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VRHADTPTDAQRAREQFLSTGALQPDAVASSVLNSWQRSRELHVHPDRVELPYVRDPDTDTPLMHAAAPV LRRMAEDLSDQSVSVVLTSADGLVLDRVAADTEFERVLDDVRLARGYSYAEEFAGTNGIGTALETGRPAF IRGSEHYVGTLGGLACAGSPIREPVTRRILGVIDLTCRARQADPLLFVLAKSAGSQIEDRLRTMNNETET ALLDAYLKQSRRYPGGVLAIGGDVVLMNRYLRQALDAADQTVLLDHAAELTRSSFTSTTVAHLPSGASVK ISAAERIIVGVRSDSVVFHVSVHVAESIPVRSSQHIPRLAGQSSSFRRSAQQVERCYRDREWVVIEGERG SGRTYLGYSVVHFVTPERSIPVLHIDNFDTPESFVAAFESETDSADFAVIVSDVDELPDEVLNPMAAIMQ TRAGRGWIAATTSTERDSQLVDLLMLPFFTHTVTVPALRHRIEDLQELVPMILNELSRGEARMDGEAMRQ LAKLPWPGNIAQLRHVLTETVRRQRSGVIGVDKLPAECRSVTRRKLTPLEAMERDAIVRSLLENDGNKAD AAAALGMSRATIYRKIKDFGIA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1970 | - | - | 100% (583) | sigma factor |
| M. smegmatis MC2 155 | MSMEG_3008 | - | 2e-50 | 28.01% (582) | putative sigma 54 type regulator |
| M. smegmatis MC2 155 | MSMEG_1542 | - | 8e-20 | 32.20% (205) | transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_4955 | - | 8e-19 | 31.54% (241) | putative GAF sensor protein |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2793c | - | 1e-14 | 31.43% (175) | putative transcriptional regulator |
| M. marinum M | MMAR_4913 | - | 2e-18 | 31.35% (252) | putative regulatory protein |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0493 | - | 1e-18 | 31.69% (243) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4895 | - | 1e-69 | 30.91% (605) | Fis family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4913|M.marinum_M --MATMRTANEIA----AARLSMPALRALRDRFVAGRVDSTYLDSTPVRR
MUL_0493|M.ulcerans_Agy99 MLVATMRTANEIA----AARLSMPALRALRDRFVAGRVDSTYLYSTPVRR
MAB_2793c|M.abscessus_ATCC_199 --MATTRTSARCG----PARVSLTSVRDAHELFVTGQVDGSYLESIPLPR
Mflv_4955|M.gilvum_PYR-GCK --MAASKPSARRASPPPPTPPSASRLQAVHELFVAGEVDTGYLNSHAVRP
MSMEG_1970|M.smegmatis_MC2_155 -----MVRHADTP----------TDAQRAREQFLS----TGALQPDAVAS
Mvan_4895|M.vanbaalenii_PYR-1 -----MPNSSAR----------MLRVAAARADFLEY----GGGGAAGVSE
: *: . :
MMAR_4913|M.marinum_M IVADSWRRSLATGVDPDRGGGQIAQLSDTVERLRSAHPLAPVLPLIRRLL
MUL_0493|M.ulcerans_Agy99 IVADSWRRSLATGVDPDRGGGQIAQLSDTVERLRSAHPLAPVLPLIRRLL
MAB_2793c|M.abscessus_ATCC_199 LVTDSWQRSLATGVDPDRGPGEAAAATQLTE-LRNSHPLARALPVIRRLL
Mflv_4955|M.gilvum_PYR-GCK VVAQSWERSRAGGVDPDIGAARSAAAAAAVDRLRETHPLAPALPVIRRLL
MSMEG_1970|M.smegmatis_MC2_155 SVLNSWQRSRELHVHPDR-----VELPYVRDPDTDTPLMHAAAPVLRRMA
Mvan_4895|M.vanbaalenii_PYR-1 VVVASWERSQAAGVDIAHP-----NAQFTDEIDAASLLVRCARPVLQQLQ
* **.** *. : : : . *:::::
MMAR_4913|M.marinum_M IDDAADSGVIVAVTSADGTLLWVDGDRRACRKAESMDFVPGADWSERGAG
MUL_0493|M.ulcerans_Agy99 IDDAADSGVIVAVTSADGTLLWVDGDRRACRKAESMDFVPGADWSERGAG
MAB_2793c|M.abscessus_ATCC_199 VDHAADSGALVGVTAADGALLWVEGDSGAGRKAAAMNFVPGADWSERAVG
