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TSQPTANGDAPRAPELDALPKSWDPGAVESDLYDGWVKAGYFTADPTSAKPAYSIVLPPPNVTGSLHMGH ALDHTLMDALTRRKRMQGYEVLWLPGMDHAGIATQTVVEKQLSADGKTKEDFGRELFIDKVWDWKRESGG TIGGQMRRLGDGVDWSRDRFTMDEGLSRAVRTIFKRLFDAGLIYQAERLVNWSPVLETAISDLEVKYEDV EGELVSFRYGSMEDSEPHIVVATTRLETMLGDTAIAVHPDDERYRHLVGTTLPHPFIDRQIVIVADHHVD PEFGTGAVKVTPAHDPNDFEIGLRHQLPMPSIMDTKGRIADTRTQFDGLDRFEARFAVRQALADEGRIVE EKRPYLHSVGHSERSGEPIEPRLSLQWWVKVESLAKAAGDAVRNGRTVIHPASLEPRWFGWVDNMHDWCI SRQLWWGHRIPIWHGPNGETVCVGPDETPPEGWEQDPDVLDTWFSSALWPFSTMGWPDHTAELAKFYPTT VLVTGYDILFFWVARMMMFGTFVGDDPAITGGGARGPQVPFENVFLHGLIRDEHGRKMSKSRGNGIDPLD WVEMFGADALRFTLARGASPGGDLAIGEDHARASRNFATKLFNATRFALLNGASPAPLPPSDQLTDADRW ILGRLEEVRIEVDAALDNYEFSRACESLYHFAWDEFCDWYLELAKVQLGQEEAHTARTTAVLAFALDVLL KLLHPVMPFVTEVLWKALTGGESLVIADWPTATGYAVDQGATQRVADMQKLITEVRRFRSDQGLADRQKV PARLSDVAAAGLEEHVPAVTALAWLTPPADEFTPSAAVEVRLSTATVVVEVDTSGTVDVAAERRRLEKDL AAAQKELSGTSGKLGNEAFLAKAPADVVDKIRARQQVANEEVERIQARLAALSASE*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_3951 | valS | - | 100% (897) | valyl-tRNA synthetase |
M. vanbaalenii PYR-1 | Mvan_2769 | ileS | 1e-56 | 24.59% (980) | isoleucyl-tRNA synthetase |
M. vanbaalenii PYR-1 | Mvan_4803 | - | 9e-10 | 29.13% (206) | methionyl-tRNA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2475c | valS | 0.0 | 81.76% (877) | valyl-tRNA synthetase |
M. gilvum PYR-GCK | Mflv_2630 | valS | 0.0 | 89.33% (900) | valyl-tRNA synthetase |
M. tuberculosis H37Rv | Rv2448c | valS | 0.0 | 81.76% (877) | valyl-tRNA synthetase |
M. leprae Br4923 | MLBr_01472 | valS | 0.0 | 77.46% (896) | valyl-tRNA synthetase |
M. abscessus ATCC 19977 | MAB_1603 | valS | 0.0 | 81.54% (883) | valyl-tRNA synthetase |
M. marinum M | MMAR_3772 | valS | 0.0 | 81.00% (879) | valyl-tRNA synthetase protein ValS |
M. avium 104 | MAV_1724 | valS | 0.0 | 82.45% (883) | valyl-tRNA synthetase |
M. smegmatis MC2 155 | MSMEG_4630 | valS | 0.0 | 88.96% (824) | valyl-tRNA synthetase |
M. thermoresistible (build 8) | TH_0609 | valS | 0.0 | 83.18% (880) | PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA |
