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M. ulcerans Agy99 MUL_0957 (fadD6)

annotation: acyl-CoA synthetase
coordinates: 1004227 - 1006008
length: 593

LSDRQSHVRTRVKLTDVAARVPGLLIDAPSIMRGAVTGLLPRPKSKASIGTVFQDRAARFGDRVFLKFGD
QQMTYGEANATANRYAAVLAARGVGPGDVVGIMLRNSPNTVVAMLAVVKCGAIAGMLNYHQRGEVLAHSL
GLLDAKVLVAESDLVSAVSESGGAAGEVVTIEALERFAATAPANNPASASAVQAQDTAFYIFTSGTTGFP
KASVMTHHRWLRALAVFGGLGLRLKSSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWDE
VIASNATAFIYIGEVCRYLLNQPTKPTDRKHKVRVIAGNGLRPEIWGEFTKRFDIDRVCEFYAASEGNSA
FINIFNVPKSTGISPMPLAYVAYDPDTGAPLRDESGRVRRVPAGEPGLLLSRVNRLQPFDGYTDPAASEK
KLVRDAFRKGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALASDPSVEECTVYGVEV
PNTGGRAGMAAVKLRDGAEFDGQSLVRAVYDQLPAYALPLFVRLVQAMAHTTTFKSRKVELREQAYGADV
DDPLYVLAGRSEGYVPYYDAYPDEVAAGKRPQG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_0957fadD6-100% (593)acyl-CoA synthetase
M. ulcerans Agy99MUL_4069fadD173e-4030.61% (477) acyl-CoA synthetase
M. ulcerans Agy99MUL_1660-7e-3927.39% (533) acyl-CoA synthetase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1238fadD60.082.75% (597) acyl-CoA synthetase
M. gilvum PYR-GCKMflv_2185-0.066.83% (597) acyl-CoA synthetase
M. tuberculosis H37RvRv1206fadD60.082.75% (597) acyl-CoA synthetase
M. leprae Br4923MLBr_01346-8e-3225.24% (527) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_1342-0.066.50% (588) acyl-CoA synthetase
M. marinum MMMAR_4232fadD60.099.66% (593) fatty-acid-CoA ligase FadD6
M. avium 104MAV_1351-0.082.26% (592) acyl-CoA synthetase
M. smegmatis MC2 155MSMEG_5086-0.071.26% (588) acyl-CoA synthetase
M. thermoresistible (build 8)TH_2434-0.066.78% (587) PUTATIVE very-long-chain acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_4510-0.068.73% (598) acyl-CoA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          MDLNFSIVTRPVERLVATAQNGLEVLRLGGLETGSFPSPSQIVESVPMYK
                                                                                      

MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          LRRYFPPGNRPGQPLLGAPVLMVHPMMMSADMWDVTREEGAVGILHVRGL
                                                                                      

MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          DPWVIDFGSPDKVEGGMRRNLADHIVALSEAVDTVKEVTGNDVHLVGYSQ
                                                                                      

MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          GGMFCYQAAAYRRSENIASIVAFGSPVDTLAALPMGIPPNFGVVLANFMA
                                                                                      

MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          DHVFNRLDIPSWLARAGFQMLDPLKTVKARVDFVRQLHNREALLSREQQR
                                                                                      

MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          RFLESEGWIAWSGPAISELLKQFIAHNRMMTGGFAVNGQMVTLTDITCPV
                                                                                      

MUL_0957|M.ulcerans_Agy99           --------------------------------------------------
MMAR_4232|M.marinum_M               --------------------------------------------------
Mb1238|M.bovis_AF2122/97            --------------------------------------------------
Rv1206|M.tuberculosis_H37Rv         --------------------------------------------------
MAV_1351|M.avium_104                --------------------------------------------------
Mflv_2185|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4510|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_5086|M.smegmatis_MC2_155      --------------------------------------------------
TH_2434|M.thermoresistible__bu      --------------------------------------------------
MAB_1342|M.abscessus_ATCC_1997      --------------------------------------------------
MLBr_01346|M.leprae_Br4923          LAFVGEVDDIGQPASVRGIRRAAPNAEVYESLIRTGHFGLVVGSRAAQQS
                                                                                      