Mflv_4955|M.gilvum_PYR-GCK VEDAIGSGVVVAVSAADGTLLWVEGDPGACRRAEAMNFVPGADWSERSAG
MSMEG_1970|M.smegmatis_MC2_155 EDLSDQSVSVVLTSADGLVLDRVAADTEFERVLDDVRLARGYSYAEEFAG
Mvan_4895|M.vanbaalenii_PYR-1 IDTADMPLVIALTDKKARVVQRIDSSSAVARLLDRVDLAPGFSYAESTMG
: : . :. . .: : .. * : :. * .::* *
MMAR_4913|M.marinum_M TNAPGTALALDRELQIRGSEHFSRLVQPWNCTAVPVHDPSTGVLIGAIDL
MUL_0493|M.ulcerans_Agy99 TNAPGTALALDRELQIRGSEHFSRLVQPWNCTAVPVHDPSTGVLIGAIDL
MAB_2793c|M.abscessus_ATCC_199 TNAPGTALALDREVQIRGSEHFCRLVRPWSCTAVPIHDPLSGTPLGSLDL
Mflv_4955|M.gilvum_PYR-GCK TNAPGTALTLGREMQIHGSEHFSRVVQPWSCTAAPVHDPTTGALLGAIDL
MSMEG_1970|M.smegmatis_MC2_155 TNGIGTALETGRPAFIRGSEHYVGTLGGLACAGSPIREPVTRRILGVIDL
Mvan_4895|M.vanbaalenii_PYR-1 TNGIGTVFEAGQPISVVGPEHFSENLHLFACTGAPVIDPVTGRVEGVLDI
**. **.: .: : *.**: : *:. *: :* : * :*:
MMAR_4913|M.marinum_M TGGESVASPQTLALLRATGVAVESQLALLR-------------------S
MUL_0493|M.ulcerans_Agy99 TGGESVASPQTLALLRATGVAVESQLALLR-------------------S
MAB_2793c|M.abscessus_ATCC_199 TGGVDIASPQTLALVRATAVAVEHFIALDY-------------------P
Mflv_4955|M.gilvum_PYR-GCK TGGGQVATSQTLALVRATAVAVENHLALLR-------------------L
MSMEG_1970|M.smegmatis_MC2_155 TCRARQADPLLFVLAKSAGSQIEDRLRTMNNETETALLDAYLKQSRRY-P
Mvan_4895|M.vanbaalenii_PYR-1 STLSSSWSPLMHTLVKSAAKDIGRNFLLDRGQAQRAIFETYLKVTARSDR
: . .* :::. : :
MMAR_4913|M.marinum_M GAVQPQ-------------PSRQAQLSVLGAQRPSWRVA----GMGPTML
MUL_0493|M.ulcerans_Agy99 GAVQPQ-------------PSRQAQLSVLGAQRPSWRVA----GMGPTML
MAB_2793c|M.abscessus_ATCC_199 GRVQVD-------------ADTGPRLTLLGVGRPVLHTAD---GERTHRL
Mflv_4955|M.gilvum_PYR-GCK AGAGAEP------------AARKPHLVVLGGDRPRWVTTDSVGHLQITHL
MSMEG_1970|M.smegmatis_MC2_155 GGVLAIGGDVVLMNRYLRQALDAADQTVLLDHAAELTRSS-FTSTTVAHL
Mvan_4895|M.vanbaalenii_PYR-1 QAVFAFGESVFVANSAAQQMFDADEQRIMREHAMFLMAGK--DRVSDTIA
. ::
MMAR_4913|M.marinum_M AGRHADILVLLDRHPEGLSADHLAVLLDDRE--------------LDVVT
MUL_0493|M.ulcerans_Agy99 AGRHADILVLLDRHPEGLSADHLAVLLDDRE--------------LDVVT
MAB_2793c|M.abscessus_ATCC_199 SGRHAEILALLLRHPEGLSADHLAMLLDEND--------------LDVVT
Mflv_4955|M.gilvum_PYR-GCK TGRHADILVLLSRHPEGLSADHLAVLLDDKD--------------LDVVT
MSMEG_1970|M.smegmatis_MC2_155 PSGASVKISAAERIIVGVRSDSVVFHVSVHV--------------AESIP
Mvan_4895|M.vanbaalenii_PYR-1 LPGQRLVHVRGTRILAGVAVAGMVVIADLVTSSQPGTPDDFSEQQLPQVA
* *: :.. . :.
MMAR_4913|M.marinum_M IR--------------------AEMSRLRR---------------VVGEQ
MUL_0493|M.ulcerans_Agy99 AR--------------------AEMSRLRR---------------VVGEH
MAB_2793c|M.abscessus_ATCC_199 IR--------------------AEMSRLRR---------------IVGGE
Mflv_4955|M.gilvum_PYR-GCK VR--------------------AEMSRLRK---------------VIGAE
MSMEG_1970|M.smegmatis_MC2_155 VRSSQHIPRLA-----------GQSSSFRRSAQQVERCYRDREWVVIEGE
Mvan_4895|M.vanbaalenii_PYR-1 IATPQTSQIVGGLWRSRDSLAGGSTPAWIRACGDLRQALEQVQPALVVGE
.. . : :: .
