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M. vanbaalenii PYR-1 Mvan_4510 (-)

annotation: acyl-CoA synthetase
coordinates: 4843699 - 4845504
length: 601

TNRSGTRSSVGLLDIAKQVPGLLKDAPTIVRGVVTGFGARPTAKTSIGKVFQDRAAQYPNNVFLKFEDRE
ITYREANDTVNRYAAVLAAKGVGHGDVVGIMMRNSPEPILLMLAAVKCGAISGMLNYHQRDEVLKHSLGL
LSAAVVVAETEFVEAITESGADTDGLITLDELKQLAETAPTTNPATTSAVLAKDKAFYIFTSGTTGMPKA
SVMTHYRWLRALAGFGGLGLRLNSSDTLYCCLPLYHNNALTVALSSVINSGATLALGKSFSASRFWDDVI
RYDATAFVYIGEICTYLLNQPEKPTDRRHKVRVICGNGLRPAIWDAFTERFGIKRVCEFYAASEGNTAFV
NVLNIDKTTGICPTPIAFVEYDENTGEPVRDEQGRVRRVKKGEPGLLLSKVSNYQPFDGYTDKKESEKKL
VRDAFKEGDVWFNTGDLMRAQGLGHAAFTDRLGDTFRWKGENVATTEVEAAVSTHHQIEECTVFGVEVPD
TGGRAGMVAIQLKEGHELDGQSLAKAVFEKLPSYAVPLFVRVVQELAHTSTFKSQKGDLRKEGYGGSSGE
GGDDDVKIDDPLYVLSGREEGYVPFYDEYPHEVREGKKPK*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_4510--100% (601)acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_3301-1e-4025.98% (535) acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_5208-1e-3728.85% (468) acyl-CoA synthetase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1238fadD60.067.50% (600) acyl-CoA synthetase
M. gilvum PYR-GCKMflv_2185-0.088.17% (600) acyl-CoA synthetase
M. tuberculosis H37RvRv1206fadD60.067.50% (600) acyl-CoA synthetase
M. leprae Br4923MLBr_01346-8e-3726.07% (537) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_1342-0.062.81% (597) acyl-CoA synthetase
M. marinum MMMAR_4232fadD60.068.90% (598) fatty-acid-CoA ligase FadD6
M. avium 104MAV_1351-0.068.46% (596) acyl-CoA synthetase
M. smegmatis MC2 155MSMEG_5086-0.076.71% (601) acyl-CoA synthetase
M. thermoresistible (build 8)TH_2434-0.071.40% (598) PUTATIVE very-long-chain acyl-CoA synthetase
M. ulcerans Agy99MUL_0957fadD60.068.73% (598) acyl-CoA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          MDLNFSIVTRPVERLVATAQNGLEVLRLGGLETGSFPSPSQIVESVPMYK
                                                                                      

Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          LRRYFPPGNRPGQPLLGAPVLMVHPMMMSADMWDVTREEGAVGILHVRGL
                                                                                      

Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          DPWVIDFGSPDKVEGGMRRNLADHIVALSEAVDTVKEVTGNDVHLVGYSQ
                                                                                      

Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          GGMFCYQAAAYRRSENIASIVAFGSPVDTLAALPMGIPPNFGVVLANFMA
                                                                                      

Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          DHVFNRLDIPSWLARAGFQMLDPLKTVKARVDFVRQLHNREALLSREQQR
                                                                                      

Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          RFLESEGWIAWSGPAISELLKQFIAHNRMMTGGFAVNGQMVTLTDITCPV
                                                                                      

Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          LAFVGEVDDIGQPASVRGIRRAAPNAEVYESLIRTGHFGLVVGSRAAQQS
                                                                                      

Mb1238|M.bovis_AF2122/97            ----------------------MSD---YYGGAHTTVRLIDLATRMPRVL
Rv1206|M.tuberculosis_H37Rv         ----------------------MSD---YYGGAHTTVRLIDLATRMPRVL
MMAR_4232|M.marinum_M               ----------------------MSD---RQSHVRTRVKLTDVAARVPGLL
MUL_0957|M.ulcerans_Agy99           ----------------------MSD---RQSHVRTRVKLTDVAARVPGLL
MAV_1351|M.avium_104                ----------------------MSD---RDGGARTAVKLTDIAARVPTVL
Mvan_4510|M.vanbaalenii_PYR-1       ----------------------MTN----RSGTRSSVGLLDIAKQVPGLL
Mflv_2185|M.gilvum_PYR-GCK          ----------------------MSN----KSGTRSSVGLLDIAKQVPGLV
MSMEG_5086|M.smegmatis_MC2_155      ----------------------MTD----QKATRNSVGLLDLATRLPGFL
TH_2434|M.thermoresistible__bu      ----------------------MSNERHNRSATRERVGLLDIAGRLPRMA
MAB_1342|M.abscessus_ATCC_1997      ----------------------MSASSTIPSNPRDRVRLTDVLAQLPGLA
MLBr_01346|M.leprae_Br4923          WPTVAEWVCWLAANANKPANIHIMPDQPVEHTASGVAISSRLAHGLGEVS
                                                          :             .    :   :  . 

Mb1238|M.bovis_AF2122/97            ADTPVIVRGAMTGLLAR-------------------------PNSKASIG
Rv1206|M.tuberculosis_H37Rv         ADTPVIVRGAMTGLLAR-------------------------PNSKASIG
MMAR_4232|M.marinum_M               IDAPSIMRGAVTGLLPR-------------------------PKSKASIG
MUL_0957|M.ulcerans_Agy99           IDAPSIMRGAVTGLLPR-------------------------PKSKASIG
MAV_1351|M.avium_104                ADLPVIARGTLTGLLAQ-------------------------PGSHKSIG
Mvan_4510|M.vanbaalenii_PYR-1       KDAPTIVRGVVTGFGAR-------------------------PTAKTSIG
Mflv_2185|M.gilvum_PYR-GCK          KDTPTMLRGVVTGFGAR-------------------------PSAKTSIG
MSMEG_5086|M.smegmatis_MC2_155      MDAPVILRGVATGFTAR-------------------------PSAKTSIG
TH_2434|M.thermoresistible__bu      LDVPVMLRGVIAGFGAR-------------------------PSAKTSIG
MAB_1342|M.abscessus_ATCC_1997      LDLPIMARGILSGIKST-------------------------PKGRWSIG
MLBr_01346|M.leprae_Br4923          ETALALARGVADAIVAANRSVHTLAVETVRTLPRLARLGQLNDHTRISLG
                                         : **   .: .                             : *:*

Mb1238|M.bovis_AF2122/97            TVFQDRAARYGDRVFLKFGDQQLTYRDANATANRYAAVLAARGVGPGDVV
Rv1206|M.tuberculosis_H37Rv         TVFQDRAARYGDRVFLKFGDQQLTYRDANATANRYAAVLAARGVGPGDVV
MMAR_4232|M.marinum_M               TVFQDRAARFGDRVFLKFGDQQMTYGEANATANRYAAVLAARGVGPGDVV
MUL_0957|M.ulcerans_Agy99           TVFQDRAARFGDRVFLKFGDQQMTYGEANATANRYAAVLAARGVGPGDVV
MAV_1351|M.avium_104                TVFQDRAARYGDRVFLRFGDQQLTYRDANAAANRYAAVLAARGVGHGDVV
Mvan_4510|M.vanbaalenii_PYR-1       KVFQDRAAQYPNNVFLKFEDREITYREANDTVNRYAAVLAAKGVGHGDVV
Mflv_2185|M.gilvum_PYR-GCK          KVFQDRAAQYSNNVFLKFEDREITYGEANEIVNRYAAVLAAKGVGHGDVV
MSMEG_5086|M.smegmatis_MC2_155      KVFQDRAAQYADRVFIKFGDERLTYKTANETVNRYAAVLAARGVGHGDVV
TH_2434|M.thermoresistible__bu      KVFQERAARYADKVFLKFEDQQLTYRQANETVNRYAAALAARGVGQGDVV
MAB_1342|M.abscessus_ATCC_1997      GVFAERAAKHADRVFLRFEGQDITYAQANATANRYAATLASQGVGRGDVV
MLBr_01346|M.leprae_Br4923          RIIGEQAHDAPRGEFLLFDGRVHTYEAVDRRVNNVVRGLIAVGVRQGDRV
                                     :: ::*       *: * ..  **  .:  .*. .  * : **  ** *

