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RTTSPAASPSTTALQAVARYGYVPSMLIGLNGAGIAVAAAGAPKYWLVAILAVAIATGFLVERIIPYDPE WNHDRADGTRDRIHVAVNETLILASVAAIPLLAAIVPAHQLWPHSWPFVAQVLTAILVADFGITVVHLAS HKVGVLWRFHAVHHSVTRFYGLNGLMKHPLHQTVEMTAGVAPLILVGLPVDVASALALAVAIQLLLQHSN AEYRIGPAKYVLALNEGHRFHHLKWAGIGDVNFGLFTLVWDHLMRTFSYDPARRFDSTQLGMAAKPDYPN GYLRQMIYPFTRRGGCASEATTTPNGATQTSTPDPVSKNRC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3683 | - | - | 100% (322) | hypothetical protein Mvan_3683 |
| M. vanbaalenii PYR-1 | Mvan_3171 | - | 1e-08 | 26.63% (184) | sterol desaturase-related protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1844 | erg3 | 4e-06 | 25.88% (170) | membrane-bound C-5 sterol desaturase erg3 |
| M. gilvum PYR-GCK | Mflv_3418 | - | 1e-09 | 28.48% (151) | sterol desaturase-related protein |
| M. tuberculosis H37Rv | Rv1814 | erg3 | 4e-06 | 25.88% (170) | membrane-bound C-5 sterol desaturase erg3 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0067 | - | 1e-104 | 61.38% (290) | hypothetical protein MAB_0067 |
| M. marinum M | MMAR_3832 | erg3_2 | 1e-09 | 26.23% (183) | membrane-bound C-5 sterol desaturase Erg3_2 |
| M. avium 104 | MAV_2902 | - | 8e-08 | 27.17% (173) | C-5 sterol desaturase |
| M. smegmatis MC2 155 | MSMEG_2812 | - | 6e-13 | 29.24% (171) | C-5 sterol desaturase |
| M. thermoresistible (build 8) | TH_2226 | - | 3e-09 | 26.40% (178) | MEMBRANE-BOUND C-5 STEROL DESATURASE ERG3 |
| M. ulcerans Agy99 | MUL_3066 | erg3 | 4e-08 | 25.95% (185) | membrane-bound C-5 sterol desaturase Erg3 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1844|M.bovis_AF2122/97 ---------------------------MRDPVLFAIPCFLLLLILEWTAA
Rv1814|M.tuberculosis_H37Rv ---------------------------MRDPVLFAIPCFLLLLILEWTAA
MAV_2902|M.avium_104 -------------MSALSGYLTALPPQLRDPVLVAIPFFLLLLTLEWTAA
MUL_3066|M.ulcerans_Agy99 -------------MSALPGFLAVLPGEMRDPVLFAIPFFLFLLTVEWAAA
Mflv_3418|M.gilvum_PYR-GCK -----------------MEFLEFLPPQMREPVLFAIPFFLLLLAIEWTAA
TH_2226|M.thermoresistible__bu ------------VDQVVVPFLDVLPAPMRDPVLFAIPFFLLLLALEWTAA
MMAR_3832|M.marinum_M ------------------------MERAVPIFLTGFMVLVGLDFLSYRLG
MSMEG_2812|M.smegmatis_MC2_155 ------------------------MDITMTMLLWTAPAFVVLSIVEWLDE
Mvan_3683|M.vanbaalenii_PYR-1 MRTTSPAASPSTTALQAVARYGYVPSMLIGLNGAGIAVAAAGAPKYWLVA
MAB_0067|M.abscessus_ATCC_1997 -------------MAIWFVRYGYVPLMLLGINGVAIALAHRPWAPLWMVV
:
Mb1844|M.bovis_AF2122/97 RKLESIETAAT---GQPRPASGAYLTRDSVASISMGLVSIATTAGWKSLA
Rv1814|M.tuberculosis_H37Rv RKLESIETAAT---GQPRPASGAYLTRDSVASISMGLVSIATTAGWKSLA