MUL_0957|M.ulcerans_Agy99           ----------------------MSD---RQSHVRTRVKLTDVAARVPGLL
MMAR_4232|M.marinum_M               ----------------------MSD---RQSHVRTRVKLTDVAARVPGLL
Mb1238|M.bovis_AF2122/97            ----------------------MSD---YYGGAHTTVRLIDLATRMPRVL
Rv1206|M.tuberculosis_H37Rv         ----------------------MSD---YYGGAHTTVRLIDLATRMPRVL
MAV_1351|M.avium_104                ----------------------MSD---RDGGARTAVKLTDIAARVPTVL
Mflv_2185|M.gilvum_PYR-GCK          ----------------------MSN----KSGTRSSVGLLDIAKQVPGLV
Mvan_4510|M.vanbaalenii_PYR-1       ----------------------MTN----RSGTRSSVGLLDIAKQVPGLL
MSMEG_5086|M.smegmatis_MC2_155      ----------------------MTD----QKATRNSVGLLDLATRLPGFL
TH_2434|M.thermoresistible__bu      ----------------------MSNERHNRSATRERVGLLDIAGRLPRMA
MAB_1342|M.abscessus_ATCC_1997      ----------------------MSASSTIPSNPRDRVRLTDVLAQLPGLA
MLBr_01346|M.leprae_Br4923          WPTVAEWVCWLAANANKPANIHIMPDQPVEHTASGVAISSRLAHGLGEVS
                                                          :             .    :   :  . 

MUL_0957|M.ulcerans_Agy99           IDAPSIMRGAVTGLLPR-------------------------PKSKASIG
MMAR_4232|M.marinum_M               IDAPSIMRGAVTGLLPR-------------------------PKSKASIG
Mb1238|M.bovis_AF2122/97            ADTPVIVRGAMTGLLAR-------------------------PNSKASIG
Rv1206|M.tuberculosis_H37Rv         ADTPVIVRGAMTGLLAR-------------------------PNSKASIG
MAV_1351|M.avium_104                ADLPVIARGTLTGLLAQ-------------------------PGSHKSIG
Mflv_2185|M.gilvum_PYR-GCK          KDTPTMLRGVVTGFGAR-------------------------PSAKTSIG
Mvan_4510|M.vanbaalenii_PYR-1       KDAPTIVRGVVTGFGAR-------------------------PTAKTSIG
MSMEG_5086|M.smegmatis_MC2_155      MDAPVILRGVATGFTAR-------------------------PSAKTSIG
TH_2434|M.thermoresistible__bu      LDVPVMLRGVIAGFGAR-------------------------PSAKTSIG
MAB_1342|M.abscessus_ATCC_1997      LDLPIMARGILSGIKST-------------------------PKGRWSIG
MLBr_01346|M.leprae_Br4923          ETALALARGVADAIVAANRSVHTLAVETVRTLPRLARLGQLNDHTRISLG
                                         : **   .: .                             : *:*

