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SINMFDVTEADDADTLARLHGRLTAAADADGLLDVAYRTIDSPVGSLLLAATPVGVVRVAFDVEIHDAVL ARLAETLSPRILYAPHRLDAVARQLDEYFAKQRTTFDVPVDLRLADGFRRSVVEHLRDIGYGRRESYAQV AAAIGSPRAVRAVGTACAHNPLPVVIPCHRVVRSDGTIGQYVGGPHAKTALLDLEAVRE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2495 | - | - | 100% (200) | methylated-DNA--protein-cysteine methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_4323 | - | 5e-21 | 36.42% (162) | methylated-DNA--protein-cysteine methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1349c | ogt | 1e-25 | 40.00% (170) | methylated-DNA--protein-cysteine methyltransferase |
| M. gilvum PYR-GCK | Mflv_3909 | - | 3e-83 | 79.17% (192) | methylated-DNA--protein-cysteine methyltransferase |
| M. tuberculosis H37Rv | Rv1316c | ogt | 1e-25 | 40.00% (170) | methylated-DNA--protein-cysteine methyltransferase |
| M. leprae Br4923 | MLBr_01151 | ogt | 3e-21 | 36.97% (165) | putative methylated-DNA-protein-cysteine methyltransferase |
| M. abscessus ATCC 19977 | MAB_3012 | - | 2e-15 | 31.36% (169) | methylated-DNA--protein-cysteine methyltransferase |
| M. marinum M | MMAR_4082 | ogt | 2e-22 | 40.24% (169) | methylated-DNA--protein-cysteine methyltransferase Ogt |
| M. avium 104 | MAV_1536 | - | 3e-24 | 38.51% (161) | methylated-DNA--protein-cysteine methyltransferase |
| M. smegmatis MC2 155 | MSMEG_4316 | - | 6e-60 | 63.74% (182) | methylated-DNA--protein-cysteine methyltransferase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3946 | ogt | 4e-23 | 41.42% (169) | methylated-DNA--protein-cysteine methyltransferase Ogt |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2495|M.vanbaalenii_PYR-1 -----MSINMFDVTEADDADTLARLHGRLTAAADADGLLDVAYRTIDSPV
Mflv_3909|M.gilvum_PYR-GCK MIDIAFDVPGFDIPTSDEDDTLRRLHDRLAEAAEPAGVLDVAYRTIDSPV
MSMEG_4316|M.smegmatis_MC2_155 -----------------MNDTLIRLHRRLEQSATTDGLLDVAYTTVDTPV
MMAR_4082|M.marinum_M ---------------------------------------MTHYRIVDSPI
MUL_3946|M.ulcerans_Agy99 ---------------------------------------MTHYRIIDSPI
MAV_1536|M.avium_104 ---------------------------------------MIEYRTVDSPI
MLBr_01151|M.leprae_Br4923 ---------------------------------------MIHCRSMDSPI
Mb1349c|M.bovis_AF2122/97 ---------------------------------------MIHYRTIDSPI
Rv1316c|M.tuberculosis_H37Rv ---------------------------------------MIHYRTIDSPI
MAB_3012|M.abscessus_ATCC_1997 -------------------------------------MSTVGHCFFDTAI
.*:.:
Mvan_2495|M.vanbaalenii_PYR-1 GSLLLAATPVGVVRVAFDVEIHDAVLARLAETLSPRILYAPHRLDAVARQ
Mflv_3909|M.gilvum_PYR-GCK GTLLLAATPAGLVRVAFDVEGHEVVLARLAESVSPRILRAPDRLDDVARQ
MSMEG_4316|M.smegmatis_MC2_155 GPLLLAATEIGLVRVAFATEDHDAVLDTLAQRLSPRILRAPQRLADAARQ
MMAR_4082|M.marinum_M GPLTLAGHDGVLTNLRMVDQTYEPSRVGWEV--------DDEAFADAVSQ
MUL_3946|M.ulcerans_Agy99 GPLTLAGHDGVLTNLRMVDQTYEPSRVGWEV--------DDEAFADAVSQ
MAV_1536|M.avium_104 GLLTLAGRDPVLTNLRMVDQTYEPSRTGWTE--------NPRAFAGAVEQ
MLBr_01151|M.leprae_Br4923 GPLILAGHGSVLTNLQMVDQTYEPSRVGWLP--------ENGAFAEAVSQ
Mb1349c|M.bovis_AF2122/97 GPLTLAGHGSVLTNLRMLEQTYEPSRTHWTP--------DPGAFSGAVDQ
Rv1316c|M.tuberculosis_H37Rv GPLTLAGHGSVLTNLRMLEQTYEPSRTHWTP--------DPGAFSGAVDQ
MAB_3012|M.abscessus_ATCC_1997 GSCAIAWSDRGIVALQLPERDDAATLARIRRPAG-SELAPPDFVAQAIDG
* :* :. : : . . .
