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M. thermoresistible (build 8) TH_1138 (fadD17)

annotation: POSSIBLE FATTY-ACID-CoA SYNTHETASE FADD17 (FATTY-ACID-CoA SYNTHASE) (FATTY-ACID-CoA LIGASE)
coordinates: 2207730 - 2209253
length: 508

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1138fadD17-100% (508)POSSIBLE FATTY-ACID-CoA SYNTHETASE FADD17 (FATTY-ACID-CoA SYNTHASE) (FATTY-ACID-CoA LIGASE)
M. thermoresistible (build 8)TH_4470-e-13853.24% (509) PUTATIVE AMP-dependent synthetase and ligase
M. thermoresistible (build 8)TH_4217-3e-4832.17% (460) PUTATIVE putative AMP-dependent synthetase and ligase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3536fadD170.068.55% (496) acyl-CoA synthetase
M. gilvum PYR-GCKMflv_1549-0.071.51% (509) acyl-CoA synthetase
M. tuberculosis H37RvRv3506fadD170.068.55% (496) acyl-CoA synthetase
M. leprae Br4923MLBr_02546fadD25e-2927.42% (496) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_4160-0.064.03% (506) acyl-CoA synthetase
M. marinum MMMAR_4994fadD170.066.40% (494) fatty-acid-CoA synthetase FadD17
M. avium 104MAV_0650-0.070.16% (496) acyl-CoA synthetase
M. smegmatis MC2 155MSMEG_5908-0.077.56% (499) acyl-CoA synthetase
M. ulcerans Agy99MUL_4069fadD170.066.60% (494) acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_5208-0.073.16% (503) acyl-CoA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


Mb3536|M.bovis_AF2122/97            ----MTPTHPTVTELLLPLSEIDDRGVYFED------SFTSWRDHIRHG-
Rv3506|M.tuberculosis_H37Rv         ----MTPTHPTVTELLLPLSEIDDRGVYFED------SFTSWRDHIRHG-
MMAR_4994|M.marinum_M               -----MSADPTVPQLLVPLAEIGDRGIYFED------SFTSWADHIGHG-
MUL_4069|M.ulcerans_Agy99           -----MSADPTVPQLLVPLAEIGDRGIYFED------SFTSWADHIGHG-
MAV_0650|M.avium_104                ---MELSDDLTVTELLVPLTEIDDRGVYFED------SFTSWRDHLQHG-
TH_1138|M.thermoresistible__bu      -------MAETVTALLEPLIDVEDRGVWFED------EFTPWRAHLEQA-
MSMEG_5908|M.smegmatis_MC2_155      --MTETIDPQTVTALLAPLADVTDRGVHEGD------SFVSWSEHITAG-
Mflv_1549|M.gilvum_PYR-GCK          ----MTAPAPTVSALLSALSDVDDRGVHSIDPGSAVTSFISWRNHIRDG-
Mvan_5208|M.vanbaalenii_PYR-1       --------MATVSSLLAELTEVDDRGVRWVDPETGSVSFVSWRNHIRDG-
MAB_4160|M.abscessus_ATCC_1997      ---MSTSEDATVTRLLVNLADVEDRGLHFEG------SFTSWRDHIAES-
MLBr_02546|M.leprae_Br4923          MTKLRHYLERGAAEVHYLRSIFESGALGFEPP----LTYAAMAVAMRKWG
                                               .. :      . . .:           : .    :    

Mb3536|M.bovis_AF2122/97            -AAIAAALRERLDPARPPHVG-----------------------------
Rv3506|M.tuberculosis_H37Rv         -AAIAAALRERLDPARPPHVG-----------------------------
MMAR_4994|M.marinum_M               -AAIAAALRERLDPTRPPHVG-----------------------------
MUL_4069|M.ulcerans_Agy99           -AAIAAALRERLDPTRPPHVG-----------------------------
MAV_0650|M.avium_104                -AAIAAALRARLDPARPPHVG-----------------------------
TH_1138|M.thermoresistible__bu      -SALAAALTARLDPNRPPHVG-----------------------------
MSMEG_5908|M.smegmatis_MC2_155      -AQVGAALRARLDPQRPGHVG-----------------------------
Mflv_1549|M.gilvum_PYR-GCK          -ATLASALRSRLDPDRPGHVG-----------------------------
Mvan_5208|M.vanbaalenii_PYR-1       -AALAAALRDRLDPDRPAHVG-----------------------------
MAB_4160|M.abscessus_ATCC_1997      -RRLASVLRARLDPSKPPHIG-----------------------------
MLBr_02546|M.leprae_Br4923          DLAMLPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGG
                                       : ..:  * .* :.  :.                             