MUL_0957|M.ulcerans_Agy99           TVFQDRAARFGDRVFLKFGDQQMTYGEANATANRYAAVLAARGVGPGDVV
MMAR_4232|M.marinum_M               TVFQDRAARFGDRVFLKFGDQQMTYGEANATANRYAAVLAARGVGPGDVV
Mb1238|M.bovis_AF2122/97            TVFQDRAARYGDRVFLKFGDQQLTYRDANATANRYAAVLAARGVGPGDVV
Rv1206|M.tuberculosis_H37Rv         TVFQDRAARYGDRVFLKFGDQQLTYRDANATANRYAAVLAARGVGPGDVV
MAV_1351|M.avium_104                TVFQDRAARYGDRVFLRFGDQQLTYRDANAAANRYAAVLAARGVGHGDVV
Mflv_2185|M.gilvum_PYR-GCK          KVFQDRAAQYSNNVFLKFEDREITYGEANEIVNRYAAVLAAKGVGHGDVV
Mvan_4510|M.vanbaalenii_PYR-1       KVFQDRAAQYPNNVFLKFEDREITYREANDTVNRYAAVLAAKGVGHGDVV
MSMEG_5086|M.smegmatis_MC2_155      KVFQDRAAQYADRVFIKFGDERLTYKTANETVNRYAAVLAARGVGHGDVV
TH_2434|M.thermoresistible__bu      KVFQERAARYADKVFLKFEDQQLTYRQANETVNRYAAALAARGVGQGDVV
MAB_1342|M.abscessus_ATCC_1997      GVFAERAAKHADRVFLRFEGQDITYAQANATANRYAATLASQGVGRGDVV
MLBr_01346|M.leprae_Br4923          RIIGEQAHDAPRGEFLLFDGRVHTYEAVDRRVNNVVRGLIAVGVRQGDRV
                                     :: ::*       *: * ..  **  .:  .*. .  * : **  ** *

MUL_0957|M.ulcerans_Agy99           GIMLRNSPNTVVAMLAVVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLVA
MMAR_4232|M.marinum_M               GIMLRNSPNTVVAMLAVVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLVA
Mb1238|M.bovis_AF2122/97            GIMLRNSPSTVLAMLATVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLIA
Rv1206|M.tuberculosis_H37Rv         GIMLRNSPSTVLAMLATVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLIA
MAV_1351|M.avium_104                AIMLRNSPNTVLAMLAAVKCGAVAGMLNYHQRGEVLAHSLGLLDAKVLIA
Mflv_2185|M.gilvum_PYR-GCK          GIMMRNSPEPILLMLAAVKCGAISGMLNYHQRDEVLKHSVGLLSASVMVA
Mvan_4510|M.vanbaalenii_PYR-1       GIMMRNSPEPILLMLAAVKCGAISGMLNYHQRDEVLKHSLGLLSAAVVVA
MSMEG_5086|M.smegmatis_MC2_155      GVMLRNSPDAVLLMLAIVKCGAIAGMLNYHQRGDVLKHSIGLLSATAVVA
TH_2434|M.thermoresistible__bu      GVMLKNEPRTVLLMLATVKLGAIAGMLNHHQKGDVLAHSIGLLDAKIVVS
MAB_1342|M.abscessus_ATCC_1997      GIMLRNSPETVLLMLATVKLGAIAGMLNYNQRGHVLAHSIGLLDSKLLIT
MLBr_01346|M.leprae_Br4923          GVLMETRPSALVAIAALSRLGAVAVMMRP---DADLAASVRIGGATKILT
                                    .:::.. * .:: : *  : **:: *:.    .  *  *: : .:  :::

MUL_0957|M.ulcerans_Agy99           ESDLVSAVSESGG---------------------AAGEVVTIEALERFAA
MMAR_4232|M.marinum_M               ESDLVSAVSESGG---------------------AAGEVVTIEDLERFAA
Mb1238|M.bovis_AF2122/97            ESDLVSAVAECGASRG-----------------RVAGDVLTVEDVERFAT
Rv1206|M.tuberculosis_H37Rv         ESDLVSAVAECGASRG-----------------RVAGDVLTVEDVERFAT
MAV_1351|M.avium_104                ETDLVSAVAERGGS--------------------GSTETLTVEDLERFAV
Mflv_2185|M.gilvum_PYR-GCK          ETDFVEPITESGAD---------------------TDGLMTLDELKKLAE
Mvan_4510|M.vanbaalenii_PYR-1       ETEFVEAITESGAD---------------------TDGLITLDELKQLAE
MSMEG_5086|M.smegmatis_MC2_155      EPDFVDHIVESGAD---------------------TTGLMTVEELRRLAT
TH_2434|M.thermoresistible__bu      APDLVKQVEESDAD---------------------VADLLSADDLDRLSV
MAB_1342|M.abscessus_ATCC_1997      EAEFEEAISESGVN---------------------VVSQLTIDELDRMSV
MLBr_01346|M.leprae_Br4923          DPANLGVVLAYGRQLTGQVLVLGGGESRDLHLPEDALQQNQVIDMEKIDP
                                     .     :   .                                : ::  