M. ulcerans Agy99 | MUL_3719 | valS | 0.0 | 80.66% (879) | valyl-tRNA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment Mvan_3951|M.vanbaalenii_PYR-1 MTSQPTANGDAPRAPELDALPKSWDPGAVESDLYDGWVKAGYFTADPTSA Mflv_2630|M.gilvum_PYR-GCK MTSQPHANGDARSVPELDALPKSWDPGTVESDLYDGWVEAGYFTADPSSD MSMEG_4630|M.smegmatis_MC2_155 MTASPENR--------ADALPKSWDPGAVEAELYQGWVDAGYFTADPASD TH_0609|M.thermoresistible__bu ----------------VESLPKTWDPAAVETELYEGWVRAGYFTADPSSS MAB_1603|M.abscessus_ATCC_1997 MTQTPDTN-------AASSLPTSWDPGAVEAELYQGWVDAGYFTADPSSD Mb2475c|M.bovis_AF2122/97 ------------------MLPKSWDPAAMESAIYQKWLDAGYFTADPTST Rv2448c|M.tuberculosis_H37Rv ------------------MLPKSWDPAAMESAIYQKWLDAGYFTADPTST MMAR_3772|M.marinum_M MTASADSA--------ADQLPKSWDPAAMEGDIYQKWADAGYFVADPTSS MUL_3719|M.ulcerans_Agy99 MTASADSA--------ADQLPKSWDPAAMEGDIYQKWADAGYFVADPTSS MLBr_01472|M.leprae_Br4923 MTTSPSSS--------ADLLPKSWDPGAMESVIYQKWLNSGYFAADPAST MAV_1724|M.avium_104 MTAS-RSP--------ATDLPKSWDPAAAEYAIYRQWVDAGYFTANPASD **.:***.: * :* * :***.*:*:* Mvan_3951|M.vanbaalenii_PYR-1 KPAYSIVLPPPNVTGSLHMGHALDHTLMDALTRRKRMQGYEVLWLPGMDH Mflv_2630|M.gilvum_PYR-GCK KPAYSIVLPPPNVTGSLHMGHALDHTLMDALTRRKRMQGYEVLWLPGMDH MSMEG_4630|M.smegmatis_MC2_155 KPPYSIVLPPPNVTGSLHMGHALDHTLMDVLTRRKRMQGYEVLWLPGMDH TH_0609|M.thermoresistible__bu KPSYSIVLPPPNVTGSLHMGHALDHTLMDALTRRKRMQGYEVLWLPGMDH MAB_1603|M.abscessus_ATCC_1997 KPGYSIVLPPPNVTGSLHMGHALDHTLMDALTRRKRMQGYEVLWLPGMDH Mb2475c|M.bovis_AF2122/97 KPAYSIVLPPPNVTGSLHMGHALEHTMMDALTRRKRMQGYEVLWQPGTDH Rv2448c|M.tuberculosis_H37Rv KPAYSIVLPPPNVTGSLHMGHALEHTMMDALTRRKRMQGYEVLWQPGTDH MMAR_3772|M.marinum_M KPPYSIVLPPPNVTGSLHMGHALEHTMMDALTRRKRMQGYEVLWQPGMDH MUL_3719|M.ulcerans_Agy99 KPPYSIVLPPPNVTGSLHMGHALEHTMMDALTRRKRMQGYEVLWQPGMDH MLBr_01472|M.leprae_Br4923 KPGYSIVLPPPNVTGSLHMGHALEHTMMDALTRRKRMQGYEVLWQPGMDH MAV_1724|M.avium_104 KPGYSIVLPPPNVTGSLHMGHALEHTMMDALTRRKRMQGYEVLWQPGMDH ** ********************:**:**.************** ** ** Mvan_3951|M.vanbaalenii_PYR-1 AGIATQTVVEKQLSADGKTKEDFGRELFIDKVWDWKRESGGTIGGQMRRL Mflv_2630|M.gilvum_PYR-GCK AGIATQSVVEKQLAADGKTKEDFGRELFIDKVWDWKRESGGTIGAQMRRI MSMEG_4630|M.smegmatis_MC2_155 AGIATQTVVEKQLAADGKTKEDLGREEFVAKVWDWKRESGGTIGGQMRRL TH_0609|M.thermoresistible__bu AGIATQTVVEKQLAAQGIRKEDLGREKFIEKVWEWKRQSGGTIGAQMRRL MAB_1603|M.abscessus_ATCC_1997 AGIATQSVVEKQLAADGKTKEDFGRELFIEKVWDWKRESGGTIGGQMRRL Mb2475c|M.bovis_AF2122/97 AGIATQSVVEQQLAVDGKTKEDLGRELFVDKVWDWKRESGGAIGGQMRRL Rv2448c|M.tuberculosis_H37Rv AGIATQSVVEQQLAVDGKTKEDLGRELFVDKVWDWKRESGGAIGGQMRRL MMAR_3772|M.marinum_M AGIATQTVVEKQLAADGKTKEDFGRELFVDKVWDWKRESGGAIGGQMRRL MUL_3719|M.ulcerans_Agy99 AGIATQTVVEKQLAADGKTKEDFGRELFVDKVWDWKRESGGAIGGQMRRL MLBr_01472|M.leprae_Br4923 AGIATQSVVEKQLAINGKIKEDFGRELFVDKVWDWKRESGGAIAGQMRRL MAV_1724|M.avium_104 AGIATQSVVEKQLAVDGKTKEDFGRELFIEKVWDWKRESGGAIGGQMRRL ******:***:**: :* ***:*** *: ***:***:***:*..