Mb3536|M.bovis_AF2122/97            ----VLLQNTPFFSATLVAGALSGIVPVGLNPVRRGAALAGDIAKADCQL
Rv3506|M.tuberculosis_H37Rv         ----VLLQNTPFFSATLVAGALSGIVPVGLNPVRRGAALAGDIAKADCQL
MMAR_4994|M.marinum_M               ----VLLQNTPFFSAMLAAAGMSGIIPVGLNPVRRGAALARDIEHADCQM
MUL_4069|M.ulcerans_Agy99           ----VLLRNTPFFSAMLTAAGMSGIIPVGLNPVRRGAALARDIEHADCQM
MAV_0650|M.avium_104                ----VLLENTPFFSAVLVAAGMSGIVPVGLNPVRRGDALRRDIARADCQL
TH_1138|M.thermoresistible__bu      ----VLSGNTPMFSALLVAAAMTGLVPVGLNPTRRGAALVRDIERADCRL
MSMEG_5908|M.smegmatis_MC2_155      ----VLLGNTTFFSSLLVAAGLTGLVPVGLNPTRRGEALRRDIVRADCQV
Mflv_1549|M.gilvum_PYR-GCK          ----VLLGNTPFFGTVLAAAALSGIVPVGLNPTRRGDALRRDADHADCQF
Mvan_5208|M.vanbaalenii_PYR-1       ----VLLGNTPFFGTVLVAAALSGIVPVGLNPTRRGAALQRDVDHADCQL
MAB_4160|M.abscessus_ATCC_1997      ----VILENTPGFARLLTAAALAGLVLVGLNSTRRGSALRRDIELADCQF
MLBr_02546|M.leprae_Br4923          DGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKV
                                        ::  *   *     . .  *   : **.   *  :       ..:.

Mb3536|M.bovis_AF2122/97            VLTGSGS-------AEVPADVEHINVDSPEWTDEVAAHRDTEVRFRSADL
Rv3506|M.tuberculosis_H37Rv         VLTGSGS-------AEVPADVEHINVDSPEWTDEVAAHRDTEVRFRSADL
MMAR_4994|M.marinum_M               VLADTAS-------ASTLDGIEHVNVDSAEWAEVIDAHRNSEISFQNAAP
MUL_4069|M.ulcerans_Agy99           VLADTAS-------ASTLDGIEHVNVDSAEWAEVIDAHRNSEISFQNAAP
MAV_0650|M.avium_104                VLADANS-------AGTLGDIEHLNVDSAAWADEVAAHRGAPIVFRSASP
TH_1138|M.thermoresistible__bu      VLADDPE-----SVPAG---VDFIDVTAPRFADELAAHRGAPVRFRRAAP
MSMEG_5908|M.smegmatis_MC2_155      VLTDTPD-----LVPAGMNEVPVIDVESADWAAELDAHRGAPVRFAATRA
Mflv_1549|M.gilvum_PYR-GCK          VLADAENV----AQCGGLSGLDVIDVESEAFAEELSAHRGADAGFIEPDP
Mvan_5208|M.vanbaalenii_PYR-1       VLADRS---------APHDGIAAVDVESSLFADELATHRGAAVDFPDPDP
MAB_4160|M.abscessus_ATCC_1997      VVADESD--------------------------TVAGLQHPQIEIADVRP
MLBr_02546|M.leprae_Br4923          IIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSSS
                                    :: .                                  .     :     

