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VPLRLRPGGPVRSLLVVVGTAALAGAVIGIVGAAFQWCLRAAEGLRLDVVEWAQRLPGPGWLIPVALVAF CAAVARTLVRWEPQAAGSGIPHVEAVFLGETSPPRLRVLPARFVGGVLGIGSGLVLGREGPTVHMGAAIG AQAARRSCLSDGDVRLVQTALAGAGLAVAFNAPIAGVLFTLEEVTRSLRARTVLATVAATVTAVLASRLI LADQPDFDVHAVVAPGLAWLPLFVVFGVLTGLLGAAYNVVVVWSTDRVAAIPRVPTELKAAAIGAAVGAL LWVAPLTVGDGDTLTQMILDGHGFVLLAAVGLLAARFFTGPMSYAAAVPGGLFAPLLAVGALWGYVFVTC LGAIAPESASALVIPMALVGMAAFFGATVRAPLTGVVIVLEMTATTTVALPMLAACVSAVLAARAVGSAP IYASLRDRMLVEPVAAPGVDEGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2009 | - | - | 100% (443) | Cl- channel, voltage-gated family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0148c | - | 3e-22 | 28.57% (378) | transmembrane protein |
| M. tuberculosis H37Rv | Rv0143c | - | 3e-22 | 28.57% (378) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_0353 | - | 9e-24 | 28.68% (380) | hypothetical protein MMAR_0353 |
| M. avium 104 | MAV_4918 | - | 9e-16 | 28.57% (287) | chloride transporter, chloride channel (ClC) family protein |
| M. smegmatis MC2 155 | MSMEG_6465 | - | 7e-26 | 29.95% (394) | chloride channel |
| M. thermoresistible (build 8) | TH_2100 | - | 2e-23 | 29.62% (449) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_1164 | - | 8e-18 | 29.02% (286) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_4719 | - | 1e-165 | 69.71% (416) | Cl- channel, voltage-gated family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6465|M.smegmatis_MC2_155 ----------------------MRTRPRIDGG-LGNFVRNSGYVRKWLIL
TH_2100|M.thermoresistible__bu ------------------------MREVAGGGRIGGYVNRLGYLPRWLLL
Mb0148c|M.bovis_AF2122/97 MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRLGVSIRSAGYLRKWFLL
Rv0143c|M.tuberculosis_H37Rv MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRFGVSIRSAGYLRKWFLL
MMAR_0353|M.marinum_M MSP------------------------AAAGGRFGASIRNAGYLQKWFLL
MAV_4918|M.avium_104 ------------------------MPAP----------RSDRNALDFFCA
MUL_1164|M.ulcerans_Agy99 ------------------------MPASFSGRFASVLRRASRRDVDFFCA
Mflv_2009|M.gilvum_PYR-GCK -----------------------------MPLRLRPGGP-VRSLLVVVGT
Mvan_4719|M.vanbaalenii_PYR-1 -----------------------------MDPGVGDARPSLHRSAVLSAA
MSMEG_6465|M.smegmatis_MC2_155 GIAIGVIAGLGAVVFYLALDGAGRVLLGYLGGYDIPKPSGDGGNPGSPGF
TH_2100|M.thermoresistible__bu GVVIGVIAGLGAVVFYLALDYSTRLLLGHLGGYDIPEAVGDGGDPGSAGF
Mb0148c|M.bovis_AF2122/97 GITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGSTGF
Rv0143c|M.tuberculosis_H37Rv GITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGSTGF
MMAR_0353|M.marinum_M GITIGGIAGLGAVVFYLALKYTGEFLLGYLADYHIPTPVGEGGSHGSSGF
MAV_4918|M.avium_104 VIIVGVLAGIAGVATTLVLRVVQHATYHYSFGALLAGVAASSPIRRVLG-
MUL_1164|M.ulcerans_Agy99 VVIVGLLAGVAGLSTTVVLRFVEHLTYHYAFGSLLEGITGSSPVRRALG-
Mflv_2009|M.gilvum_PYR-GCK AALAGAVIGIVGAAFQWCLRAAEGLRLDVVEWAQRLPGPG----------
Mvan_4719|M.vanbaalenii_PYR-1 AIVAGVVIGLVGGAFRWCLQAAESLRVDVVEWAQRLPGPG----------
* : *: . * .