****: Mvan_3951|M.vanbaalenii_PYR-1 GDGVDWSRDRFTMDEGLSRAVRTIFKRLFDAGLIYQAERLVNWSPVLETA Mflv_2630|M.gilvum_PYR-GCK GDGVDWSRDRFTMDDTLSRAVRTIFKRLFDAGLIYQAERLVNWSPVLETA MSMEG_4630|M.smegmatis_MC2_155 GDGVDWSRDRFTMDEGLSRAVRTIFKRLFDAGLIYQAERLVNWSPVLETA TH_0609|M.thermoresistible__bu GDGVDWSRDRFTMDEGLSRAVRTIFKQLYDAGLIYQAERLVNWSPVLQTA MAB_1603|M.abscessus_ATCC_1997 GDGVDWSRDRFTMDEGLSRAVRTIFKKLFDAGLIYRAERLVNWSPELKTA Mb2475c|M.bovis_AF2122/97 GDGVDWSRDRFTMDEGLSRAVRTIFKRLYDAGLIYRAERLVNWSPVLQTA Rv2448c|M.tuberculosis_H37Rv GDGVDWSRDRFTMDEGLSRAVRTIFKRLYDAGLIYRAERLVNWSPVLQTA MMAR_3772|M.marinum_M GDGVDWSRDRFTMDEGLSRAVRTIFKRLYDAGLIYQAERLVNWSPVLQTA MUL_3719|M.ulcerans_Agy99 GDGVDWSRDRFTMDEGLSRAVRTIFKRLYDAGLIYQAERLVNWSPVLQTA MLBr_01472|M.leprae_Br4923 GDGVDWSRDRFTMDDGLSRAVRMIFKRLYDAGLIYRAERLVNWSPVLRTA MAV_1724|M.avium_104 GDGVDWSRDRFTMDEGLSRAVRTIFKRLYDAGLIYRAERLVNWSPVLQTA **************: ****** ***:*:******:********* *.** Mvan_3951|M.vanbaalenii_PYR-1 ISDLEVKYEDVEGELVSFRYGSMEDSEPHIVVATTRLETMLGDTAIAVHP Mflv_2630|M.gilvum_PYR-GCK ISDLEVKYEDVEGELVSFRYGSMDDSEPHIVVATTRLETMLADTAIAVHP MSMEG_4630|M.smegmatis_MC2_155 ISDLEVKYEDVEGELVSFRYGSMNDDEPHIVVATTRVETMLGDTAIAVHP TH_0609|M.thermoresistible__bu ISDLEVKYEDVEGELVSFRYGSMSDDEPHIVVATTRLETMLGDTAIAVHP MAB_1603|M.abscessus_ATCC_1997 ISDLEVKYEEVEGELVSFRYGSLNDNEPHLVVATTRLETMLGDTAIAVHP Mb2475c|M.bovis_AF2122/97 ISDLEVNYRDVEGELVSFRYGSLDDSQPHIVVATTRVETMLGDTAIAVHP Rv2448c|M.tuberculosis_H37Rv ISDLEVNYRDVEGELVSFRYGSLDDSQPHIVVATTRVETMLGDTAIAVHP MMAR_3772|M.marinum_M ISDLEVNYLEVEGELVSFRYGSLEDSQPHIVVATTRVETMLGDTAIAVHP MUL_3719|M.ulcerans_Agy99 ISDLEVNYLEVEGELVSFRYGSLEDSQPHIVVATTRVETMLGDTAIAVHP MLBr_01472|M.leprae_Br4923 LSDIEVIYDEIEGELISFRYGSLDDDEPHIVVATTRVETMLGDTGIAVHP MAV_1724|M.avium_104 LSDIEVNYEEVEGELVSFRYGSLDDSGPHIVVATTRVETMLGDTAIAVHP :**:** * ::****:******:.*. **:******:****.**.