Mvan_2495|M.vanbaalenii_PYR-1 LDEYFAKQRTTFDVP-VDLRLADGFRRSVVEHLRDIGYGRRESYAQVAAA
Mflv_3909|M.gilvum_PYR-GCK LDEYFAKRRTTFDVA-VDLTLARGFRRNVVEHLRHIGYGRRASYADVAAA
MSMEG_4316|M.smegmatis_MC2_155 IDEYFAGARTQFDVA-LDHSLSHGFRQLVQRRLSQIPYGHTMSYKGVAEI
MMAR_4082|M.marinum_M LDAYFAGERFDFDLA-LDLRGTE-FQRRVWRALLTIPYGETRSYGEIAER
MUL_3946|M.ulcerans_Agy99 LDAYFAGERFDFDLA-LDLRGTE-FQRRVWQALLTIPYGETRSYGEIAER
MAV_1536|M.avium_104 LGAYFAGELTEFDIE-LDLRGSE-FQRRVWRALQTIPYGETRSYGEIAEQ
MLBr_01151|M.leprae_Br4923 LDAYFAGELTEFAIE-LDLCGTE-FQQRVWQALLTIPYGETRSYGEIAEQ
Mb1349c|M.bovis_AF2122/97 LNAYFAGELTEFDVE-LDLRGTD-FQQRVWKALLTIPYGETRSYGEIADQ
Rv1316c|M.tuberculosis_H37Rv LNAYFAGELTEFDVE-LDLRGTD-FQQRVWKALLTIPYGETRSYGEIADQ
MAB_3012|M.abscessus_ATCC_1997 IRRVLAGDDDDLQWARLDLDGTTDFDREVYAATRAIGPGRTRSYGEVAAS
: :* : :* : * : * * *. ** :*
Mvan_2495|M.vanbaalenii_PYR-1 IGSPRAVRAVGTACAHNPLPVVIPCHRVVRSDGTIGQY--VGGPHAKTAL
Mflv_3909|M.gilvum_PYR-GCK VGSPRAVRAVGSACAHNPLPVVIPCHRVVRSDGTSGQY--IGGPEAKTAL
MSMEG_4316|M.smegmatis_MC2_155 VGNPNAVRAVGSACSTNPLPVVVPCHRVLRSDGSLGGY--IGGLDAKTAL
MMAR_4082|M.marinum_M IGARGAARAVGLANGRNPVAVIVPCHRVIGASGGLTGY--GGGLDRKQAL
MUL_3946|M.ulcerans_Agy99 IGARGAARAVGLANGRNPVAVVVPCHRVIGASGGLTGY--GGGLDRKQAL
MAV_1536|M.avium_104 IGAPGAARAVGLANGHNPIAIVVPCHRVIGASGKLTGY--GGGLDRKQTL
MLBr_01151|M.leprae_Br4923 VGAPGAARAVGLANSRNPIAIIVPCHRVIGASGQLIGY--GGGLNRKLTL
Mb1349c|M.bovis_AF2122/97 IGAPGAARAVGLANGHNPIAIIVPCHRVIGASGKLTGY--GGGINRKRAL
Rv1316c|M.tuberculosis_H37Rv IGAPGAARAVGLANGHNPIAIIVPCHRVIGASGKLTGY--GGGINRKRAL
MAB_3012|M.abscessus_ATCC_1997 VGEPGAAQAVGQSLGRNPIPLLVPCHRVLAADRSLHGFSAYGGVVTKREL
:* *.:*** : . **:.:::*****: :. : ** * *
Mvan_2495|M.vanbaalenii_PYR-1 LDLEAVRE---------------
Mflv_3909|M.gilvum_PYR-GCK LQLESSSG---------------
MSMEG_4316|M.smegmatis_MC2_155 LELERAA----------------
MMAR_4082|M.marinum_M LELERACVPADLTVRADLTLFDC
MUL_3946|M.ulcerans_Agy99 LELERACVPADLTVRADLTLFDC
MAV_1536|M.avium_104 LALERRHSP------ASLTLFD-
MLBr_01151|M.leprae_Br4923 LELEKHQVL------TSLTLFD-
Mb1349c|M.bovis_AF2122/97 LELEKSRAP------ADLTLFD-
Rv1316c|M.tuberculosis_H37Rv LELEKSRAP------ADLTLFD-
MAB_3012|M.abscessus_ATCC_1997 LRLEHTPGFD------DPTLF--
* **