Mb1238|M.bovis_AF2122/97            GIMLRNSPSTVLAMLATVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLIA
Rv1206|M.tuberculosis_H37Rv         GIMLRNSPSTVLAMLATVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLIA
MMAR_4232|M.marinum_M               GIMLRNSPNTVVAMLAVVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLVA
MUL_0957|M.ulcerans_Agy99           GIMLRNSPNTVVAMLAVVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLVA
MAV_1351|M.avium_104                AIMLRNSPNTVLAMLAAVKCGAVAGMLNYHQRGEVLAHSLGLLDAKVLIA
Mvan_4510|M.vanbaalenii_PYR-1       GIMMRNSPEPILLMLAAVKCGAISGMLNYHQRDEVLKHSLGLLSAAVVVA
Mflv_2185|M.gilvum_PYR-GCK          GIMMRNSPEPILLMLAAVKCGAISGMLNYHQRDEVLKHSVGLLSASVMVA
MSMEG_5086|M.smegmatis_MC2_155      GVMLRNSPDAVLLMLAIVKCGAIAGMLNYHQRGDVLKHSIGLLSATAVVA
TH_2434|M.thermoresistible__bu      GVMLKNEPRTVLLMLATVKLGAIAGMLNHHQKGDVLAHSIGLLDAKIVVS
MAB_1342|M.abscessus_ATCC_1997      GIMLRNSPETVLLMLATVKLGAIAGMLNYNQRGHVLAHSIGLLDSKLLIT
MLBr_01346|M.leprae_Br4923          GVLMETRPSALVAIAALSRLGAVAVMMRP---DADLAASVRIGGATKILT
                                    .:::.. * .:: : *  : **:: *:.    .  *  *: : .:  :::

Mb1238|M.bovis_AF2122/97            ESDLVSAVAECGASRG-----------------RVAGDVLTVEDVERFAT
Rv1206|M.tuberculosis_H37Rv         ESDLVSAVAECGASRG-----------------RVAGDVLTVEDVERFAT
MMAR_4232|M.marinum_M               ESDLVSAVSESGG---------------------AAGEVVTIEDLERFAA
MUL_0957|M.ulcerans_Agy99           ESDLVSAVSESGG---------------------AAGEVVTIEALERFAA
MAV_1351|M.avium_104                ETDLVSAVAERGGS--------------------GSTETLTVEDLERFAV
Mvan_4510|M.vanbaalenii_PYR-1       ETEFVEAITESGAD---------------------TDGLITLDELKQLAE
Mflv_2185|M.gilvum_PYR-GCK          ETDFVEPITESGAD---------------------TDGLMTLDELKKLAE
MSMEG_5086|M.smegmatis_MC2_155      EPDFVDHIVESGAD---------------------TTGLMTVEELRRLAT
TH_2434|M.thermoresistible__bu      APDLVKQVEESDAD---------------------VADLLSADDLDRLSV
MAB_1342|M.abscessus_ATCC_1997      EAEFEEAISESGVN---------------------VVSQLTIDELDRMSV
MLBr_01346|M.leprae_Br4923          DPANLGVVLAYGRQLTGQVLVLGGGESRDLHLPEDALQQNQVIDMEKIDP
                                     .     :   .                                : ::  

