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AAITMRNIVKKYGDGYPAVNDVSLDIADGEFVILVGPSGCGKSTLLRMIVGLEDITSGDMMIGDKRVNDM APRDRNLAMVFQNYALYPHLTVFENIAFPLRLAGKLSDEEIRQRVNEAAKTLELGEHLDRKPANLSGGQR QRVAMGRAIVREADAFLFDEPLSNLDAKLRGQMRTEILRLQRKLGVTTVYVTHDQTEAMTLGDRVAVLKK GLLQQVASPRELYDQPVNLFVAGFIGSPPMNFVPARVKGSEIELPFATIPLRDEWRGVVEDGKLYIAGIR PGAFEDAEFVDSDKASRGVTFDVTIDVTEWLGNEQYAFVPFEASAEISKQLAELASELDSEQLRHQICVE LDPLSRVRSGDRATLWLDAERIHLFDPHSGDNLTRATESTGRHAATTG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2541 | - | - | 100% (399) | ABC transporter-related protein |
| M. vanbaalenii PYR-1 | Mvan_4484 | - | e-106 | 53.35% (388) | ABC transporter-related protein |
| M. vanbaalenii PYR-1 | Mvan_2621 | - | 1e-78 | 45.10% (388) | ABC transporter-related protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1270 | sugC | 1e-111 | 55.13% (390) | sugar-transport ATP-binding protein ABC transporter SugC |
| M. gilvum PYR-GCK | Mflv_3854 | - | 0.0 | 91.69% (409) | ABC transporter related |
| M. tuberculosis H37Rv | Rv1238 | sugC | 1e-111 | 55.13% (390) | sugar-transport ATP-binding protein ABC transporter SugC |
| M. leprae Br4923 | MLBr_01089 | - | 1e-107 | 52.32% (388) | putative ABC-transport protein, ATP-binding component |
| M. abscessus ATCC 19977 | MAB_1375 | - | 1e-117 | 57.95% (390) | sugar ABC transporter, ATP-binding protein SugC |
| M. marinum M | MMAR_4203 | sugC | 1e-109 | 53.73% (389) | sugar-transport ATP-binding protein ABC transporter SugC |
| M. avium 104 | MAV_1377 | sugC | 1e-111 | 54.87% (390) | ABC transporter, ATP-binding protein SugC |
| M. smegmatis MC2 155 | MSMEG_5058 | - | 1e-108 | 54.71% (393) | ABC transporter, ATP-binding protein SugC |
| M. thermoresistible (build 8) | TH_4034 | - | 1e-106 | 53.83% (392) | PUTATIVE ABC transporter, ATP-binding protein SugC |
| M. ulcerans Agy99 | MUL_2252 | - | 4e-82 | 52.81% (320) | sugar-transport ATP-binding protein ABC transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2541|M.vanbaalenii_PYR-1 MAAITMRNIVKKYGDGYP----AVNDVSLDIADGEFVILVGPSGCGKSTL
Mflv_3854|M.gilvum_PYR-GCK MAAITMRNIVKKYGDGYP----AVNDVSLDIADGEFVILVGPSGCGKSTL
Mb1270|M.bovis_AF2122/97 MAEIVLDHVNKSYPDGHT----AVRDLNLTIADGEFLILVGPSGCGKTTT
Rv1238|M.tuberculosis_H37Rv MAEIVLDHVNKSYPDGHT----AVRDLNLTIADGEFLILVGPSGCGKTTT
MMAR_4203|M.marinum_M MAEIVLEHVNKSYPDGHT----AVRDLNITISDGEFLILVGPSGCGKTTT
MAV_1377|M.avium_104 MAEIVLDHVSKSYPDGAT----AVRDLNLTIADGEFLILVGPSGCGKTTT
