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VKRKRLDPARQAAFDVLRAVSERDAYANLALPALLRDRGITGRDAAFATELTYGTCRTRGLLDAVIAAAA GRPVDKIDPVLLDLLRLGSYQLLRTRVDDHAAVSTTVDQAGIEFDSSRAGFVNGVLRTIARRDEASWVEE LAPSATGDPIGHLAFVHAHPRWVAQAFADALGARAGELGALLASDDSRPEVHLVARPGALTAAELAEQVG GGVGRYSPYAVYLGEGDPGQLAAVREGTALVQDEGSQLVARALTLAPLVGPDGGRWLDLCAGPGGKTALL AALGAPEGVTVTAVEPAPRRADLVEQNTAGLPVEVVRVDGREPGLAPGFDRVLVDAPCTGLGALRRRPEA RWRRQPGDVPPLAKLQRELLASAIRLTRPGGVVLYATCSPHLAETAGVVADALRRHPVTALDTRELFEPA TDTGDGTSVQLWPHRHGTDAMFAAALRVN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2688 | - | - | 100% (449) | Fmu (Sun) domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4338 | - | 4e-05 | 27.20% (250) | HemK family modification methylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1442 | fmu | 0.0 | 80.09% (447) | Fmu protein (SUN protein) |
| M. gilvum PYR-GCK | Mflv_3729 | - | 0.0 | 89.73% (448) | Fmu (Sun) domain-containing protein |
| M. tuberculosis H37Rv | Rv1407 | fmu | 0.0 | 80.09% (447) | Fmu protein (SUN protein) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2810c | - | 1e-178 | 71.75% (446) | Fmu protein (SUN protein) |
| M. marinum M | MMAR_2216 | fmu | 0.0 | 79.87% (447) | Fmu protein |
| M. avium 104 | MAV_3371 | - | 0.0 | 83.03% (436) | Fmu protein |
| M. smegmatis MC2 155 | MSMEG_3065 | sun | 0.0 | 80.80% (448) | ribosomal RNA small subunit methyltransferase B |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1803 | fmu | 0.0 | 78.97% (447) | Fmu protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2688|M.vanbaalenii_PYR-1 -------------------------------MK------------RKRLD
Mflv_3729|M.gilvum_PYR-GCK ----------------------MTRPDKKRPPR------------RKRLD
MSMEG_3065|M.smegmatis_MC2_155 --------------------MKPNHPPRKRPPR------------RKPLD
Mb1442|M.bovis_AF2122/97 ------------------------MTPRSRGPR------------RRPLD
Rv1407|M.tuberculosis_H37Rv ------------------------MTPRSRGPR------------RRPLD
MMAR_2216|M.marinum_M MSPGQDKRQRNRPDRKPRRSEGTGVPNQRRGPR------------RRPLD
MUL_1803|M.ulcerans_Agy99 ------------------------MPNQRRGPR------------RRPLD
MAV_3371|M.avium_104 --------------------------------------------------
MAB_2810c|M.abscessus_ATCC_199 ---------------------MSTRPPRRRSNQDSRRSAGPAERARRKLD