Mb1238|M.bovis_AF2122/97            TAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGG
Rv1206|M.tuberculosis_H37Rv         TAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGG
MMAR_4232|M.marinum_M               TAPANNPASASAVQAQDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGG
MUL_0957|M.ulcerans_Agy99           TAPANNPASASAVQAQDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGG
MAV_1351|M.avium_104                SAPATNPASASAVQARDTAFYIFTSGTTGFPKASVMTHLRWLKALAAFGG
Mvan_4510|M.vanbaalenii_PYR-1       TAPTTNPATTSAVLAKDKAFYIFTSGTTGMPKASVMTHYRWLRALAGFGG
Mflv_2185|M.gilvum_PYR-GCK          TAPTTNPATTSAVLAKDKAFYIFTSGTTGMPKASVMTHYRWLRALAGFGG
MSMEG_5086|M.smegmatis_MC2_155      TAPTTNPASASAVLAKDKAFYIFTSGTTGLPKASVMTHYRWLRALAGFGG
TH_2434|M.thermoresistible__bu      DAPTTNPAITSSILAREKAFYIFTSGTTGLPKASVMTHYRWLRALAGFGA
MAB_1342|M.abscessus_ATCC_1997      LAPTANPSATEAVMTKDRAFYIFTSGTTGLPKASVMTHYRWLRGMSGIGD
MLBr_01346|M.leprae_Br4923          NAVDLPAWYRPNSGLARDLAFIACSTVGGELVAKQITNYRWAVSAFGTAS
                                     *    .             :*  * . *   *. :*: **  .    . 

Mb1238|M.bovis_AF2122/97            MGLRLKGSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWD
Rv1206|M.tuberculosis_H37Rv         MGLRLKGSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWD
MMAR_4232|M.marinum_M               LGLRLKSSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWD
MUL_0957|M.ulcerans_Agy99           LGLRLKSSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWD
MAV_1351|M.avium_104                IGLRLKSSDTLYCCLPLYHNNALTVALSSVINSGATLALGKSFSASKFWD
Mvan_4510|M.vanbaalenii_PYR-1       LGLRLNSSDTLYCCLPLYHNNALTVALSSVINSGATLALGKSFSASRFWD
Mflv_2185|M.gilvum_PYR-GCK          LGMRLNSNDTLYCCLPLYHNNALTVALSSVLNSGATLAIGKSFSASKFWD
MSMEG_5086|M.smegmatis_MC2_155      LGLRLRSNDTLYCCLPLYHNNALTVSVGSVLNSGASLALGKSFSASRFWD
TH_2434|M.thermoresistible__bu      LGMRLRSSDTLYCCLPLYHNNALTVAVSSVLSAGATLALGKSFSASRFWD
MAB_1342|M.abscessus_ATCC_1997      MALRLRPDDVLYSCLPLYHNNALTLAVSTTVNAGATLAIGRSFSVSRFWD
MLBr_01346|M.leprae_Br4923          T-AALDRRDTVYCLTPLHHESALLVSLGGAVVGGARIALSRGLCSNRFVH
                                        *   *.:*.  **:*:.** :::. .: .** :*:.:.:. .:* .

