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RVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLI GPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGF STFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPTRYLGLVTAVEYGRRARLAV QAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAE VVEFDPLSETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHP MCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDG AVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2848c | cobB | - | 100% (457) | cobyrinic acid a,c-diamide synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2873c | cobB | 0.0 | 100.00% (457) | cobyrinic acid a,c-diamide synthase |
| M. gilvum PYR-GCK | Mflv_4048 | - | 0.0 | 72.77% (448) | cobyrinic acid a,c-diamide synthase |
| M. leprae Br4923 | MLBr_02327 | - | 3e-05 | 26.74% (172) | hypothetical protein MLBr_02327 |
| M. abscessus ATCC 19977 | MAB_3155c | - | 1e-151 | 61.20% (451) | cobyrinic acid A,C-diamide synthase (CobB) |
| M. marinum M | MMAR_1885 | cobB | 0.0 | 79.29% (449) | cobyrinic acid a,C-diamide synthase CobB |
| M. avium 104 | MAV_3704 | cobB | 0.0 | 79.03% (453) | cobyrinic acid a,c-diamide synthase |
| M. smegmatis MC2 155 | MSMEG_2617 | cobB | 0.0 | 71.88% (448) | cobyrinic acid a,c-diamide synthase |
| M. thermoresistible (build 8) | TH_1982 | cobB | 1e-129 | 70.30% (330) | PROBABLE COBYRINIC ACID A,C-DIAMIDE SYNTHASE COBB |
| M. ulcerans Agy99 | MUL_2113 | cobB | 0.0 | 79.06% (449) | cobyrinic acid a,c-diamide synthase |
| M. vanbaalenii PYR-1 | Mvan_2304 | - | 0.0 | 72.26% (447) | cobyrinic acid a,c-diamide synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2848c|M.tuberculosis_H37Rv ------MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDF
Mb2873c|M.bovis_AF2122/97 ------MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDF
MMAR_1885|M.marinum_M -----MNSIPGVVIAAPASGSGKTTVATGLIGALRQAGRRVAPFKVGPDF
MUL_2113|M.ulcerans_Agy99 -----MNSIPGVVIAAPASGSGKTTVATGLIGALRQAGRRVAPFKVGPDF
MAV_3704|M.avium_104 -----MVNVPAVVVAAPASGSGKTTVATGLIGALRRAGRRVAAFKVGPDF
MSMEG_2617|M.smegmatis_MC2_155 ----MVGTTPAVVIAAPASGSGKTTVSTGLIGALRAAGHTVAPFKVGPDF
TH_1982|M.thermoresistible__bu --------------------------------------------------
Mflv_4048|M.gilvum_PYR-GCK ------MSTPAVVIAAPSSGSGKTTVATGLMGALRRAGHRVAPFKVGPDF
Mvan_2304|M.vanbaalenii_PYR-1 MGKDEGLSTPAVVIAAPASGSGKTTVATGLMGALRLAGHRVAPFKVGPDF
MAB_3155c|M.abscessus_ATCC_199 -----------MVIAAPASGSGKTTVATGLMGALRHAGHRVAPFKVGPDY
MLBr_02327|M.leprae_Br4923 -------------------------------------------MRIG---
Rv2848c|M.tuberculosis_H37Rv IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLF
Mb2873c|M.bovis_AF2122/97 IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLF
MMAR_1885|M.marinum_M IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGAQGADIAVVEGVMGLF
MUL_2113|M.ulcerans_Agy99 IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGAQGADIAVVEGVMGLF
MAV_3704|M.avium_104 IDPGYHGLAAGRPGRNLDPVLVGENLIGPLYAHGAAGADIAVVEGVMGLF
MSMEG_2617|M.smegmatis_MC2_155 IDPGYHAVAAGRPGRNLDPVLVGEDLIGPLYAHGSAGADIAVVEGVMGLF
TH_1982|M.thermoresistible__bu --------------------------------------------------
Mflv_4048|M.gilvum_PYR-GCK IDPGYHALATGRPGRNLDPVLVGEPLIGPLYRHGSDDADIAIVEGVMGLF
Mvan_2304|M.vanbaalenii_PYR-1 IDPGYHALATARPGRNLDPVLVGESLIGPLYRHGSDDADIAVVEGVMGLF
MAB_3155c|M.abscessus_ATCC_199 IDPGYHALATGRPGRNLDSVLVGDDLIGPLFRHGSRNADIAVVEGVMGLF
MLBr_02327|M.leprae_Br4923 ----------------------------------------LVLPDVMGTY
Rv2848c|M.tuberculosis_H37Rv DGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTF
Mb2873c|M.bovis_AF2122/97 DGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTF
MMAR_1885|M.marinum_M DGRIEHAVAGPATGSSAHVANLLGTPVILVVDARGQSHSIAALLHGFSTF
MUL_2113|M.ulcerans_Agy99 DGRIEHAVAGPATGSSAHVANLLGTPVILVVDARGQSHSIAALLHGFSTF
MAV_3704|M.avium_104 DGRIGPSGASPASGSTAHVAALLGAPVVLVVDARGQSQSIAALLHGFSTF
MSMEG_2617|M.smegmatis_MC2_155 DGRICDQMTGTPQGSAAQVASLLGAPVILVVDARGQSQSIAALLHGFTTF
TH_1982|M.thermoresistible__bu --------------------------VVLVVDARGQSHSIAALLHGFVTF
Mflv_4048|M.gilvum_PYR-GCK DGRISDGGAGPARGSTAHVAGLLGAPVVLVVDARGQSHSVAALLHGFATF
Mvan_2304|M.vanbaalenii_PYR-1 DGRISDAAVGPAQGSTAHVASLLGAPVVLVVDARGQSHSVAALLHGFATF
MAB_3155c|M.abscessus_ATCC_199 DGRVG-----DAKGSTAEIAALLGAPVVLVVDAKGYSQSLSALLHGFVAH
MLBr_02327|M.leprae_Br4923 G----------------------DGGNAVVLRQRLLLRGIAAEIVELTLA
:*: : :.::* : :
Rv2848c|M.tuberculosis_H37Rv DTAT--RIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPT
Mb2873c|M.bovis_AF2122/97 DTAT--RIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPT
MMAR_1885|M.marinum_M DSKT--RIAGVILNRVGSARHEHVLRQACEQAGVPVVGAIPRSAELELPT
MUL_2113|M.ulcerans_Agy99 DSKT--RIAGVILNRVGSARHEHVLRQACEQAGVPVVGAIPRSAELELPT
MAV_3704|M.avium_104 DAAT--RVAGVILNRVGSARHEQVLRQACEQAGVPVLGAIPRSAELELPT
MSMEG_2617|M.smegmatis_MC2_155 DSAV--HVAGVILNRVGSPRHEAVLRQACEHAGVAVLGAIPRADELSVPS
TH_1982|M.thermoresistible__bu DPAT--RLAGVILNRVGSARHEQALRTACDQAGVPVLGAVPRTDELAVPS
Mflv_4048|M.gilvum_PYR-GCK DQTV--RLAGVILNRVGSSRHDEVLRQACDHAGVAVLGSIPRADELAVPS
Mvan_2304|M.vanbaalenii_PYR-1 DSSV--RLAGVILNRVGSARHEQVLRQACEQAGAVVLGSIPRADELAVPS
MAB_3155c|M.abscessus_ATCC_199 AAEAGIRIAGVILNRVGSARHRDILTAAADRAGLRVFGALPRTDELSVPS
MLBr_02327|M.leprae_Br4923 DPVP----ESLDLYTLGG-AEDYAQRLATRHL-----------------L
.: * :*. . * :
Rv2848c|M.tuberculosis_H37Rv RYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDP
Mb2873c|M.bovis_AF2122/97 RYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDP
MMAR_1885|M.marinum_M RYLGLVTAVEYGRRARLAVEAMTALIARHVDVEAVLAAAGSSVGDAPWDP
MUL_2113|M.ulcerans_Agy99 RYLGLVTAVEYGRRARLAVEAMTALIARHVDVEAVLAAAGSSVGDAPWDP
MAV_3704|M.avium_104 RYLGLVTAVEYGRRARLAVEAMTALVARHLDLAAVAAVAAARPVATPWDP
MSMEG_2617|M.smegmatis_MC2_155 RHLGLITAVEHGRQARDAVAAMTELVGRHVDLAAVMACASARVSAQPWSP
TH_1982|M.thermoresistible__bu RHLGLITAVEHGWHARAAVAAMTDLVGRHVDLAAVVAIAGARVTAEPWTP
Mflv_4048|M.gilvum_PYR-GCK RHLGLVTAEEHGRHATAAVAAMTELVARHVDLAAVTAVAGGDVADAPWTP
Mvan_2304|M.vanbaalenii_PYR-1 RHLGLVTAVEHGRRATAAVQAMTELVARHVDLAAVASVASSRVDDAPWTP
MAB_3155c|M.abscessus_ATCC_199 RHLGLVTAVEHGQAALGAISAMAQLVATHVNVGAIAAAAHSDVTSPIWEP
MLBr_02327|M.leprae_Br4923 RYPGLQHAASYG-APVLAICAAVQVLGQWYETASRERVDGVGLLD-----
*: ** * .:* . *: * . ::. : :
Rv2848c|M.tuberculosis_H37Rv VIAVG---NTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLS
Mb2873c|M.bovis_AF2122/97 VIAVG---NTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLS
MMAR_1885|M.marinum_M VTAIG--GAPAG-HATIAMAAGKAFSFAYAEHAELLRAAGADVVEFDPLG
MUL_2113|M.ulcerans_Agy99 VTAIG--GAPAG-HATIAMAAGKAFSFAYAEHAELLRAAGADVVEFDPLG
MAV_3704|M.avium_104 AAAVGDPGGRGGERATVAVATGKAFSFGYAEHAELLAAAGARVAEFDPLV
MSMEG_2617|M.smegmatis_MC2_155 CVETS-FPVADVAGVTVALASGKAFSFGYAEHAELLRGTGATVAEFDPLV
TH_1982|M.thermoresistible__bu --HQV-APTG--AGARVALAAGKAFSFGYPEYAELLRATGAEVVEFDPLT
Mflv_4048|M.gilvum_PYR-GCK ------AQFAAGPTATVALAAGKAFTFGYAEHREILCAAGADVVTFDPLC
Mvan_2304|M.vanbaalenii_PYR-1 ------PPRTSPARVTVALAAGRAFSFGYAEHRELLCASGADVVEFDPLC
MAB_3155c|M.abscessus_ATCC_199 AEAVG---APTDREPVVALAAGQAFTFGYAEHRELLAAAGALVAEFDPRS
MLBr_02327|M.leprae_Br4923 ----------------VTTAPQDVRTIGELVSTPLLTSLNQRLSGFEN--
:: *. . ::. :* . . : *:
Rv2848c|M.tuberculosis_H37Rv ETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAG
Mb2873c|M.bovis_AF2122/97 ETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAG
MMAR_1885|M.marinum_M EPLPADSTGVLLPGGFPEQFTAELSANDLVRRQIKDLAHAGAPLHAECAG
MUL_2113|M.ulcerans_Agy99 EPLPADSTGVLLPGGFPEQFTAELSANDLVRRQIKDLAHAGAPLHAECAG
MAV_3704|M.avium_104 DALPDGTNALLLPGGFPEQFTAELSANEVVRRQINELAAAGAPVHAECAG
MSMEG_2617|M.smegmatis_MC2_155 DPLPDGADALVLPGGFPEQFTAELSANDLVRQQISELARRGAPIHAECAG
TH_1982|M.thermoresistible__bu DELPERTAALVLPGGFPEQFTTELAANTAAREQIRAAAAAGIPIHAECAG
Mflv_4048|M.gilvum_PYR-GCK DPLPAHTSALVLPGGFPEEFVTELSANEPVRSQIRALAAAGAPIHAECAG
Mvan_2304|M.vanbaalenii_PYR-1 DPLPPDAAALVLPGGFPEEFGTELSANEVVREQIRALAAGGAPVQAECAG
MAB_3155c|M.abscessus_ATCC_199 DSLPAETAALVIPGGFPEQFATDLSANATLRQQVGEMVG---PIHAECAG
MLBr_02327|M.leprae_Br4923 -----HRGGTVLG-----------------------------PAATPLGA
. :: * : ..