***** Mvan_3951|M.vanbaalenii_PYR-1 DDERYRHLVGTTLPHPFIDRQIVIVADHHVDPEFGTGAVKVTPAHDPNDF Mflv_2630|M.gilvum_PYR-GCK EDDRYRELVGTTLPHPFLDTELIVVADSHVDPEFGTGAVKVTPAHDPNDF MSMEG_4630|M.smegmatis_MC2_155 DDERYRHLVGKTLPHPFVDRDMVIVADTHVDPEFGTGAVKVTPAHDPNDF TH_0609|M.thermoresistible__bu EDERYKHLVGKTLPHPFLDRELVIVADEHVDPEFGSGAVKVTPAHDPNDF MAB_1603|M.abscessus_ATCC_1997 DDERYRHLIGTELAHPFQDRSIPIVADNHVDPEFGTGAVKVTPAHDPNDF Mb2475c|M.bovis_AF2122/97 DDERYRHLVGTSLAHPFVDRELAIVADEHVDPEFGTGAVKVTPAHDPNDF Rv2448c|M.tuberculosis_H37Rv DDERYRHLVGTSLAHPFVDRELAIVADEHVDPEFGTGAVKVTPAHDPNDF MMAR_3772|M.marinum_M DDERYRHLVGTTLAHPFVDRQLIIVADGHVDPEFGTGAVKVTPAHDPNDF MUL_3719|M.ulcerans_Agy99 DDERYRHLVGTTLAHPFVDRQLIIVADGHVDPEFGTGAVKVTPAHDPNDF MLBr_01472|M.leprae_Br4923 DDKRYQHLVGTTLPHPFIDRELVIVADEHVDPEFGTGAVKVTPAHDPNDF MAV_1724|M.avium_104 DDERYRHLVGSSLPHPFVDRQLLIVADEHVDPEFGTGAVKVTPAHDPNDF :*.**:.*:*. *.*** * .: :*** *******:************** Mvan_3951|M.vanbaalenii_PYR-1 EIGLRHQLPMPSIMDTKGRIADTRTQFDGLDRFEARFAVRQALADEGRIV Mflv_2630|M.gilvum_PYR-GCK EIGLRHQLPMPTMLETRGRVAGTGTQFDGMDRFEARVAVREALAEQGRIV MSMEG_4630|M.smegmatis_MC2_155 EIGMRHGLPMPTIMDTKGRIADTGTQFDGMDRFEARVKVREALAAQGRIV TH_0609|M.thermoresistible__bu EIGMRHGLPMITIMDTRGRIADTGTQFDGMDRFEARVKVREALAEQGRIV MAB_1603|M.abscessus_ATCC_1997 EIGLRHNLPMPTIMDVHGRICDSGTQFDGMDRFEARVKVREALAEQGRIV Mb2475c|M.bovis_AF2122/97 EIGVRHQLPMPSILDTKGRIVDTGTRFDGMDRFEARVAVRQALAAQGRVV Rv2448c|M.tuberculosis_H37Rv EIGVRHQLPMPSILDTKGRIVDTGTRFDGMDRFEARVAVRQALAAQGRVV MMAR_3772|M.marinum_M EIGMRHQLPMPSILDTKGRIVDTGTQFDGMDRFEARVAVREALAAQGRVV MUL_3719|M.ulcerans_Agy99 EIGMRHQLPMPSILDTKGRIVDTGTQFDGMDRFEARVAVREALAAQGRVV MLBr_01472|M.leprae_Br4923 EIGLRHNLPMPNVMDVKAVIVDTGTEFDGMDRFEARIAVREALAVQGRIV MAV_1724|M.avium_104 EIGLRHQLPMISIMDTKGRIADTGTQFDGMDRFAARVAVREALAAQGRIV ***:** *** .:::.:. : .: *.***:*** **. **:*** :**:* Mvan_3951|M.vanbaalenii_PYR-1 EEKRPYLHSVGHSERSGEPIEPRLSLQWWVKVESLAKAAGDAVRNGRTVI Mflv_2630|M.gilvum_PYR-GCK AEKRPYLHSVGHSERSGEPIEPRLSLQWWVRVETLAKAAGDAVRNGDTVI MSMEG_4630|M.smegmatis_MC2_155 AEKRPYLHSVGHSERSGEPIEPRLSLQWWVKVESLAKAAGDAVRNGDTVI TH_0609|M.thermoresistible__bu AEKRPYVHSVGHSERSGEPIEPRLSLQWWVKVADLAKAAGDAVRNGETVI MAB_1603|M.abscessus_ATCC_1997 AEKRPYLHSVGHSERSGEPIEPRLSMQWWVKVESLARKAGDAVRSGDTVI Mb2475c|M.bovis_AF2122/97 EEKRPYLHSVGHSERSGEPIEPRLSLQWWVRVESLAKAAGDAVRNGDTVI Rv2448c|M.tuberculosis_H37Rv EEKRPYLHSVGHSERSGEPIEPRLSLQWWVRVESLAKAAGDAVRNGDTVI MMAR_3772|M.marinum_M EEKRPYLHSVGHSDRSGEPIEPRLSLQWWVRVESLAKAAGDAVRNGDTVI MUL_3719|M.ulcerans_Agy99 EEKRPYLHSVGHSDRSGEPFEPRLSLQWWVRVESLAKAAGDAVRNGDTVI MLBr_01472|M.leprae_Br4923 EEKRPYRHSVGHSERSGEVIEPRLSLQWWVRVESLAKAAGDAVRNGDTVI MAV_1724|M.avium_104 EEKRPYLHSVGHSERSGEPIEPRLSLQWWVRVESLAKAAGDAVRNGDTVI ***** ******:**** :*****:****:* **: ******.