MSMEG_6465|M.smegmatis_MC2_155 DRPWAIPLISCGGALVSAWFVAKFAPEAEGHGTDDAIEAVHTDPRKIRVR
TH_2100|M.thermoresistible__bu QRPWAIPLIACTGALVSAWLIARFAPEAEGHGTDDAIEAVHTDPRRIRGR
Mb0148c|M.bovis_AF2122/97 ARPWAIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAIRGR
Rv0143c|M.tuberculosis_H37Rv ARPWAIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAIRGR
MMAR_0353|M.marinum_M VRPWAIPLITTGGALLSAFIVARFAPEATGHGTDEAIEAVHTNPRSIRSR
MAV_4918|M.avium_104 ------PMVGAALAGLGWWLLRRRTDVPP-------LAETIARSERVPRL
MUL_1164|M.ulcerans_Agy99 ------PMVGGALAGLGWWLLRRRTDVPP-------LAGTIADHARIPRR
Mflv_2009|M.gilvum_PYR-GCK ---WLIPVALVAFCAAVARTLVRWEPQAAGSGIPHVEAVFLGETSPPRLR
Mvan_4719|M.vanbaalenii_PYR-1 ---WLVPMGVVAACATAAALLVRWEPLAVGSGIPHVEAVFLGEAAPPPLR
*: . : : .
MSMEG_6465|M.smegmatis_MC2_155 AIVVKTIASALTIGSGGSGGREGPAAHISAGFGSLLTRWLN-LSDEDGRL
TH_2100|M.thermoresistible__bu AIVVKTVASALTIGSGGSGGREGPAAQISAGFGSLLTRRLD-LSDDDGRI
Mb0148c|M.bovis_AF2122/97 AVLVKMVASALTIGSGGSGGREGPTAQISAGFCSLLTRRLN-LSNEDGRT
Rv0143c|M.tuberculosis_H37Rv AVLVKMVASALTIGSGGSGGREGPTAQISAGFCSLLTRRLN-LSNEDGRT
MMAR_0353|M.marinum_M AVLVKMVASALTIGSGGSGGREGPTAQISAGFCSFLTRRLG-LSDEDGRT
MAV_4918|M.avium_104 AWSIDAVLQVLLVGSGASLGREGAPRQFASALGDFGIGWLRRLSSRDREI
MUL_1164|M.ulcerans_Agy99 TWSIDALLQVVLVGSGASLGREGAPRQFAAALSDFATTWLRRLSPGDREI
Mflv_2009|M.gilvum_PYR-GCK VLPARFVGGVLGIGSGLVLGREGPTVHMGAAIGAQAARRSC-LSDGDVRL
Mvan_4719|M.vanbaalenii_PYR-1 LVFARFVGGVLAIGGGLVLGREGPTVHIGAAVGAEAARRTR-LPSSEAAT
: .: :*.* ****.. ::.:.. *. :
MSMEG_6465|M.smegmatis_MC2_155 AVSLGIGAGIGAIFGAPLGGAVLAASIVYRDDFDYRALIPGFITSASAYA
TH_2100|M.thermoresistible__bu AVSLGIGAGIGAIFGAPLGGAVLAASIGYRKDFDYTVLVPGFIASAAAYA
Mb0148c|M.bovis_AF2122/97 AVALGIGAGIGAIFAAPLGGAALGASIPYRDDFDYRNLLPGFIASGTAYA
Rv0143c|M.tuberculosis_H37Rv AVALGIGAGIGAIFAAPLGGAALGASIPYRDDFDYRNLLPGFIASGTAYA
MMAR_0353|M.marinum_M AVALGIGAGIGAIFAAPLGGAVLAASITYRDDFDYRSLLPGFITSGTAYA
MAV_4918|M.avium_104 LLACAAGAGLGAVYAVPLAGALFAARILLR-TWRLRAVGAAFLSSGVAVA
