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PNSSARMLRVAAARADFLEYGGGGAAGVSEVVVASWERSQAAGVDIAHPNAQFTDEIDAASLLVRCARPV LQQLQIDTADMPLVIALTDKKARVVQRIDSSSAVARLLDRVDLAPGFSYAESTMGTNGIGTVFEAGQPIS VVGPEHFSENLHLFACTGAPVIDPVTGRVEGVLDISTLSSSWSPLMHTLVKSAAKDIGRNFLLDRGQAQR AIFETYLKVTARSDRQAVFAFGESVFVANSAAQQMFDADEQRIMREHAMFLMAGKDRVSDTIALPGQRLV HVRGTRILAGVAVAGMVVIADLVTSSQPGTPDDFSEQQLPQVAIATPQTSQIVGGLWRSRDSLAGGSTPA WIRACGDLRQALEQVQPALVVGEQGAGKFTLVAELFHSVYPGGRAISVDAGQLESGCAPSDLGSLLGDSA EPTLHIIRDIDQASTDGVERLEAYLAAVAEVTGPVWVVATGSDSAASADLPFRELLHHFEVSITIPPLRC RTDDLPTLTAALLRGIAPERKVRLSPEAQRVIARYSWPRNISQLREALVHALRRRPVGEIQESDLPGYCQ TASRHALTPLEAAERDAIVAALRDTAGNRVAAAAHLGMSRSSLYRKIKTYGIVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4895 | - | - | 100% (615) | Fis family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0790 | - | 7e-17 | 29.50% (200) | putative GAF sensor protein |
| M. vanbaalenii PYR-1 | Mvan_1466 | - | 2e-14 | 28.27% (191) | putative GAF sensor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_0123 | - | 2e-17 | 31.34% (201) | putative GAF sensor protein |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2793c | - | 2e-13 | 29.28% (181) | putative transcriptional regulator |
| M. marinum M | MMAR_4913 | - | 1e-16 | 25.74% (303) | putative regulatory protein |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1970 | - | 1e-69 | 30.91% (605) | sigma factor |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0493 | - | 5e-16 | 29.26% (188) | putative regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4913|M.marinum_M --MATMRTANEIAAARLSMPALRALRDRFVAGRVDSTYLDSTPVRR---I
MUL_0493|M.ulcerans_Agy99 MLVATMRTANEIAAARLSMPALRALRDRFVAGRVDSTYLYSTPVRR---I
MAB_2793c|M.abscessus_ATCC_199 --MATTRTSARCGPARVSLTSVRDAHELFVTGQVDGSYLESIPLPR---L
Mflv_0123|M.gilvum_PYR-GCK --MPSNVGSPLVPEPAVAVGEDPRSYARLMSAVYDATMAGDRAPARPREV
Mvan_4895|M.vanbaalenii_PYR-1 ------------------MPNSSARMLRVAAARADFLEYGGGGAAGVSEV
MSMEG_1970|M.smegmatis_MC2_155 ------------------MVRHADTPTDAQRAREQFLSTGALQPDAVASS
: . :
MMAR_4913|M.marinum_M VADSWRRSLATGVDPDRGGGQIAQLSDTVERLRSAHPLAPVLPLIRRLLI
MUL_0493|M.ulcerans_Agy99 VADSWRRSLATGVDPDRGGGQIAQLSDTVERLRSAHPLAPVLPLIRRLLI
MAB_2793c|M.abscessus_ATCC_199 VTDSWQRSLATGVDPDRGPGEAAAATQLTE-LRNSHPLARALPVIRRLLV
Mflv_0123|M.gilvum_PYR-GCK IGDSWRRIMASGIEPDE-HAEPVVETGALEMLRRSSGLMEVLDDISHGLG
Mvan_4895|M.vanbaalenii_PYR-1 VVASWERSQAAGVDIAHPNAQFTDEIDAASLLVRC-----ARPVLQQLQI
MSMEG_1970|M.smegmatis_MC2_155 VLNSWQRSRELHVHPDRVELPYVRDPDTDTPLMHA-----AAPVLRRMAE
: **.* :. . . * . . : :
MMAR_4913|M.marinum_M DDAADSGVIVAVTSADGTLLWVDGDRRACRKAESMDFVPGADWSERGAGT
