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VQFGCAIAVIGLIAGVAGAATTLLLHAIEHLTFHYSFGTLLSGIEGSNPVRRAVGPLLGGALAGWGWWAL RRRQDRPPLTGTADAGLQVLLVGSGASLGREGAPRQLAAAWGDIGVSRLALTAADRRILLACAAGAGLGA VYSVPLGGALFATRILLRTWHPRALGTALITSSIAVMVAAPVTHLEHPLSWPDSRLSYLFVFLALALAPV ATAVGLVFDRMMHGAPRLTLRSWMVIPGIAAAGLLTGVCSIWLPELPGNGRSILQVSMGSGLTLTSAALI LLLKPLLTMLFLRAGAAGGLLTPALATGAAAGSLAALALNHWAGTQLHVAAVSLSCAAGLLAITQRSPLF AALFVWELARPPLWLLLVFAVGAYAAYGLAALRRRHQKEAGREITAAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4538 | - | - | 100% (398) | Cl- channel, voltage-gated family protein |
| M. vanbaalenii PYR-1 | Mvan_4719 | - | 3e-15 | 26.40% (322) | Cl- channel, voltage-gated family protein |
| M. vanbaalenii PYR-1 | Mvan_2837 | - | 8e-05 | 26.92% (312) | hypothetical protein Mvan_2837 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0148c | - | 9e-21 | 28.93% (318) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_2009 | - | 3e-15 | 26.84% (313) | Cl- channel, voltage-gated family protein |
| M. tuberculosis H37Rv | Rv0143c | - | 9e-21 | 28.93% (318) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0501 | - | 1e-135 | 62.22% (397) | transmembrane protein |
| M. avium 104 | MAV_4918 | - | 1e-131 | 60.96% (397) | chloride transporter, chloride channel (ClC) family protein |
| M. smegmatis MC2 155 | MSMEG_6465 | - | 2e-17 | 26.83% (287) | chloride channel |
| M. thermoresistible (build 8) | TH_2100 | - | 4e-17 | 28.21% (319) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_1164 | - | 1e-134 | 61.96% (397) | transmembrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6465|M.smegmatis_MC2_155 ----------------------MRTRPRIDGG-LGNFVRNSGYVRKWLIL
TH_2100|M.thermoresistible__bu ------------------------MREVAGGGRIGGYVNRLGYLPRWLLL
Mb0148c|M.bovis_AF2122/97 MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRLGVSIRSAGYLRKWFLL
Rv0143c|M.tuberculosis_H37Rv MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRFGVSIRSAGYLRKWFLL
MMAR_0501|M.marinum_M ---------------------MTILPASSSGRFASVLRRASRPDVDFFCA
MUL_1164|M.ulcerans_Agy99 ------------------------MPASFSGRFASVLRRASRRDVDFFCA
MAV_4918|M.avium_104 ------------------------MPAP----------RSDRNALDFFCA
Mvan_4538|M.vanbaalenii_PYR-1 --------------------------------------------MQFGCA
Mflv_2009|M.gilvum_PYR-GCK ------------------------MPLRLRPG------GPVRSLLVVVGT
MSMEG_6465|M.smegmatis_MC2_155 GIAIGVIAGLGAVVFYLALDGAGRVLLGYLGGYDIPKPSGDGGNPGSPGF
TH_2100|M.thermoresistible__bu GVVIGVIAGLGAVVFYLALDYSTRLLLGHLGGYDIPEAVGDGGDPGSAGF
Mb0148c|M.bovis_AF2122/97 GITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGSTGF
Rv0143c|M.tuberculosis_H37Rv GITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGSTGF
MMAR_0501|M.marinum_M VVIVGLLAGVAGLSTTVVLRFVEHLTYHYAFGSLLEGITGSSPVRRALG-
MUL_1164|M.ulcerans_Agy99 VVIVGLLAGVAGLSTTVVLRFVEHLTYHYAFGSLLEGITGSSPVRRALG-
MAV_4918|M.avium_104 VIIVGVLAGIAGVATTLVLRVVQHATYHYSFGALLAGVAASSPIRRVLG-
Mvan_4538|M.vanbaalenii_PYR-1 IAVIGLIAGVAGAATTLLLHAIEHLTFHYSFGTLLSGIEGSNPVRRAVG-
Mflv_2009|M.gilvum_PYR-GCK AALAGAVIGIVGAAFQWCLRAAEGLRLDVVEWAQRLPGPG----------
* : *: . * .