MUL_0957|M.ulcerans_Agy99           TAPANNPASASAVQAQDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGG
MMAR_4232|M.marinum_M               TAPANNPASASAVQAQDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGG
Mb1238|M.bovis_AF2122/97            TAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGG
Rv1206|M.tuberculosis_H37Rv         TAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGG
MAV_1351|M.avium_104                SAPATNPASASAVQARDTAFYIFTSGTTGFPKASVMTHLRWLKALAAFGG
Mflv_2185|M.gilvum_PYR-GCK          TAPTTNPATTSAVLAKDKAFYIFTSGTTGMPKASVMTHYRWLRALAGFGG
Mvan_4510|M.vanbaalenii_PYR-1       TAPTTNPATTSAVLAKDKAFYIFTSGTTGMPKASVMTHYRWLRALAGFGG
MSMEG_5086|M.smegmatis_MC2_155      TAPTTNPASASAVLAKDKAFYIFTSGTTGLPKASVMTHYRWLRALAGFGG
TH_2434|M.thermoresistible__bu      DAPTTNPAITSSILAREKAFYIFTSGTTGLPKASVMTHYRWLRALAGFGA
MAB_1342|M.abscessus_ATCC_1997      LAPTANPSATEAVMTKDRAFYIFTSGTTGLPKASVMTHYRWLRGMSGIGD
MLBr_01346|M.leprae_Br4923          NAVDLPAWYRPNSGLARDLAFIACSTVGGELVAKQITNYRWAVSAFGTAS
                                     *    .             :*  * . *   *. :*: **  .    . 

MUL_0957|M.ulcerans_Agy99           LGLRLKSSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWD
MMAR_4232|M.marinum_M               LGLRLKSSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWD
Mb1238|M.bovis_AF2122/97            MGLRLKGSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWD
Rv1206|M.tuberculosis_H37Rv         MGLRLKGSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWD
MAV_1351|M.avium_104                IGLRLKSSDTLYCCLPLYHNNALTVALSSVINSGATLALGKSFSASKFWD
Mflv_2185|M.gilvum_PYR-GCK          LGMRLNSNDTLYCCLPLYHNNALTVALSSVLNSGATLAIGKSFSASKFWD
Mvan_4510|M.vanbaalenii_PYR-1       LGLRLNSSDTLYCCLPLYHNNALTVALSSVINSGATLALGKSFSASRFWD
MSMEG_5086|M.smegmatis_MC2_155      LGLRLRSNDTLYCCLPLYHNNALTVSVGSVLNSGASLALGKSFSASRFWD
TH_2434|M.thermoresistible__bu      LGMRLRSSDTLYCCLPLYHNNALTVAVSSVLSAGATLALGKSFSASRFWD
MAB_1342|M.abscessus_ATCC_1997      MALRLRPDDVLYSCLPLYHNNALTLAVSTTVNAGATLAIGRSFSVSRFWD
MLBr_01346|M.leprae_Br4923          T-AALDRRDTVYCLTPLHHESALLVSLGGAVVGGARIALSRGLCSNRFVH
                                        *   *.:*.  **:*:.** :::. .: .** :*:.:.:. .:* .

