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SFTTIHESADDAVAEIGDGATLLIGGFGLAGMPFDLIDALVRQGSRDLTVVSNNAGNGEVGIAALLKAER VRKIVCSFPRQSDSFVFDELYRTGRVELELVPQGNLAERIRAAGAGIGAFFCPTGVGTPLAEGKESRTIG DRTYLLEYPISGDFALIAADTADSAGNLVYRKTARNFGPVMATAATTTIAQARRIVCSGQLDPEAVVTPG IYVDDLVQIPRPRSPIGGAAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4403 | - | - | 100% (232) | 3-oxoacid CoA-transferase, A subunit |
| M. vanbaalenii PYR-1 | Mvan_0564 | - | 4e-87 | 69.20% (224) | 3-oxoacid CoA-transferase, A subunit |
| M. vanbaalenii PYR-1 | Mvan_4893 | - | 3e-47 | 42.86% (231) | 3-oxoacid CoA-transferase, A subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2532c | scoA | 1e-46 | 43.04% (237) | succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha |
| M. gilvum PYR-GCK | Mflv_0526 | - | 1e-88 | 70.98% (224) | 3-oxoacid CoA-transferase, A subunit |
| M. tuberculosis H37Rv | Rv2504c | scoA | 1e-46 | 43.04% (237) | succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0605c | - | 2e-09 | 24.35% (230) | putative CoA-transferase alpha subunit |
| M. marinum M | MMAR_3851 | scoA | 1e-46 | 43.91% (230) | succinyl-CoA:3-ketoacid-coenzyme A transferase (alpha |
| M. avium 104 | MAV_4786 | - | 3e-51 | 47.44% (215) | succinyl-CoA:3-ketoacid-coenzyme A transferase 1 |
| M. smegmatis MC2 155 | MSMEG_1898 | - | 3e-47 | 43.48% (230) | succinyl-CoA:3-ketoacid-coenzyme A transferase 1, precursor |
| M. thermoresistible (build 8) | TH_1756 | - | 6e-11 | 25.00% (232) | POSSIBLE COA-TRANSFERASE (ALPHA SUBUNIT) |
| M. ulcerans Agy99 | MUL_3782 | scoA | 5e-46 | 43.48% (230) | succinyl-CoA:3-ketoacid-coenzyme a transferase (alpha |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4403|M.vanbaalenii_PYR-1 MSFTTIHESADDAVAEIGD-GATLLIGGFGLAGMPFDLIDALVRQGSRDL
Mflv_0526|M.gilvum_PYR-GCK MSRTVVCDRAEDAVAGIED-GATVLVGGFGMAGMPTTLIDALIRQGAADL
MMAR_3851|M.marinum_M --MDKVVATVAEAVADITD-GASLAVGGFGLCGIPEALIAALVDSGVTDL
MUL_3782|M.ulcerans_Agy99 --MDKVVATVAEAVADITD-GASLAVGGFGLCGIPEALIAALVDSGVTDL
Mb2532c|M.bovis_AF2122/97 --MDKVVATAAEAVADIAN-GSSLAVGGFGLCGIPEALIAALVDSGVTDL
Rv2504c|M.tuberculosis_H37Rv --MDKVVATAAEAVADIAN-GSSLAVGGFGLCGIPEALIAALVDSGVTDL
MSMEG_1898|M.smegmatis_MC2_155 MTIDKVVGSAAEAVADVPR-GAAIAVGGFGLAGIPWFLIEALLEQGADDL
MAV_4786|M.avium_104 --MSKVHPDAESALHGLLKDGITVAAGGFGLCGIPEKLIQALVDSGIKDL
MAB_0605c|M.abscessus_ATCC_199 --MGDKRTTLDEVVAELRS-GMTIGLGGWGSRRKPMAFVRAILRSDITDL
TH_1756|M.thermoresistible__bu --MSDKRTSLDAVVAELRD-GMTIGIGGWGSRRKPMAFVRAILRSDVKDL
.: : * :: **:* * :: *:: .. **
Mvan_4403|M.vanbaalenii_PYR-1 TVVSNNAGNGEVGIAALLKAERVRKIVCSFPRQSDS----FVFDELYRTG
Mflv_0526|M.gilvum_PYR-GCK TIVSNNAGNGDTGLAALLAAGRVTKVICSFPRQADS----YVFDALYRAG
MMAR_3851|M.marinum_M ETVSNNCGVDGVGLGVLLQHKRIRRTVSSYVGENK------EFARQFLSG