MSMEG_6465|M.smegmatis_MC2_155 DRPWAIPLISCGGALVSAWFVAKFAPEAEGHGTDDAIEAVHTDPRKIRVR
TH_2100|M.thermoresistible__bu QRPWAIPLIACTGALVSAWLIARFAPEAEGHGTDDAIEAVHTDPRRIRGR
Mb0148c|M.bovis_AF2122/97 ARPWAIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAIRGR
Rv0143c|M.tuberculosis_H37Rv ARPWAIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAIRGR
MMAR_0501|M.marinum_M ------PMVGGALAGLGWWLLRRRTDVPP-------LAGTIADHARIPRR
MUL_1164|M.ulcerans_Agy99 ------PMVGGALAGLGWWLLRRRTDVPP-------LAGTIADHARIPRR
MAV_4918|M.avium_104 ------PMVGAALAGLGWWLLRRRTDVPP-------LAETIARSERVPRL
Mvan_4538|M.vanbaalenii_PYR-1 ------PLLGGALAGWGWWALRRRQDRPP-------LTG-----------
Mflv_2009|M.gilvum_PYR-GCK ---WLIPVALVAFCAAVARTLVRWEPQAAGSGIPHVEAVFLGETSPPRLR
*: . : : .
MSMEG_6465|M.smegmatis_MC2_155 AIVVKTIASALTIGSGGSGGREGPAAHISAGFGSLLTRWLN-LSDEDGRL
TH_2100|M.thermoresistible__bu AIVVKTVASALTIGSGGSGGREGPAAQISAGFGSLLTRRLD-LSDDDGRI
Mb0148c|M.bovis_AF2122/97 AVLVKMVASALTIGSGGSGGREGPTAQISAGFCSLLTRRLN-LSNEDGRT
Rv0143c|M.tuberculosis_H37Rv AVLVKMVASALTIGSGGSGGREGPTAQISAGFCSLLTRRLN-LSNEDGRT
MMAR_0501|M.marinum_M TWSIDALLQVVLVGSGASLGREGAPRQFAAALSDFATTWLRRLSPGDREI
MUL_1164|M.ulcerans_Agy99 TWSIDALLQVVLVGSGASLGREGAPRQFAAALSDFATTWLRRLSPGDREI
MAV_4918|M.avium_104 AWSIDAVLQVLLVGSGASLGREGAPRQFASALGDFGIGWLRRLSSRDREI
Mvan_4538|M.vanbaalenii_PYR-1 --TADAGLQVLLVGSGASLGREGAPRQLAAAWGDIGVSRLA-LTAADRRI
Mflv_2009|M.gilvum_PYR-GCK VLPARFVGGVLGIGSGLVLGREGPTVHMGAAIGAQAARRSC-LSDGDVRL
.: :*** ****.. ::.:. *: * .
