRNQLGYTVALGIPELRTAIAGSYQDRHGLEVDPGDVVI
Mb3595|M.bovis_AF2122/97 EPVRAAAAAALHLNQLGYSVALGIPELRDAIAADYQRRHGITVEPDAVVI
Rv3565|M.tuberculosis_H37Rv EPVRAAAAAALHLNQLGYSVALGIPELRDAIAADYQRRHGITVEPDAVVI
MMAR_5054|M.marinum_M EPIRAAAAAALHLNELGYTVALGIPELRAAIAADYHRQHGISVEPEAVVI
MUL_4130|M.ulcerans_Agy99 EPIRAAAAAALHLNELGYTVALGIPELRAAIAADYHRQHGISVEPEAVVI
MAV_0596|M.avium_104 EPVRAAAAAAVHSNELGYSVSLGTPELRAAIAADYRRQHGLEVEPDAVVI
MSMEG_6017|M.smegmatis_MC2_155 APVRDAAAAALGRNQLGYTVALGIPELREQIAQTYHTRHDIDVGVDDVVL
TH_2065|M.thermoresistible__bu APVRAAAAATLERNQLGYTVALGIPELREAIAAGYQSRYGLSVGADEVVI
MAB_0685|M.abscessus_ATCC_1997 AVVLDAVREALGTQVLGYTETLGLPELRSAIAAYHRERSDIAVTADDVVV
MLBr_01794|M.leprae_Br4923 PTVAEAVHRAVDNGDTGYPYGTTFAEAISEFASQRWQWHDLDVS--RTAI
: *. :: **. .* :* .: * ..:
Mvan_5290|M.vanbaalenii_PYR-1 TTGSSGGFLLTFLACFDPGDRVAIASPGYPCYRNILTALGCEVVELPCGP
Mflv_1476|M.gilvum_PYR-GCK TTGSSGGFLLAFLACFDVGDRVAIASPGYPCYRNILSALGCEVVELPCGP
Mb3595|M.bovis_AF2122/97 TTGSSGGFLLAFLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGP
Rv3565|M.tuberculosis_H37Rv TTGSSGGFLLAFLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGP
MMAR_5054|M.marinum_M TTGSSGGFLLTFLACFDVGDRVALASPGYPCYRNILSALGCEVVEIPCGP
MUL_4130|M.ulcerans_Agy99 TTGSSGGFLLTFLACFDVGDRVALASPGYPCYRNILSALGCEVVEIPCGP
MAV_0596|M.avium_104 TTGSSGGFLLTFLACFDVGDRVAVASPGYPCYRNILSALGCEVVEIPCGP
MSMEG_6017|M.smegmatis_MC2_155 TTGSSGGFLLTFLACFDVGDRVAITSPGYPCYRNILSALGCEVVEIPCGP
TH_2065|M.thermoresistible__bu TTGSSGGFLLAFLACFDVGDRVAIASPGYPCYRNILSALGCEVVELQCGP
MAB_0685|M.abscessus_ATCC_1997 TTGSSGGFTLLFLAAFDVGDTVVMTRPGYPAYRNCLAALGCRVVELDCGP
MLBr_01794|M.leprae_Br4923 VPDVMLGVVEMLRLITDRGDGVIVSPPVYPPFYAFVTHDGRRVLEAPLGR
... *. : * ** * :: * ** : :: * .*:* *
Mvan_5290|M.vanbaalenii_PYR-1 KTRFQPTLQMLTELDPP-------VSGVIVASPANPSGTVIPPAELAAIA
Mflv_1476|M.gilvum_PYR-GCK DTRFQPTLQMLTELDPP-------VSGVIVASPANPTGTVIAPEELAAIA
Mb3595|M.bovis_AF2122/97 QTRFQPTAQMLAEIDPP-------LRGVVVASPANPTGTVIPPEELAAIA
Rv3565|M.tuberculosis_H37Rv QTRFQPTAQMLAEIDPP-------LRGVVVASPANPTGTVIPPEELAAIA
MMAR_5054|M.marinum_M ETRFQPTADMLAQIDPP-------VQGVIVASPANPTGTVIPPEELAAIA
MUL_4130|M.ulcerans_Agy99 ETRFQPTADMLAQIDPP-------VQGVIVASPANPTGTVIPPEELAAIA
MAV_0596|M.avium_104 QTRFQPTAAMLAELDPP-------VQGVIVASPANPTGTVIAPEELAAIA
