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MARLSEPSPYVEFDRTQWRALRMSTPLKLTEDELVRLRGLGEKIDLLEVEEVYLPLARLIHLQVAARQAL FATTAQFLGEPQQNPDRPVPFIIGVAGSVAVGKSTTARVLQALLARWEHHPRVDLVTTDGFLYSNSELSR RNLMHRKGFPESYDRRGLMRFVTAIKSGADAACAPVYSHLLYDIVAGEKQIIEHPDILILEGLNVLQTGP ALMVSDLFDFSVYVDARIEDIENWYISRFLSMRAGAFADPASHFHHYSTLTDEQAVFAARDIWHSINRPN LIENILPTRPRATLVLRKDSDHSINRLRLRKL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4658 | - | - | 100% (312) | pantothenate kinase |
| M. vanbaalenii PYR-1 | Mvan_2086 | frcK | 7e-06 | 28.46% (123) | putative fructose transport system kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1122c | coaA | 1e-157 | 85.26% (312) | pantothenate kinase |
| M. gilvum PYR-GCK | Mflv_2058 | - | 1e-174 | 96.47% (312) | pantothenate kinase |
| M. tuberculosis H37Rv | Rv1092c | coaA | 1e-157 | 85.26% (312) | pantothenate kinase |
| M. leprae Br4923 | MLBr_01954 | coaA | 1e-156 | 84.62% (312) | pantothenate kinase |
| M. abscessus ATCC 19977 | MAB_1234c | - | 1e-147 | 81.09% (312) | pantothenate kinase |
| M. marinum M | MMAR_4376 | coaA | 1e-154 | 83.97% (312) | pantothenate kinase CoaA |
| M. avium 104 | MAV_1214 | coaA | 1e-151 | 85.10% (302) | pantothenate kinase |
| M. smegmatis MC2 155 | MSMEG_5252 | coaA | 1e-165 | 91.35% (312) | pantothenate kinase |
| M. thermoresistible (build 8) | TH_2162 | coaA | 1e-162 | 89.10% (312) | Probable pantothenate kinase coaA (Pantothenic acid kinase) |
| M. ulcerans Agy99 | MUL_0189 | coaA | 1e-154 | 83.97% (312) | pantothenate kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1122c|M.bovis_AF2122/97 MSRLSEPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVE
Rv1092c|M.tuberculosis_H37Rv MSRLSEPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVE
MMAR_4376|M.marinum_M MSRLSEPSPYVEFDRRQWRALRMSTPLALTEAELIGLRGLGEQIDLLEVE
MUL_0189|M.ulcerans_Agy99 MSRLSEPSPYVEFDRRQWRALRMSTPLALTEAELIGLRGLGEQIDLLEVE
MLBr_01954|M.leprae_Br4923 MPRLSEPSPYVEFDRKQWRALRMSTPLALTEEELIGLRGLGEQIDLLEVE
MAV_1214|M.avium_104 ----------MEFDRKQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVE
MAB_1234c|M.abscessus_ATCC_199 MPRLSEPSPYVEFDRKQWRALRKSTPLVLTEEELIGLRGLGEQIDLTEVA
Mvan_4658|M.vanbaalenii_PYR-1 MARLSEPSPYVEFDRTQWRALRMSTPLKLTEDELVRLRGLGEKIDLLEVE
Mflv_2058|M.gilvum_PYR-GCK MARLSEPSPYVEFDRAQWRALRMSTPLKLTEDELVRLRGIGEKIDLLEVE
MSMEG_5252|M.smegmatis_MC2_155 MPRPSEPSPYVEFDRSQWRSLRMSTPLKLSEDELVRLRGMGEKLDLLEVE
TH_2162|M.thermoresistible__bu MARLNEPSPYVEFDRTQWRALRKSTPLKLTEEEVVKLRGLGEKLDLLEVE
:**** ***:** **** *:* *:: ***:**::** **
Mb1122c|M.bovis_AF2122/97 EVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVA
Rv1092c|M.tuberculosis_H37Rv EVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVA
MMAR_4376|M.marinum_M EVFLPLARLLHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVA
MUL_0189|M.ulcerans_Agy99 EVFLPLARLLHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVA
MLBr_01954|M.leprae_Br4923 EVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPGRPVPFIIGVAGSVA
MAV_1214|M.avium_104 EVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFVIGVAGSVA
MAB_1234c|M.abscessus_ATCC_199 EVYLPLARLIHLQVAARQRLFAATATFLG--DQHPDRLVPFVIGVAGSVA
Mvan_4658|M.vanbaalenii_PYR-1 EVYLPLARLIHLQVAARQALFATTAQFLGEPQQNPDRPVPFIIGVAGSVA
Mflv_2058|M.gilvum_PYR-GCK EVYLPLARLIHLQVAARQALFATTADFLGEPQQNPDRPVPFVIGVAGSVA
MSMEG_5252|M.smegmatis_MC2_155 EVYLPLARLIHLQVAARQRLFATTAEFLGEPQQNPDRPVPFIIGVAGSVA
TH_2162|M.thermoresistible__bu EVYLPLARLIHLQVAARQRLFAATAEFLGEPVDSQDRPVPFIIGVAGSVA
**:******:******** ***:** *** : .* ***:********
Mb1122c|M.bovis_AF2122/97 VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFP
Rv1092c|M.tuberculosis_H37Rv VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFP
MMAR_4376|M.marinum_M VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELERRNLMHRKGFP
MUL_0189|M.ulcerans_Agy99 VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELERRNLMHRKGFP
MLBr_01954|M.leprae_Br4923 VGKSTTARVLQALLARWDHHTRVDLVTTDGFLYPNAELGRRNLMHRKGFP
MAV_1214|M.avium_104 VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELDRRNLMHRKGFP
MAB_1234c|M.abscessus_ATCC_199 VGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELSRRNIMHRKGFP
Mvan_4658|M.vanbaalenii_PYR-1 VGKSTTARVLQALLARWEHHPRVDLVTTDGFLYSNSELSRRNLMHRKGFP
Mflv_2058|M.gilvum_PYR-GCK VGKSTTARVLQALLARWEHHPRVDLVTTDGFLYSNSELSRRNLMHRKGFP
MSMEG_5252|M.smegmatis_MC2_155 VGKSTTARVLQALLARWEHHPRVDLVTTDGFLYPNAELARRNLMHRKGFP
TH_2162|M.thermoresistible__bu VGKSTTARVLQALLARWEHHPRVDLVTTDGFLYPNAELARRNIMHRKGFP
*****************:**.************.*:** ***:*******
Mb1122c|M.bovis_AF2122/97 ESYNRRALMRFVTSVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILIL
Rv1092c|M.tuberculosis_H37Rv ESYNRRALMRFVTSVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILIL
MMAR_4376|M.marinum_M ESYNRRALMRFVTSVKSGSDYACAPVYSHLHYNIIPGAKQVVRHPDILIL
MUL_0189|M.ulcerans_Agy99 ESYNRRALMRFVTSVKSGSDYACAPVYSHLHYNIIPGAKQVVRHPDILIL
MLBr_01954|M.leprae_Br4923 ESYNRRALMRFVTSVKSGADYACAPVYSHLRYDTIPGAKHVVRHPDILIL
MAV_1214|M.avium_104 ESYNRRALMRFVTSVKSGSDYACAPVYSHLKYDIIPGAKHVVRHPDILIL
MAB_1234c|M.abscessus_ATCC_199 ESYNRRGLLRFVTEVKSGAREVTAPVYSHLLYDIIKNEKHVVQQPDILIL
Mvan_4658|M.vanbaalenii_PYR-1 ESYDRRGLMRFVTAIKSGADAACAPVYSHLLYDIVAGEKQIIEHPDILIL
Mflv_2058|M.gilvum_PYR-GCK ESYDRRGLMRFVTTVKSGSDVACAPVYSHLLYDIVPGEKQIIEHPDILIL
