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VDENKDVLVTVRNGIGRITLNRPKAINSLTHPMVTDIAQALKAWETDDAVTAVIVSGAGDRGLCAGGDVV AIYHDARAGGSESRRFWHDEYLLNAYIGRYPKPYVAIMNGITMGGGVGISAHGSVRVVTETTKMAMPEVG IGFIPDVGGTFILSRTPGLLGVHAALTGAAFSGADAIAMGFADHFVPQDRLAAFADAIEADGVDAAVAAF AQEPPPSALLAQRDWIDHCYAGETVADIVVALRGHDAEPAIDAAELIESRSPVAASVTLEAVRRAAKLDT LEDVLRQEFRTSVASLRSHDLVEGIRALLIDKDKNPQWSPASLSTVTPADIEAYFAPADPDLTFDEE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4680 | - | - | 100% (347) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4588 | - | 8e-22 | 31.31% (214) | enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_1985 | - | 7e-18 | 30.50% (200) | enoyl-CoA hydratase/isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1100c | echA9 | 1e-137 | 69.30% (342) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_2037 | - | 1e-166 | 82.71% (347) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1071c | echA9 | 1e-137 | 69.30% (342) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02401 | - | 1e-132 | 67.25% (342) | 3-hydroxyisobutyryl-CoA hydrolase |
| M. abscessus ATCC 19977 | MAB_1187c | - | 1e-117 | 61.75% (332) | enoyl-CoA hydratase |
| M. marinum M | MMAR_4395 | echA9 | 1e-138 | 69.01% (342) | enoyl-CoA hydratase EchA9 |
| M. avium 104 | MAV_1196 | - | 1e-134 | 67.93% (343) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_5276 | - | 1e-145 | 69.74% (347) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_0674 | echA9 | 1e-147 | 71.88% (345) | POSSIBLE ENOYL-CoA HYDRATASE ECHA9 (ENOYL HYDRASE) |
| M. ulcerans Agy99 | MUL_0209 | echA9 | 1e-138 | 68.71% (342) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1100c|M.bovis_AF2122/97 -----------MTGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLA
Rv1071c|M.tuberculosis_H37Rv -----------MTGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLA
MMAR_4395|M.marinum_M -----------MTGESDEVLTRVDGGVGFISLNRPKAINSLNQTMVDLLS
MUL_0209|M.ulcerans_Agy99 -----------MTGESDEVLTRVDGGVGFITLNRPKAINSLNQTMVDLLS
MAV_1196|M.avium_104 -----------MTDGSDEVLTQVDGNVGLITLNRPKAINSLNQPMIDALS
MLBr_02401|M.leprae_Br4923 -----------MAGESDEVLARVEAGIGLITLNRPKAINSLNQQMVDALT
