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SKVHPDAESALHGLLKDGITVAAGGFGLCGIPEKLIQALVDSGIKDLTIVGNNAGVDDFGMGLLLKGRQV KKVIASYVGENKEFERQVLSGELDLVLTPQGTLAEKLRAGGAGIPGFYTRTGYGTTLAEGKDTRVFDGVE YVLEEGIRADLAIVKAWKGDKAGNLVYRKTARNFNPMIATCAAVTVAEVEELVEVGDLDPDLIHTPGIYV DRIIQGIGYEKRIEFRTTSGGAALKNDSPIRERMAQRAAKELRDGYYVNLGIGIPTLVANFIPDDIQVTL QSENGLLGIGAYPSEDTVDPDLINAGKQTITSLPGSSFFSSADSFAMIRGGHIDLSILGALEVASNGDLA NWMVPGKMVKGPGGAMDLVSGVKRVIVLMDHTAKDGSPKVLEQCTLPLTGKGVVDMIITNLCVFDVEPGR GLLLTELHPGVTVEEVRAKTGCDFTVAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4786 | - | - | 100% (449) | succinyl-CoA:3-ketoacid-coenzyme A transferase 1 |
| M. avium 104 | MAV_0609 | - | 7e-08 | 25.79% (221) | coenzyme A transferase, subunit A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2531c | scoB | 9e-73 | 64.00% (200) | succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta |
| M. gilvum PYR-GCK | Mflv_1350 | - | 7e-70 | 62.19% (201) | 3-oxoacid CoA-transferase, B subunit |
| M. tuberculosis H37Rv | Rv2503c | scoB | 9e-73 | 64.00% (200) | succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0605c | - | 8e-07 | 24.23% (227) | putative CoA-transferase alpha subunit |
| M. marinum M | MMAR_3851 | scoA | 2e-70 | 55.84% (231) | succinyl-CoA:3-ketoacid-coenzyme A transferase (alpha |
| M. smegmatis MC2 155 | MSMEG_1899 | - | 3e-70 | 63.50% (200) | succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B |
| M. thermoresistible (build 8) | TH_1756 | - | 3e-08 | 24.03% (258) | POSSIBLE COA-TRANSFERASE (ALPHA SUBUNIT) |
| M. ulcerans Agy99 | MUL_3782 | scoA | 7e-70 | 55.41% (231) | succinyl-CoA:3-ketoacid-coenzyme a transferase (alpha |
| M. vanbaalenii PYR-1 | Mvan_4892 | - | 5e-73 | 64.11% (209) | 3-oxoacid CoA-transferase, B subunit |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2531c|M.bovis_AF2122/97 --------------------------------------------------
Rv2503c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4892|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1350|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1899|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4786|M.avium_104 MSKVHPDAESALHGLLKDGITVAAGGFGLCGIPEKLIQALVDSGIKDLTI
MAB_0605c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1756|M.thermoresistible__bu --------------------------------------------------
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2531c|M.bovis_AF2122/97 --------------------------------------------------
Rv2503c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4892|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1350|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1899|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4786|M.avium_104 VGNNAGVDDFGMGLLLKGRQVKKVIASYVGENKEFERQVLSGELDLVLTP
MAB_0605c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1756|M.thermoresistible__bu --------------------------------------------------
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2531c|M.bovis_AF2122/97 --------------------------------------------------
Rv2503c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4892|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1350|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1899|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4786|M.avium_104 QGTLAEKLRAGGAGIPGFYTRTGYGTTLAEGKDTRVFDGVEYVLEEGIRA
MAB_0605c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1756|M.thermoresistible__bu --------------------------------------------------
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2531c|M.bovis_AF2122/97 --------------------------------------------------
Rv2503c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_4892|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1350|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1899|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4786|M.avium_104 DLAIVKAWKGDKAGNLVYRKTARNFNPMIATCAAVTVAEVEELVEVGDLD
MAB_0605c|M.abscessus_ATCC_199 --------------------------------------------------
TH_1756|M.thermoresistible__bu --------------------------------------------------
MMAR_3851|M.marinum_M --------------------------------------------------
MUL_3782|M.ulcerans_Agy99 --------------------------------------------------
Mb2531c|M.bovis_AF2122/97 -------------------------------MSAP---GWSRDEMAARVA
Rv2503c|M.tuberculosis_H37Rv -------------------------------MSAP---GWSRDEMAARVA
Mvan_4892|M.vanbaalenii_PYR-1 -------------------------------MTATFTTGWTRNQIAARAA
Mflv_1350|M.gilvum_PYR-GCK -------------------------------------MSWTRTEMAARAA
MSMEG_1899|M.smegmatis_MC2_155 -------------------------------------MSWNRDDMAARAA
MAV_4786|M.avium_104 PDLIHTPGIYVDRIIQGIGYEKRIEFRTTSGGAALKNDSPIRERMAQRAA
MAB_0605c|M.abscessus_ATCC_199 --------------------------------------MGDKRTTLDEVV
TH_1756|M.thermoresistible__bu --------------------------------------MSDKRTSLDAVV
MMAR_3851|M.marinum_M --------------------------------------MDKVVATVAEAV
MUL_3782|M.ulcerans_Agy99 --------------------------------------MDKVVATVAEAV
..
