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VGKDEGLSTPAVVIAAPASGSGKTTVATGLMGALRLAGHRVAPFKVGPDFIDPGYHALATARPGRNLDPV LVGESLIGPLYRHGSDDADIAVVEGVMGLFDGRISDAAVGPAQGSTAHVASLLGAPVVLVVDARGQSHSV AALLHGFATFDSSVRLAGVILNRVGSARHEQVLRQACEQAGAVVLGSIPRADELAVPSRHLGLVTAVEHG RRATAAVQAMTELVARHVDLAAVASVASSRVDDAPWTPPPRTSPARVTVALAAGRAFSFGYAEHRELLCA SGADVVEFDPLCDPLPPDAAALVLPGGFPEEFGTELSANEVVREQIRALAAGGAPVQAECAGLTYLVDDL DGHPMCGVLSGSASFTESLTLGYRDAVAVADSPLHNIGDRVVGHEFHRTTVHFVDARQPAWRYSGRGAKM VEDGAVLGGVHAGYLHTHPAAHPRAIARFVAAAATTRLAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2304 | - | - | 100% (460) | cobyrinic acid a,c-diamide synthase |
| M. vanbaalenii PYR-1 | Mvan_5521 | - | 3e-05 | 31.74% (167) | glutamine amidotransferase |
| M. vanbaalenii PYR-1 | Mvan_0700 | - | 4e-05 | 22.57% (257) | phosphate acetyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2873c | cobB | 0.0 | 72.26% (447) | cobyrinic acid a,c-diamide synthase |
| M. gilvum PYR-GCK | Mflv_4048 | - | 0.0 | 83.26% (454) | cobyrinic acid a,c-diamide synthase |
| M. tuberculosis H37Rv | Rv2848c | cobB | 0.0 | 72.26% (447) | cobyrinic acid a,c-diamide synthase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3155c | - | 1e-156 | 63.54% (458) | cobyrinic acid A,C-diamide synthase (CobB) |
| M. marinum M | MMAR_1885 | cobB | 0.0 | 72.00% (450) | cobyrinic acid a,C-diamide synthase CobB |
| M. avium 104 | MAV_3704 | cobB | 0.0 | 71.33% (457) | cobyrinic acid a,c-diamide synthase |
| M. smegmatis MC2 155 | MSMEG_2617 | cobB | 0.0 | 75.77% (454) | cobyrinic acid a,c-diamide synthase |
| M. thermoresistible (build 8) | TH_1982 | cobB | 1e-129 | 69.76% (334) | PROBABLE COBYRINIC ACID A,C-DIAMIDE SYNTHASE COBB |
| M. ulcerans Agy99 | MUL_2113 | cobB | 0.0 | 71.78% (450) | cobyrinic acid a,c-diamide synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2873c|M.bovis_AF2122/97 ------MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDF
Rv2848c|M.tuberculosis_H37Rv ------MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDF
MMAR_1885|M.marinum_M -----MNSIPGVVIAAPASGSGKTTVATGLIGALRQAGRRVAPFKVGPDF
MUL_2113|M.ulcerans_Agy99 -----MNSIPGVVIAAPASGSGKTTVATGLIGALRQAGRRVAPFKVGPDF
MAV_3704|M.avium_104 -----MVNVPAVVVAAPASGSGKTTVATGLIGALRRAGRRVAAFKVGPDF
Mvan_2304|M.vanbaalenii_PYR-1 MGKDEGLSTPAVVIAAPASGSGKTTVATGLMGALRLAGHRVAPFKVGPDF
Mflv_4048|M.gilvum_PYR-GCK ------MSTPAVVIAAPSSGSGKTTVATGLMGALRRAGHRVAPFKVGPDF
MSMEG_2617|M.smegmatis_MC2_155 ----MVGTTPAVVIAAPASGSGKTTVSTGLIGALRAAGHTVAPFKVGPDF
