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MIHRVTATNLATHTPDGRPRARGAGIGFSGQPGPLNALTDVAGVQIGVTTLIDGDGPLIVGQGPIRTGVT AILPRGRSGVGQPCAAGWYSLNGNGEMTGTTWIDEVGSFNLPVVLSNTHAVGACHTGVVRWANRVAPRLA RQWLLPVCAETWDGYLNDINGGHVRPEHVEAALDAATAGPVAEGSVGGGTGMNCYEFKGGNGTASRLVPY GRRTYTVAAFVQANFGSRAELTITGSHIGPQLMDDNPLDGDWFARDLAAAPPPGAGSVIAVVATDAPLLP GQCKALARRVPLGLARTGTTGSHFSGDIFLAFSTAEVPDLASTFPLGPVGDDELGSITFLPWGRMDDLYA AVVQCVEEAVLNALVVNTDMVGRDGHRSPRLPLDRLPALLSRRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3384 | - | - | 100% (394) | peptidase S58, DmpA |
| M. vanbaalenii PYR-1 | Mvan_4294 | - | 2e-09 | 30.36% (303) | peptidase S58, DmpA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1368 | - | 8e-11 | 28.33% (300) | hydrolase |
| M. gilvum PYR-GCK | Mflv_3141 | - | 0.0 | 86.55% (394) | peptidase S58, DmpA |
| M. tuberculosis H37Rv | Rv1333 | - | 9e-11 | 28.33% (300) | hydrolase |
| M. leprae Br4923 | MLBr_01167 | - | 2e-16 | 30.11% (362) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_1477 | - | 2e-08 | 27.35% (373) | hypothetical protein MAB_1477 |
| M. marinum M | MMAR_4065 | dmpA | 3e-14 | 27.61% (373) | L-aminopeptidase/D-esterase DmpA |
| M. avium 104 | MAV_1553 | - | 6e-14 | 28.98% (383) | peptidase family protein T4 |
| M. smegmatis MC2 155 | MSMEG_2092 | - | 5e-71 | 43.96% (364) | D-aminopeptidase |
| M. thermoresistible (build 8) | TH_1833 | - | 9e-77 | 44.56% (377) | D-aminopeptidase |
| M. ulcerans Agy99 | MUL_3929 | dmpA | 2e-14 | 27.61% (373) | L-aminopeptidase/D-esterase DmpA |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1368|M.bovis_AF2122/97 ----------------------------------MNSITDVGGIRVGHYQ
Rv1333|M.tuberculosis_H37Rv ----------------------------------MNSITDVGGIRVGHYQ
MMAR_4065|M.marinum_M ----------------------------------MSSITDIGGIRVGHYQ
MUL_3929|M.ulcerans_Agy99 ----------------------------------MSSITDIGGIRVGHYQ
MAV_1553|M.avium_104 ----------------------------------MNAITDVGGIRVGHHQ
MLBr_01167|M.leprae_Br4923 ---------------------------MILMAAPMNSITDISGIQVGHYH
MAB_1477|M.abscessus_ATCC_1997 ------------------------------MSLFSGAITDVPGILVGHHQ
Mvan_3384|M.vanbaalenii_PYR-1 MIHRVTATNLATHTPDGRPRARGAGIGFSGQPGPLNALTDVAGVQIGVTT
Mflv_3141|M.gilvum_PYR-GCK MIHRVTGIDFATTTPDGTSRARGVGIPFQGTPGPLNALTDVAGVEVGATT