Mb2531c|M.bovis_AF2122/97 AEFEDGQYVNLG----IGMPTLIPNHIPDGVHVVLHSENGILGVGPYPRR
Rv2503c|M.tuberculosis_H37Rv AEFEDGQYVNLG----IGMPTLIPNHIPDGVHVVLHSENGILGVGPYPRR
Mvan_4892|M.vanbaalenii_PYR-1 AEMIDGQYVDLG----IGLPTLIPGHLSPGVRVILHSENGILGTGGYPDE
Mflv_1350|M.gilvum_PYR-GCK RELRDGDYVNLG----IGLPTLIPDHLPEGSDVTLHAENGILGVGPFPYD
MSMEG_1899|M.smegmatis_MC2_155 TELHDGDYVNLG----IGLPTLIPDHLPAGSQVTLHSENGILGVGPFPYD
MAV_4786|M.avium_104 KELRDGYYVNLG----IGIPTLVANFIPDDIQVTLQSENGLLGIGAYPSE
MAB_0605c|M.abscessus_ATCC_199 AELRSGMTIGLGGWGSRRKPMAFVRAILRSDITDLTVVT----YGGPDLG
TH_1756|M.thermoresistible__bu AELRDGMTIGIGGWGSRRKPMAFVRAILRSDVKDLTVVT----YGGPDLG
MMAR_3851|M.marinum_M ADITDGASLAVGGFGLCGIPEALIAALVDSGVTDLETVSNNCGVDGVGLG
MUL_3782|M.ulcerans_Agy99 ADITDGASLAVGGFGLCGIPEALIAALVDSGVTDLETVSNNCGVDGVGLG
:: .* : :* * . : . * . .
Mb2531c|M.bovis_AF2122/97 EDVDADLINAGKETVTTLPGAA----FFSSSTSFGIIRGGHLDVAVLGAM
Rv2503c|M.tuberculosis_H37Rv EDVDADLINAGKETVTTLPGAA----FFSSSTSFGIIRGGHLDVAVLGAM
Mvan_4892|M.vanbaalenii_PYR-1 DSVDADLINAGKETVTVNRGAA----FFDSATSFGMIRGGHIDAAVLGAM
Mflv_1350|M.gilvum_PYR-GCK DEVDPDLVNAGKQTVSVVAGAS----FFDSATSFAMIRGGHVDVAVLGGM
MSMEG_1899|M.smegmatis_MC2_155 DEVDPDLVNAGKQTVSVVAGAS----YFDSATSFAMIRGGHVDVAVLGGM
MAV_4786|M.avium_104 DTVDPDLINAGKQTITSLPGSS----FFSSADSFAMIRGGHIDLSILGAL
MAB_0605c|M.abscessus_ATCC_199 LLCSAGKVKKAYYGFVSLDSPPFYDPWFAKARTTGAIESREMDEGMVKCG
TH_1756|M.thermoresistible__bu LLCAAGKVRRAYYGFVSLDSPPFYDPWFAKARTSGAIEVREMDEGMLRCG
MMAR_3851|M.marinum_M VLLQHKRIRRTVSSYVGENKE------FARQFLSGELEVELTPQGTLAER
MUL_3782|M.ulcerans_Agy99 VLLQHKRIRRTVSSYVGENKE------FARQFLSGELEVELTPQGTLAER
:. * . :. . :
Mb2531c|M.bovis_AF2122/97 QVSVTGDLANWMIPG------------------KMVKGMGGAMDLVHGAR
Rv2503c|M.tuberculosis_H37Rv QVSVTGDLANWMIPG------------------KMVKGMGGAMDLVHGAR
Mvan_4892|M.vanbaalenii_PYR-1 QVSRNGDLANWMVPG------------------KMVKGMGGAMDLVHGAA
Mflv_1350|M.gilvum_PYR-GCK QVAVNGDLANWMVPG------------------SMVKGMGGAMDLVNGAA
MSMEG_1899|M.smegmatis_MC2_155 QVAANGDLANWMVPG------------------SMVKGMGGAMDLVSGAR
MAV_4786|M.avium_104 EVASNGDLANWMVPG------------------KMVKGPGGAMDLVSGVK
MAB_0605c|M.abscessus_ATCC_199 LEAAAARLPFLPIRAGLGSDVMN-------FWGDELKTVTSPYADSSGQA
TH_1756|M.thermoresistible__bu LQAAAQRLPFLPIRAGLGSSVPD-------FWEGELKTVTSPYPAPGGGH
MMAR_3851|M.marinum_M LRAGGMGIPGFYTPAGVGTQIADGGLPWRYDASGAVAVVSPPKETREFDG
MUL_3782|M.ulcerans_Agy99 LRAGGMGIPGFYTPAGVGTQIADGGLPWRYDASGAVAVVSPPKETREFDG
: :. . : .