Mvan_2688|M.vanbaalenii_PYR-1 PARQAAFDVLRAVSERDAYANLALPALLRDRGITGRDAAFATELTYGTCR
Mflv_3729|M.gilvum_PYR-GCK PARQAAFDVLRAVSERDSYANLALPALLRDRRITGRDAAFATELTYGTCR
MSMEG_3065|M.smegmatis_MC2_155 PARRVAFDVLRAVSERDAYANLALPAMLRERGIDGRDAAFATELTYGACR
Mb1442|M.bovis_AF2122/97 PARRAAFETLRAVSARDAYANLVLPALLAQRGIGGRDAAFATELTYGTCR
Rv1407|M.tuberculosis_H37Rv PARRAAFETLRAVSARDAYANLVLPALLAQRGIGGRDAAFATELTYGTCR
MMAR_2216|M.marinum_M PARGAAFNALRAVSERNAYANLVLPALLRERGITGRDAAFATELTYGACR
MUL_1803|M.ulcerans_Agy99 PARGAAFNALRAVSERNAYANLVLPALLRERGITGRDAALATELTYGACR
MAV_3371|M.avium_104 --------MLRAVSERDAYANLALPALLRERGITGRDAAFATELTYGTCR
MAB_2810c|M.abscessus_ATCC_199 PPRQAALDVLRAVSRQDAYANLALPALLRERGITGRDAAFATELTYGTCR
***** :::****.***:* :* * *****:*******:**
Mvan_2688|M.vanbaalenii_PYR-1 TRGLLDAVIAAAAGRPVDKIDPVLLDLLRLGSYQLLRTRVDDHAAVSTTV
Mflv_3729|M.gilvum_PYR-GCK AKGLLDAVIAAAAGRPVDHIDPILLDLLRLGAYQILRTRVDDHAAVSTTV
MSMEG_3065|M.smegmatis_MC2_155 SLGLLDAVIERAAGRPTDRIDPVLLDLLRLGTYQLLRTRVEPHAAVSTTV
Mb1442|M.bovis_AF2122/97 ARGLLDAVIGAAAERSPQAIDPVLLDLLRLGTYQLLRTRVDAHAAVSTTV
Rv1407|M.tuberculosis_H37Rv ARGLLDAVIGAAAERSPQAIDPVLLDLLRLGTYQLLRTRVDAHAAVSTTV
MMAR_2216|M.marinum_M ARGLLDAIIGAAAGRSPEAIDPVLLDLLRLGAYQLLRTRVDAHAAVSTTV
MUL_1803|M.ulcerans_Agy99 ARGLLDAIIGAAAGRSPEAIDPFLLDLLRLGAYQLLRTRVDAHAAVSTTV
MAV_3371|M.avium_104 TRGLLDAVIGAAAGRPPEAIDPVLLDLLRLGTYQLLRTRVDAHAAVSTTV
MAB_2810c|M.abscessus_ATCC_199 ARGLLDAVIEAAAGRTIDQVDEGLRDPLRLGAYQLLRTRVEPHAALSTTV
: *****:* ** *. : :* * * ****:**:*****: ***:****
Mvan_2688|M.vanbaalenii_PYR-1 DQAGIEFDSSRAGFVNGVLRTIARRDEASWVEELAPSATGDPIGHLAFVH
Mflv_3729|M.gilvum_PYR-GCK EQAGLEFDTARAGFVNGVLRTIARRDEADWVAELAPPAATDPVGHLAFVH
MSMEG_3065|M.smegmatis_MC2_155 EQAGIEFDSARAGFVNGVLRTISGRDEQAWIAELAPSAETDPVGHTAFVH
Mb1442|M.bovis_AF2122/97 EQAGIEFDSARAGFVNGVLRTIAGRDERSWVGELAPDAQNDPIGHAAFVH
Rv1407|M.tuberculosis_H37Rv EQAGIEFDSARAGFVNGVLRTIAGRDERSWVGELAPDAQNDPIGHAAFVH
MMAR_2216|M.marinum_M EQAGIEFDSARAGFVNAVLRTIADRDEQSWVQELAPDPRRDPVGHAAFVH
MUL_1803|M.ulcerans_Agy99 EQAGIEFDSARAGFVNAVLRTIADRDEQSWVQELAPDPRRDPVGHAAFVH
MAV_3371|M.avium_104 EQAAIEFDSARAGFVNGVLRRIAGRDERSWVQELAPDPARDPIGHAAFVH
MAB_2810c|M.abscessus_ATCC_199 DAVAVEFDQGRAGFVNAVLRTISRRDEADWVEELAP-PESDRIGRLAFAT
: ..:*** .******.*** *: *** *: **** . * :*: **.