* *** Mvan_3951|M.vanbaalenii_PYR-1 HPASLEPRWFGWVDNMHDWCISRQLWWGHRIPIWHGPNGETVCVGPDETP Mflv_2630|M.gilvum_PYR-GCK HPASLEPRWFAWVDNMHDWCISRQLWWGHRIPIWHGPNGETVCVGPDETP MSMEG_4630|M.smegmatis_MC2_155 HPPSLEPRWFAWVDNMHDWCISRQLWWGHRIPIWHGPDGETVCVGPDETP TH_0609|M.thermoresistible__bu HPKSLEPRWFAWVDDMHDWCISRQLWWGHRIPIWHGPNGEKVCVGPDETP MAB_1603|M.abscessus_ATCC_1997 HPASLEPRWFAWVDDMHDWCISRQLWWGHRIPIWHGPGGEIVCLGPDEAA Mb2475c|M.bovis_AF2122/97 HPASMEPRWFSWVDDMHDWCISRQLWWGHRIPIWYGPDGEQVCVGPDETP Rv2448c|M.tuberculosis_H37Rv HPASMEPRWFSWVDDMHDWCISRQLWWGHRIPIWYGPDGEQVCVGPDETP MMAR_3772|M.marinum_M HPASLEPRWFAWVDDMHDWCISRQLWWGHRIPIWYGPNGEKVCVGPDETP MUL_3719|M.ulcerans_Agy99 HPASLEPRWFAWVDDMHDWCISRQLWWGHRIPIWYGPDGEKVCVGPDETP MLBr_01472|M.leprae_Br4923 HPASMESRWFAWVDDMRDWCISRQLWWGHRIPIWYGPNGEQVCVGPDETP MAV_1724|M.avium_104 HPTSMEPRWFAWVDDMHDWCISRQLWWGHRIPIWYGPNGEQRCVGPDETP ** *:*.***.***:*:*****************:**.** *:****:. Mvan_3951|M.vanbaalenii_PYR-1 PEGWEQDPDVLDTWFSSALWPFSTMGWPDHTAELAKFYPTTVLVTGYDIL Mflv_2630|M.gilvum_PYR-GCK PEGWEQDPDVLDTWFSSALWPFSTMGWPDHTPELAKFYPTTVLVTGYDIL MSMEG_4630|M.smegmatis_MC2_155 PEGWEQDPDVLDTWFSSALWPFSTMGWPDHTPELAKFYPTSVLVTGYDIL TH_0609|M.thermoresistible__bu PEGWEQDPDVLDTWFSSALWPFSTMGWPDHTPELAKFYPTDVLVTGYDIL MAB_1603|M.abscessus_ATCC_1997 PEGYEQDPDVLDTWFSSALWPFSTMGWPEATPELEKFYPTSVLVTGYDIL Mb2475c|M.bovis_AF2122/97 PQGWEQDPDVLDTWFSSALWPFSTLGWPDKTAELEKFYPTSVLVTGYDIL Rv2448c|M.tuberculosis_H37Rv PQGWEQDPDVLDTWFSSALWPFSTLGWPDKTAELEKFYPTSVLVTGYDIL MMAR_3772|M.marinum_M PQGWEQDSDVLDTWFSSALWPFSTLGWPELTPELEKFYPTSVLVTGYDIL MUL_3719|M.ulcerans_Agy99 PQGWEQDSDVLDTWFSSALWPFSTLGWPELTPELEKFYPTSVLVTGYDIL MLBr_01472|M.leprae_Br4923 PEGWQQDPDVLDTWFSSALWPFSTLGWPQMTPELEKFYPTSILVTGYDIL MAV_1724|M.avium_104 PEGWEQDPDVLDTWFSSALWPFSTLGWPEKTPELEKFYPTSVLVTGYDIL *:*::**.****************:***: *.** ***** :******** Mvan_3951|M.vanbaalenii_PYR-1 FFWVARMMMFGTFVGDDPAITGGGAR---GPQVPFENVFLHGLIRDEHGR Mflv_2630|M.gilvum_PYR-GCK FFWVARMMMFGTFVGGDPAIIGDGAAKKSSPQVPFKNVFLHGLIRDEFGR MSMEG_4630|M.smegmatis_MC2_155 FFWVARMMMFGTFVGDDPAVTLEGAR---GRQVPFENVFLHGLIRDEFGR TH_0609|M.thermoresistible__bu FFWVARMMMFGTFVGDHPAITLDGAR---GPQVPFRNVFLHGLIRDKHGR MAB_1603|M.abscessus_ATCC_1997 FFWVARMMMFGTFVADGPALH--------GGKVPFDNVFLHGLIRDQFGQ Mb2475c|M.bovis_AF2122/97 FFWVARMMMFGTFVGDDAAITLDGRR---GPQVPFTDVFLHGLIRDESGR