MSMEG_2092|M.smegmatis_MC2_155 ---------------MGRARDYDIIIGDLQT-GPLNAITDVDGVRVGHTT
TH_1833|M.thermoresistible__bu ---------------VARARDYGATIGVLPT-GPNNAITDVAGVRVGHTT
.::**: *: :*
Mb1368|M.bovis_AF2122/97 RLDPDASLGAG---WACGVTVVLPP---PGTVGAVDCRGGAPGTRETDLL
Rv1333|M.tuberculosis_H37Rv RLDPDASLGAG---WACGVTVVLPP---PGTVGAVDCRGGAPGTRETDLL
MMAR_4065|M.marinum_M RLDPDASLGAG---WASGVTVVLAP---PGTVGAVDCRGGAPGTRETDLL
MUL_3929|M.ulcerans_Agy99 RLDPDASLGAG---WASGVTVVLAP---PGTVGAVDCRGGAPGTRETDLL
MAV_1553|M.avium_104 RLDPDASLGAG---WACGVTVVLTP---PGTVGAVDCRGGAPGTRETDLL
MLBr_01167|M.leprae_Br4923 RLDPDASLGAG---WACGVTVVLTP---PGTVGAVDCRGGVPGTRETDLL
MAB_1477|M.abscessus_ATCC_1997 RVDADASLGAG---WATGTTVVLAP---PGTTGAVDVRGGAPGTRESDLL
Mvan_3384|M.vanbaalenii_PYR-1 LIDGDGPLIVGQGPIRTGVTAILPRGRSGVGQPCAAGWYSLNGNGEMTGT
Mflv_3141|M.gilvum_PYR-GCK LIDGDGPLCVGAGPVRTGVTAILPRGRDGVGQPCAAGWYSLNGNGEMTGT
MSMEG_2092|M.smegmatis_MC2_155 LVSGSGPRNPGNGPVRTGVTVVIPR-EEPWNRPLFAAPHRLNGNGELTGQ
TH_1833|M.thermoresistible__bu LIEGSGPRVTGQGPVRTGVTVVIPR-DEPWNHPLFAAAHRLNGNGELTGQ
:. ... * *.*.::. *. *
Mb1368|M.bovis_AF2122/97 DPANSVRFVDALLLAGGSAYGLAAADGVMRWLEEHRRGVAMDSGVVPIVP
Rv1333|M.tuberculosis_H37Rv DPANSVRFVDALLLAGGSAYGLAAADGVMRWLEEHRRGVAMDSGVVPIVP
MMAR_4065|M.marinum_M DPVNSVRFVDAVLLAGGSAYGLAAADGVMRWLEEHQRGVAMGAGVVPIVP
MUL_3929|M.ulcerans_Agy99 DPVNSVRFVDAVLLAGGSAYGLAAADGVMRWLEEHQRGVAMGTGVVPIVP
MAV_1553|M.avium_104 DPANTVRFVDAVLLAGGSAYGLAAADGVMRWLEEHDRGVAMDGGVVPIVP
MLBr_01167|M.leprae_Br4923 DPANSVRFVDAVLLAGGSAYGLAAADGVMRWLEEHERGVVMLGGVVPIVP
MAB_1477|M.abscessus_ATCC_1997 DPANTVATVDAVVLTGGSAYGLAAADGVMRWLEERGRGVPLSGGTVPIVP
Mvan_3384|M.vanbaalenii_PYR-1 TWIDEVGSFNLPVVLSNTHAVGACHTGVVRWANRVAPRLARQWLLPVCAE
Mflv_3141|M.gilvum_PYR-GCK TWIDEVGSFNLPVVLSNTHAVGACHTGVVQWANRVAPRLGRQWLLPVCAE
MSMEG_2092|M.smegmatis_MC2_155 HWVAESGQLTSYIGLTNTHSVGVVRDALIAHEKSVRG-DEFFFSLPVVGE
TH_1833|M.thermoresistible__bu HWVEESGQLTSYIGLTNTHSVGVVRDALIAHEKNARGADEFFFALPVVGE
. : .: . .:: :
Mb1368|M.bovis_AF2122/97 GAVIFDLPVGGWNCRPTADFGYSACAAAGVD--------VAVGTVGVGVG
Rv1333|M.tuberculosis_H37Rv GAVIFDLPVGGWNCRPTADFGYSACAAAGVD--------VAVGTVGVGVG
MMAR_4065|M.marinum_M GAVIFDLPVGGWGQRPTAEFGYLACDAAVSDQDPGATASLAVGTVGAGVG
MUL_3929|M.ulcerans_Agy99 GAVIFDLPVGGWGQRPTAEFGYLACDAAVSDQDPGATASLAVGTVGAGVG
MAV_1553|M.avium_104 GAVIFDLPVGGWQCRPTAEFGYLACAAARDDD------APAVGTVGAGVG