MUL_0957|M.ulcerans_Agy99           EVIASNATAFIYIGEVCRYLLNQPTKPTDRKHKVRVIAGNGLRPEIWGEF
MMAR_4232|M.marinum_M               EVIASNATAFIYIGEVCRYLLNQPTKPTDRKHKVRVIAGNGLRPEIWGEF
Mb1238|M.bovis_AF2122/97            EVIANRATAFVYIGEICRYLLNQPAKPTDRAHQVRVICGNGLRPEIWDEF
Rv1206|M.tuberculosis_H37Rv         EVIANRATAFVYIGEICRYLLNQPAKPTDRAHQVRVICGNGLRPEIWDEF
MAV_1351|M.avium_104                EVIANDATAFIYIGEVCRYLLNQPAKPTDRAHRVRLIAGNGLRPEIWDEF
Mflv_2185|M.gilvum_PYR-GCK          DVIRYDATAFVYIGEICAYLLNQPEKPTDRKHKVRVICGNGLRPAIWDDF
Mvan_4510|M.vanbaalenii_PYR-1       DVIRYDATAFVYIGEICTYLLNQPEKPTDRRHKVRVICGNGLRPAIWDAF
MSMEG_5086|M.smegmatis_MC2_155      EVIDYGATAFVYIGEICGYLLNQPPKPTDRAHKVRVIVGNGLRPAIWDEF
TH_2434|M.thermoresistible__bu      EVIRHDATAFVYIGEICGYLLNQPPKPTDRAHRVRVICGNGLRPAIWDDF
MAB_1342|M.abscessus_ATCC_1997      EVIASRATAFIYIGELCRYLLNQPPKPTDRKHRVRVIVGNGLRPELWGEF
MLBr_01346|M.leprae_Br4923          EVRQYGVTVVSYTWAMLRELVDDPAFVLHGNHPVRLFMGSGMPTGLWERV
                                    :*    .*.. *   :   *:::*    .  * **:: *.*: . :*  .

MUL_0957|M.ulcerans_Agy99           TKRFDIDRVCEFYAASEGNSAFINIFNVPKSTGISPMP----LAYVAYDP
MMAR_4232|M.marinum_M               TKRFDIDRVCEFYAASEGNSAFINIFNVPKSTGISPMP----LAYVAYDP
Mb1238|M.bovis_AF2122/97            TTRFGVARVCEFYAASEGNSAFINIFNVPRTAGVSPMP----LAFVEYDL
Rv1206|M.tuberculosis_H37Rv         TTRFGVARVCEFYAASEGNSAFINIFNVPRTAGVSPMP----LAFVEYDL
MAV_1351|M.avium_104                TQRFGIARVCEFYASSEGNAAFINVFNVPRSTGIFPLP----LAYVEYDP
Mflv_2185|M.gilvum_PYR-GCK          TKRFGIDRVCEFYSASESNTAFVNFFNLDKTTGICPSP----IAFVEYDE
Mvan_4510|M.vanbaalenii_PYR-1       TERFGIKRVCEFYAASEGNTAFVNVLNIDKTTGICPTP----IAFVEYDE
MSMEG_5086|M.smegmatis_MC2_155      IERFGISRVCEFYAASEGNTAFVNVFNVSKSTGICPSP----VAFVEYDP
TH_2434|M.thermoresistible__bu      VERFGIERVCEFYSASEGNTAFVNAFNIDKTTGICPSP----VAFVEFDQ
MAB_1342|M.abscessus_ATCC_1997      TARFGIKRVCEFYSASESNTAFVNALNIDRTVGICPMP----IAYVKYDV
MLBr_01346|M.leprae_Br4923          VEAFAPAHVVEFFATVDGQAVLANVSGAKIGSKGRPLPGAGHVELGAYDA
                                       *   :* **::: :.::.: *  .        * *    :    :* 