Mvan_2688|M.vanbaalenii_PYR-1 AHPRWVAQAFADALGARAGELGALLASDDSRPEVHLVARPGALTAAELAE
Mflv_3729|M.gilvum_PYR-GCK AHPRWIGQAFADALGARAGELGALLASDDSRPEVHLAARPGMLTAAELAE
MSMEG_3065|M.smegmatis_MC2_155 AHPRWIAQAFTDALGAAAGELDALLASDDARPVVHLAARPTAITAEELAE
Mb1442|M.bovis_AF2122/97 AHPRWIAQAFADALGAAVGELEAVLASDDERPAVHLAARPGVLTAGELAR
Rv1407|M.tuberculosis_H37Rv AHPRWIAQAFADALGAAVGELEAVLASDDERPAVHLAARPGVLTAGELAR
MMAR_2216|M.marinum_M AHPRWIAQAFADALGPSAAELDAVLASDDERPQVHLAARPGVLTAAALAD
MUL_1803|M.ulcerans_Agy99 THPRWIAQAFADALGPSAAELDAVLASDDERPQVHLAARPGVLTAAALAD
MAV_3371|M.avium_104 AHPRWIAQAFADALGAAAAELDAVLASDDERPQVHLAARPGALTAAELAD
MAB_2810c|M.abscessus_ATCC_199 AHPRWIAQSFSDALGPAGSELAQVLASDDERPLVHLAARPGRIDAEALAE
:****:.*:*:****. .** :***** ** ***.*** : * **
Mvan_2688|M.vanbaalenii_PYR-1 QVGGGVGRYSPYAVYLGEGDPGQLAAVREGTALVQDEGSQLVARALTLAP
Mflv_3729|M.gilvum_PYR-GCK QTGGTVGRYSPYAVYLGDGDPGGVAAVRESRALVQDEGSQLVARALTLAP
MSMEG_3065|M.smegmatis_MC2_155 QAGGTVGRYSPYAVYLTGGDPGRVPAVRDGAAQVQDEGSQLVARALTLAE
Mb1442|M.bovis_AF2122/97 AVRGTVGRYSPFAVYLPRGDPGRLAPVRDGQALVQDEGSQLVARALTLAP
Rv1407|M.tuberculosis_H37Rv AVRGTVGRYSPFAVYLPRGDPGRLAPVRDGQALVQDEGSQLVARALTLAP
MMAR_2216|M.marinum_M EVRGTVGRYSPYAVYLLGGDPGLLAPVRDGQALVQDEGSQLVARALTLAP
MUL_1803|M.ulcerans_Agy99 EVRGTVGRYSPYAVYLLGGDPGLLAPVRDGQALVQDEGSQLVARALTLAP
MAV_3371|M.avium_104 AVGGTVGRHSPFAVYLAGGDPGRLAPVRDGLALVQDEGSQLVARALTLAP
MAB_2810c|M.abscessus_ATCC_199 AVGGTVGRYSPFAVYLPGGDPGRLEPVRDGLAQVQDEGSQLIARATALAP
. * ***:**:**** **** : .**:. * ********:*** :**
Mvan_2688|M.vanbaalenii_PYR-1 LVGPDGGRWLDLCAGPGGKTALLAALGAPEGV----TVTAVEPAPRRADL
Mflv_3729|M.gilvum_PYR-GCK VDGPDGGRWLDLCAGPGGKTALLAALGQPSGA----TVTAVEPAPRRAEL
MSMEG_3065|M.smegmatis_MC2_155 VDGTDEGRWLDLCSGPGGKTALLASIGAASGA----RVTAVEPAERRADL
Mb1442|M.bovis_AF2122/97 VDG-DTGRWLDLCAGPGGKTALLAGLGLQCAA----RVTAVEPSPHRADL
Rv1407|M.tuberculosis_H37Rv VDG-DTGRWLDLCAGPGGKTALLAGLGLQCAA----RVTAVEPSPHRADL
MMAR_2216|M.marinum_M VEG-DSGRWLDLCAGPGGKTALLAALGVATGA----RVTAVEPSSHRADL
MUL_1803|M.ulcerans_Agy99 VEG-DSGRWLDLCAGPGGKTALLAALGVATGA----RVTAVEPSSHRADL
MAV_3371|M.avium_104 VDG-DCGRWLDLCAGPGGKTALLASLGAQRFSGPQFRVTAVEPAPRRADL
MAB_2810c|M.abscessus_ATCC_199 LQG-ADEQWLDLCAGPGGKTALLGALAAQRGA----HVTAVEVAPHRAEL
: * :*****:*********..:. ***** : :**:*
Mvan_2688|M.vanbaalenii_PYR-1 VEQNTAGLPVEVVRVDGREPGLAPG-FDRVLVDAPCTGLGALRRRPEARW
Mflv_3729|M.gilvum_PYR-GCK VEQNTAGLPVDVVRVDGRESGLTPG-FDRVLVDAPCTGLGALRRRPEARW