MLBr_01089|M.leprae_Br4923 MAEIVLEHVNKNYPNGAT----AVHDLSITVADGEFLILIGPSGCGKTTT
MSMEG_5058|M.smegmatis_MC2_155 MAEIVLDRVTKSYPDGAGGVRAAVKEFSMTIADGEFIILVGPSGCGKSTT
TH_4034|M.thermoresistible__bu MAEIVLDKVTKSYPDGAGGVRHAVKDLSLTIADGEFIILVGPSGCGKSTT
MAB_1375|M.abscessus_ATCC_1997 MAEIVLNQVSKTYTDGSA----AVRDVSLNIADGEFIILVGPSGCGKSTT
MUL_2252|M.ulcerans_Agy99 MASVSFEGATRRYPGADR---PAVDSLDLVVDDGEFVVLVGPSGCGKTTS
** : : : * .. ** ...: : ****::*:*******:*
Mvan_2541|M.vanbaalenii_PYR-1 LRMIVGLEDITSGDMMIGDKRVNDMAPRDRNLAMVFQNYALYPHLTVFEN
Mflv_3854|M.gilvum_PYR-GCK LRMIVGLEDITSGDMMIGDKRVNDMAPRDRNLAMVFQNYALYPHLTVFEN
Mb1270|M.bovis_AF2122/97 LNMIAGLEDISSGELRIAGERVNEKAPKDRDIAMVFQSYALYPHMTVRQN
Rv1238|M.tuberculosis_H37Rv LNMIAGLEDISSGELRIAGERVNEKAPKDRDIAMVFQSYALYPHMTVRQN
MMAR_4203|M.marinum_M LNMIAGLEDISSGELRIGGERVNEKAPKDRDIAMVFQSYALYPHMTVRQN
MAV_1377|M.avium_104 LNMIAGLEDISSGELRIGGERVNEKAPKDRDIAMVFQSYALYPHMTVRQN
MLBr_01089|M.leprae_Br4923 LNMIAGLEDISSGELRIDGDRVNEKAPKDRDIAMVFQSYALYPHMTVRQN
MSMEG_5058|M.smegmatis_MC2_155 LNMIAGLEEITSGELRIGGERVNEKAPKDRDIAMVFQSYALYPHMTVRQN
TH_4034|M.thermoresistible__bu LNMIAGLEDITSGEIRIDGERVNEVAPKDRDIAMVFQSYALYPHMTVRQN
MAB_1375|M.abscessus_ATCC_1997 LNMIAGLEDISSGELTIAGERVNEKAPKDRDIAMVFQSYALYPHMTVRQN
MUL_2252|M.ulcerans_Agy99 LRMLAGLEKVDAGRIRIAERDVTNVDPKSRDVAMVFQNYALYPHMTVAQN
*.*:.***.: :* : * *.: *:.*::*****.******:** :*
Mvan_2541|M.vanbaalenii_PYR-1 IAFPLRLAGKLSDEEIRQRVNEAAKTLELGEHLDRKPANLSGGQRQRVAM
Mflv_3854|M.gilvum_PYR-GCK IAFPLRLAGKLSDDEIRQRVNDAATTLELGEHLDRKPANLSGGQRQRVAM
Mb1270|M.bovis_AF2122/97 IAFPLTLA-KMRKADIAQKVSETAKILDLTNLLDRKPSQLSGGQRQRVAM
Rv1238|M.tuberculosis_H37Rv IAFPLTLA-KMRKADIAQKVSETAKILDLTNLLDRKPSQLSGGQRQRVAM
MMAR_4203|M.marinum_M IAFPLTLA-KMKKAAIAQKVEETAKILDLTSFLDRKPSQLSGGQRQRVAM
MAV_1377|M.avium_104 IAFPLTLA-KMKKPEIAQKVAETAKILDLTDFLDRKPSQLSGGQRQRVAM
MLBr_01089|M.leprae_Br4923 IAFPLMLA-KVKKAEIAQKVSETAQILDLTDLLDRKPSQLSGGQRQRVAM
MSMEG_5058|M.smegmatis_MC2_155 IAFPLTLA-KVPKAEIAAKVEETAKILDLSELLDRKPGQLSGGQRQRVAM
TH_4034|M.thermoresistible__bu IAFPLTLA-KMKKADIARKVEETAKILDLTELLDRKPAQLSGGQRQRVAM
MAB_1375|M.abscessus_ATCC_1997 IAFPLTLA-KMSKDDINAKVAEAAKILDLTDYLDRKPANLSGGQRQRVAM
MUL_2252|M.ulcerans_Agy99 MGFALKVA-KTPKAEIRDRVLQAAKLLDLEAYLDRKPKDLSGGQRQRVAM
:.*.* :* * . * :* ::* *:* ***** :***********
Mvan_2541|M.vanbaalenii_PYR-1 GRAIVREADAFLFDEPLSNLDAKLRGQMRTEILRLQRKLGVTTVYVTHDQ
Mflv_3854|M.gilvum_PYR-GCK GRAIVREADAFLFDEPLSNLDAKLRGQMRTEILRLQRKLGVTTVYVTHDQ