MUL_3782|M.ulcerans_Agy99 ETVSNNCGVDGVGLGVLLQHKRIRRTVSSYVGENK------EFARQFLSG
Mb2532c|M.bovis_AF2122/97 ETVSNNCGIDGVGLGLLLQHKRIRRTVSSYVGENK------EFARQFLAG
Rv2504c|M.tuberculosis_H37Rv ETVSNNCGIDGVGLGLLLQHKRIRRTVSSYVGENK------EFARQFLAG
MSMEG_1898|M.smegmatis_MC2_155 TIVSNNCGVDGAGLGLLLEAGRISRVIASYVGENK------EFARQYLAG
MAV_4786|M.avium_104 TIVGNNAGVDDFGMGLLLKGRQVKKVIASYVGENK------EFERQVLSG
MAB_0605c|M.abscessus_ATCC_199 TVVT----YGGPDLGLLCSAGKVKKAYYGFVSLDSPPFYDPWFAKARTTG
TH_1756|M.thermoresistible__bu TVVT----YGGPDLGLLCAAGKVRRAYYGFVSLDSPPFYDPWFAKARTSG
* . .:. * :: : .: . * :*
Mvan_4403|M.vanbaalenii_PYR-1 RVELELVPQGNLAERIRAAGAGIGAFFCPTGVGTPLAEG-----------
Mflv_0526|M.gilvum_PYR-GCK KVDLEVVPQGNLAERIRAAGAGIGAFFCPTGVGTPLVEG-----------
MMAR_3851|M.marinum_M ELEVELTPQGTLAERLRAGGMGIPGFYTPAGVGTQIADGGLPWRYDASGA
MUL_3782|M.ulcerans_Agy99 ELEVELTPQGTLAERLRAGGMGIPGFYTPAGVGTQIADGGLPWRYDASGA
Mb2532c|M.bovis_AF2122/97 ELEVELTPQGTLAERLRAGGMGIPAFYTPAGVGTQVADGGLPWRYDASGG
Rv2504c|M.tuberculosis_H37Rv ELEVELTPQGTLAERLRAGGMGIPAFYTPAGVGTQVADGGLPWRYDASGG
MSMEG_1898|M.smegmatis_MC2_155 ELTVELTPQGTLAERMRAGGSGIGAFFTPTGVGTLVAEGGLPWRYHPDGT
MAV_4786|M.avium_104 ELDLVLTPQGTLAEKLRAGGAGIPGFYTRTGYGTTLAEG-----------
MAB_0605c|M.abscessus_ATCC_199 AIESREMDEGMVKCGLEAAAARLPFLPIRAGLGSDVMNFWGD-------E
TH_1756|M.thermoresistible__bu AIEVREMDEGMLRCGLQAAAQRLPFLPIRAGLGSSVPDFWEG-------E
: :* : :.*.. : : :* *: : :
Mvan_4403|M.vanbaalenii_PYR-1 -------KESRTIGDRTYLLEYPISGDFALIAADTADSAGNLVYRKTARN
Mflv_0526|M.gilvum_PYR-GCK -------KEIRTIDGRDYVLEYPIFGDVALIGAHVADQVGNLLYRKTARN
MMAR_3851|M.marinum_M VAVVSPPKETREFDGATYVLERGIRTDFALVHAWKGDRHGNLLYRYSAAN
MUL_3782|M.ulcerans_Agy99 VAVVSPPKETREFDGATYVLERGIRTDFALVHAWKGDRHGNLLYRYSAAN
Mb2532c|M.bovis_AF2122/97 VAVVSPAKETREFDGVTYVLERGIRTDFALVHAWQGDRHGNLMYRHAAAN
Rv2504c|M.tuberculosis_H37Rv VAVVSPAKETREFDGVTYVLERGIRTDFALVHAWQGDRHGNLMYRHAAAN
MSMEG_1898|M.smegmatis_MC2_155 VALASPAKEVRTFNGKDMVLEESIVTDFALVRAAVVDRAGNCKFHAAARN
MAV_4786|M.avium_104 -------KDTRVFDGVEYVLEEGIRADLAIVKAWKGDKAGNLVYRKTARN
MAB_0605c|M.abscessus_ATCC_199 LKTVTSPYADSSGQAETLVAMPALNLDAAFVHLNLGDATGNAAYTGVDPY
TH_1756|M.thermoresistible__bu LKTVTSPYPAPGGGHETLIAMPALNLDAAFVHLNLGDARGNAAYTGIDPY
: : * *:: * ** :
Mvan_4403|M.vanbaalenii_PYR-1 FGPVMATAATTTIAQARRIVCSGQ----LDPEAVVTPGIYVDDLVQIP--
Mflv_0526|M.gilvum_PYR-GCK FGPVMATAALLTVVEVSRVVDTGQ----IDPETVVTPGIYVDRVLDLS--
MMAR_3851|M.marinum_M FNPECAPAGRITIAEVEHLVEPGE----IDPATVHTPGVFVQRVVHVP--
MUL_3782|M.ulcerans_Agy99 FNPECAPAGRITIAEVEHLVEPGE----IGPATVHTPGVFVQRVVHVP--
Mb2532c|M.bovis_AF2122/97 FNPECASAGRITIAEVEHLVEPGE----IDPATVHTPGVFVHRVVHVP--
Rv2504c|M.tuberculosis_H37Rv FNPECASAGRITIAEVEHLVEPGE----IDPATVHTPGVFVHRVVHVP--
MSMEG_1898|M.smegmatis_MC2_155 FNPPAAMAGRITVAEAEKVVEVGE----LHPDEIHLPGIFVQRVVALTPE
