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DKVVATVAEAVADITDGASLAVGGFGLCGIPEALIAALVDSGVTDLETVSNNCGVDGVGLGVLLQHKRIR RTVSSYVGENKEFARQFLSGELEVELTPQGTLAERLRAGGMGIPGFYTPAGVGTQIADGGLPWRYDASGA VAVVSPPKETREFDGATYVLERGIRTDFALVHAWKGDRHGNLLYRYSAANFNPECAPAGRITIAEVEHLV EPGEIDPATVHTPGVFVQRVVHVPNPIKRIEKETVRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3851 | scoA | - | 100% (248) | succinyl-CoA:3-ketoacid-coenzyme A transferase (alpha subunit) ScoA |
| M. marinum M | MMAR_5040 | - | 2e-12 | 25.71% (245) | CoA-transferase (alpha subunit) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2532c | scoA | 1e-132 | 91.50% (247) | succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha |
| M. gilvum PYR-GCK | Mflv_1349 | - | 6e-83 | 62.55% (251) | 3-oxoacid CoA-transferase, A subunit |
| M. tuberculosis H37Rv | Rv2504c | scoA | 1e-132 | 91.50% (247) | succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0605c | - | 2e-09 | 23.85% (239) | putative CoA-transferase alpha subunit |
| M. avium 104 | MAV_4786 | - | 6e-71 | 55.84% (231) | succinyl-CoA:3-ketoacid-coenzyme A transferase 1 |
| M. smegmatis MC2 155 | MSMEG_1898 | - | 2e-82 | 62.15% (251) | succinyl-CoA:3-ketoacid-coenzyme A transferase 1, precursor |
| M. thermoresistible (build 8) | TH_1756 | - | 3e-12 | 26.50% (234) | POSSIBLE COA-TRANSFERASE (ALPHA SUBUNIT) |
| M. ulcerans Agy99 | MUL_3782 | scoA | 1e-142 | 99.60% (248) | succinyl-CoA:3-ketoacid-coenzyme a transferase (alpha |
| M. vanbaalenii PYR-1 | Mvan_4893 | - | 4e-93 | 69.80% (245) | 3-oxoacid CoA-transferase, A subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1349|M.gilvum_PYR-GCK MTLDKVVGSARGAVDDIP-SGSSLAVGGFGLAGIPWFLIEALLEQGADDL
MSMEG_1898|M.smegmatis_MC2_155 MTIDKVVGSAAEAVADVP-RGAAIAVGGFGLAGIPWFLIEALLEQGADDL
MMAR_3851|M.marinum_M --MDKVVATVAEAVADIT-DGASLAVGGFGLCGIPEALIAALVDSGVTDL
MUL_3782|M.ulcerans_Agy99 --MDKVVATVAEAVADIT-DGASLAVGGFGLCGIPEALIAALVDSGVTDL
Mb2532c|M.bovis_AF2122/97 --MDKVVATAAEAVADIA-NGSSLAVGGFGLCGIPEALIAALVDSGVTDL
Rv2504c|M.tuberculosis_H37Rv --MDKVVATAAEAVADIA-NGSSLAVGGFGLCGIPEALIAALVDSGVTDL
Mvan_4893|M.vanbaalenii_PYR-1 -MSSKVYDSAAAAVSDIA-TGATLAVGGFGLCGIPDALIEAVAASSTTDL
MAV_4786|M.avium_104 --MSKVHPDAESALHGLLKDGITVAAGGFGLCGIPEKLIQALVDSGIKDL
MAB_0605c|M.abscessus_ATCC_199 --MGDKRTTLDEVVAELR-SGMTIGLGGWGSRRKPMAFVRAILRSDITDL
TH_1756|M.thermoresistible__bu --MSDKRTSLDAVVAELR-DGMTIGIGGWGSRRKPMAFVRAILRSDVKDL
.. .: : * ::. **:* * :: *: .. **
Mflv_1349|M.gilvum_PYR-GCK TIVSNNCGVDGGGLGLLLEAHRITRVIASYVGDNKE------FARQYLSG
MSMEG_1898|M.smegmatis_MC2_155 TIVSNNCGVDGAGLGLLLEAGRISRVIASYVGENKE------FARQYLAG
MMAR_3851|M.marinum_M ETVSNNCGVDGVGLGVLLQHKRIRRTVSSYVGENKE------FARQFLSG
MUL_3782|M.ulcerans_Agy99 ETVSNNCGVDGVGLGVLLQHKRIRRTVSSYVGENKE------FARQFLSG