MUL_0493|M.ulcerans_Agy99 DDAADSGVIVAVTSADGTLLWVDGDRRACRKAESMDFVPGADWSERGAGT
MAB_2793c|M.abscessus_ATCC_199 DHAADSGALVGVTAADGALLWVEGDSGAGRKAAAMNFVPGADWSERAVGT
Mflv_0123|M.gilvum_PYR-GCK PLVADGENILVVADAKGRVLWRSGSPSVLMNADRLGFVEGANWGERAVGT
Mvan_4895|M.vanbaalenii_PYR-1 DTADMPLVIALTDKKARVVQRIDSSSAVARLLDRVDLAPGFSYAESTMGT
MSMEG_1970|M.smegmatis_MC2_155 DLSDQSVSVVLTSADGLVLDRVAADTEFERVLDDVRLARGYSYAEEFAGT
: . : .. : :. * .:.* **
MMAR_4913|M.marinum_M NAPGTALALDRELQIRGSEHFSRLVQPWNCTAVPVHDPSTGVLIGAIDLT
MUL_0493|M.ulcerans_Agy99 NAPGTALALDRELQIRGSEHFSRLVQPWNCTAVPVHDPSTGVLIGAIDLT
MAB_2793c|M.abscessus_ATCC_199 NAPGTALALDREVQIRGSEHFCRLVRPWSCTAVPIHDPLSGTPLGSLDLT
Mflv_0123|M.gilvum_PYR-GCK NAIGTALVSQRAVQVFSAEHFLRSHHSWTCAGAPIRDPRTGQVIGVVDVS
Mvan_4895|M.vanbaalenii_PYR-1 NGIGTVFEAGQPISVVGPEHFSENLHLFACTGAPVIDPVTGRVEGVLDIS
MSMEG_1970|M.smegmatis_MC2_155 NGIGTALETGRPAFIRGSEHYVGTLGGLACAGSPIREPVTRRILGVIDLT
*. **.: : : ..**: *:. *: :* : * :*::
MMAR_4913|M.marinum_M GGESVASPQTLALLRATGVAVES---------------------------
MUL_0493|M.ulcerans_Agy99 GGESVASPQTLALLRATGVAVES---------------------------
MAB_2793c|M.abscessus_ATCC_199 GGVDIASPQTLALVRATAVAVEH---------------------------
Mflv_0123|M.gilvum_PYR-GCK GPAATVHPTTVALVDAVARLAES---------------------------
Mvan_4895|M.vanbaalenii_PYR-1 TLSSSWSPLMHTLVKSAAKDIGRNFLLDRGQAQRAIFETYLKVTARSDRQ
MSMEG_1970|M.smegmatis_MC2_155 CRARQADPLLFVLAKSAGSQIEDRLRTMNNETETALLDAYLKQSRRYPGG
* .* :..
MMAR_4913|M.marinum_M --------------------------------------------------
MUL_0493|M.ulcerans_Agy99 --------------------------------------------------
MAB_2793c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0123|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4895|M.vanbaalenii_PYR-1 AVFAFGESVFVANSAAQQMFDADEQRIMREHAMFLMAGKDRVSDTIALPG
MSMEG_1970|M.smegmatis_MC2_155 VLAIGGDVVLMNRYLRQALDAADQTVLLDHAAELTRSSFTSTTVAHLPSG
MMAR_4913|M.marinum_M --------------------------------------------QLALLR
MUL_0493|M.ulcerans_Agy99 --------------------------------------------QLALLR
MAB_2793c|M.abscessus_ATCC_199 --------------------------------------------FIALDY
Mflv_0123|M.gilvum_PYR-GCK --------------------------------------------HLRVEH
Mvan_4895|M.vanbaalenii_PYR-1 QRLVHVRGTRILAGVAVAGMVVIADLVTSSQPGTPDDFSEQQLPQVAIAT
MSMEG_1970|M.smegmatis_MC2_155 ASVKISAAERIIVG-------------------------VRSDSVVFHVS
:
MMAR_4913|M.marinum_M SGAVQ-PQPSRQAQLSVLGAQRPSWRVA-GMGPTMLAGRHADILVLLDRH
MUL_0493|M.ulcerans_Agy99 SGAVQ-PQPSRQAQLSVLGAQRPSWRVA-GMGPTMLAGRHADILVLLDRH
MAB_2793c|M.abscessus_ATCC_199 PGRVQ-VDADTGPRLTLLGVGRPVLHTADGERTHRLSGRHAEILALLLRH