MAB_1187c|M.abscessus_ATCC_199 -----------MT---DQIETRVEKGVGLLTLNRPKAINSLTYDMIAAMN
MSMEG_5276|M.smegmatis_MC2_155 ------------MTENEDILVNVRNGVGILTLNRPKAINSLTEAMVAEIG
TH_0674|M.thermoresistible__bu -----------VTAKNEDVLVNVEGGVGLLTLNRPKAINSLTHGMVTTMA
Mvan_4680|M.vanbaalenii_PYR-1 ------------MDENKDVLVTVRNGIGRITLNRPKAINSLTHPMVTDIA
Mflv_2037|M.gilvum_PYR-GCK MPSVGRRSTLHSVDENEDVLVTVANGIGRITLNRPKAINSLTHPMVTAID
.:: . * .:* ::**********. *: :
Mb1100c|M.bovis_AF2122/97 TVLMSWEHEDAVHAVVLSGAGERGLCAGGDVVAVYHSARKDGVEARRFWR
Rv1071c|M.tuberculosis_H37Rv TVLMSWEHEDAVHAVVLSGAGERGLCAGGDVVAVYHSARKDGVEARRFWR
MMAR_4395|M.marinum_M TVLTRWERDGEVRAVVVSGAGERGLCAGGDVVAVYHSARKDGAEARRFWR
MUL_0209|M.ulcerans_Agy99 TVFTRWERDGEVRAVVVSGAGERGLCAGGDVVAVYHSARKDGAEARRFWR
MAV_1196|M.avium_104 AVLTDWARDDKVRAVLLSGAGERGLCAGGDVVSIYHSARKDGVEARRFWR
MLBr_02401|M.leprae_Br4923 AILTSWADDDAVRAVVLSGAGERGLCAGGDVVAIYHSALKDGVEARRFWR
MAB_1187c|M.abscessus_ATCC_199 AVLAEWEADDAVRVVVLSGAGERGLCAGGDVVAVHDSAKIDGVAARRFFR
MSMEG_5276|M.smegmatis_MC2_155 KALHAWENDDSVHTVLLTGAGERGLCAGGDVVALYHSAKAGGADARRFWY
TH_0674|M.thermoresistible__bu ERLAAWENDDSVRAVLLTGAGERGLCAGGDVVAIYHSAKADGAEARRFWF
Mvan_4680|M.vanbaalenii_PYR-1 QALKAWETDDAVTAVIVSGAGDRGLCAGGDVVAIYHDARAGGSESRRFWH
Mflv_2037|M.gilvum_PYR-GCK ATLKTWQTDDSVTAVLVTGAGERGLCAGGDVVAIYHDAKVGGALTRRFWH
: * :. * .*:::***:**********:::..* .* :***:
Mb1100c|M.bovis_AF2122/97 HEYLLNALIGRFAKPYVALMDGIVMGGGVGVSAHANTRVVTDTSKVAMPE
Rv1071c|M.tuberculosis_H37Rv HEYLLNALIGRFAKPYVALMDGIVMGGGVGVSAHANTRVVTDTSKVAMPE
MMAR_4395|M.marinum_M DEYLMNGQIGRFSKPYVALMDGIVMGGGVGVSAHGDIRVVTDTSKVAMPE
MUL_0209|M.ulcerans_Agy99 DEYLMNGQIGRFSKPYVALMDGIVMGGGVGVSAHGDIRVVTDTSKVAMPE
MAV_1196|M.avium_104 DEYQLNAQISEFAKPYVAVMDGIVMGGGVGVSAHANTRVVTDTSKVAMPE
MLBr_02401|M.leprae_Br4923 SEYLLNSQIARFPKPYVSLMDGIVMGGGVGIGAHANTRVVTDTSQVAMPE
MAB_1187c|M.abscessus_ATCC_199 DEYVLNAQIARFPKPYVALMDGIVMGGGVGVGGHANIRIVTDTSKVAMPE
MSMEG_5276|M.smegmatis_MC2_155 DEYLVNAYIGNYPKPYVAVMDGIVMGGGVGVAGHGSIRVVTDTTKMAMPE
TH_0674|M.thermoresistible__bu DEYRLNAHIGRYPKPYVSIMDGIVMGGGVGVGAHGNVRVVTDTTKMAMPE
Mvan_4680|M.vanbaalenii_PYR-1 DEYLLNAYIGRYPKPYVAIMNGITMGGGVGISAHGSVRVVTETTKMAMPE