MSMEG_6465|M.smegmatis_MC2_155 AVSLGIGAGIGAIFGAPLGGAVLAASIVYRDDFDYRALIPGFITSASAYA
TH_2100|M.thermoresistible__bu AVSLGIGAGIGAIFGAPLGGAVLAASIGYRKDFDYTVLVPGFIASAAAYA
Mb0148c|M.bovis_AF2122/97 AVALGIGAGIGAIFAAPLGGAALGASIPYRDDFDYRNLLPGFIASGTAYA
Rv0143c|M.tuberculosis_H37Rv AVALGIGAGIGAIFAAPLGGAALGASIPYRDDFDYRNLLPGFIASGTAYA
MMAR_0501|M.marinum_M LLACAAGAGLGAVYAVPLAGALFALRIMLN-TWNIRALGAALITSSLAVA
MUL_1164|M.ulcerans_Agy99 LLACAAGAGLGAVYAVPLAGALFALRIMLN-TWNIRALGAALITSSLAVA
MAV_4918|M.avium_104 LLACAAGAGLGAVYAVPLAGALFAARILLR-TWRLRAVGAAFLSSGVAVA
Mvan_4538|M.vanbaalenii_PYR-1 LLACAAGAGLGAVYSVPLGGALFATRILLR-TWHPRALGTALITSSIAVM
Mflv_2009|M.gilvum_PYR-GCK VQTALAGAGLAVAFNAPIAGVLFTLEEVTR-SLRARTVLATVAATVTAVL
: ***:.. : .*:.*. : . : . . :: *
MSMEG_6465|M.smegmatis_MC2_155 VLGSILGFDPLFGFLVGDYRFGQALDLAWFVVLGVIAGGVGWLYARVFYG
TH_2100|M.thermoresistible__bu VFGSILGFDPLFGHVAADFRFDHAALLLWFVVLGVLSAGVGYLYARTFYG
Mb0148c|M.bovis_AF2122/97 VLGAFLGFDPLFGYIDAEYRFEKAWPLLWFVVIGLIAAAVGYLYARVFHA
Rv0143c|M.tuberculosis_H37Rv VLGAFLGFDPLFGYIDAEYRFEKAWPLLWFVVIGLIAAAVGYLYARVFHA
MMAR_0501|M.marinum_M IGSLVTHDRPELDWPSAESTY---LLSAHALALAPVAFVVGVAFNRIMAA
MUL_1164|M.ulcerans_Agy99 IGSLVTHDRPELDWPSAESTY---LLSAHALALAPVAFVVGVAFNRIMAA
MAV_4918|M.avium_104 VGSAVTGDQPNLRWPVEESTY---LLTAHGLLLAPVALAVGLVFNRLMAV
Mvan_4538|M.vanbaalenii_PYR-1 VAAPVTHLEHPLSWPDSRLSY---LFVFLALALAPVATAVGLVFDRMMHG
Mflv_2009|M.gilvum_PYR-GCK ASRLILADQPDFDVHAVVAPG--LAWLPLFVVFGVLTGLLGAAYNVVVVW
. : : :. :: :* : .
MSMEG_6465|M.smegmatis_MC2_155 TVAVTKMLPGG-KIVKPALGGLAVGLMALAIPQVLASGYGWAEKAAATET
TH_2100|M.thermoresistible__bu IRAVTADLPGG-RIVKPALGGLAVGLLGLALPQVLSSGYGWAQKATVTDT
Mb0148c|M.bovis_AF2122/97 SVAITRRLPGG-PVLKPAIGGLLVGLLGLPIPQILSSGYGWAQLAADRGT
Rv0143c|M.tuberculosis_H37Rv SVAITRRLPGG-PVLKPAIGGLLVGLLGLPIPQILSSGYGWAQLAADRGT
MMAR_0501|M.marinum_M ARPASLVRSWT-LIPGLAAAGLAIGICSHWWPELPGNGKSILTVSLASGM
MUL_1164|M.ulcerans_Agy99 ARPASLVRSWT-LIPGLAAAGLAIGICSHWWPELPGNGKSILTVSLPSGM
MAV_4918|M.avium_104 ARPARPMRTWT-LIPALAGAGLVTGVCSHWWPELPGNGRSILTVSLASGM
Mvan_4538|M.vanbaalenii_PYR-1 A-PRLTLRSWM-VIPGIAAAGLLTGVCSIWLPELPGNGRSILQVSMGSGL
Mflv_2009|M.gilvum_PYR-GCK STDRVAAIPRVPTELKAAAIGAAVGALLWVAPLTVGDGDTLTQMILDGHG
. * * * * ..*