MAV_2902|M.avium_104 RKLEHLT---------ARPAPGAHRTRDSLTSISMGLVSVATTAGWKTLA
MUL_3066|M.ulcerans_Agy99 RKLEKLEAGAT---ETPRPVSGSYHTRDSVATISMGLVSLVTIAFWKTMA
Mflv_3418|M.gilvum_PYR-GCK RKLEHAVEGGADEDG--TPAAGAYHTRDSWASLSMGLVSTVTMSVWKFFA
TH_2226|M.thermoresistible__bu RRLAHVEAGEGWEEGDRRPPPGAFHTPDARASISMGLVSIATMGAWKFLA
MMAR_3832|M.marinum_M KQRNRSR--------------PSVSARDTAANLSVYALARLTRSVGS-VT
MSMEG_2812|M.smegmatis_MC2_155 RQDPQYA--------------QKFSARDYAGNWATYALNAVFKFAGQYLL
Mvan_3683|M.vanbaalenii_PYR-1 ILAVAIATGFLVERIIPYDPEWNHDRADGTRDRIHVAVN-ETLILASVAA
MAB_0067|M.abscessus_ATCC_1997 LILVAIGLSFLAERVAPYSPEWNESMGDARRDAAHAFVN-ETALLLTVLV
* :
Mb1844|M.bovis_AF2122/97 LLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWA
Rv1814|M.tuberculosis_H37Rv LLGYAAIYAYLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWA
MAV_2902|M.avium_104 LFGYAAIYAYLAPWHLPATRWYTWAIPILGVDLLYYAYHRIAHRVRLIWA
MUL_3066|M.ulcerans_Agy99 LLGYAAIYTYVAPWHLSPGRWYTWVIAIVGVDLLYYTYHRIAHRVRLIWA
Mflv_3418|M.gilvum_PYR-GCK LLGYAAIYAYLAPWQLSPTQWYTWVIAIVGVDLLFYVYHRTAHRVRLVWA
TH_2226|M.thermoresistible__bu LLGYVAIYAYLAPWHLPADRWYTWVIALVGVDLLFYVYHRMAHRVQVVWA
MMAR_3832|M.marinum_M AVPLVLIASALTPIHLPTAQWWTWACALVLTDLAYYGRHRMTHRIRVFWA
MSMEG_2812|M.smegmatis_MC2_155 PFSTIVIASSLTPLRLSPRHWWVWVACLIATDFCYYWAHRADHRVRLLWT
Mvan_3683|M.vanbaalenii_PYR-1 IPLLAAIVPAHQLWPHSWPFVAQVLTAILVADFGITVVHLASHKVGVLWR
MAB_0067|M.abscessus_ATCC_1997 VPAVALLSPFHTWWPSSIPFVLQVLIAAAVADFGITLMHYASHKVPALWR
: . . .*: * *:: .*
Mb1844|M.bovis_AF2122/97 THQAHHSSEYFNFATALRQKWNNSG----EILMWVPLPLMGLPPWMVFCS
Rv1814|M.tuberculosis_H37Rv THQAHHSSEYFNFATALRQKWNNSG----EILMWVPLPLMGLPPWMVFCS
MAV_2902|M.avium_104 THQAHHSSEYYNFATALRQKWNNSG----EILMWIPLPLLGIPPWMVFFS
MUL_3066|M.ulcerans_Agy99 THQAHHSSEYFNFATALRQKWNNSG----EVLMWVPLPLLGLPPWMVFFG
Mflv_3418|M.gilvum_PYR-GCK THQAHHSSRYFNFATALRQKWNNSG----EILMWIPLPLLGVPPWMVFVA
TH_2226|M.thermoresistible__bu THQAHHSSEYFNLATALRQKWNNSG----EVLLWIPLPLLGVPPWLVFFS
MMAR_3832|M.marinum_M AHHVHHSSQYLNLSTGMRTPWLVPGWLFISAVVYVPLALIGFPVWMIFAC
MSMEG_2812|M.smegmatis_MC2_155 AHSVHHSSRFFNLSTNLRLPWFHPVSYTLRSLAWVPVALLGFPVWMIFVL
Mvan_3683|M.vanbaalenii_PYR-1 FHAVHHSVTRFYGLNGLMKHPLHQT--VEMTAGVAPLILVGLP-VDVASA
MAB_0067|M.abscessus_ATCC_1997 LHAVHHSIKRFYGFNGLMKHPVHGG--LELMAGTAPLLIMGLP-QAVAEA
* .*** . : *: ::*.* :
Mb1844|M.bovis_AF2122/97 WSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGG
Rv1814|M.tuberculosis_H37Rv WSLNLIYQFWVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGG
MAV_2902|M.avium_104 FSLNLIYQFWIHTERIDKLPRPFEFVFNTPSHHRVHHGMDKVYLDKNYGG