MMAR_4913|M.marinum_M LIASRPYR---------------------------LTEPIATDVGDVFDA
MUL_0493|M.ulcerans_Agy99 LIASRPYR---------------------------LTEPIATDVGDVFDA
MAB_2793c|M.abscessus_ATCC_199 LIGSRPYR---------------------------LLKKVRSDMADVFSA
Mflv_4955|M.gilvum_PYR-GCK NLGSRPYR---------------------------LLTSITSDLGEVYEA
MSMEG_1970|M.smegmatis_MC2_155 RGSGRTYLGYSVVHFVTPERSIPVLHIDNFDTPESFVAAFESETDSADFA
Mvan_4895|M.vanbaalenii_PYR-1 QGAGKFTLVAELFHSVYP-----------------GGRAISVDAGQLESG
..: . : . .
MMAR_4913|M.marinum_M VRRGDLAEALRHYAG-----------------------------------
MUL_0493|M.ulcerans_Agy99 VRRGDLAEALRHYAG-----------------------------------
MAB_2793c|M.abscessus_ATCC_199 LRAGEIANAMDHYHG-----------------------------------
Mflv_4955|M.gilvum_PYR-GCK LDAADVETALDRYPG-----------------------------------
MSMEG_1970|M.smegmatis_MC2_155 VIVSDVDELPDEVLNPMAAIMQTRAGRGWI--------------------
Mvan_4895|M.vanbaalenii_PYR-1 CAPSDLGSLLGDSAEPTLHIIRDIDQASTDGVERLEAYLAAVAEVTGPVW
.::
MMAR_4913|M.marinum_M --------------------ALLPQSVSPGVARVRTELSNTLRAAVVAS-
MUL_0493|M.ulcerans_Agy99 --------------------ALLPQSVSPGIARVRTELSNTLRAAVVAS-
MAB_2793c|M.abscessus_ATCC_199 --------------------ELLPRSAAPAVARLRLELSTSLRGAVLAS-
Mflv_4955|M.gilvum_PYR-GCK --------------------PLLTQSVSPAIARLRTQLSATLRAAVLAES
MSMEG_1970|M.smegmatis_MC2_155 --AATTSTERDSQLVDLLMLPFFTHTVTVPALRHRIEDLQELVPMILNEL
Mvan_4895|M.vanbaalenii_PYR-1 VVATGSDSAASADLPFRELLHHFEVSITIPPLRCRTDDLPTLTAALLRGI
: : : * * : * ::
MMAR_4913|M.marinum_M -------NDADLLANWLRLPEA--------------RDDRQGWRMLYDRS
MUL_0493|M.ulcerans_Agy99 -------NDADLLANWLRLPEA--------------HDDRQGWRMLYDRS
MAB_2793c|M.abscessus_ATCC_199 -------GDLHLLRRWLDLPEA--------------RDNREGWQGLHDHP
Mflv_4955|M.gilvum_PYR-GCK -----AQGRTDLLRRWLEQPEG--------------RDDRDGWQALRDSA
MSMEG_1970|M.smegmatis_MC2_155 S-RGEARMDGEAMRQLAKLPWPGNIAQLRHVLTETVRRQRSGVIGVDKLP
Mvan_4895|M.vanbaalenii_PYR-1 APERKVRLSPEAQRVIARYSWPRNISQLREALVHALRRRPVGEIQESDLP
. . : * . .
MMAR_4913|M.marinum_M PAGSPRRAQAQGHLAGLDFDLA----------------------------
MUL_0493|M.ulcerans_Agy99 PAGSPRRAQAQGHLAGLDFDLA----------------------------
MAB_2793c|M.abscessus_ATCC_199 GAGAVARSEARGHLIALDSDLA----------------------------
Mflv_4955|M.gilvum_PYR-GCK GLTPVARARARGHLAGLDFELG----------------------------
MSMEG_1970|M.smegmatis_MC2_155 AECRSVTRRKLTPLEAMERDAIVRSLLENDGNKADAAAALGMSRATIYRK
Mvan_4895|M.vanbaalenii_PYR-1 GYCQTASRHALTPLEAAERDAIVAALRDTAGNRVAAAAHLGMSRSSLYRK
. * . : :
MMAR_4913|M.marinum_M --------
MUL_0493|M.ulcerans_Agy99 --------
MAB_2793c|M.abscessus_ATCC_199 --------
Mflv_4955|M.gilvum_PYR-GCK --------
MSMEG_1970|M.smegmatis_MC2_155 IKDFGIA-
Mvan_4895|M.vanbaalenii_PYR-1 IKTYGIVA