Mflv_0123|M.gilvum_PYR-GCK DRTLNRLRALTAPILARMGSPALVVDTDGWVAAVDAMPLHHRILLPERLG
Mvan_4895|M.vanbaalenii_PYR-1 PQTSQIVGGLWRSRDSLAGGSTPAWIRACGDLRQALEQVQPALVVGEQGA
MSMEG_1970|M.smegmatis_MC2_155 VHVAESIPVRSSQHIPRLAGQSSSFRRSAQQVERCYRDREWVVIEGERGS
: . . . ::
MMAR_4913|M.marinum_M ---------------------------PEGLSADHLAVLLDDRELDVVTI
MUL_0493|M.ulcerans_Agy99 ---------------------------PEGLSADHLAVLLDDRELDVVTA
MAB_2793c|M.abscessus_ATCC_199 ---------------------------PEGLSADHLAMLLDENDLDVVTI
Mflv_0123|M.gilvum_PYR-GCK ---------------------------PGRVRLATLGMCAVEPLPGGWLV
Mvan_4895|M.vanbaalenii_PYR-1 GKFTLVAELFHSVYPGGRAISVDAGQLESGCAPSDLGSLLGDSAEPTLHI
MSMEG_1970|M.smegmatis_MC2_155 GRTYLGYSVVHFVTP------------ERSIPVLHIDNFDTPESFVAAFE
:
MMAR_4913|M.marinum_M RAEMSRLRRVVGEQLIA--SRPYRLTEPIAT-DVGDVFDAVRRGDLAE--
MUL_0493|M.ulcerans_Agy99 RAEMSRLRRVVGEHLIA--SRPYRLTEPIAT-DVGDVFDAVRRGDLAE--
MAB_2793c|M.abscessus_ATCC_199 RAEMSRLRRIVGGELIG--SRPYRLLKKVRS-DMADVFSALRAGEIAN--
Mflv_0123|M.gilvum_PYR-GCK RPAGGED----GEDADE--AQPSRATLDVSDPDRPSLVMVGRSGSWRH--
Mvan_4895|M.vanbaalenii_PYR-1 IRDIDQASTDGVERLEAYLAAVAEVTGPVWVVATGSDSAASADLPFRE--
MSMEG_1970|M.smegmatis_MC2_155 SETDSADFAVIVSDVDELPDEVLNPMAAIMQTRAGRGWIAATTSTERDSQ
. . : . .
MMAR_4913|M.marinum_M -----ALRHYAGALLPQSVSPGVARVRTELSNTLRA------AVVASNDA
MUL_0493|M.ulcerans_Agy99 -----ALRHYAGALLPQSVSPGIARVRTELSNTLRA------AVVASNDA
MAB_2793c|M.abscessus_ATCC_199 -----AMDHYHGELLPRSAAPAVARLRLELSTSLRG------AVLASGDL
Mflv_0123|M.gilvum_PYR-GCK -----DLSLRHAEILVALALSPQGRSAPQLAEDLYGDRS-KVVTVRAEMS
Mvan_4895|M.vanbaalenii_PYR-1 -----LLHHFEVSITIPPLRCRTDDLPTLTAALLRGIAPERKVRLSPEAQ
MSMEG_1970|M.smegmatis_MC2_155 LVDLLMLPFFTHTVTVPALRHRIEDLQELVPMILNELSR-GEARMDGEAM
: : . * . :
MMAR_4913|M.marinum_M DLLANWLRLPEARDDRQGWRMLYDRSPAGSPRRAQAQGHLAGLDFDLA--
MUL_0493|M.ulcerans_Agy99 DLLANWLRLPEAHDDRQGWRMLYDRSPAGSPRRAQAQGHLAGLDFDLA--
MAB_2793c|M.abscessus_ATCC_199 HLLRRWLDLPEARDNREGWQGLHDHPGAGAVARSEARGHLIALDSDLA--
Mflv_0123|M.gilvum_PYR-GCK RLRKQFAGILATQPYRFAGAIELSVRYPADRRMVLPPSNAPVIRAARENG
Mvan_4895|M.vanbaalenii_PYR-1 RVIARYSWPRNISQLREALVHALRRRPVGEIQESDLPGYCQTASRHALTP
MSMEG_1970|M.smegmatis_MC2_155 RQLAKLPWPGNIAQLRHVLTETVRRQRSGVIGVDKLPAECRSVTRRKLTP
. * . .
MMAR_4913|M.marinum_M ---------------------------------------------
MUL_0493|M.ulcerans_Agy99 ---------------------------------------------
MAB_2793c|M.abscessus_ATCC_199 ---------------------------------------------
Mflv_0123|M.gilvum_PYR-GCK ---------------------------------------------
Mvan_4895|M.vanbaalenii_PYR-1 LEAAERDAIVAALRDTAGNRVAAAAHLGMSRSSLYRKIKTYGIVA
MSMEG_1970|M.smegmatis_MC2_155 LEAMERDAIVRSLLENDGNKADAAAALGMSRATIYRKIKDFGIA-