MUL_1164|M.ulcerans_Agy99 LLACAAGAGLGAVYAVPLAGALFALRIMLN-TWNIRALGAALITSSLAVA
Mflv_2009|M.gilvum_PYR-GCK VQTALAGAGLAVAFNAPIAGVLFTLEEVTR-SLRARTVLATVAATVTAVL
Mvan_4719|M.vanbaalenii_PYR-1 MQAALGGAGLAVAFNAPLAGVLFTLEEVTK-SWRLQAVLVSVFAAAAAVG
: ***:.. : .*:.*. : . : . :: *
MSMEG_6465|M.smegmatis_MC2_155 VLGSILGFDPLFGFLVGDYRFGQALDLAWFVVLGVIAGGVGWLYARVFYG
TH_2100|M.thermoresistible__bu VFGSILGFDPLFGHVAADFRFDHAALLLWFVVLGVLSAGVGYLYARTFYG
Mb0148c|M.bovis_AF2122/97 VLGAFLGFDPLFGYIDAEYRFEKAWPLLWFVVIGLIAAAVGYLYARVFHA
Rv0143c|M.tuberculosis_H37Rv VLGAFLGFDPLFGYIDAEYRFEKAWPLLWFVVIGLIAAAVGYLYARVFHA
MMAR_0353|M.marinum_M VLGAFMGFDPLFGYIDAEYRFEKAWPLLWFVVIGVVAAAIGYLYARVFHA
MAV_4918|M.avium_104 VGSAVTGDQPNLRWPVEES---TYLLTAHGLLLAPVALAVGLVFNRLMAV
MUL_1164|M.ulcerans_Agy99 IGSLVTHDRPELDWPSAES---TYLLSAHALALAPVAFVVGVAFNRIMAA
Mflv_2009|M.gilvum_PYR-GCK ASRLILADQPDFDVHAVVAP--GLAWLPLFVVFGVLTGLLGAAYNVVVVW
Mvan_4719|M.vanbaalenii_PYR-1 TSRLLLGDHPDFGVPTVPAP--ELVWLPLFLVFGVLTGFLGAGYNLVVLW
. * : : :. :: :* : .
MSMEG_6465|M.smegmatis_MC2_155 TVAVTKMLPGG-KIVKPALGGLAVGLMALAIPQVLASGYGWAEKAAATET
TH_2100|M.thermoresistible__bu IRAVTADLPGG-RIVKPALGGLAVGLLGLALPQVLSSGYGWAQKATVTDT
Mb0148c|M.bovis_AF2122/97 SVAITRRLPGG-PVLKPAIGGLLVGLLGLPIPQILSSGYGWAQLAADRGT
Rv0143c|M.tuberculosis_H37Rv SVAITRRLPGG-PVLKPAIGGLLVGLLGLPIPQILSSGYGWAQLAADRGT
MMAR_0353|M.marinum_M SVGLAHRLPGG-PVIKPAVGGLLVGLMGLLIPQILSSGYGWAQLAADRNA
MAV_4918|M.avium_104 ARPARPMRTWT-LIPALAGAGLVTGVCSHWWPELPGNGRSILTVSLASGM
MUL_1164|M.ulcerans_Agy99 ARPASLVRSWT-LIPGLAAAGLAIGICSHWWPELPGNGKSILTVSLPSGM
Mflv_2009|M.gilvum_PYR-GCK STDRVAAIPRVPTELKAAAIGAAVGALLWVAPLTVGDGDTLTQMILDGHG
Mvan_4719|M.vanbaalenii_PYR-1 ALDHVAAIRRIPTLVQAGAIGAAVGLLLCVAPLTVGDGDTLTQMLLGGHQ
. * * * ..*
MSMEG_6465|M.smegmatis_MC2_155 LMNIPLWIVLVLPVAKIVATSLSIGTGGSGGIFGPGVVIGAFVGAALWRL
TH_2100|M.thermoresistible__bu LMALPLWLVLVVPFAKILATGLSIGTGGSGGIFGPGVVIGAFVGAALWRL
Mb0148c|M.bovis_AF2122/97 LLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAIWRL
Rv0143c|M.tuberculosis_H37Rv LLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAIWRL
MMAR_0353|M.marinum_M LMAIPLWIIIVLPVAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAIWRL
MAV_4918|M.avium_104 TLASALAILLLKP----VLTALFLRAGGAGGLLTPSLATGAAAGTALVLT
MUL_1164|M.ulcerans_Agy99 TLSAAAVILVLKP----LLTALVLRVGGAGGMLTPSLATGAAAGSLLVLA
Mflv_2009|M.gilvum_PYR-GCK FVLLAAVGLLAAR---FFTGPMSYAAAVPGGLFAPLLAVGALWGYVFVTC
Mvan_4719|M.vanbaalenii_PYR-1 FVLLATAGLLAAR---FLTGPLCYSAAVPGGLFAPLLAIGALWGTLFVGC
: . :: . : .. .**:: * :. ** * :
MSMEG_6465|M.smegmatis_MC2_155 GDALALPGIPDSPAIFVVVGMMACFGCVAHAPLAVMIMVCEMTSSF-AVI
TH_2100|M.thermoresistible__bu GEAVDAPGLPESPGVFVVVGMMACFGSVAHVPLAVLLMVAEMTGSF-SVV
Mb0148c|M.bovis_AF2122/97 GELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSF-SVV
Rv0143c|M.tuberculosis_H37Rv GELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSF-SVV
MMAR_0353|M.marinum_M GELTGLPGVPDAPGIFVVVAMMTCFGSVSRAPLAVMIMVAEMTGSF-SVV
MAV_4918|M.avium_104 --INWATGSQLHVPAVSLAGAAGVLAVTQGSPIWAAIFVWELAR-----P
MUL_1164|M.ulcerans_Agy99 --ILAVAGTHLHGPVISLAAAAGVLAVTQGSPIWAAIFVWELAR-----P
Mflv_2009|M.gilvum_PYR-GCK LGAIAPESASALVIPMALVGMAAFFGATVRAPLTGVVIVLEMTATTTVAL
Mvan_4719|M.vanbaalenii_PYR-1 FGAVWPDDPTFLAIPMALAGMAAFFGATVRAPLTGLLIVIEMTATTSVAV
. . :.. :. . *: ::* *::
MSMEG_6465|M.smegmatis_MC2_155 PCAMVGVGVACLTISRSDVAIYRAQRARREPEPA-----------
TH_2100|M.thermoresistible__bu PGAMVAVGLAYLLITRTDVSIYAAQRMDRESAAAERARRGAGGDS
Mb0148c|M.bovis_AF2122/97 PGAIIAVGIAALLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA
Rv0143c|M.tuberculosis_H37Rv PGAIIAVGIAALLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA
MMAR_0353|M.marinum_M PGAILAVGIASLLMSRTNVTIYEAQRLNRETAEAERAARAADRGN
MAV_4918|M.avium_104 PLWLFLLFLLTATAAHGLKVLAQGR----TTTHAG----------
MUL_1164|M.ulcerans_Agy99 PIWMLVVFLVTAVGAHGLKTLVLGRRLPLRDHRAG----------
Mflv_2009|M.gilvum_PYR-GCK PMLAACVSAVLAARAVGSAPIYASLRDRMLVEPVAAPGVDEGR--
Mvan_4719|M.vanbaalenii_PYR-1 PMMIATAAAVVSANALGSAPIYDSLRERMPVS----SGPDRS---
* : :