MSMEG_6465|M.smegmatis_MC2_155 LMNIPLWIVLVLPVAKIVATSLSIGTGGSGGIFGPGVVIGAFVGAALWRL
TH_2100|M.thermoresistible__bu LMALPLWLVLVVPFAKILATGLSIGTGGSGGIFGPGVVIGAFVGAALWRL
Mb0148c|M.bovis_AF2122/97 LLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAIWRL
Rv0143c|M.tuberculosis_H37Rv LLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAIWRL
MMAR_0501|M.marinum_M TLSAAAVILVLKP----LLTALFLRVGGAGGMLTPSLATGAAAGSLLVLA
MUL_1164|M.ulcerans_Agy99 TLSAAAVILVLKP----LLTALVLRVGGAGGMLTPSLATGAAAGSLLVLA
MAV_4918|M.avium_104 TLASALAILLLKP----VLTALFLRAGGAGGLLTPSLATGAAAGTALVLT
Mvan_4538|M.vanbaalenii_PYR-1 TLTSAALILLLKP----LLTMLFLRAGAAGGLLTPALATGAAAGSLAALA
Mflv_2009|M.gilvum_PYR-GCK FVLLAAVGLLAAR---FFTGPMSYAAAVPGGLFAPLLAVGALWGYVFVTC
: . :: . : .. .**:: * :. ** *
MSMEG_6465|M.smegmatis_MC2_155 GDALALPGIPDSPAIFVVVGMMACFGCVAHAPLAVMIMVCEMTSSFAVIP
TH_2100|M.thermoresistible__bu GEAVDAPGLPESPGVFVVVGMMACFGSVAHVPLAVLLMVAEMTGSFSVVP
Mb0148c|M.bovis_AF2122/97 GELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSFSVVP
Rv0143c|M.tuberculosis_H37Rv GELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSFSVVP
MMAR_0501|M.marinum_M --IDAVAGTHLHGPVISLAAAAGVLAVTQGSPIWAAIFVWELARPPIWML
MUL_1164|M.ulcerans_Agy99 --ILAVAGTHLHGPVISLAAAAGVLAVTQGSPIWAAIFVWELARPPIWML
MAV_4918|M.avium_104 --INWATGSQLHVPAVSLAGAAGVLAVTQGSPIWAAIFVWELARPPLWLF
Mvan_4538|M.vanbaalenii_PYR-1 --LNHWAGTQLHVAAVSLSCAAGLLAITQRSPLFAALFVWELARPPLWLL
Mflv_2009|M.gilvum_PYR-GCK LGAIAPESASALVIPMALVGMAAFFGATVRAPLTGVVIVLEMTATTTVAL
. . : . :. . *: ::* *:: .
MSMEG_6465|M.smegmatis_MC2_155 CAMVGVGVACLTISRSDVAIYRAQRARREPEPA-----------
TH_2100|M.thermoresistible__bu GAMVAVGLAYLLITRTDVSIYAAQRMDRESAAAERARRGAGGDS
Mb0148c|M.bovis_AF2122/97 GAIIAVGIAALLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA
Rv0143c|M.tuberculosis_H37Rv GAIIAVGIAALLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA
MMAR_0501|M.marinum_M VVFLVTAVGAHGLKTLVLGRRLPL-RDHRAG-------------
MUL_1164|M.ulcerans_Agy99 VVFLVTAVGAHGLKTLVLGRRLPL-RDHRAG-------------
MAV_4918|M.avium_104 LLFLLTATAAHGLKVLAQGR-----TTTHAG-------------
Mvan_4538|M.vanbaalenii_PYR-1 LVFAVGAYAAYGLAALRRRHQKEAGREITAAA------------
Mflv_2009|M.gilvum_PYR-GCK PMLAACVSAVLAARAVGSAPIYASLRDRMLVEPVAAPGVDEGR-
: .