MSMEG_6017|M.smegmatis_MC2_155 ETRFQPTAAMLEALDPP-------VQGVIVASPANPTGTVIAPEELAAIA
TH_2065|M.thermoresistible__bu QTRFQPTARMLAELDPP-------VRGVIVASPANPTGTVIPPEELAAIA
MAB_0685|M.abscessus_ATCC_1997 ETRYQPTVAMLEALAQADG---RVPAGLIVASPANPTGTIIDAGKLEAIA
MLBr_01794|M.leprae_Br4923 DGRLDLAALQDAFSRARRSSGPNGKVAYLLCNPHNPTGSVHTVAELHGVA
. * : : . ::..* **:*:: :* .:*
Mvan_5290|M.vanbaalenii_PYR-1 TWCESSGVRLISDEVYHGLVYPGAPATS-CAWETSREAVVVNSFSKYFAM
Mflv_1476|M.gilvum_PYR-GCK AWCETSGVRLISDEVYHGLVYPGAPATS-CAWETSRESIVVNSFSKYFAM
Mb3595|M.bovis_AF2122/97 SWCDASDVRLISDEVYHGLVYQGAPQTS-CAWQTSRNAVVVNSFSKYYAM
Rv3565|M.tuberculosis_H37Rv SWCDASDVRLISDEVYHGLVYQGAPQTS-CAWQTSRNAVVVNSFSKYYAM
MMAR_5054|M.marinum_M SWCDASGARLISDEVYHGLVYEGAPPTS-CAWQTSRNAVVVNSFSKYYAM
MUL_4130|M.ulcerans_Agy99 SWCDASGARLISDEVYHGLVYEGAPPTS-CARQTSRNALVVNSFSKYYAM
MAV_0596|M.avium_104 SWCEASGARLVSDEVYHGLVYEGAPPTS-CAWQTSRNAVVVNSFSKYYAM
MSMEG_6017|M.smegmatis_MC2_155 RWCDASGARLVSDEIYHGLVYEGAPETT-CAWETSRNAVVVNSFSKYFAM
TH_2065|M.thermoresistible__bu RWCEDNDVRLISDEVYHGLVYPGAPETS-CAWQTSREAVVVNSFSKYFAM
MAB_0685|M.abscessus_ATCC_1997 LWCEANGTLLISDEIYHGLSY-GDQKTS-SAWEFSRESVVMGSVSKYFSM
MLBr_01794|M.leprae_Br4923 ELARRFGVRVISDEIHAPLVLSGARFTPYLSIPGAENAFALMSATKGWNL
. .. ::***:: * * *. : :.::..: * :* : :
Mvan_5290|M.vanbaalenii_PYR-1 TGWRLGWLLVPDELKRAVDRLTGNFTICPPALPQIAAVSAFTPESIAEAE
Mflv_1476|M.gilvum_PYR-GCK TGWRLGWLLVPDELKRAVDRLTGNFTICPPVLPQLAAVAAFTPESVAEAE
Mb3595|M.bovis_AF2122/97 TGWRLGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPEATAEAD
Rv3565|M.tuberculosis_H37Rv TGWRLGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPEATAEAD
MMAR_5054|M.marinum_M TGWRLGWLLVPTELRRAVDCLTGNFTICPPVLSQVAAVSAFTPEATKEAD
MUL_4130|M.ulcerans_Agy99 TGWRLGWLLVPTELRRAVDCLTGNFTICPPVLSQVAAVSAFTPEATKEAD
MAV_0596|M.avium_104 TGWRLGWLLVPVELRRAVECLTGNFTICPPVLSQLAAVAAFTPEATAEAD
MSMEG_6017|M.smegmatis_MC2_155 TGWRLGWLLVPEKLRRAVDCLTGNFTICPPALAQYAALAAFTPESLAEAE
TH_2065|M.thermoresistible__bu TGWRLGWLLVPPALLRAVDRLTGNFTICPPALAQVAAVEAFHPESIAEAE
MAB_0685|M.abscessus_ATCC_1997 TGWRLGWMLVPRRFLRAVDRLSSNFTICPPAVSQYGALAAFSPEARDELD
MLBr_01794|M.leprae_Br4923 CGLKAAIAIAGREAAADLRRIPKEVSHGPSHLGIIAHTAAFR-TGSSWLD
* : . :. : :. :.: *. : . ** . :