Rv2448c|M.tuberculosis_H37Rv FFWVARMMMFGTFVGDDAAITLDGRR---GPQVPFTDVFLHGLIRDESGR MMAR_3772|M.marinum_M FFWVARMMMFGTFVGGDEVITLDGRR---GAQVPFTDVFLHGLIRDEFGR MUL_3719|M.ulcerans_Agy99 FFWVARMMMFGTFVGGDEVITLDGRR---GAQVPFTDVFLHGLIRDEFGR MLBr_01472|M.leprae_Br4923 FFWVARMMMLGTFVGGDDAITLGGCR---GPQVPFTDVFLHGLIRDEFGR MAV_1724|M.avium_104 FFWVARMMMFGTFVGDDDAITLDGRR---GPQVPFTDVFLHGLIRDESGR *********:****.. .: . :*** :*********: *: Mvan_3951|M.vanbaalenii_PYR-1 KMSKSRGNGIDPLDWVEMFGADALRFTLARGASPGGDLAIGEDHARASRN Mflv_2630|M.gilvum_PYR-GCK KMSKSRGNGIDPLDWVETFGADALRFTLARGASPGGDLAIGEDHARASRN MSMEG_4630|M.smegmatis_MC2_155 KMSKSRGNGIDPLDWVEKFGADALRFTLARGASPGGDLSIGEDHARASRN TH_0609|M.thermoresistible__bu KMSKSAGNGIDPLDWVQTYGADALRFTLARGASPGSDLSIGDDHARASRN MAB_1603|M.abscessus_ATCC_1997 KMSKSKGNGIDPLDWVEMFGADALRFTLARGASPGGDLSIGEDAARASRN Mb2475c|M.bovis_AF2122/97 KMSKSKGNVIDPLDWVEMFGADALRFTLARGASPGGDLAVSEDAVRASRN Rv2448c|M.tuberculosis_H37Rv KMSKSKGNVIDPLDWVEMFGADALRFTLARGASPGGDLAVSEDAVRASRN MMAR_3772|M.marinum_M KMSKSKGNVIDPLDWIDTFGADALRFTLARGASPGSDLAVGEDAVRASRN MUL_3719|M.ulcerans_Agy99 KMSKSKGNVIDPLDWIDTFGADALRFTLARGASPGSDLAVGEDAVRASRN MLBr_01472|M.leprae_Br4923 KMSKSRGNVIDPLAWMDMFGADALRFTLARGSSPGGDLAIGEDHVRASRN MAV_1724|M.avium_104 KMSKSKGNVIDPLDWVDMFGADALRFTLARGASPGGDLAIGEDHVRASRN ***** ** **** *:: :************:***.**::.:* .***** Mvan_3951|M.vanbaalenii_PYR-1 FATKLFNATRFALLNGASPAPLPPSDQLTDADRWILGRLEEVRIEVDAAL Mflv_2630|M.gilvum_PYR-GCK FATKLFNATRFALLNGASPAPLPPTAELTDADRWILGRLEEVRADVDAAL MSMEG_4630|M.smegmatis_MC2_155 FATKLFNATRFALMNGAAPAPLPAASELTDADRWILGRLEEVRAEVDSAF TH_0609|M.thermoresistible__bu FVTKLFNATRFALLNGAAPAPLPDAAELTDADRWILGRLEEVRTEVDSAF MAB_1603|M.abscessus_ATCC_1997 FTTKLFNATRFALMNGAALGELPDVAELTDADRWILGRLEQVRAEVDGAL Mb2475c|M.bovis_AF2122/97 FGTKLFNATRYALLNGAAPAPLPSPNELTDADRWILGRLEEVRAEVDSAF Rv2448c|M.tuberculosis_H37Rv FGTKLFNATRYALLNGAAPAPLPSPNELTDADRWILGRLEEVRAEVDSAF MMAR_3772|M.marinum_M FGTKLFNATRYALLNGAALAPLPPLGELTDADRWILGRLEEVRAEVDSAF MUL_3719|M.ulcerans_Agy99 FGTKLFNATRYALLNGAALAPLPPLGELTDADRWILGRLEEVRAEVDSAF MLBr_01472|M.leprae_Br4923 FGTKLFNATRYALLNGAALVPLPALTALTDADRWILGRLEQVRAEVDSAF MAV_1724|M.avium_104 FCTKLFNATRYALLNGAQLAQLPPLDELTDADRWILGRLEEVRAEVDSAF * ********:**:*** ** *************:** :**.