Mb3536|M.bovis_AF2122/97            A-------DLFMLIFTSGTSGDPKAVKCSHRKVAIAGVTITQRFSLGRDD
Rv3506|M.tuberculosis_H37Rv         A-------DLFMLIFTSGTSGDPKAVKCSHRKVAIAGVTITQRFSLGRDD
MMAR_4994|M.marinum_M               A-------DLFMLIYTSGTSGDPKAVKCSHSKVAIAGVTMTQRFGLGRDD
MUL_4069|M.ulcerans_Agy99           A-------DLFMLIYTSGTSGDPKAVKCGHSKVAIAGVTMTQRFGLGRDD
MAV_0650|M.avium_104                A-------DLFMLIFTSGTSGEPKAVKCSHGKAAIAGVTMTQRFGLGRDD
TH_1138|M.thermoresistible__bu      D-------DLFMLIFTSGTSGDPKAVRVTHDKVAHPGTMLATRFGLGPAD
MSMEG_5908|M.smegmatis_MC2_155      D-------DLFMLIFTSGTSGEPKAVRVTHDKVAFPGRMLAERFGLAPSD
Mflv_1549|M.gilvum_PYR-GCK          E-------DLFMLIFTSGTSGDPKAVRCTHEKVALPGLMLAERFGLGPAD
Mvan_5208|M.vanbaalenii_PYR-1       D-------DLFMLIFTSGTSGHPKAVRCTHEKVAFPGVMLAQRFGLGAAD
MAB_4160|M.abscessus_ATCC_1997      D-------DLYMLIFTSGTSGDPKAVQITHAKVASAGIMLSSRFGLGSTD
MLBr_02546|M.leprae_Br4923          APAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSKVPFRAHE
                                               ::* ****:* **...        .   :  :. :   :

Mb3536|M.bovis_AF2122/97            VCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASQFLADVRRYGATY
Rv3506|M.tuberculosis_H37Rv         VCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASQFLADVRRYGATY
MMAR_4994|M.marinum_M               VCYVSMPLFHSNAVLVGWAVAVACQGSMALRRKFSASQFLSDVRRYGATY
MUL_4069|M.ulcerans_Agy99           VCYVSMPLFHSNAVLVGWAVAVACQGSMALRRKFSASQFLSDVRRYGATY
MAV_0650|M.avium_104                VCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASGFLPDVRRYGATY
TH_1138|M.thermoresistible__bu      TCYLSMPLFHSNAIMAGWAVAVAAGASVALRRRFSASQFIPDVRRYRASY
MSMEG_5908|M.smegmatis_MC2_155      TAYLSMPLFHSNAIMAGWSVAVAAGASIALRRKFSASGFIEDVRRYGATY
Mflv_1549|M.gilvum_PYR-GCK          TCYLSMPLFHSNAIMAGWAPAVAAGASIALRRKFSASQFIPDIRRFGATY
Mvan_5208|M.vanbaalenii_PYR-1       TCYLSMPLFHSNAIMAGWAPGVAAGASIALRRKFSASQFIPDVRRFGATY
MAB_4160|M.abscessus_ATCC_1997      VCYLSMPMFHSNAVMAGWSVAVAAGASIALRRKFSASGFLDDVREYGATY
MLBr_02546|M.leprae_Br4923          VTLLPAPMFHALGYLH-ATLAMFLGSTLVLRRRFKPATVLEDIEKHQATA
                                    .  :. *:**: . :   : .    .::.***:*..: .: *:... *: 

Mb3536|M.bovis_AF2122/97            ANYVGKPLSYVLATPE----LPDDADNPLRAVYGNEGVPGDIDRFGRRFG
Rv3506|M.tuberculosis_H37Rv         ANYVGKPLSYVLATPE----LPDDADNPLRAVYGNEGVPGDIDRFGRRFG
MMAR_4994|M.marinum_M               ANYVGKPLSYVLATPE----RPDDADNPLRAVYGNEGVPGDSERFGCRFG
MUL_4069|M.ulcerans_Agy99           ANYVGKPLSYVLATPE----RPDDADNPLRAVYGNEGVPGDIERFGCRFG
MAV_0650|M.avium_104                ANYVGKPLSYVLATPE----RPDDAQNPLRAVYGNEGVPADIERFARRFG
TH_1138|M.thermoresistible__bu      ANYVGKPLSYILATPP----RADDADNPLRILYGNEGAPRDIARFARRFD
MSMEG_5908|M.smegmatis_MC2_155      ANYVGKPLSYILATDP----RPDDADNPLKILYGNEGAARDLQRFAERFG
Mflv_1549|M.gilvum_PYR-GCK          ANYVGKPLSYILATPQ----LPDDADNPLRIAYGNEGAPRDLSRFAERFA
Mvan_5208|M.vanbaalenii_PYR-1       ANYVGKPLSYILATPE----KPDDADNPLRVAYGNEGAPRDLRRFAERFG
MAB_4160|M.abscessus_ATCC_1997      ANYVGKPMSYVLATPQ----RPDDAENPLRIMYGNEAAAGDTDRFATRFG
MLBr_02546|M.leprae_Br4923          MVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRALEELG
                                       *   :* :* *       .* :.  :    *.:  .    *   .: 