MAV_4786|M.avium_104 FNPMIATCAAVTVAEVEELVEVGD----LDPDLIHTPGIYVDRIIQGIG-
MAB_0605c|M.abscessus_ATCC_199 FDDLYCLAAERRYLSVERVVSTEELVKAVPLQSLLLNRMMVDKVVEAPG-
TH_1756|M.thermoresistible__bu FDDLYLMAAERRYLSVERVVSTEELVKSVPPQALLVNRMMVDAVVEAPG-
*. .. .. .:* : : : : *. ::
Mvan_4403|M.vanbaalenii_PYR-1 -----RPRSPIGGAAP----------------------------------
Mflv_0526|M.gilvum_PYR-GCK -----AIPETSTEAAS----------------------------------
MMAR_3851|M.marinum_M -NPIKRIEKETVRP------------------------------------
MUL_3782|M.ulcerans_Agy99 -NPIKRIEKETVRP------------------------------------
Mb2532c|M.bovis_AF2122/97 -NPAKKIERETVRQ------------------------------------
Rv2504c|M.tuberculosis_H37Rv -NPAKKIERETVRQ------------------------------------
MSMEG_1898|M.smegmatis_MC2_155 QAAHKDIEKRTTRPRPVTEEPEEMTR------------------------
MAV_4786|M.avium_104 --YEKRIEFRTTSGGAALKNDSPIRERMAQRAAKELRDGYYVNLGIGIPT
MAB_0605c|M.abscessus_ATCC_199 -GAHFTIGAADYGRDEKFQRHYAEAAGDPE-TWQKFVDTYLSGSEEDYQA
TH_1756|M.thermoresistible__bu -GAHFTTAAPDYDRDEKFQRHYAQAAGSED-TWREFVDTYLSGSEDDYQA
Mvan_4403|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0526|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1898|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4786|M.avium_104 LVANFIPDDIQVTLQSENGLLGIGAYPSEDTVDPDLINAGKQTITSLPGS
MAB_0605c|M.abscessus_ATCC_199 AVKRFKEAQA----------------------------------------
TH_1756|M.thermoresistible__bu AVRTFEQEASS---------------------------------------
Mvan_4403|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0526|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1898|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4786|M.avium_104 SFFSSADSFAMIRGGHIDLSILGALEVASNGDLANWMVPGKMVKGPGGAM
MAB_0605c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1756|M.thermoresistible__bu --------------------------------------------------
Mvan_4403|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0526|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1898|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4786|M.avium_104 DLVSGVKRVIVLMDHTAKDGSPKVLEQCTLPLTGKGVVDMIITNLCVFDV
MAB_0605c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1756|M.thermoresistible__bu --------------------------------------------------
Mvan_4403|M.vanbaalenii_PYR-1 --------------------------------
Mflv_0526|M.gilvum_PYR-GCK --------------------------------
MMAR_3851|M.marinum_M --------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------
MSMEG_1898|M.smegmatis_MC2_155 --------------------------------
MAV_4786|M.avium_104 EPGRGLLLTELHPGVTVEEVRAKTGCDFTVAL
MAB_0605c|M.abscessus_ATCC_199 --------------------------------
TH_1756|M.thermoresistible__bu --------------------------------