MUL_0957|M.ulcerans_Agy99           DTGAPLRDESGRVRRVPAGEPGLLLSRVNRLQPFDGYTDPAASEKKLVRD
MMAR_4232|M.marinum_M               DTGAPLRDESGRVRRVPAGEPGLLLSRVNRLQPFDGYTDPAASEKKLVRD
Mb1238|M.bovis_AF2122/97            DTGDPLRDASGRVRRVPDGEPGLLLSRVNRLQPFDGYTDPVASEKKLVRN
Rv1206|M.tuberculosis_H37Rv         DTGDPLRDASGRVRRVPDGEPGLLLSRVNRLQPFDGYTDPVASEKKLVRN
MAV_1351|M.avium_104                DTGAPLRGDDGRVRRVPPGQPGLLLSPVNRLQPFDGYTDPESSEKKLVRN
Mflv_2185|M.gilvum_PYR-GCK          -SGDPLRDENGRVKKVKKGEPGLLLSKVSNFQPFDGYTDKKESEKKLVRD
Mvan_4510|M.vanbaalenii_PYR-1       NTGEPVRDEQGRVRRVKKGEPGLLLSKVSNYQPFDGYTDKKESEKKLVRD
MSMEG_5086|M.smegmatis_MC2_155      DTGEPVRGADGKLRKVKSGEPGLLLSKVSSFQPFDGYTDSSATEKKLVRN
TH_2434|M.thermoresistible__bu      ETGEPLRGADGRVRKVKRGEPGLLLSKVSSFQPFDGYTDPQATEKKLVRN
MAB_1342|M.abscessus_ATCC_1997      ESGEPVRNDKGFLTKVGPGESGLLLSKVTDLAPFDGYTDPTASEKKLVRD
MLBr_01346|M.leprae_Br4923          EQDLILENDRGFVQVADVNQIGVLLAASR------GPIDPTASVK---RG
                                      .  :..  * :  .  .: *:**:         *  *   : *   *.

MUL_0957|M.ulcerans_Agy99           AFRKGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALA
MMAR_4232|M.marinum_M               AFRKGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALA
Mb1238|M.bovis_AF2122/97            AFRDGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALA
Rv1206|M.tuberculosis_H37Rv         AFRDGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALA
MAV_1351|M.avium_104                AFRDGDCWFNTGDVMSPQGLGHAAFVDRLGDTFRWKGENVATTQVEAALA
Mflv_2185|M.gilvum_PYR-GCK          AFKDGDVWFNTGDLMRSQGFGHAAFTDRLGDTFRWKGENVATTEVEAAVS
Mvan_4510|M.vanbaalenii_PYR-1       AFKEGDVWFNTGDLMRAQGLGHAAFTDRLGDTFRWKGENVATTEVEAAVS
MSMEG_5086|M.smegmatis_MC2_155      AFKDGDVWFNTGDLMRSQGFGHAAFADRLGDTFRWKGENVATTEVEAAVA
TH_2434|M.thermoresistible__bu      AFRDGDVWFNTGDLMRYQGFGHAAFVDRLGDTFRWKGENVATTEVEAAVS
MAB_1342|M.abscessus_ATCC_1997      AFKKGDTWFNTGDLMRNLGWGHAAFGDRLGDTFRWKGENVATTEVEAAIE
MLBr_01346|M.leprae_Br4923          VFAPADTWIATEYLLRRDYDGDYWLAGRRSSVVRTARGLVYTEPVTDALG
                                    .*  .* *: *  ::     *.  : .* ....*     * *  *  *: 

MUL_0957|M.ulcerans_Agy99           SDPSVEECTVYGVEVPNTGGRAGMAAVKLRDGAEFDGQSLVRAVYDQLPA
MMAR_4232|M.marinum_M               SDPSVEECTVYGVEVPNTGGRAGMAAVKLRDGAEFDGQSLARAVYDQLPA
Mb1238|M.bovis_AF2122/97            SDQTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQALARTVYGHLPG
Rv1206|M.tuberculosis_H37Rv         SDQTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQALARTVYGHLPG
MAV_1351|M.avium_104                SDGSVEDCTVFGVEVPRTGGRAGMAAIKLRDGAEFDGRSLARTVYEQLPV
Mflv_2185|M.gilvum_PYR-GCK          TDPQVEEATVFGVEVPDTGGRAGMVAIQLKDGKEFDGKALAKAAFDKLPG
Mvan_4510|M.vanbaalenii_PYR-1       THHQIEECTVFGVEVPDTGGRAGMVAIQLKEGHELDGQSLAKAVFEKLPS
MSMEG_5086|M.smegmatis_MC2_155      SHHKIEECTVFGVEVPGAGGRAGMAAVQLKDGEEFDGKALADAFYGHLPA
TH_2434|M.thermoresistible__bu      ADPTVDEATVYGVEVEGTGGRAGMVALKLNEGCEFDGKSFAETLYKRLPV
MAB_1342|M.abscessus_ATCC_1997      HNDAVEESTVFGVQVPGTDGRAGMAAIKLHDGVELDPKALSDTVYQNLPA
MLBr_01346|M.leprae_Br4923          FITGVDLAATYSVAVDDR--ELAVSAVTLLPGAAITAADLTEAVAS-MPV
                                        :: .:.:.* :     . .: *: *  *  :    :  :    :* 