TH_1982|M.thermoresistible__bu --------------------------------------------------
MAB_3155c|M.abscessus_ATCC_199 -----------MVIAAPASGSGKTTVATGLMGALRHAGHRVAPFKVGPDY
Mb2873c|M.bovis_AF2122/97 IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLF
Rv2848c|M.tuberculosis_H37Rv IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLF
MMAR_1885|M.marinum_M IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGAQGADIAVVEGVMGLF
MUL_2113|M.ulcerans_Agy99 IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGAQGADIAVVEGVMGLF
MAV_3704|M.avium_104 IDPGYHGLAAGRPGRNLDPVLVGENLIGPLYAHGAAGADIAVVEGVMGLF
Mvan_2304|M.vanbaalenii_PYR-1 IDPGYHALATARPGRNLDPVLVGESLIGPLYRHGSDDADIAVVEGVMGLF
Mflv_4048|M.gilvum_PYR-GCK IDPGYHALATGRPGRNLDPVLVGEPLIGPLYRHGSDDADIAIVEGVMGLF
MSMEG_2617|M.smegmatis_MC2_155 IDPGYHAVAAGRPGRNLDPVLVGEDLIGPLYAHGSAGADIAVVEGVMGLF
TH_1982|M.thermoresistible__bu --------------------------------------------------
MAB_3155c|M.abscessus_ATCC_199 IDPGYHALATGRPGRNLDSVLVGDDLIGPLFRHGSRNADIAVVEGVMGLF
Mb2873c|M.bovis_AF2122/97 DGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTF
Rv2848c|M.tuberculosis_H37Rv DGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTF
MMAR_1885|M.marinum_M DGRIEHAVAGPATGSSAHVANLLGTPVILVVDARGQSHSIAALLHGFSTF
MUL_2113|M.ulcerans_Agy99 DGRIEHAVAGPATGSSAHVANLLGTPVILVVDARGQSHSIAALLHGFSTF
MAV_3704|M.avium_104 DGRIGPSGASPASGSTAHVAALLGAPVVLVVDARGQSQSIAALLHGFSTF
Mvan_2304|M.vanbaalenii_PYR-1 DGRISDAAVGPAQGSTAHVASLLGAPVVLVVDARGQSHSVAALLHGFATF
Mflv_4048|M.gilvum_PYR-GCK DGRISDGGAGPARGSTAHVAGLLGAPVVLVVDARGQSHSVAALLHGFATF
MSMEG_2617|M.smegmatis_MC2_155 DGRICDQMTGTPQGSAAQVASLLGAPVILVVDARGQSQSIAALLHGFTTF
TH_1982|M.thermoresistible__bu --------------------------VVLVVDARGQSHSIAALLHGFVTF
MAB_3155c|M.abscessus_ATCC_199 DGRVG-----DAKGSTAEIAALLGAPVVLVVDAKGYSQSLSALLHGFVAH
*:*****:* *:*::****** :.
Mb2873c|M.bovis_AF2122/97 DTAT--RIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPT
Rv2848c|M.tuberculosis_H37Rv DTAT--RIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPT
MMAR_1885|M.marinum_M DSKT--RIAGVILNRVGSARHEHVLRQACEQAGVPVVGAIPRSAELELPT
MUL_2113|M.ulcerans_Agy99 DSKT--RIAGVILNRVGSARHEHVLRQACEQAGVPVVGAIPRSAELELPT
MAV_3704|M.avium_104 DAAT--RVAGVILNRVGSARHEQVLRQACEQAGVPVLGAIPRSAELELPT
Mvan_2304|M.vanbaalenii_PYR-1 DSSV--RLAGVILNRVGSARHEQVLRQACEQAGAVVLGSIPRADELAVPS
Mflv_4048|M.gilvum_PYR-GCK DQTV--RLAGVILNRVGSSRHDEVLRQACDHAGVAVLGSIPRADELAVPS
MSMEG_2617|M.smegmatis_MC2_155 DSAV--HVAGVILNRVGSPRHEAVLRQACEHAGVAVLGAIPRADELSVPS