MLBr_01167|M.leprae_Br4923 GAVIFDLSVGDFHCRPTAEFGYLACQAAYDAAVGGQDATVAVGTVGAGVG
MAB_1477|M.abscessus_ATCC_1997 AAVIFDLPVGAWKNRPDTEFGYRAAELADDAP--------EWGAVGAGAG
Mvan_3384|M.vanbaalenii_PYR-1 TWDGYLNDINGGHVRP--EHVEAALDAATAGP-------VAEGSVGGGTG
Mflv_3141|M.gilvum_PYR-GCK TWDGYLNDINGGHVRP--DHVEAALDAARGGP-------VAEGSVGGGTG
MSMEG_2092|M.smegmatis_MC2_155 TCDGILNDLNGFHVRP--EHVAEAIENATDGP-------VEEGAVGGGTG
TH_1833|M.thermoresistible__bu TCDGILNDINGFHVKP--EHVAAAIDAAADGP-------VPEGAVGGGTG
:. :* :. * * *:** *.*
Mb1368|M.bovis_AF2122/97 ARAGALKGGVGTASATLQ---SGVTVGVLAVVNAAGNVVDPATGLPWMAD
Rv1333|M.tuberculosis_H37Rv ARAGALKGGVGTASATLQ---SGVTVGVLAVVNAAGNVVDPATGLPWMAD
MMAR_4065|M.marinum_M ARAGVLKGGVGTASVKLP---SGVTVGAVVVVNSVGNVVDPATGLPWMAE
MUL_3929|M.ulcerans_Agy99 ARAGVLKGGVGTASVKLP---SGVTVGAVVVVNSVGNVVDPATGLPWMAE
MAV_1553|M.avium_104 ARAGALKGGVGTASRSLP---SGVTVGALAVVNSAGEVVDRATGLPWMTD
MLBr_01167|M.leprae_Br4923 ARAGVLKGGVGTASITLE---SGPTVGAVVVVNSVGDVVDRATGLPWMTD
MAB_1477|M.abscessus_ATCC_1997 ARAGTLKGGVGSASVNVG---DGIVVGALVVANPVGLVINPATGRPWTAD
Mvan_3384|M.vanbaalenii_PYR-1 MNCYEFKGGNGTASRLVPYGRRTYTVAAFVQANFGSRAELTITGSHIGPQ
Mflv_3141|M.gilvum_PYR-GCK MNCYDFKGGNGTASRIVPYGSRTYTVAAFVQANFGARAELTIAGRHVGPE
MSMEG_2092|M.smegmatis_MC2_155 MVAHGYKGGIGTSSRVVG----DHTVGVLVQANHGARERLMIDGVPVG-R
TH_1833|M.thermoresistible__bu MIAHGYKGGIGTSSRVVG----DYTVGVLVQANHGARERLTIDGVPVG-R
. *** *::* : .*.... .* . *
Mb1368|M.bovis_AF2122/97 LVGEFALRAPPAEQIAALAQLSSPLGAFNTP----FNTTIGVIACDAALS
Rv1333|M.tuberculosis_H37Rv LVGEFALRAPPAEQIAALAQLSSPLGAFNTP----FNTTIGVIACDAALS
MMAR_4065|M.marinum_M LSGEFGLTRPPADQLDELARLPSPLDPQNAPQDRPLNTTIAVVATDAALS
MUL_3929|M.ulcerans_Agy99 LSGEFGLTRPPADQLDELARLPSPLDPQDAPQDRPLNTTIAVVATDAALS
MAV_1553|M.avium_104 LVEQFGLRPPPVEQIEAFAALPSPSNPLDNP----LNTVIAVVATDAALS
MLBr_01167|M.leprae_Br4923 LIDEFALRPPSPEQIAGFAQLKSPLSA--------LNTTIGVVATDATLS
MAB_1477|M.abscessus_ATCC_1997 ILPELS--APPAAEIEKLRDLPDKSVS--------LNTTIGVVATNAALS
Mvan_3384|M.vanbaalenii_PYR-1 LMDDNPLDGDWFA--RDLAAAPPPGAG----------SVIAVVATDAPLL
Mflv_3141|M.gilvum_PYR-GCK MLDDNPLDGDWFA--RDLDGAPP-GAG----------SVIAVIATDAPLL
MSMEG_2092|M.smegmatis_MC2_155 LLPPPPTP-------VIMPGQPPEGTG----------SIIVLVATDAPLI
TH_1833|M.thermoresistible__bu LLPEPPSP-------AAMPGRPPEGTG----------SIIVLVATDAPLI
: : : * ::* :*.*