MSMEG_3065|M.smegmatis_MC2_155 VEENTRGLGVEVHRVDGRESGLQPG-FDRVLVDAPCTGLGALRRRPESRW
Mb1442|M.bovis_AF2122/97 VAQNTRGLPVELLRVDGRHTDLDPG-FDRVLVDAPCTGLGALRRRPEARW
Rv1407|M.tuberculosis_H37Rv VAQNTRGLPVELLRVDGRHTDLDPG-FDRVLVDAPCTGLGALRRRPEARW
MMAR_2216|M.marinum_M VADNTGGLPVDLVRGDGRYTDLEPV-FDRVLVDAPCTGLGALRRRPEARW
MUL_1803|M.ulcerans_Agy99 VADNTGGLPVDLVRGDGRYTDLEPV-FDRVLVDAPCTGLGALRRRPEARW
MAV_3371|M.avium_104 VVENTRGLPVEVLRVDGRHTGLQPA-FDRVLVDAPCTGLGALRRRPEARW
MAB_2810c|M.abscessus_ATCC_199 VANATKSLPVTVVTADGRDSDLAAASFDRVLVDAPCTGLGALRRRPEARW
* : * .* * : *** ..* . *********************:**
Mvan_2688|M.vanbaalenii_PYR-1 RRQPGDVPPLAKLQRELLASAIRLTRPGGVVLYATCSPHLAETAGVVADA
Mflv_3729|M.gilvum_PYR-GCK RRQPGDVPALAKLQRELLAAAIRLTRPGGVVLYATCSPHLAETAGVVADA
MSMEG_3065|M.smegmatis_MC2_155 RRQPGDVAALTRLQRELLAAAIRLTRPGGVVLYATCSPHLAETVGVVADA
Mb1442|M.bovis_AF2122/97 RRQPADVAALAKLQRELLSAAIALTRPGGVVLYATCSPHLAETVGAVADA
Rv1407|M.tuberculosis_H37Rv RRQPADVAALAKLQRELLSAAIALTRPGGVVLYATCSPHLAETVGAVADA
MMAR_2216|M.marinum_M RRQPSDVPTLVKLQRELLAAAINLTRPGGVVLYATCSPHLAETVGVVADA
MUL_1803|M.ulcerans_Agy99 RRQPSDVPTLVKLQRELLAAAINLTRPGGVVFYATCSPHLAETVGVVADA
MAV_3371|M.avium_104 RRQPGDVPTLTKLQRELLGAAIALTRPGGVVLYATCSPHLAETVGVVADA
MAB_2810c|M.abscessus_ATCC_199 RRQPGDIPELVKLQRELLASAIQLTRPGGVIVYSTCSPHLAETVGVVSDA
****.*:. *.:******.:** *******:.*:*********.*.*:**
Mvan_2688|M.vanbaalenii_PYR-1 LRRHPVTALDTRELFEPATD-TGDGTSVQLWPHRHGTDAMFAAALRVN--
Mflv_3729|M.gilvum_PYR-GCK LRRQPVTALDTGELFSPATD-TGDGPSVQLWPHRHGTDAMFAAALRVDAA
MSMEG_3065|M.smegmatis_MC2_155 IRRHPVTAMDTRPLFAPVDD-LGAGPHVQLWPHRHGTDAMFAAALRVDPD
Mb1442|M.bovis_AF2122/97 LRRHPVHALDTRPLFEPVLAGLGEGPHVQLWPHRHGTDAMFAAALRRLT-
Rv1407|M.tuberculosis_H37Rv LRRHPVHALDTRPLFEPVIAGLGEGPHVQLWPHRHGTDAMFAAALRRLT-
MMAR_2216|M.marinum_M LRRHPVDALDTRALFEPITEGLGEGPYVQLWPHRHGTDAMFAAALRRRA-
MUL_1803|M.ulcerans_Agy99 LRRHPVDALDTRALFEPITEGLGEGPYVQLWPHRHGTDAMFAAALRRRA-
MAV_3371|M.avium_104 LRRHPVSALDARPLFEPVAD-LGDGPHVQLWPHRHGTDAMFAAALRREAG
MAB_2810c|M.abscessus_ATCC_199 VRRYAVSAEDARAVFPGVAG-LGDADAVQLWPHRHGTDAMFTALLRKHA-
:** .* * *: :* * . **************:* **
Mvan_2688|M.vanbaalenii_PYR-1 --
Mflv_3729|M.gilvum_PYR-GCK AR
MSMEG_3065|M.smegmatis_MC2_155 VR
Mb1442|M.bovis_AF2122/97 --
Rv1407|M.tuberculosis_H37Rv --
MMAR_2216|M.marinum_M --
MUL_1803|M.ulcerans_Agy99 --
MAV_3371|M.avium_104 --
MAB_2810c|M.abscessus_ATCC_199 --