MSMEG_5252|M.smegmatis_MC2_155 ESYNRRALMRFVTAVKSGADEAAAPVYSHLLYDIVPGEYQIVRHPDILIL
TH_2162|M.thermoresistible__bu ESYDRRALMRFVTAVKSGAEEACVPVYSHLLYDIVPGEKQIIRRPDILIL
***:**.*:**** :***: . .****** *: : . :::.:******
Mb1122c|M.bovis_AF2122/97 EGLNVLQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRTTAFADP
Rv1092c|M.tuberculosis_H37Rv EGLNVLQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRTTAFADP
MMAR_4376|M.marinum_M EGLNVLQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRSTAFANP
MUL_0189|M.ulcerans_Agy99 EGLNVLQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRSTAFANP
MLBr_01954|M.leprae_Br4923 EGLNVLQTGPTLMVSDLFDFSLYVDARIQDIEQWYVSRFLAMRGTAFADP
MAV_1214|M.avium_104 EGLNVLQTGPTLMVSDLFDFGIYVDARIEDIEQWYISRFLAMRSTAFADP
MAB_1234c|M.abscessus_ATCC_199 EGLNVLQTGPTLMVSDLFDFSIYVDARIEDIEQWYISRFLAMRSTSFANP
Mvan_4658|M.vanbaalenii_PYR-1 EGLNVLQTGPALMVSDLFDFSVYVDARIEDIENWYISRFLSMRAGAFADP
Mflv_2058|M.gilvum_PYR-GCK EGLNVLQTGPALMVSDLFDFSVYVDARIEDIENWYISRFLKMREGAFADP
MSMEG_5252|M.smegmatis_MC2_155 EGLNVLQTGPALMVSDLFDFSVYVDARIEDIEQWYISRFLTMRSTAFADP
TH_2162|M.thermoresistible__bu EGLNVLQTGPALMVSDLFDFSVYVDARIDDIEQWYISRFLTMRSTAFANP
**********:*********.:******:***:**:**** ** :**:*
Mb1122c|M.bovis_AF2122/97 ESHFHHYAAFSDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDA
Rv1092c|M.tuberculosis_H37Rv ESHFHHYAAFSDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDA
MMAR_4376|M.marinum_M ESHFHHYSALPDPEAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDA
MUL_0189|M.ulcerans_Agy99 ESHFHHYSALPDPEAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDA
MLBr_01954|M.leprae_Br4923 ESHFHHYSALTDSKAIIAAREIWRSINRPNLVENILPTRPRATLVLRKDA
MAV_1214|M.avium_104 ESHFHHYAALNDTKAVAAAREIWRSINRPNLVENILPTRPRATLVLRKDA
MAB_1234c|M.abscessus_ATCC_199 SSHFHHYAKLSDKQATLAAQEIWHSINLPNLLENILPTRPRATLVLRKDA
Mvan_4658|M.vanbaalenii_PYR-1 ASHFHHYSTLTDEQAVFAARDIWHSINRPNLIENILPTRPRATLVLRKDS
Mflv_2058|M.gilvum_PYR-GCK ASHFHHYSTLTDEQAVFAARDIWHSINRPNLIENILPTRPRATLVLRKDS
MSMEG_5252|M.smegmatis_MC2_155 ASHFHSYSTLTDEQAVFAARDIWHSINRPNLIENILPTRPRATLVLRKDA
TH_2162|M.thermoresistible__bu ASHFHHYATLTDEQAIFAARDIWHSINRPNLIENILPTRPRATLVLRKDS
**** *: : * :* **::**::** ***:*****************:
Mb1122c|M.bovis_AF2122/97 DHSINRLRLRKL
Rv1092c|M.tuberculosis_H37Rv DHSINRLRLRKL
MMAR_4376|M.marinum_M DHSIKRLRLRKL
MUL_0189|M.ulcerans_Agy99 DHSIKRLRLRKL
MLBr_01954|M.leprae_Br4923 DHSINRLRLRKL
MAV_1214|M.avium_104 DHSINRLRLRKL
MAB_1234c|M.abscessus_ATCC_199 DHSINRLRLRKL
Mvan_4658|M.vanbaalenii_PYR-1 DHSINRLRLRKL
Mflv_2058|M.gilvum_PYR-GCK DHSINRLRLRKL
MSMEG_5252|M.smegmatis_MC2_155 DHSINRLRLRKL
TH_2162|M.thermoresistible__bu DHSINRIRLRKL
****:*:*****