Mb2532c|M.bovis_AF2122/97 ETVSNNCGIDGVGLGLLLQHKRIRRTVSSYVGENKE------FARQFLAG
Rv2504c|M.tuberculosis_H37Rv ETVSNNCGIDGVGLGLLLQHKRIRRTVSSYVGENKE------FARQFLAG
Mvan_4893|M.vanbaalenii_PYR-1 EVFSNNCGVDDHGLGVLLSLGRIRRVTASYVGENKE------FARQYLAG
MAV_4786|M.avium_104 TIVGNNAGVDDFGMGLLLKGRQVKKVIASYVGENKE------FERQVLSG
MAB_0605c|M.abscessus_ATCC_199 TVVT----YGGPDLGLLCSAGKVKKAYYGFVSLDSPPFYDPWFAKARTTG
TH_1756|M.thermoresistible__bu TVVT----YGGPDLGLLCAAGKVRRAYYGFVSLDSPPFYDPWFAKARTSG
. .. .:*:* :: :. .:*. :. * : :*
Mflv_1349|M.gilvum_PYR-GCK ELTVELTPQGTLAERLRAGGSGIGAFFTPTGVGTLVADGGLPWRYHPDGS
MSMEG_1898|M.smegmatis_MC2_155 ELTVELTPQGTLAERMRAGGSGIGAFFTPTGVGTLVAEGGLPWRYHPDGT
MMAR_3851|M.marinum_M ELEVELTPQGTLAERLRAGGMGIPGFYTPAGVGTQIADGGLPWRYDASGA
MUL_3782|M.ulcerans_Agy99 ELEVELTPQGTLAERLRAGGMGIPGFYTPAGVGTQIADGGLPWRYDASGA
Mb2532c|M.bovis_AF2122/97 ELEVELTPQGTLAERLRAGGMGIPAFYTPAGVGTQVADGGLPWRYDASGG
Rv2504c|M.tuberculosis_H37Rv ELEVELTPQGTLAERLRAGGMGIPAFYTPAGVGTQVADGGLPWRYDASGG
Mvan_4893|M.vanbaalenii_PYR-1 ELEVELTPQGTLAERLRAGGTGIPAFFTPAGVGTPVADGGMPWRYAADGS
MAV_4786|M.avium_104 ELDLVLTPQGTLAEKLRAGGAGIPGFYTRTGYGTTLAEG-----------
MAB_0605c|M.abscessus_ATCC_199 AIESREMDEGMVKCGLEAAAARLPFLPIRAGLGSDVMNFWG-------DE
TH_1756|M.thermoresistible__bu AIEVREMDEGMLRCGLQAAAQRLPFLPIRAGLGSSVPDFWE-------GE
: :* : :.*.. : : :* *: : :
Mflv_1349|M.gilvum_PYR-GCK VALASPPKEVRTFGGRQMLLEESIVTDFALVRAAVADRAGNCVFHAAARN
MSMEG_1898|M.smegmatis_MC2_155 VALASPAKEVRTFNGKDMVLEESIVTDFALVRAAVVDRAGNCKFHAAARN
MMAR_3851|M.marinum_M VAVVSPPKETREFDGATYVLERGIRTDFALVHAWKGDRHGNLLYRYSAAN
MUL_3782|M.ulcerans_Agy99 VAVVSPPKETREFDGATYVLERGIRTDFALVHAWKGDRHGNLLYRYSAAN
Mb2532c|M.bovis_AF2122/97 VAVVSPAKETREFDGVTYVLERGIRTDFALVHAWQGDRHGNLMYRHAAAN
Rv2504c|M.tuberculosis_H37Rv VAVVSPAKETREFDGVTYVLERGIRTDFALVHAWQGDRHGNLMYRHAAAN
Mvan_4893|M.vanbaalenii_PYR-1 VAIASPPKETRVFGEKRYVLEEAIIADFALVHARLGDTDGNLVFEKTAMN
MAV_4786|M.avium_104 -------KDTRVFDGVEYVLEEGIRADLAIVKAWKGDKAGNLVYRKTARN
MAB_0605c|M.abscessus_ATCC_199 LKTVTSPYADSSGQAETLVAMPALNLDAAFVHLNLGDATGNAAYTGVDPY
TH_1756|M.thermoresistible__bu LKTVTSPYPAPGGGHETLIAMPALNLDAAFVHLNLGDARGNAAYTGIDPY
: .: * *:*: * ** :
Mflv_1349|M.gilvum_PYR-GCK FNPPAAMAGRITVVEAERVVEVGELHPDE----VHLPGIFVQRVVELSPD
MSMEG_1898|M.smegmatis_MC2_155 FNPPAAMAGRITVAEAEKVVEVGELHPDE----IHLPGIFVQRVVALTPE
MMAR_3851|M.marinum_M FNPECAPAGRITIAEVEHLVEPGEIDPAT----VHTPGVFVQRVVHVPN-
MUL_3782|M.ulcerans_Agy99 FNPECAPAGRITIAEVEHLVEPGEIGPAT----VHTPGVFVQRVVHVPN-
Mb2532c|M.bovis_AF2122/97 FNPECASAGRITIAEVEHLVEPGEIDPAT----VHTPGVFVHRVVHVPN-
Rv2504c|M.tuberculosis_H37Rv FNPECASAGRITIAEVEHLVEPGEIDPAT----VHTPGVFVHRVVHVPN-
Mvan_4893|M.vanbaalenii_PYR-1 FNPLAAMAGRITIAQVEELVEPGAIEPGR----VHLPGVFVQRVVHTGP-
MAV_4786|M.avium_104 FNPMIATCAAVTVAEVEELVEVGDLDPDL----IHTPGIYVDRIIQGIG-