Mb3536|M.bovis_AF2122/97            CVVMDGFGSTEGGVAITRTL---DTPAGALGPLPGGIQIVDP-DTGEPCP
Rv3506|M.tuberculosis_H37Rv         CVVMDGFGSTEGGVAITRTL---DTPAGALGPLPGGIQIVDP-DTGEPCP
MMAR_4994|M.marinum_M               CVVQDGFGSTEGGVAIARTP---DTPAGSLGPLPENIEILDP-ETGQQCP
MUL_4069|M.ulcerans_Agy99           CVVQDGFGSTEGGVAIARTP---DTPAGSLGPLPENIEIVDP-ETGQQCP
MAV_0650|M.avium_104                CVVQDGFGSTEGGVAIARTP---DTPPGSLGPLPAGIDIVDP-DTGASCP
TH_1138|M.thermoresistible__bu      VLVVDGFGSTEGGVAIARTP---DTPDGALGPLTDEVAIIDV-DTGEPCP
MSMEG_5908|M.smegmatis_MC2_155      VHVVDGFGSTEGGVAVARTP---DTPDGALGPLTDQVAIIDV-DTGEPCP
Mflv_1549|M.gilvum_PYR-GCK          VRVVDGFGSSEGGVSIARTP---DTPEGALGPLTGGVTILDV-DTGAECP
Mvan_5208|M.vanbaalenii_PYR-1       VTVVDGFGSSEGGVSIARTP---DTPEGALGPLVGGVTIVDV-DTGAECP
MAB_4160|M.abscessus_ATCC_1997      AVVVDGFGSTEGGVALGWAP---GTPPGAIGPLTPDIQILDI-QTGRPCP
MLBr_02546|M.leprae_Br4923          PVIYNMYGSTEIAFATIAGPKDLQINSATVGPVVKGVKVKILDDSGKEVP
                                      : : :**:* ..:            .::**:   : :    ::*   *

Mb3536|M.bovis_AF2122/97            TGV-------------VGELVNTAGPGGFEGYYNDEAAEAERMAGGVYHS
Rv3506|M.tuberculosis_H37Rv         TGV-------------VGELVNTAGPGGFEGYYNDEAAEAERMAGGVYHS
MMAR_4994|M.marinum_M               VGA-------------VGELVNTAGPGRFEGYYNDEAASAQRMSGGVYHS
MUL_4069|M.ulcerans_Agy99           VGA-------------VGELVNTAGPGRFEGYYNDEAASAQRMSGGVYHS
MAV_0650|M.avium_104                PGV-------------VGELVNTAGPGRFEGYYNDEAAEAERMAGGVYHS
TH_1138|M.thermoresistible__bu      PGK-------------IGEIVNPTGPGWFRGYYNDPDAEAERMAGGVYHT
MSMEG_5908|M.smegmatis_MC2_155      PGR-------------VGELVNPTGPGWFRGYYNDPQAEAERMAGGVYHT
Mflv_1549|M.gilvum_PYR-GCK          PGV-------------IGELVNTDGPGQFRGYYKDPEAEADRMRGGIYHS
Mvan_5208|M.vanbaalenii_PYR-1       PGV-------------VGELVNTEGPGQFRGYYRDPDAEAERMRGGVYHS
MAB_4160|M.abscessus_ATCC_1997      PAIFDQSGKVINAAEATGELVNVTGPGRFTGYYKNPEADAERMVGGRYHS
MLBr_02546|M.leprae_Br4923          RGQ-------------VGRIFVGNAFP-FEGYTG---GGGKQIIDGLLSS
                                     .               *.:.   .   * **     . ..:: .*   :