Rv2848c|M.tuberculosis_H37Rv LLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVV
Mb2873c|M.bovis_AF2122/97 LLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVV
MMAR_1885|M.marinum_M LIYLASELDGYPMCDVLAGSARFTPHLTLGYRDAVAVADSALYAAGHRVV
MUL_2113|M.ulcerans_Agy99 LIYLASELDGYPMCDVLAGSARFTPHLTLGYRDAVAVADSALYAAGHRVV
MAV_3704|M.avium_104 LLYLVSELDGHPMCGVLAGQARFTPQLTLAYRDAVAVVDSPLYAAGQRAV
MSMEG_2617|M.smegmatis_MC2_155 LTYLVDDLDGAPMCGVLRGSAKFTERLTLGYRDAVAVVDSSMHAAGERVV
TH_1982|M.thermoresistible__bu LLYLLDELDGHPMCGVLAGSARFTERLVLGYRDAVAVTDSPLHRAGERVV
Mflv_4048|M.gilvum_PYR-GCK LTYLVDELDGHPMCGVLAGSASFTPSLTLGYRDAVAVAESSLHAVGERVT
Mvan_2304|M.vanbaalenii_PYR-1 LTYLVDDLDGHPMCGVLSGSASFTESLTLGYRDAVAVADSPLHNIGDRVV
MAB_3155c|M.abscessus_ATCC_199 LTYLCRDLDGVPMCGVLDARARFTDSLTLGYREAVALTGSVLFEEGERLS
MLBr_02327|M.leprae_Br4923 VVKGAGNRVGDHFDGVIQGSVMATYMHGPCLARNPELADLLLSKVVGELA
: : * : .*: . . * :. : .
Rv2848c|M.tuberculosis_H37Rv GHEFHRTAVTFADSYQP-AWVYQGQDVDDVRDGAVHSG-VHASYLHTHPA
Mb2873c|M.bovis_AF2122/97 GHEFHRTAVTFADSYQP-AWVYQGQDVDDVRDGAVHSG-VHASYLHTHPA
MMAR_1885|M.marinum_M GHEFHRTTVTFSDRYEP-AWVYRGNDAAAVRDGVVHAG-VHASYLHTHPA
MUL_2113|M.ulcerans_Agy99 GHEFHRTTVTFSDRYEP-AWVYRGNDAAAVRDGVVHAG-VHVSYLHTHPA
MAV_3704|M.avium_104 GHEFHRTTVTFSDDYLP-AWMYR-TQESGHRDGAVRAG-VHASYLHTHPA
MSMEG_2617|M.smegmatis_MC2_155 GHEFHRTTVTFDDDLPP-AWAFAGRGGAPARDGAVLRG-VHAGYLHTHPA
TH_1982|M.thermoresistible__bu GHEFHRTAVTFAERYPP-VWAFRGADGSAGHDGAVHRG-VQAGYLHVHPA
Mflv_4048|M.gilvum_PYR-GCK GHEFHRTAVQFASDRQA-AWQYRGRGGAAVEDGAVLGG-VHAGYLHTHAA
Mvan_2304|M.vanbaalenii_PYR-1 GHEFHRTTVHFVDARQP-AWRYSGRGAKMVEDGAVLGG-VHAGYLHTHPA
MAB_3155c|M.abscessus_ATCC_199 GHEFHRTTVDYPEDGAPRAWAWRTADGVRREGTVVGEGRIHASYLHTHPA
MLBr_02327|M.leprae_Br4923 PLELPEVELLRRERLAAR--------------------------------
*: .. : . .
Rv2848c|M.tuberculosis_H37Rv ATPGAVARFV--AHAACNTPRA--------
Mb2873c|M.bovis_AF2122/97 ATPGAVARFV--AHAACNTPRA--------
MMAR_1885|M.marinum_M STPDAVARFV--AHAARAGHGI--------
MUL_2113|M.ulcerans_Agy99 STPDAVARFV--AHAARAGHGI--------
MAV_3704|M.avium_104 AAPAAVARFVGCALAARADPGRTRAHPGNH
MSMEG_2617|M.smegmatis_MC2_155 AHPQAIARFVASAVPTN-------------
TH_1982|M.thermoresistible__bu AHPHAVSRFVAAGTAGRA------------
Mflv_4048|M.gilvum_PYR-GCK AHPQAIARFVAAAATTKLAG----------
Mvan_2304|M.vanbaalenii_PYR-1 AHPRAIARFVAAAATTRLAG----------
MAB_3155c|M.abscessus_ATCC_199 AHPSATARFVARAAATGLSNDARSG-----
MLBr_02327|M.leprae_Br4923 ------------------------------