*: Mvan_3951|M.vanbaalenii_PYR-1 DNYEFSRACESLYHFAWDEFCDWYLELAKVQLGQEEAHTARTTAVLAFAL Mflv_2630|M.gilvum_PYR-GCK DNYEFNRACEALYHFAWDEFCDWYLELAKVQLGQEDPQTARTTAVLATVL MSMEG_4630|M.smegmatis_MC2_155 DNYEFNRACEALYHFAWDEFCDWYVELAKVQLGQEEVHTARTTAVLAAVL TH_0609|M.thermoresistible__bu DSYEFSRACETLYHFAWDEFCDWYVELAKVQLSEG---ISHTTAVLAAVL MAB_1603|M.abscessus_ATCC_1997 DRYEFSVACEGLYHFAWDEFCDWYLELAKVQMVDR---AESTRVVLATVL Mb2475c|M.bovis_AF2122/97 DGYEFSRACESLYHFAWDEFCDWYLELAKTQLAQG---LTHTTAVLAAGL Rv2448c|M.tuberculosis_H37Rv DGYEFSRACESLYHFAWDEFCDWYLELAKTQLAQG---LTHTTAVLAAGL MMAR_3772|M.marinum_M DSYEFSRACEALYHFAWDEFCDWYVELAKTQLAEG---LSATTAVLAAGL MUL_3719|M.ulcerans_Agy99 DSYEFSRACEALYHFAWDEFCDWYVELAKTQLAEG---LSATTAVLAAGL MLBr_01472|M.leprae_Br4923 DGYEFSRACEALYHFAWDEFCDWYLELAKAQLADG---LTHTTAVLAAAL MAV_1724|M.avium_104 DNYEFSRACESLYHFAWDEFCDWYVELAKTQLAEG---ITHTTAVLATTL * ***. *** *************:****.*: : * .*** * Mvan_3951|M.vanbaalenii_PYR-1 DVLLKLLHPVMPFVTEVLWKALTGGESLVIADWPTATGYAVDQGATQRVA Mflv_2630|M.gilvum_PYR-GCK DVLLKLLHPVMPFVTEVLWKTLTGGESLVIADWPTATGFASDHAAAQRIT MSMEG_4630|M.smegmatis_MC2_155 DTLLKLLHPVMPFVTETLWKTLTGGESVVVATWPEPSGFAPDTVATQRIT TH_0609|M.thermoresistible__bu DTLLKLLHPVMPFVTEKLWKTLTDGESLVIAKWPQPSGFSLDSIAAQRVA MAB_1603|M.abscessus_ATCC_1997 DTLLRLLHPVIPFVTEVLWKSVTGGESVVIAAWPTGSGIELDGTAAQRIA Mb2475c|M.bovis_AF2122/97 DTLLRLLHPVIPFLTEALWLALTGRESLVSADWPEPSGISVDLVAAQRIN Rv2448c|M.tuberculosis_H37Rv DTLLRLLHPVIPFLTEALWLALTGRESLVSADWPEPSGISVDLVAAQRIN MMAR_3772|M.marinum_M DTLLRLLHPVIPFITEALWQALTGQESLVIADWPQPSGITLDPVAAQRIS MUL_3719|M.ulcerans_Agy99 DTLLRLLHPVIPFITEALWQALTGQESLVIADWPQPSGITLDPVAAQRIS MLBr_01472|M.leprae_Br4923 DTLLRLLHPVMPFITETLWQALTQLESLVIATWPEPSGISLDLVAAQRIS MAV_1724|M.avium_104 DTLLRLLHPVIPFITEALWQALTGNESLVIADWPRSSGVGLDQVATQRIT *.**:*****:**:** ** ::* **:* * ** :* * *:**: Mvan_3951|M.vanbaalenii_PYR-1 DMQKLITEVRRFRSDQGLADRQKVPARLSDVAAAGLEEHVPAVTALAWLT Mflv_2630|M.gilvum_PYR-GCK DMQKLITEVRRFRSDQGLADRQKVPARLSEVSAAGLDAHVPAVTALAWLT MSMEG_4630|M.smegmatis_MC2_155 DMQKLITEVRRFRSDQGLADRQKVPARLTDVEAAGLTAQLPAVAALAWLT TH_0609|M.thermoresistible__bu DMQRLITEVRRFRSDQGLADRQKVPARLSDIPGADLQAQLPAIRALAWLT MAB_1603|M.abscessus_ATCC_1997 DMQKLVTEVRRFRSDQGLGDRQKVAARLSGVGEAGLDDQLAAVTSLAWLT Mb2475c|M.bovis_AF2122/97 DMQKLVTEVRRFRSDQGLADRQKVPARMHGVRDSDLSNQVAAVTSLAWLT Rv2448c|M.tuberculosis_H37Rv DMQKLVTEVRRFRSDQGLADRQKVPARMHGVRDSDLSNQVAAVTSLAWLT MMAR_3772|M.marinum_M DMQNLVTEIRRFRSDQGLADRQKVPARLIGVEESDLGAQVAAVTSLAWLT MUL_3719|M.ulcerans_Agy99 DMQNLVTEIRRFRSDQGLADRQKVPARLIGVEESDLGAQVAAVTSLAWLT MLBr_01472|M.leprae_Br4923 DMQKLVTEIRRFRSDQGLVDRQKVPARLSGVEDSDLATQVGFVTSLALLT MAV_1724|M.avium_104 DMQKLVTEVRRFRSDQGLADRQKVPARLAGVTESDLDTQVSAVTSLAWLT ***.