Mflv_2037|M.gilvum_PYR-GCK DEYLLNSYIGRYPKPYVAIMNGITMGGGVGISAHGSVRVVTETTKMAMPE
** :*. *..:.****::*:**.******:..*.. *:**:*:::****
Mb1100c|M.bovis_AF2122/97 VGIGFIPDVGGVYLLSRAPGALGLHAALTGAPFSGADAIALGFADHFVPH
Rv1071c|M.tuberculosis_H37Rv VGIGFIPDVGGVYLLSRAPGALGLHAALTGAPFSGADAIALGFADHFVPH
MMAR_4395|M.marinum_M VGIGFIPDVGGAYLLSRAPGALGLHAALTGAPFSGADAIALGFADHFVPH
MUL_0209|M.ulcerans_Agy99 VGIGFIPDVGGAYLLSRAPGALGLHTALTGAPFSGADAIALGFADHFVPH
MAV_1196|M.avium_104 VGIGFIPDVGGVYLLSRAPGGLGLHAALTGAPFSGADAIAMGFADHYVPH
MLBr_02401|M.leprae_Br4923 VGIGFIPDVGGTYLLSRAPGALGLHVALTGAPFSGADAIELGFADHYVPH
MAB_1187c|M.abscessus_ATCC_199 VGIGFIPDVGGTYLLSRAPGQLGLHAALTGAPFSGADAIALGFADHYVPH
MSMEG_5276|M.smegmatis_MC2_155 VGIGFVPDVGGTYLLSRAPGALGLHAALTGAPFSGADAIAMGFADHYVPH
TH_0674|M.thermoresistible__bu VGIGFIPDVGGTYLLSRAPGKLGLHAALTGAPFSGADAIVMGFADHYVPH
Mvan_4680|M.vanbaalenii_PYR-1 VGIGFIPDVGGTFILSRTPGLLGVHAALTGAAFSGADAIAMGFADHFVPQ
Mflv_2037|M.gilvum_PYR-GCK VGIGFIPDVGGTFILSRTPGLLGVHAAMTGAPFSGADAIEMGFADHFVPQ
*****:*****.::***:** **:*.*:***.******* :*****:**:
Mb1100c|M.bovis_AF2122/97 GDLDAFTQKIVTGGVESALAAHAVEPPPSTLAAQRDWIDECYAGDSVADI
Rv1071c|M.tuberculosis_H37Rv GDLDAFTQKIVTGGVESALAAHAVEPPPSTLAAQRDWIDECYAGDSVADI
MMAR_4395|M.marinum_M AELGAFSAAIASDGIESALAHHAVEPPPSGLAAQRGWIDECYAGDTVADI
MUL_0209|M.ulcerans_Agy99 AELGAFSAAIASDGIESALAHHAVEPPPSGLAAQRGWIDECYAGDTVADI
MAV_1196|M.avium_104 ADVEAFRRAVVADGVESALAKYAVEPPPGELAAQRDWIDECYAGQTVEDI
MLBr_02401|M.leprae_Br4923 SDLNAFTRAVVTDGVNSALAGYAIEPPPSYLAAQRDWIDECYVGETVKDI
MAB_1187c|M.abscessus_ATCC_199 DRLEKFTKAIIDSDIATALAVHGTNAPSSDLLAQRNWIDECYGGESVADI
MSMEG_5276|M.smegmatis_MC2_155 DKLADFIESVVAEGVEQALSAHAVEPPASALMEQRAWIDESYAGATVADI
TH_0674|M.thermoresistible__bu DKIDEFTRAVIADGVDAALAAHAQEPPASPLAEQRSWIDECYTGDTVADI
Mvan_4680|M.vanbaalenii_PYR-1 DRLAAFADAIEADGVDAAVAAFAQEPPPSALLAQRDWIDHCYAGETVADI
Mflv_2037|M.gilvum_PYR-GCK DQLEAFVAAVEADGVDAAVAAHAQQPPPSPLSAHREWIDSCYAAGTADDI
: * : .: *:: .. :.*.. * :* *** .* . :. **
Mb1100c|M.bovis_AF2122/97 VAALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRAAKLDTLEDVLIQD
Rv1071c|M.tuberculosis_H37Rv VAALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRAAKLDTLEDVLIQD
MMAR_4395|M.marinum_M IAALRGHDAGPANDAANVIASRSPIALSVTLEAVRRAAKLETLEDVLVQD
MUL_0209|M.ulcerans_Agy99 IAALRGHDAGPANDAADVIASRSPIALSVTLEAVRRAAKLETLEDVLVQD
MAV_1196|M.avium_104 VAALRAHGAGPAHDAADLIATRSPIALSVTLAAVRRAADLPTLKDVLVQD
MLBr_02401|M.leprae_Br4923 ITALRGHDAEPAEGAFNLIVSRSPVALSVTLEAMRRAAKLETLTDVLTQD
MAB_1187c|M.abscessus_ATCC_199 VAALQARGDERARAAADQILTRSPIALSVTLAAVRRARELPSLEAVLTQE
MSMEG_5276|M.smegmatis_MC2_155 LAALQNHDAPEARAAADLIATRSPVALAVTLEAVRRAEKLDTLEEALRQE
TH_0674|M.thermoresistible__bu IAALRAHDAPAAGEAADLIATRSPIALSVTLESVRRAAKLQSLEDTLRQE
Mvan_4680|M.vanbaalenii_PYR-1 VVALRGHDAEPAIDAAELIESRSPVAASVTLEAVRRAAKLDTLEDVLRQE
Mflv_2037|M.gilvum_PYR-GCK VSALRAHGAQPATDAADLIASRSPVAVSVALEAVRRAAGLATLEDVLRQE
: **: :. * * : * :***:* :*:* ::*** * :* .* *:
Mb1100c|M.bovis_AF2122/97 YRVSSASLRSHDLVEGIRAQLIDKDRNPNWSPATLDAITAADIEAYFEPV
Rv1071c|M.tuberculosis_H37Rv YRVSSASLRSHDLVEGIRAQLIDKDRNPNWSPATLDAITAADIEAYFEPV
MMAR_4395|M.marinum_M YRVSSASLRSHDLVEGIRAQLIDKDRNPKWSPATFAEITESDVAAYFAPV
MUL_0209|M.ulcerans_Agy99 YRVSSASLRSHDLVEGIRAQLIDKDRNPKWSPATFAEITESDVAAYFAPV
MAV_1196|M.avium_104 YRVSSASLRSHDLVEGIRAQLIDKDRNPQWSPARLADVTAADVEAYFAPV
MLBr_02401|M.leprae_Br4923 YRVSSASLHSHDLVEGIRAQLVHKDRNPQWAPTTLAEVTAADICGYFEPV
MAB_1187c|M.abscessus_ATCC_199 YRVSSQSVRSHDLVEGIRAQLVDKDRNPQWVPKTLAEVTKADVEEFFQPV
MSMEG_5276|M.smegmatis_MC2_155 YRISSAAVRSHDFVEGIRAQLVDKDRNPKWSPASIADVTQADIDAYFVPA
TH_0674|M.thermoresistible__bu YRVSCASLKSHDLVEGIRAQLVDKDRNPKWRPATLAEVTEADVEAYFAPV
Mvan_4680|M.vanbaalenii_PYR-1 FRTSVASLRSHDLVEGIRALLIDKDKNPQWSPASLSTVTPADIEAYFAPA
Mflv_2037|M.gilvum_PYR-GCK FRTSIAALRSHDLVEGIRALLIDKDKNPQWSPATLADVTAADIEAYFVSA
:* * :::***:****** *:.**:**:* * : :* :*: :* ..
Mb1100c|M.bovis_AF2122/97 DDDLSF-----
Rv1071c|M.tuberculosis_H37Rv DDDLSF-----
MMAR_4395|M.marinum_M DDDLSF-----
MUL_0209|M.ulcerans_Agy99 DDDLSF-----
MAV_1196|M.avium_104 DDDLSF-----
MLBr_02401|M.leprae_Br4923 DDDLSF-----
MAB_1187c|M.abscessus_ATCC_199 SDDLEWP----
MSMEG_5276|M.smegmatis_MC2_155 DPELEFEKEN-
TH_0674|M.thermoresistible__bu DPELTFEGETQ
Mvan_4680|M.vanbaalenii_PYR-1 DPDLTFDEE--
Mflv_2037|M.gilvum_PYR-GCK DPDINFEEQS-
. :: :