MAB_0605c|M.abscessus_ATCC_199 FDDLYCLAAERRYLSVERVVSTEELVKAVPLQSLLLNRMMVDKVVEAPGG
TH_1756|M.thermoresistible__bu FDDLYLMAAERRYLSVERVVSTEELVKSVPPQALLVNRMMVDAVVEAPGG
*: .. ..*.:*. : : : *. ::
Mflv_1349|M.gilvum_PYR-GCK QAARKGIEKRT------------TRPR----IPQEVSA------------
MSMEG_1898|M.smegmatis_MC2_155 QAAHKDIEKRT------------TRPRPVTEEPEEMTR------------
MMAR_3851|M.marinum_M --PIKRIEKET------------VRP------------------------
MUL_3782|M.ulcerans_Agy99 --PIKRIEKET------------VRP------------------------
Mb2532c|M.bovis_AF2122/97 --PAKKIERET------------VRQ------------------------
Rv2504c|M.tuberculosis_H37Rv --PAKKIERET------------VRQ------------------------
Mvan_4893|M.vanbaalenii_PYR-1 --QTKRIEKRT------------VRTAQGAR-------------------
MAV_4786|M.avium_104 --YEKRIEFRTTSGGAALKNDSPIRERMAQRAAKELRDGYYVNLGIGIPT
MAB_0605c|M.abscessus_ATCC_199 AHFTIGAADYG-------------RDEKFQRHYAEAAGDPETWQKFVDTY
TH_1756|M.thermoresistible__bu AHFTTAAPDYD-------------RDEKFQRHYAQAAGSEDTWREFVDTY
*
Mflv_1349|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1898|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4893|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4786|M.avium_104 LVANFIPDDIQVTLQSENGLLGIGAYPSEDTVDPDLINAGKQTITSLPGS
MAB_0605c|M.abscessus_ATCC_199 LSGSEEDYQAAVKRFKEAQA------------------------------
TH_1756|M.thermoresistible__bu LSGSEDDYQAAVRTFEQEASS-----------------------------
Mflv_1349|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1898|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4893|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4786|M.avium_104 SFFSSADSFAMIRGGHIDLSILGALEVASNGDLANWMVPGKMVKGPGGAM
MAB_0605c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1756|M.thermoresistible__bu --------------------------------------------------
Mflv_1349|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1898|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4893|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4786|M.avium_104 DLVSGVKRVIVLMDHTAKDGSPKVLEQCTLPLTGKGVVDMIITNLCVFDV
MAB_0605c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1756|M.thermoresistible__bu --------------------------------------------------
Mflv_1349|M.gilvum_PYR-GCK --------------------------------
MSMEG_1898|M.smegmatis_MC2_155 --------------------------------
MMAR_3851|M.marinum_M --------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------
Mb2532c|M.bovis_AF2122/97 --------------------------------
Rv2504c|M.tuberculosis_H37Rv --------------------------------
Mvan_4893|M.vanbaalenii_PYR-1 --------------------------------
MAV_4786|M.avium_104 EPGRGLLLTELHPGVTVEEVRAKTGCDFTVAL
MAB_0605c|M.abscessus_ATCC_199 --------------------------------
TH_1756|M.thermoresistible__bu --------------------------------