MUL_3066|M.ulcerans_Agy99 FSVSLIYQFWVHTERINKLPRWFEFIFNTPSHHRVHHGMDQMYLDKNYGG
Mflv_3418|M.gilvum_PYR-GCK FSISLIYQFWIHTEHIGKLWRPFEFVFNTPSHHRVHHGMDPLYLDKNYGG
TH_2226|M.thermoresistible__bu FSISLIYQFWIHTERIGKLPAPIEFVFNTPSHHRVHHGMDPEYLDKNYGG
MMAR_3832|M.marinum_M HAIVLFYQFPIHTERINRLPRPIEYLFNTPSHHRVHHGANNPYLNKNYGG
MSMEG_2812|M.smegmatis_MC2_155 NTAGLLFQIPCHTERIGTLWPAWEFMFNTPSHHRVHHGSNMSYIDKNYGG
Mvan_3683|M.vanbaalenii_PYR-1 LALAVAIQLLLQHSNAEYRIGPAKYVLALNEGHRFHHLKWAGIGDVNFGL
MAB_0067|M.abscessus_ATCC_1997 LTVLIAVQLLLQHSNADYRIGRLRVVLALNEGHRFHHLKWAGIGDVNFGL
: : *: : .. . :: . **.** : *:*
Mb1844|M.bovis_AF2122/97 ILIIWDRLFGSFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSA
Rv1814|M.tuberculosis_H37Rv ILIIWDRLFGSFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSA
MAV_2902|M.avium_104 ILIVWDRLFGTFQAELFRPHYGLTKQVDTFNVWKLQTREYVAIARDWRSA
MUL_3066|M.ulcerans_Agy99 ILIIWDRLFRSFQAETARPHYGLTKPVDTFNIWKLQTREYVAIARDWRSA
Mflv_3418|M.gilvum_PYR-GCK ILIIWDRLFGTFQPEVFRPHYGLTKPVDTFNIWKLQTHEYAAIWRDARAA
TH_2226|M.thermoresistible__bu ILIIWDRLFGTFCEEKFRPRYGLTKPVDTYNIWRLQTHEYLAIARDVAKA
MMAR_3832|M.marinum_M ILIVWDRLFGSYAEEDEPVRYGLQQNIATHNPIKLNYHEFVAMLSDVGRA
MSMEG_2812|M.smegmatis_MC2_155 VFIVWDRLFGTYAAEVEPVRYGLIHDVGSQNPVKFNYLETVAMLRDVAHA
Mvan_3683|M.vanbaalenii_PYR-1 FTLVWDHLMRTFSYDPARRFDSTQLGMAAKPDYPNGYLRQMIYPFTRRGG
MAB_0067|M.abscessus_ATCC_1997 FTLVWDHLLRTFSFDPARRFHSDDLGMAAKPNYPAGYTAQLAEPFRTSGA
. ::**:*: :: : . : : .
Mb1844|M.bovis_AF2122/97 TRLRDRLGYVFGPPGWEPRTID--KSNAAASLVTSR--------------
Rv1814|M.tuberculosis_H37Rv TRLRDRLGYVFGPPGWEPRTID--KSNAAASLVTSR--------------
MAV_2902|M.avium_104 SRLRDRLGYVFGPPGWAPRSAG--RTAAGAPVVTSL--------------
MUL_3066|M.ulcerans_Agy99 TRLRDRLGYAFGPPGWQPSTTATPRAEDAATVTTSGWRPT----------
Mflv_3418|M.gilvum_PYR-GCK RGVRAKLGYIFGPPGWQPAQVQ-----TPAPVAP----------------
TH_2226|M.thermoresistible__bu RNWRERLGYIFGPPGWQPAPAG-----APTPAPARD--------------
MMAR_3832|M.marinum_M KTWRGRVGYLLRPPGWSEVAET------PAPRSHDSDDHAVPVDGQHWAA
MSMEG_2812|M.smegmatis_MC2_155 KTWRARFGYVFGPPGWSEKAV-------PAPSLTT---------------
Mvan_3683|M.vanbaalenii_PYR-1 CASEATTTPNGATQTSTPDPVS-------KNRC-----------------
MAB_0067|M.abscessus_ATCC_1997 CHFDGLQSEVTATGRQPST-------------------------------
.
Mb1844|M.bovis_AF2122/97 ----
Rv1814|M.tuberculosis_H37Rv ----
MAV_2902|M.avium_104 ----
MUL_3066|M.ulcerans_Agy99 ----
Mflv_3418|M.gilvum_PYR-GCK ----
TH_2226|M.thermoresistible__bu ----
MMAR_3832|M.marinum_M AGNG
MSMEG_2812|M.smegmatis_MC2_155 ----
Mvan_3683|M.vanbaalenii_PYR-1 ----
MAB_0067|M.abscessus_ATCC_1997 ----