Mb1368|M.bovis_AF2122/97 PAACRRIAIAAHDGLARTIRPAHTPLDGDTVFALATGAV---------AV
Rv1333|M.tuberculosis_H37Rv PAACRRIAIAAHDGLARTIRPAHTPLDGDTVFALATGAV---------AV
MMAR_4065|M.marinum_M PAGCQRVAIAAQDGLARTIRPAHTPLDGDTVFALATGAV---------QV
MUL_3929|M.ulcerans_Agy99 PAGCQRVAIAAQDGLARTIRPAHTPLDGDTVFALATGAV---------QV
MAV_1553|M.avium_104 AAACRRVAVAAHDGLARSIRPAHTPVDGDTVFVLATGAV---------EV
MLBr_01167|M.leprae_Br4923 PAACQRVAMAAQDGLARTIRPAHTALDGDTVFALATGAV---------EA
MAB_1477|M.abscessus_ATCC_1997 KAQCRRVAIAAHDGLARAIRPAHTPMDGDTLYVLATGTG---------EG
Mvan_3384|M.vanbaalenii_PYR-1 PGQCKALARRVPLGLARTG-TTGSHFSGDIFLAFSTAEVPDLASTFPLGP
Mflv_3141|M.gilvum_PYR-GCK PGQCRALARRVPLGLARTG-TTGSHFSGDIFLAFSTAEASGLASAFPLGP
MSMEG_2092|M.smegmatis_MC2_155 PTQCARLAQRAALGIARTG-GAGENGSGDIAFCFATGNG--FVGDFAAEP
TH_1833|M.thermoresistible__bu PTQCARLAQRSALGIARTG-GAGENGSGDMAFCFTTGNT--FAGDFAATA
* :* *:**: : .** ::*.
Mb1368|M.bovis_AF2122/97 PPEAGVPAALSPETQLVTAVGAAAADCLARAVLAGVLNAQPVAGIPTYR-
Rv1333|M.tuberculosis_H37Rv PPEAGVPAALSPETQLVTAVGAAAADCLARAVLAGVLNAQPVAGIPTYR-
MMAR_4065|M.marinum_M PPDPAIPAALSPETGLLTAVGAAAADCLAQAVLVGVIAAESVAGIPSYR-
MUL_3929|M.ulcerans_Agy99 PPDPAIPAALSPETGLLTAVGAAAADCLAQAVLVGVIAAESVAGIPSYR-
MAV_1553|M.avium_104 PPEADTPAAFSPETRLATEVGAAAADCLAHAVLGGVLAADSVAGIPSYR-
MLBr_01167|M.leprae_Br4923 TATADVPVAMSPETGLITEVGAAADDCLARAVLVAVLAAESVAGIPTYC-
MAB_1477|M.abscessus_ATCC_1997 DADP-----------LTAAVGIAAADCVERAVVRAVVGAASVAGIPAYR-
Mvan_3384|M.vanbaalenii_PYR-1 VGDDELGSITFLPWGRMDDLYAAVVQCVEEAVLNALVVNTDMVGRDGHRS
Mflv_3141|M.gilvum_PYR-GCK PGEDELGTISFLPWGRMDTVYAAVVQSVEEAVLNALVVNTDMVGRDGHRS
MSMEG_2092|M.smegmatis_MC2_155 -GPD-VAQINMLANRLIDGLFYATVEATEEAIINAMFAAETMEGPEGLVV
TH_1833|M.thermoresistible__bu -GPD-VVEVRMLANRLIDRLFYAAIEATEEAIVNALFAAETMEGPEGLVV
: *. :. .*:: .:. : *
Mb1368|M.bovis_AF2122/97 DMFPGAFGS------------
Rv1333|M.tuberculosis_H37Rv DMFPGAFGS------------
MMAR_4065|M.marinum_M DVLPGALQTSGTESR------
MUL_3929|M.ulcerans_Agy99 DVLPGALQTSGTESR------
MAV_1553|M.avium_104 DVLPGALGR------------
MLBr_01167|M.leprae_Br4923 GMFPGAFGTTIGGGNR-----
MAB_1477|M.abscessus_ATCC_1997 DVLPGAFS-------------
Mvan_3384|M.vanbaalenii_PYR-1 PRLPLDRLPALLSRRP-----
Mflv_3141|M.gilvum_PYR-GCK PRLPLDRLTELLGGRP-----
MSMEG_2092|M.smegmatis_MC2_155 HALPRDETAELVKRYRSMVVG
TH_1833|M.thermoresistible__bu TALPREQTAELLRRYRQLR--
:*