MUL_0957|M.ulcerans_Agy99           YALPLFVRLVQAMAHTTTFKSRKVELREQAYG----------ADVDDPLY
MMAR_4232|M.marinum_M               YALPLFVRLVQAMAHTTTFKSRKVELREQAYG----------ADVDDPLY
Mb1238|M.bovis_AF2122/97            YALPLFVRVVGSLAHTTTFKSRKVELRNQAYG----------ADIEDPLY
Rv1206|M.tuberculosis_H37Rv         YALPLFVRVVGSLAHTTTFKSRKVELRNQAYG----------ADIEDPLY
MAV_1351|M.avium_104                YALPLFVRVVDSIEQTTTFKSRKVELREQGYG----------PDVKDPLY
Mflv_2185|M.gilvum_PYR-GCK          YAVPLFVRIVEELAHTSTFKSQKGDLRKEGYGGSSGEGDEDDVKVEDPIY
Mvan_4510|M.vanbaalenii_PYR-1       YAVPLFVRVVQELAHTSTFKSQKGDLRKEGYGGSSGEGGDDDVKIDDPLY
MSMEG_5086|M.smegmatis_MC2_155      YAVPLFVRVVPELAHTSTFKSQKVDLRKQGYG----------PDVTDPVY
TH_2434|M.thermoresistible__bu      YAVPLFVRVVDEIEQTTTFKSRKVDLRNEGQG----------PHIEDPLY
MAB_1342|M.abscessus_ATCC_1997      YALPLFIRIVDTLEHTTTFKSRKVELREQAYG----------ESVTDPLY
MLBr_01346|M.leprae_Br4923          GLGPDIVHVVPELTLSATYRPIVGALRTAGIP-----------KTGRQVW
                                       * ::::*  :  ::*::.    **  .                  ::

MUL_0957|M.ulcerans_Agy99           VLAGRSEGYVPYYDAYPDEVAAGKRPQG-
MMAR_4232|M.marinum_M               VLAGRSEGYVPYYDAYPDEVAAGKRPQG-
Mb1238|M.bovis_AF2122/97            VLAGPDEGYVPYYAEYPEEVSLGRRPQG-
Rv1206|M.tuberculosis_H37Rv         VLAGPDEGYVPYYAEYPEEVSLGRRPQG-
MAV_1351|M.avium_104                VLAGRDEGYVPFYDEYPDEVAEGKRP---
Mflv_2185|M.gilvum_PYR-GCK          VLSGREEGYVEFYEEYLVEVKDGKKPT--
Mvan_4510|M.vanbaalenii_PYR-1       VLSGREEGYVPFYDEYPHEVREGKKPK--
MSMEG_5086|M.smegmatis_MC2_155      VLAGRDEGYVPFYDEYPEEVTAGKRPKN-
TH_2434|M.thermoresistible__bu      VLAGREEGYVPFYEEYAAEVRDGKRPVN-
MAB_1342|M.abscessus_ATCC_1997      VLAGRAEGYVPFYPEYPEELAGGQRPKG-
MLBr_01346|M.leprae_Br4923          YFDSASNQFRRMTPGVRAELAGKHTHTHA
                                     : .  : :         *:   :