*:**:********* *****.**: : :.* :: : :** ** Mvan_3951|M.vanbaalenii_PYR-1 PPADEFTPSAAVEVRLSTA---TVVVEVDTSGTVDVAAERRRLEKDLAAA Mflv_2630|M.gilvum_PYR-GCK PPAEGFTPSASVEVRLSAS---TVVVEVDTSGTVDVDAERRRLEKDLAAA MSMEG_4630|M.smegmatis_MC2_155 EAGDGFSPSASVEVRLSQG---TVVVEVDTSGTVDVEAERRRLEKDLGGR TH_0609|M.thermoresistible__bu DAGADFNPSAALEVRLSKG---TVVVELDTRGSVDVEAERRRTEKDLAAA MAB_1603|M.abscessus_ATCC_1997 PAEEGFSPTASVEVRLSGA---TVTVEVDTSGTVDVEAERRRLEKDLAAA Mb2475c|M.bovis_AF2122/97 EPGPDFEPSVSLEVRLGPEMNRTVVVELDTSGTIDVAAERRRLEKELAGA Rv2448c|M.tuberculosis_H37Rv EPGPDFEPSVSLEVRLGPEMNRTVVVELDTSGTIDVAAERRRLEKELAGA MMAR_3772|M.marinum_M APGEGFAPSVSLEVRLGPSMNHTVVVELDTSGTIDVAAERRRLEKDLAAA MUL_3719|M.ulcerans_Agy99 APGEGFAPSVSLEVRLGPSMNHTVVVELDTSGTIDVAAERRRLEKDLAAA MLBr_01472|M.leprae_Br4923 AASNDFRPSALLEVRLGPNKDRAVVVELDTSGTIDVAAERRRMEKDLAAA MAV_1724|M.avium_104 DAGPDFRPSASVEVRLRGG---TVVVELDTSGSIDVAAERRRLEKDLAAA . * *:. :**** :*.**:** *::** ***** **:*.. Mvan_3951|M.vanbaalenii_PYR-1 QKELSGTSGKLGNEAFLAKAPADVVDKIRARQQVANEEVERIQARLAALS Mflv_2630|M.gilvum_PYR-GCK QKELAGTSAKLGNDAFLAKAPADVVDKIRARRQVAGEEVDRITARLSALP MSMEG_4630|M.smegmatis_MC2_155 PEGTGHHHGQTRQRGLPVQG-----ARPGGRQDPGQASPGQ--------- TH_0609|M.thermoresistible__bu RRELESTSKKLENEAFLAKAPAEVVEKIRNRQRLAAEEVDRLTARLAALK MAB_1603|M.abscessus_ATCC_1997 RKELDGTTSKLGNDAFLAKAPEAVVEKIRVRQQVATEEVERITARLAALA Mb2475c|M.bovis_AF2122/97 QKELASTAAKLANADFLAKAPDAVIAKIRDRQRVAQQETERITTRLAALQ Rv2448c|M.tuberculosis_H37Rv QKELASTAAKLANADFLAKAPDAVIAKIRDRQRVAQQETERITTRLAALQ MMAR_3772|M.marinum_M EKELVSTAAKLANADFLAKAPEAVVGKIRDRQRLAQEESDRITTRLAALQ MUL_3719|M.ulcerans_Agy99 EKELVSAAAKLANADFLAKAPEAVVGKIRDRQRLAQEESDRITTRLAALQ MLBr_01472|M.leprae_Br4923 QKELASTAAKLANADFLAKAPEAVVVKIRDRQRMAKEETDRIIARLAGLQ MAV_1724|M.avium_104 HKELASTTAKLANEDFLAKAPPHVVDKIRDRQRLAQEESERINARLAVLQ . : : : .:. : *: . . : Mvan_3951|M.vanbaalenii_PYR-1 ASE Mflv_2630|M.gilvum_PYR-GCK AGE MSMEG_4630|M.smegmatis_MC2_155 --- TH_0609|M.thermoresistible__bu DS- MAB_1603|M.abscessus_ATCC_1997 --- Mb2475c|M.bovis_AF2122/97 --- Rv2448c|M.tuberculosis_H37Rv --- MMAR_3772|M.marinum_M --- MUL_3719|M.ulcerans_Agy99 --- MLBr_01472|M.leprae_Br4923 --- MAV_1724|M.avium_104 ---