Mb1270|M.bovis_AF2122/97 GRAIVRHPKAFLMDEPLSNLDAKLRVQMRGEIAQLQRRLGTTTVYVTHDQ
Rv1238|M.tuberculosis_H37Rv GRAIVRHPKAFLMDEPLSNLDAKLRVQMRGEIAQLQRRLGTTTVYVTHDQ
MMAR_4203|M.marinum_M GRAIVRHPKAFLMDEPLSNLDAKLRVQMRGEIARLQKRLGTTTVYVTHDQ
MAV_1377|M.avium_104 GRAIVRHPKAFLMDEPLSNLDAKLRVQMRGEIARLQKRLGTTTVYVTHDQ
MLBr_01089|M.leprae_Br4923 GRAIVRHPKAFLMDEPLSNLDAKLRVRTRGEIARLQRRLGATTVYVTHDQ
MSMEG_5058|M.smegmatis_MC2_155 GRAIVRSPKAFLMDEPLSNLDAKLRVQMRAEISRLQDRLGTTTVYVTHDQ
TH_4034|M.thermoresistible__bu GRAIVRQPKAFLMDEPLSNLDAKLRVQMRSEIARLQSRLRTTTVYVTHDQ
MAB_1375|M.abscessus_ATCC_1997 GRAIVRSPKAFLMDEPLSNLDAKLRVQMRTEIARLQKRLGTTTVYVTHDQ
MUL_2252|M.ulcerans_Agy99 GRAIVRRPQVFLMDEPLSNLDTKLRVQTRNQIAGLQRQLGTTTVYVTHDQ
****** ...**:********:*** : * :* ** :* .*********
Mvan_2541|M.vanbaalenii_PYR-1 TEAMTLGDRVAVLKKGLLQQVASPRELYDQPVNLFVAGFIGSPPMNFVPA
Mflv_3854|M.gilvum_PYR-GCK TEAMTLGDRVAVLKKGVLQQVASPRELYDQPVNLFVAGFIGSPPMNFVPA
Mb1270|M.bovis_AF2122/97 TEAMTLGDRVVVMYGGIAQQIGTPEELYERPANLFVAGFIGSPAMNFFPA
Rv1238|M.tuberculosis_H37Rv TEAMTLGDRVVVMYGGIAQQIGTPEELYERPANLFVAGFIGSPAMNFFPA
MMAR_4203|M.marinum_M TEAMTLGDRVVVMHAGAAQQIGTPQELYERPANLFVAGFIGSPAMNFFPA
MAV_1377|M.avium_104 TEAMTLGDRVVVMHSGVAQQIGTPDELYENPANLFVAGFIGSPAMNFFPA
MLBr_01089|M.leprae_Br4923 TEAMTLGDRVVVMRSGVVQQIGTPDELYERPVNLFVAGFIGSPVMNFFPA
MSMEG_5058|M.smegmatis_MC2_155 TEAMTLGDRVVVMLAGEVQQIGTPDELYSSPANLFVAGFIGSPAMNFFPA
TH_4034|M.thermoresistible__bu TEAMTLGDRVVVMLDGVAQQIGTPDELYTQPANLFVAGFIGSPGMNFFPA
MAB_1375|M.abscessus_ATCC_1997 TEAMTLGDRVVVLRAGKVQQVGAPQELYDTPANLFVAGFIGSPSMNFFPA
MUL_2252|M.ulcerans_Agy99 VEAMTMGDRVAVLCDGVLQQCAAPRELYRRPDNVFVAGFIGSPAMNMFIL
.****:****.*: * ** .:* *** * *:********* **:.
Mvan_2541|M.vanbaalenii_PYR-1 RVKGSEIELPFATIPLRDEWRGVVEDGK---LYIAGIRPGAFEDAEFVDS
Mflv_3854|M.gilvum_PYR-GCK RVTGNEIELPFATVPLRDEWRGSVEEGK---VYIAGIRPGAFEDAEFVDT
Mb1270|M.bovis_AF2122/97 RLTAIGLTLPFGEVTLAPEVQGVIAAHPKPENVIVGVRPEHIQDAALIDA
Rv1238|M.tuberculosis_H37Rv RLTAIGLTLPFGEVTLAPEVQGVIAAHPKPENVIVGVRPEHIQDAALIDA
MMAR_4203|M.marinum_M VLTPTGLTLPFGEVTLDPQVQQVIAQHPRPANIIVGIRPEQIQDAALIDA
MAV_1377|M.avium_104 TLTPIGLKVPFGEVMLTPEVQQVIAEHPEPDNVIVGARPEHLSDAALIDG
MLBr_01089|M.leprae_Br4923 KLTPNGLTLPLGELNLSRDVQAMIGQHPVPDRVIVGVRPEHLTDAKLIDA
MSMEG_5058|M.smegmatis_MC2_155 TRTDVGVRLPFGEVTLTPHMLDLLDKQARPENIIVGIRPEHIEDSALLDG
TH_4034|M.thermoresistible__bu SLTDAGVRLPFGEALLPPDVLDTVRRHEKTDNIIAGLRPEHLEDVSLLDT