TH_1982|M.thermoresistible__bu DPAT--RLAGVILNRVGSARHEQALRTACDQAGVPVLGAVPRTDELAVPS
MAB_3155c|M.abscessus_ATCC_199 AAEAGIRIAGVILNRVGSARHRDILTAAADRAGLRVFGALPRTDELSVPS
. ::**********.** * *.::** *.*::**: ** :*:
Mb2873c|M.bovis_AF2122/97 RYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDP
Rv2848c|M.tuberculosis_H37Rv RYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDP
MMAR_1885|M.marinum_M RYLGLVTAVEYGRRARLAVEAMTALIARHVDVEAVLAAAGSSVGDAPWDP
MUL_2113|M.ulcerans_Agy99 RYLGLVTAVEYGRRARLAVEAMTALIARHVDVEAVLAAAGSSVGDAPWDP
MAV_3704|M.avium_104 RYLGLVTAVEYGRRARLAVEAMTALVARHLDLAAVAAVAAARPVATPWDP
Mvan_2304|M.vanbaalenii_PYR-1 RHLGLVTAVEHGRRATAAVQAMTELVARHVDLAAVASVASSRVDDAPWTP
Mflv_4048|M.gilvum_PYR-GCK RHLGLVTAEEHGRHATAAVAAMTELVARHVDLAAVTAVAGGDVADAPWTP
MSMEG_2617|M.smegmatis_MC2_155 RHLGLITAVEHGRQARDAVAAMTELVGRHVDLAAVMACASARVSAQPWSP
TH_1982|M.thermoresistible__bu RHLGLITAVEHGWHARAAVAAMTDLVGRHVDLAAVVAIAGARVTAEPWTP
MAB_3155c|M.abscessus_ATCC_199 RHLGLVTAVEHGQAALGAISAMAQLVATHVNVGAIAAAAHSDVTSPIWEP
*:***:** *:* * *: **: ::. *::: *: : * . * *
Mb2873c|M.bovis_AF2122/97 VIAVG---NTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLS
Rv2848c|M.tuberculosis_H37Rv VIAVG---NTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLS
MMAR_1885|M.marinum_M VTAIG---GAPAGHATIAMAAGKAFSFAYAEHAELLRAAGADVVEFDPLG
MUL_2113|M.ulcerans_Agy99 VTAIG---GAPAGHATIAMAAGKAFSFAYAEHAELLRAAGADVVEFDPLG
MAV_3704|M.avium_104 AAAVGDPGGRGGERATVAVATGKAFSFGYAEHAELLAAAGARVAEFDPLV
Mvan_2304|M.vanbaalenii_PYR-1 ------PPRTSPARVTVALAAGRAFSFGYAEHRELLCASGADVVEFDPLC
Mflv_4048|M.gilvum_PYR-GCK ------AQFAAGPTATVALAAGKAFTFGYAEHREILCAAGADVVTFDPLC
MSMEG_2617|M.smegmatis_MC2_155 CVETS-FPVADVAGVTVALASGKAFSFGYAEHAELLRGTGATVAEFDPLV
TH_1982|M.thermoresistible__bu --HQV-APTG--AGARVALAAGKAFSFGYPEYAELLRATGAEVVEFDPLT
MAB_3155c|M.abscessus_ATCC_199 AEAVG---APTDREPVVALAAGQAFTFGYAEHRELLAAAGALVAEFDPRS
:*:*:*:**:*.*.*: *:* .:** *. ***
Mb2873c|M.bovis_AF2122/97 ETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAG
Rv2848c|M.tuberculosis_H37Rv ETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAG
MMAR_1885|M.marinum_M EPLPADSTGVLLPGGFPEQFTAELSANDLVRRQIKDLAHAGAPLHAECAG
MUL_2113|M.ulcerans_Agy99 EPLPADSTGVLLPGGFPEQFTAELSANDLVRRQIKDLAHAGAPLHAECAG
MAV_3704|M.avium_104 DALPDGTNALLLPGGFPEQFTAELSANEVVRRQINELAAAGAPVHAECAG
Mvan_2304|M.vanbaalenii_PYR-1 DPLPPDAAALVLPGGFPEEFGTELSANEVVREQIRALAAGGAPVQAECAG
Mflv_4048|M.gilvum_PYR-GCK DPLPAHTSALVLPGGFPEEFVTELSANEPVRSQIRALAAAGAPIHAECAG
MSMEG_2617|M.smegmatis_MC2_155 DPLPDGADALVLPGGFPEQFTAELSANDLVRQQISELARRGAPIHAECAG