Mb3536|M.bovis_AF2122/97            GDLAYRDDAGYAYFAGRLGDWMRVDGENLGTAPIERVLMRYPDATEVAVY
Rv3506|M.tuberculosis_H37Rv         GDLAYRDDAGYAYFAGRLGDWMRVDGENLGTAPIERVLMRYPDATEVAVY
MMAR_4994|M.marinum_M               GDLAYRDAAGYAYFAGRLGDWMRVDGENLGTAPIERVLLRYPDAIEVAVY
MUL_4069|M.ulcerans_Agy99           GDLAYRDAAGYAYFAGRLGDWMRVDGENLGTAPIERVLLRYPDAIEVAVY
MAV_0650|M.avium_104                GDLAYRDEAGYAYFAGRLGDWMRVDGENLGAAPIERVLLRHPDVTEVAVY
TH_1138|M.thermoresistible__bu      GDLGYCDENGYIYFAGRLGDWMRVDGENLGTAPIERILLRHPDVVEAAVY
MSMEG_5908|M.smegmatis_MC2_155      GDLAYRDENGYVYFAGRLGDWMRVDGENLGTAPIERILLRHPGIVEVAVY
Mflv_1549|M.gilvum_PYR-GCK          GDLAYRDEDGYAYFAGRLGDWMRVDGENIGTAPIERILMRFPGVAEAAVY
Mvan_5208|M.vanbaalenii_PYR-1       GDLAYRDERGFAYFAGRLGDWMRVDGENLGTAPIERILMRFPGVTEAAVY
MAB_4160|M.abscessus_ATCC_1997      GDLAYADENGYVYFAGRLGDWLRVDGENLGTAPIERVLLRHPDITEVAVY
MLBr_02546|M.leprae_Br4923          GDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAI
                                    **:.* *  .  *::** .: :  .***: .* :* ::  .*   *.:. 

Mb3536|M.bovis_AF2122/97            PVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDLGHKQWPSYVRVS
Rv3506|M.tuberculosis_H37Rv         PVPDPVVGDQVMAALVLAPGTKFDADKFRAFLTEQPDLGHKQWPSYVRVS
MMAR_4994|M.marinum_M               AIPDPVVGDQVMAAMVLTPGAKFDVDKFRAFLAGQSDLGPKQWPSYVRIC
MUL_4069|M.ulcerans_Agy99           AIPDPVVGDQVMAAMVLTPGAKFDVDKFRAFLAGQSDLGPKQWPSYVRIC
MAV_0650|M.avium_104                PVPDPTVGDQVMAALVLAPGAEFDDEKFRAFLAEQPDLGPKQWPSYVRIS
TH_1138|M.thermoresistible__bu      PIPDPAVGDRVMAALVLTDGAEFDPGRFRDFLADQPDLGPKQWPSFVRVA
MSMEG_5908|M.smegmatis_MC2_155      PIPDPAVGDQVMAAVVPAPGSVLDPGQLGEFLAAQDDLGPKQWPSYVRVS
Mflv_1549|M.gilvum_PYR-GCK          PIPDPAVGDQVMAALVMCEGAPFEAAAFTEFLSAQADLGPKQWPRFVRVA
Mvan_5208|M.vanbaalenii_PYR-1       PIPDPAVGDQVMAALVLPDIAAFDPDSFTQFLCEQSDLGPKQWPRFVRTA
MAB_4160|M.abscessus_ATCC_1997      GVPDPTVGDRVMAALV---GADFDPVTLSEFLSAQEDLGPKQWPSFIRVS
MLBr_02546|M.leprae_Br4923          GVDDKEWGARLRAFVVKKQDATIDEDAIKAYVR--DHLARYKVPREVIFL
                                     : *   * :: * :*    : ::   :  ::    .*.  : *  :   

Mb3536|M.bovis_AF2122/97            AGLPRTMTFKVIKRQLSAEGVACADPVWPIRR----------
Rv3506|M.tuberculosis_H37Rv         AGLPRTMTFKVIKRQLSAEGVACADPVWPIRR----------
MMAR_4994|M.marinum_M               SALPRTETFKVLKRQLAADGVDCGDPVWPIRDQS--------
MUL_4069|M.ulcerans_Agy99           SALPRTETFKVLKRQLAADGVDCGDPVWPIRDQS--------
MAV_0650|M.avium_104                TELPRTVTFKVLKRQLAAQGVDCGDPVWKIGR----------
TH_1138|M.thermoresistible__bu      EVLPRTETFKVLKRQLSAEATDCADPVWPIERPRGDRCASP-
MSMEG_5908|M.smegmatis_MC2_155      TELPRTETFKVLKRQLSAEGIDCTDPVWPIVR--GARTNTTA
Mflv_1549|M.gilvum_PYR-GCK          PALPRTETFKVLKRRLSAEGVDCPDPVHPIVRP---------
Mvan_5208|M.vanbaalenii_PYR-1       TALPRTETFKILKRELSAEGTDCPDPVHPIRRP---------
MAB_4160|M.abscessus_ATCC_1997      GELPRTATFKVIKRQLSAEALETADPVWALTNGTYTRT----
MLBr_02546|M.leprae_Br4923          EELPRNPTGKVLKRELRDFEVH--------------------
                                      ***. * *::**.*