Mvan_5290|M.vanbaalenii_PYR-1 ALLHDYAANRTLLLDGLS-ALGIDRLAPTDGAFYVYADVSHL--------
Mflv_1476|M.gilvum_PYR-GCK SLLEGYGANRTMLLDGLR-ALGIDRLAPTDGAFYVYADVSHL--------
Mb3595|M.bovis_AF2122/97 GNLASYAINRSLLLDGLR-RIGIDRLAPTDGAFYVYADVSDF--------
Rv3565|M.tuberculosis_H37Rv GNLASYAINRSLLLDGLR-RIGIDRLAPTDGAFYVYADVSDF--------
MMAR_5054|M.marinum_M GNLRHYASNRSTLLDGLR-RIGIDRLAPTDGAFYVYADVSDF--------
MUL_4130|M.ulcerans_Agy99 DNLRHYASNRSTLLDGLR-RIGIDRLAPTDGAFYVYADVSDF--------
MAV_0596|M.avium_104 GHLHHYAKNRALLLDGLR-GIGITRLAPTDGAFYVYADVSDF--------
MSMEG_6017|M.smegmatis_MC2_155 GLLTHYAENRHLLLNGLR-GLGIDKLAPTDGAFYVYADVSKY--------
TH_2065|M.thermoresistible__bu ALLDHYATNRRLLIDGLR-SLGIDRLAPADGAFYVYADVSRY--------
MAB_0685|M.abscessus_ATCC_1997 GHVRRYAANRTLLIDGLA-AMGITKIAPPDGAFYAYADIEHL--------
MLBr_01794|M.leprae_Br4923 ALLQGLEANRALLRDLVTKHLPGVRYQRPQGTYLTWLDCRHLGFDEQINE
: ** * : : : : .:*:: .: *
Mvan_5290|M.vanbaalenii_PYR-1 ----TTDSLAFCSKLLDDTGVAIAPGVDFDTVRGGAFVRLSFAGPASDLE
Mflv_1476|M.gilvum_PYR-GCK ----TTDSLSFCSKLLADTGVAIAPGVDFDTVRGGAFVRLSFAGPSSDIE
Mb3595|M.bovis_AF2122/97 ----TSDSLAFCSKLLADTGVAIAPGIDFDTARGGSFVRISFAGPSGDIE
Rv3565|M.tuberculosis_H37Rv ----TSDSLAFCSKLLADTGVAIAPGIDFDTARGGSFVRISFAGPSGDIE
MMAR_5054|M.marinum_M ----TDDSLKFCSKLLADTGVAIAPGIDFDTAGGNSFVRLSFAGPSEDIR
MUL_4130|M.ulcerans_Agy99 ----TDDSFKFCSKLLADTGVAIAPGIDFDTAGGNSFVRLSFAGPSEDIR
MAV_0596|M.avium_104 ----TDNSMEFCSKLLEQTGVAIAPGIDFDTTRGNSFVRLSFAGPTTDIE
MSMEG_6017|M.smegmatis_MC2_155 ----TDNSLQFCEKLLNDTGVAIAPGIDFDTVRGNSYVRLSFAGPTHDIE
TH_2065|M.thermoresistible__bu ----TEDSIEFCSKLLADTGVAIAPGIDFDTVHGDRFVRFSFAGATSDIE
MAB_0685|M.abscessus_ATCC_1997 ----TDNAEQWCADLLARTGVAVAPGIDFDTVRGHRTVRLSFAGGSDEIA
MLBr_01794|M.leprae_Br4923 GLAAISDLSGPARWFLDHSRVALTSGHAFGTG-GVGHVRVNFATSQAILI
: . :* : **::.* *.* * **..** :
Mvan_5290|M.vanbaalenii_PYR-1 EALRRIGAWLA---
Mflv_1476|M.gilvum_PYR-GCK EALRRFGAWLP---
Mb3595|M.bovis_AF2122/97 EALRRIGSWLPSQ-
Rv3565|M.tuberculosis_H37Rv EALRRIGSWLPSQ-
MMAR_5054|M.marinum_M EALRRIESWLPER-
MUL_4130|M.ulcerans_Agy99 EALRRIESWLPER-
MAV_0596|M.avium_104 EAVRRLGSWLRAR-
MSMEG_6017|M.smegmatis_MC2_155 EALRRIGPWLG---
TH_2065|M.thermoresistible__bu EALRRIGGWLA---
MAB_0685|M.abscessus_ATCC_1997 QALARMRPALGRG-
MLBr_01794|M.leprae_Br4923 EALSRMGRALVNFR
:*: *: *