Mb1238|M.bovis_AF2122/97            EVIANRATAFVYIGEICRYLLNQPAKPTDRAHQVRVICGNGLRPEIWDEF
Rv1206|M.tuberculosis_H37Rv         EVIANRATAFVYIGEICRYLLNQPAKPTDRAHQVRVICGNGLRPEIWDEF
MMAR_4232|M.marinum_M               EVIASNATAFIYIGEVCRYLLNQPTKPTDRKHKVRVIAGNGLRPEIWGEF
MUL_0957|M.ulcerans_Agy99           EVIASNATAFIYIGEVCRYLLNQPTKPTDRKHKVRVIAGNGLRPEIWGEF
MAV_1351|M.avium_104                EVIANDATAFIYIGEVCRYLLNQPAKPTDRAHRVRLIAGNGLRPEIWDEF
Mvan_4510|M.vanbaalenii_PYR-1       DVIRYDATAFVYIGEICTYLLNQPEKPTDRRHKVRVICGNGLRPAIWDAF
Mflv_2185|M.gilvum_PYR-GCK          DVIRYDATAFVYIGEICAYLLNQPEKPTDRKHKVRVICGNGLRPAIWDDF
MSMEG_5086|M.smegmatis_MC2_155      EVIDYGATAFVYIGEICGYLLNQPPKPTDRAHKVRVIVGNGLRPAIWDEF
TH_2434|M.thermoresistible__bu      EVIRHDATAFVYIGEICGYLLNQPPKPTDRAHRVRVICGNGLRPAIWDDF
MAB_1342|M.abscessus_ATCC_1997      EVIASRATAFIYIGELCRYLLNQPPKPTDRKHRVRVIVGNGLRPELWGEF
MLBr_01346|M.leprae_Br4923          EVRQYGVTVVSYTWAMLRELVDDPAFVLHGNHPVRLFMGSGMPTGLWERV
                                    :*    .*.. *   :   *:::*    .  * **:: *.*: . :*  .

Mb1238|M.bovis_AF2122/97            TTRFGVARVCEFYAASEGNSAFINIFNVPRTAGVSPMP----LAFVEYDL
Rv1206|M.tuberculosis_H37Rv         TTRFGVARVCEFYAASEGNSAFINIFNVPRTAGVSPMP----LAFVEYDL
MMAR_4232|M.marinum_M               TKRFDIDRVCEFYAASEGNSAFINIFNVPKSTGISPMP----LAYVAYDP
MUL_0957|M.ulcerans_Agy99           TKRFDIDRVCEFYAASEGNSAFINIFNVPKSTGISPMP----LAYVAYDP
MAV_1351|M.avium_104                TQRFGIARVCEFYASSEGNAAFINVFNVPRSTGIFPLP----LAYVEYDP
Mvan_4510|M.vanbaalenii_PYR-1       TERFGIKRVCEFYAASEGNTAFVNVLNIDKTTGICPTP----IAFVEYDE
Mflv_2185|M.gilvum_PYR-GCK          TKRFGIDRVCEFYSASESNTAFVNFFNLDKTTGICPSP----IAFVEYDE
MSMEG_5086|M.smegmatis_MC2_155      IERFGISRVCEFYAASEGNTAFVNVFNVSKSTGICPSP----VAFVEYDP
TH_2434|M.thermoresistible__bu      VERFGIERVCEFYSASEGNTAFVNAFNIDKTTGICPSP----VAFVEFDQ
MAB_1342|M.abscessus_ATCC_1997      TARFGIKRVCEFYSASESNTAFVNALNIDRTVGICPMP----IAYVKYDV
MLBr_01346|M.leprae_Br4923          VEAFAPAHVVEFFATVDGQAVLANVSGAKIGSKGRPLPGAGHVELGAYDA
                                       *   :* **::: :.::.: *  .        * *    :    :* 