TH_1982|M.thermoresistible__bu DELPERTAALVLPGGFPEQFTTELAANTAAREQIRAAAAAGIPIHAECAG
MAB_3155c|M.abscessus_ATCC_199 DSLPAETAALVIPGGFPEQFATDLSANATLRQQVGEMVG---PIHAECAG
: ** : .:::******:* ::*:** * *: . *::*****
Mb2873c|M.bovis_AF2122/97 LLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVV
Rv2848c|M.tuberculosis_H37Rv LLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVV
MMAR_1885|M.marinum_M LIYLASELDGYPMCDVLAGSARFTPHLTLGYRDAVAVADSALYAAGHRVV
MUL_2113|M.ulcerans_Agy99 LIYLASELDGYPMCDVLAGSARFTPHLTLGYRDAVAVADSALYAAGHRVV
MAV_3704|M.avium_104 LLYLVSELDGHPMCGVLAGQARFTPQLTLAYRDAVAVVDSPLYAAGQRAV
Mvan_2304|M.vanbaalenii_PYR-1 LTYLVDDLDGHPMCGVLSGSASFTESLTLGYRDAVAVADSPLHNIGDRVV
Mflv_4048|M.gilvum_PYR-GCK LTYLVDELDGHPMCGVLAGSASFTPSLTLGYRDAVAVAESSLHAVGERVT
MSMEG_2617|M.smegmatis_MC2_155 LTYLVDDLDGAPMCGVLRGSAKFTERLTLGYRDAVAVVDSSMHAAGERVV
TH_1982|M.thermoresistible__bu LLYLLDELDGHPMCGVLAGSARFTERLVLGYRDAVAVTDSPLHRAGERVV
MAB_3155c|M.abscessus_ATCC_199 LTYLCRDLDGVPMCGVLDARARFTDSLTLGYREAVALTGSVLFEEGERLS
* ** :*** ***.*: . * ** * *.**:***:. * :. *.*
Mb2873c|M.bovis_AF2122/97 GHEFHRTAVTFADSYQP-AWVYQGQDVDDVRDGAVHSG-VHASYLHTHPA
Rv2848c|M.tuberculosis_H37Rv GHEFHRTAVTFADSYQP-AWVYQGQDVDDVRDGAVHSG-VHASYLHTHPA
MMAR_1885|M.marinum_M GHEFHRTTVTFSDRYEP-AWVYRGNDAAAVRDGVVHAG-VHASYLHTHPA
MUL_2113|M.ulcerans_Agy99 GHEFHRTTVTFSDRYEP-AWVYRGNDAAAVRDGVVHAG-VHVSYLHTHPA
MAV_3704|M.avium_104 GHEFHRTTVTFSDDYLP-AWMYRTQ-ESGHRDGAVRAG-VHASYLHTHPA
Mvan_2304|M.vanbaalenii_PYR-1 GHEFHRTTVHFVDARQP-AWRYSGRGAKMVEDGAVLGG-VHAGYLHTHPA
Mflv_4048|M.gilvum_PYR-GCK GHEFHRTAVQFASDRQA-AWQYRGRGGAAVEDGAVLGG-VHAGYLHTHAA
MSMEG_2617|M.smegmatis_MC2_155 GHEFHRTTVTFDDDLPP-AWAFAGRGGAPARDGAVLRG-VHAGYLHTHPA
TH_1982|M.thermoresistible__bu GHEFHRTAVTFAERYPP-VWAFRGADGSAGHDGAVHRG-VQAGYLHVHPA
MAB_3155c|M.abscessus_ATCC_199 GHEFHRTTVDYPEDGAPRAWAWRTADGVRREGTVVGEGRIHASYLHTHPA
*******:* : . . .* : .. .* * ::..***.*.*
Mb2873c|M.bovis_AF2122/97 ATPGAVARFV--AHAACNTPRA--------
Rv2848c|M.tuberculosis_H37Rv ATPGAVARFV--AHAACNTPRA--------
MMAR_1885|M.marinum_M STPDAVARFV--AHAARAGHGI--------
MUL_2113|M.ulcerans_Agy99 STPDAVARFV--AHAARAGHGI--------
MAV_3704|M.avium_104 AAPAAVARFVGCALAARADPGRTRAHPGNH
Mvan_2304|M.vanbaalenii_PYR-1 AHPRAIARFVAAAATTRLAG----------
Mflv_4048|M.gilvum_PYR-GCK AHPQAIARFVAAAATTKLAG----------
MSMEG_2617|M.smegmatis_MC2_155 AHPQAIARFVASAVPTN-------------
TH_1982|M.thermoresistible__bu AHPHAVSRFVAAGTAGRA------------
MAB_3155c|M.abscessus_ATCC_199 AHPSATARFVARAAATGLSNDARSG-----
: * * :*** . .