Mb2531c|M.bovis_AF2122/97 KVIVMMEHTAKDGSPKILERCTLP-----------LTGVGCVDRIVTELA
Rv2503c|M.tuberculosis_H37Rv KVIVMMEHTAKDGSPKILERCTLP-----------LTGVGCVDRIVTELA
Mvan_4892|M.vanbaalenii_PYR-1 RVIVVMEHTDRSGAPKIVDACTLP-----------LTGQGVVDRIITNLC
Mflv_1350|M.gilvum_PYR-GCK KVIVLMDHVSKNGAAKLVSSCDLP-----------LTGKAVVQRVITDLG
MSMEG_1899|M.smegmatis_MC2_155 RVIVLMDHVAKSGAAKLVSSCTLP-----------LTGKAVVSRVITDLG
MAV_4786|M.avium_104 RVIVLMDHTAKDGSPKVLEQCTLP-----------LTGKGVVDMIITNLC
MAB_0605c|M.abscessus_ATCC_199 ETLVAMPALNLDAAFVHLNLGDATGNAAYTGVDPYFDDLYCLAAERRYLS
TH_1756|M.thermoresistible__bu ETLIAMPALNLDAAFVHLNLGDARGNAAYTGIDPYFDDLYLMAAERRYLS
MMAR_3851|M.marinum_M ATYVLERGIRTDFALVHAWKGDRHGNLLYRYSAANFNPECAPAGRITIAE
MUL_3782|M.ulcerans_Agy99 ATYVLERGIRTDFALVHAWKGDRHGNLLYRYSAANFNPECAPAGRITIAE
. : . : :
Mb2531c|M.bovis_AF2122/97 VIDVCADG------LHLVQTAPGVSVDEVVAKTQPPLVLR----------
Rv2503c|M.tuberculosis_H37Rv VIDVCADG------LHLVQTAPGVSVDEVVAKTQPPLVLR----------
Mvan_4892|M.vanbaalenii_PYR-1 VIDVPGDGT-----LVLRELAPGVTVDDVVAATGAELTVA----------
Mflv_1350|M.gilvum_PYR-GCK VFDVTGTE------FGVVELSPGVDLDEVAAKTGAPVSDHRHRLSAASSE
MSMEG_1899|M.smegmatis_MC2_155 VFDVTGDG------FRVVELAPGVEFDHVAANTDATLVDG----------
MAV_4786|M.avium_104 VFDVEPGRG-----LLLTELHPGVTVEEVRAKTGCDFTVAL---------
MAB_0605c|M.abscessus_ATCC_199 VERVVSTEELVKAVPLQSLLLNRMMVDKVVEAPGGAHFTIGAADYGRDEK
TH_1756|M.thermoresistible__bu VERVVSTEELVKSVPPQALLVNRMMVDAVVEAPGGAHFTTAAPDYDRDEK
MMAR_3851|M.marinum_M VEHLVEPGE----IDPATVHTPGVFVQRVVHVPN------------PIKR
MUL_3782|M.ulcerans_Agy99 VEHLVEPGE----IGPATVHTPGVFVQRVVHVPN------------PIKR
* : : .: * .
Mb2531c|M.bovis_AF2122/97 --DLATQ------------------------------------
Rv2503c|M.tuberculosis_H37Rv --DLATQ------------------------------------
Mvan_4892|M.vanbaalenii_PYR-1 --L----------------------------------------
Mflv_1350|M.gilvum_PYR-GCK RDRMPSLA-----------------------------------
MSMEG_1899|M.smegmatis_MC2_155 --RVGSLV-----------------------------------
MAV_4786|M.avium_104 -------------------------------------------
MAB_0605c|M.abscessus_ATCC_199 FQRHYAEAAGDPETWQKFVDTYLSGSEEDYQAAVKRFKEAQA-
TH_1756|M.thermoresistible__bu FQRHYAQAAGSEDTWREFVDTYLSGSEDDYQAAVRTFEQEASS
MMAR_3851|M.marinum_M IEKETVRP-----------------------------------
MUL_3782|M.ulcerans_Agy99 IEKETVRP-----------------------------------