Mb1238|M.bovis_AF2122/97            DTGDPLRDASGRVRRVPDGEPGLLLSRVNRLQPFDGYTDPVASEKKLVRN
Rv1206|M.tuberculosis_H37Rv         DTGDPLRDASGRVRRVPDGEPGLLLSRVNRLQPFDGYTDPVASEKKLVRN
MMAR_4232|M.marinum_M               DTGAPLRDESGRVRRVPAGEPGLLLSRVNRLQPFDGYTDPAASEKKLVRD
MUL_0957|M.ulcerans_Agy99           DTGAPLRDESGRVRRVPAGEPGLLLSRVNRLQPFDGYTDPAASEKKLVRD
MAV_1351|M.avium_104                DTGAPLRGDDGRVRRVPPGQPGLLLSPVNRLQPFDGYTDPESSEKKLVRN
Mvan_4510|M.vanbaalenii_PYR-1       NTGEPVRDEQGRVRRVKKGEPGLLLSKVSNYQPFDGYTDKKESEKKLVRD
Mflv_2185|M.gilvum_PYR-GCK          -SGDPLRDENGRVKKVKKGEPGLLLSKVSNFQPFDGYTDKKESEKKLVRD
MSMEG_5086|M.smegmatis_MC2_155      DTGEPVRGADGKLRKVKSGEPGLLLSKVSSFQPFDGYTDSSATEKKLVRN
TH_2434|M.thermoresistible__bu      ETGEPLRGADGRVRKVKRGEPGLLLSKVSSFQPFDGYTDPQATEKKLVRN
MAB_1342|M.abscessus_ATCC_1997      ESGEPVRNDKGFLTKVGPGESGLLLSKVTDLAPFDGYTDPTASEKKLVRD
MLBr_01346|M.leprae_Br4923          EQDLILENDRGFVQVADVNQIGVLLAASR------GPIDPTASVK---RG
                                      .  :..  * :  .  .: *:**:         *  *   : *   *.

Mb1238|M.bovis_AF2122/97            AFRDGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALA
Rv1206|M.tuberculosis_H37Rv         AFRDGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALA
MMAR_4232|M.marinum_M               AFRKGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALA
MUL_0957|M.ulcerans_Agy99           AFRKGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALA
MAV_1351|M.avium_104                AFRDGDCWFNTGDVMSPQGLGHAAFVDRLGDTFRWKGENVATTQVEAALA
Mvan_4510|M.vanbaalenii_PYR-1       AFKEGDVWFNTGDLMRAQGLGHAAFTDRLGDTFRWKGENVATTEVEAAVS
Mflv_2185|M.gilvum_PYR-GCK          AFKDGDVWFNTGDLMRSQGFGHAAFTDRLGDTFRWKGENVATTEVEAAVS
MSMEG_5086|M.smegmatis_MC2_155      AFKDGDVWFNTGDLMRSQGFGHAAFADRLGDTFRWKGENVATTEVEAAVA
TH_2434|M.thermoresistible__bu      AFRDGDVWFNTGDLMRYQGFGHAAFVDRLGDTFRWKGENVATTEVEAAVS
MAB_1342|M.abscessus_ATCC_1997      AFKKGDTWFNTGDLMRNLGWGHAAFGDRLGDTFRWKGENVATTEVEAAIE
MLBr_01346|M.leprae_Br4923          VFAPADTWIATEYLLRRDYDGDYWLAGRRSSVVRTARGLVYTEPVTDALG
                                    .*  .* *: *  ::     *.  : .* ....*     * *  *  *: 

Mb1238|M.bovis_AF2122/97            SDQTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQALARTVYGHLPG
Rv1206|M.tuberculosis_H37Rv         SDQTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQALARTVYGHLPG
MMAR_4232|M.marinum_M               SDPSVEECTVYGVEVPNTGGRAGMAAVKLRDGAEFDGQSLARAVYDQLPA
MUL_0957|M.ulcerans_Agy99           SDPSVEECTVYGVEVPNTGGRAGMAAVKLRDGAEFDGQSLVRAVYDQLPA
MAV_1351|M.avium_104                SDGSVEDCTVFGVEVPRTGGRAGMAAIKLRDGAEFDGRSLARTVYEQLPV
Mvan_4510|M.vanbaalenii_PYR-1       THHQIEECTVFGVEVPDTGGRAGMVAIQLKEGHELDGQSLAKAVFEKLPS
Mflv_2185|M.gilvum_PYR-GCK          TDPQVEEATVFGVEVPDTGGRAGMVAIQLKDGKEFDGKALAKAAFDKLPG
MSMEG_5086|M.smegmatis_MC2_155      SHHKIEECTVFGVEVPGAGGRAGMAAVQLKDGEEFDGKALADAFYGHLPA
TH_2434|M.thermoresistible__bu      ADPTVDEATVYGVEVEGTGGRAGMVALKLNEGCEFDGKSFAETLYKRLPV
MAB_1342|M.abscessus_ATCC_1997      HNDAVEESTVFGVQVPGTDGRAGMAAIKLHDGVELDPKALSDTVYQNLPA
MLBr_01346|M.leprae_Br4923          FITGVDLAATYSVAVDDR--ELAVSAVTLLPGAAITAADLTEAVAS-MPV
                                        :: .:.:.* :     . .: *: *  *  :    :  :    :* 