MAB_1375|M.abscessus_ATCC_1997 TLTDVGVQLPFGEVTLDAGLYAGITARKPSGDVIVGIRPEQFEDAALVDT
MUL_2252|M.ulcerans_Agy99 PIVDSSVLLGDWLIQLPREVTVPA------PEVVVGVRPEHFEVGNLG--
: : * :.* ** : :
Mvan_2541|M.vanbaalenii_PYR-1 DKASRGVTFDVTIDVTEWLGNEQYAFVPFEASAEISKQLAELAS-ELDSE
Mflv_3854|M.gilvum_PYR-GCK DKASRGVTFDVEIDVTEWLGNEQYAFVPFEATTEISGQLAELAN-ELDSE
Mb1270|M.bovis_AF2122/97 YQRIRALTFQVKVNLVESLGADKYLYFTTESPAVHSVQLDELAEVEGESA
Rv1238|M.tuberculosis_H37Rv YQRIRALTFQVKVNLVESLGADKYLYFTTESPAVHSVQLDELAEVEGESA
MMAR_4203|M.marinum_M YQRIRALTFEVNTDLVESLGSDKYVYFSTAGCDVHSAQLDELAGLEGESE
MAV_1377|M.avium_104 YQRIRALTFEVKVDMVESLGADKYVYFSTAAWAAHSTQLDELA---AEAD
MLBr_01089|M.leprae_Br4923 HQHGTVLTFKVKVDLVESLGADKYIYFTTTGCDVYSAQLDELA---SELE
MSMEG_5058|M.smegmatis_MC2_155 YARIRALTFSVRADIVESLGADKYVHFTTEGAGAESAQLAELA---ADSG
TH_4034|M.thermoresistible__bu YARLGAVTFDVNVELVESLGAEKYVHFRAEGAGAHAAQLAQLA---AESG
MAB_1375|M.abscessus_ATCC_1997 YKRITGLTLTVNADVVESLGSDKYVHFTTEGGAAHSDELTELA---QESE
MUL_2252|M.ulcerans_Agy99 --------VEMEIDVVEELGADAYLYGRISNGGTMIDQS-----------
. : ::.* ** : * . :
Mvan_2541|M.vanbaalenii_PYR-1 QLRHQICVELDPLSRVRSGDRATLWLDAERIHLFDPHSGDNLTRAT----
Mflv_3854|M.gilvum_PYR-GCK QLRTQICVELDPLSRVRSGDKATLWLDSERLHLFDPHSGDNLTRVSHERP
Mb1270|M.bovis_AF2122/97 LHENQFVARVPAESKVAIGQSVELAFDTARLAVFDADSGANLTIPHRA--
Rv1238|M.tuberculosis_H37Rv LHENQFVARVPAESKVAIGQSVELAFDTARLAVFDADSGANLTIPHRA--
MMAR_4203|M.marinum_M VIENRFVARVSAESRATLGRPIELAFDTTRLTVFDADTGANLTNPIAAVQ
MAV_1377|M.avium_104 AHENQFVARVPAESKAAIGQTVELALDTTKLMVFDADSGVNLTVAPSDSP
MLBr_01089|M.leprae_Br4923 VRENQFVARVSAESKMAIGESIELAFGTAKIAVFDADSGVNLTVSAPTDA
MSMEG_5058|M.smegmatis_MC2_155 AGTNQFIARVSADSRVRTGEQIELAIDTTKLSIFDAATGLNLTRDITPTD
TH_4034|M.thermoresistible__bu AGENEFIARVSTESKAKKGQSLQLAFNPAKLLVFDADTGANLT--LPPSD
MAB_1375|M.abscessus_ATCC_1997 VAENEFVARLSAASKVAEGQPIELIIDTGKLVIFDAESGENLSLAATAE-
MUL_2252|M.ulcerans_Agy99 -----VVARADGSNPPERGSRVRLYPQPAQLHFFTVD-GRRIA-------
. .. . * * . :: .* * .::
Mvan_2541|M.vanbaalenii_PYR-1 ------ESTGRHAATTG
Mflv_3854|M.gilvum_PYR-GCK REQNPPESRGRHAATAG
Mb1270|M.bovis_AF2122/97 -----------------
Rv1238|M.tuberculosis_H37Rv -----------------
MMAR_4203|M.marinum_M -----------------
MAV_1377|M.avium_104 -----------------
MLBr_01089|M.leprae_Br4923 -----------------
MSMEG_5058|M.smegmatis_MC2_155 PTEAAGPDAG-------
TH_4034|M.thermoresistible__bu A----------------
MAB_1375|M.abscessus_ATCC_1997 -----------------
MUL_2252|M.ulcerans_Agy99 -----------------