Mb1238|M.bovis_AF2122/97            YALPLFVRVVGSLAHTTTFKSRKVELRNQAYG----------ADIEDPLY
Rv1206|M.tuberculosis_H37Rv         YALPLFVRVVGSLAHTTTFKSRKVELRNQAYG----------ADIEDPLY
MMAR_4232|M.marinum_M               YALPLFVRLVQAMAHTTTFKSRKVELREQAYG----------ADVDDPLY
MUL_0957|M.ulcerans_Agy99           YALPLFVRLVQAMAHTTTFKSRKVELREQAYG----------ADVDDPLY
MAV_1351|M.avium_104                YALPLFVRVVDSIEQTTTFKSRKVELREQGYG----------PDVKDPLY
Mvan_4510|M.vanbaalenii_PYR-1       YAVPLFVRVVQELAHTSTFKSQKGDLRKEGYGGSSGEGGDDDVKIDDPLY
Mflv_2185|M.gilvum_PYR-GCK          YAVPLFVRIVEELAHTSTFKSQKGDLRKEGYGGSSGEGDEDDVKVEDPIY
MSMEG_5086|M.smegmatis_MC2_155      YAVPLFVRVVPELAHTSTFKSQKVDLRKQGYG----------PDVTDPVY
TH_2434|M.thermoresistible__bu      YAVPLFVRVVDEIEQTTTFKSRKVDLRNEGQG----------PHIEDPLY
MAB_1342|M.abscessus_ATCC_1997      YALPLFIRIVDTLEHTTTFKSRKVELREQAYG----------ESVTDPLY
MLBr_01346|M.leprae_Br4923          GLGPDIVHVVPELTLSATYRPIVGALRTAGIP-----------KTGRQVW
                                       * ::::*  :  ::*::.    **  .                  ::

Mb1238|M.bovis_AF2122/97            VLAGPDEGYVPYYAEYPEEVSLGRRPQG-
Rv1206|M.tuberculosis_H37Rv         VLAGPDEGYVPYYAEYPEEVSLGRRPQG-
MMAR_4232|M.marinum_M               VLAGRSEGYVPYYDAYPDEVAAGKRPQG-
MUL_0957|M.ulcerans_Agy99           VLAGRSEGYVPYYDAYPDEVAAGKRPQG-
MAV_1351|M.avium_104                VLAGRDEGYVPFYDEYPDEVAEGKRP---
Mvan_4510|M.vanbaalenii_PYR-1       VLSGREEGYVPFYDEYPHEVREGKKPK--
Mflv_2185|M.gilvum_PYR-GCK          VLSGREEGYVEFYEEYLVEVKDGKKPT--
MSMEG_5086|M.smegmatis_MC2_155      VLAGRDEGYVPFYDEYPEEVTAGKRPKN-
TH_2434|M.thermoresistible__bu      VLAGREEGYVPFYEEYAAEVRDGKRPVN-
MAB_1342|M.abscessus_ATCC_1997      VLAGRAEGYVPFYPEYPEELAGGQRPKG-
MLBr_01346|M.leprae_Br4923          YFDSASNQFRRMTPGVRAELAGKHTHTHA
                                     : .  : :         *:   :