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VNSIPGVVIAAPASGSGKTTVATGLIGALRQAGRRVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGER LIGPLYAHGAQGADIAVVEGVMGLFDGRIEHAVAGPATGSSAHVANLLGTPVILVVDARGQSHSIAALLH GFSTFDSKTRIAGVILNRVGSARHEHVLRQACEQAGVPVVGAIPRSAELELPTRYLGLVTAVEYGRRARL AVEAMTALIARHVDVEAVLAAAGSSVGDAPWDPVTAIGGAPAGHATIAMAAGKAFSFAYAEHAELLRAAG ADVVEFDPLGEPLPADSTGVLLPGGFPEQFTAELSANDLVRRQIKDLAHAGAPLHAECAGLIYLASELDG YPMCDVLAGSARFTPHLTLGYRDAVAVADSALYAAGHRVVGHEFHRTTVTFSDRYEPAWVYRGNDAAAVR DGVVHAGVHVSYLHTHPASTPDAVARFVAHAARAGHGI
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_2113 | cobB | - | 100% (458) | cobyrinic acid a,c-diamide synthase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2873c | cobB | 0.0 | 79.06% (449) | cobyrinic acid a,c-diamide synthase |
M. gilvum PYR-GCK | Mflv_4048 | - | 0.0 | 70.89% (450) | cobyrinic acid a,c-diamide synthase |
M. tuberculosis H37Rv | Rv2848c | cobB | 0.0 | 79.06% (449) | cobyrinic acid a,c-diamide synthase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_3155c | - | 1e-148 | 59.82% (453) | cobyrinic acid A,C-diamide synthase (CobB) |
M. marinum M | MMAR_1885 | cobB | 0.0 | 99.78% (458) | cobyrinic acid a,C-diamide synthase CobB |
M. avium 104 | MAV_3704 | cobB | 0.0 | 77.49% (462) | cobyrinic acid a,c-diamide synthase |
M. smegmatis MC2 155 | MSMEG_2617 | cobB | 0.0 | 70.86% (453) | cobyrinic acid a,c-diamide synthase |
M. thermoresistible (build 8) | TH_1982 | cobB | 1e-123 | 66.27% (335) | PROBABLE COBYRINIC ACID A,C-DIAMIDE SYNTHASE COBB |
M. vanbaalenii PYR-1 | Mvan_2304 | - | 0.0 | 71.78% (450) | cobyrinic acid a,c-diamide synthase |
CLUSTAL 2.0.9 multiple sequence alignment MUL_2113|M.ulcerans_Agy99 -----MNSIPGVVIAAPASGSGKTTVATGLIGALRQAGRRVAPFKVGPDF MMAR_1885|M.marinum_M -----MNSIPGVVIAAPASGSGKTTVATGLIGALRQAGRRVAPFKVGPDF Mb2873c|M.bovis_AF2122/97 ------MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDF Rv2848c|M.tuberculosis_H37Rv ------MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDF MAV_3704|M.avium_104 -----MVNVPAVVVAAPASGSGKTTVATGLIGALRRAGRRVAAFKVGPDF MSMEG_2617|M.smegmatis_MC2_155 ----MVGTTPAVVIAAPASGSGKTTVSTGLIGALRAAGHTVAPFKVGPDF TH_1982|M.thermoresistible__bu -------------------------------------------------- Mflv_4048|M.gilvum_PYR-GCK ------MSTPAVVIAAPSSGSGKTTVATGLMGALRRAGHRVAPFKVGPDF Mvan_2304|M.vanbaalenii_PYR-1 MGKDEGLSTPAVVIAAPASGSGKTTVATGLMGALRLAGHRVAPFKVGPDF MAB_3155c|M.abscessus_ATCC_199 -----------MVIAAPASGSGKTTVATGLMGALRHAGHRVAPFKVGPDY MUL_2113|M.ulcerans_Agy99 IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGAQGADIAVVEGVMGLF MMAR_1885|M.marinum_M IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGAQGADIAVVEGVMGLF Mb2873c|M.bovis_AF2122/97 IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLF Rv2848c|M.tuberculosis_H37Rv IDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLF MAV_3704|M.avium_104 IDPGYHGLAAGRPGRNLDPVLVGENLIGPLYAHGAAGADIAVVEGVMGLF MSMEG_2617|M.smegmatis_MC2_155 IDPGYHAVAAGRPGRNLDPVLVGEDLIGPLYAHGSAGADIAVVEGVMGLF TH_1982|M.thermoresistible__bu -------------------------------------------------- Mflv_4048|M.gilvum_PYR-GCK IDPGYHALATGRPGRNLDPVLVGEPLIGPLYRHGSDDADIAIVEGVMGLF Mvan_2304|M.vanbaalenii_PYR-1 IDPGYHALATARPGRNLDPVLVGESLIGPLYRHGSDDADIAVVEGVMGLF MAB_3155c|M.abscessus_ATCC_199 IDPGYHALATGRPGRNLDSVLVGDDLIGPLFRHGSRNADIAVVEGVMGLF MUL_2113|M.ulcerans_Agy99 DGRIEHAVAGPATGSSAHVANLLGTPVILVVDARGQSHSIAALLHGFSTF MMAR_1885|M.marinum_M DGRIEHAVAGPATGSSAHVANLLGTPVILVVDARGQSHSIAALLHGFSTF Mb2873c|M.bovis_AF2122/97 DGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTF Rv2848c|M.tuberculosis_H37Rv DGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTF MAV_3704|M.avium_104 DGRIGPSGASPASGSTAHVAALLGAPVVLVVDARGQSQSIAALLHGFSTF MSMEG_2617|M.smegmatis_MC2_155 DGRICDQMTGTPQGSAAQVASLLGAPVILVVDARGQSQSIAALLHGFTTF TH_1982|M.thermoresistible__bu --------------------------VVLVVDARGQSHSIAALLHGFVTF Mflv_4048|M.gilvum_PYR-GCK DGRISDGGAGPARGSTAHVAGLLGAPVVLVVDARGQSHSVAALLHGFATF Mvan_2304|M.vanbaalenii_PYR-1 DGRISDAAVGPAQGSTAHVASLLGAPVVLVVDARGQSHSVAALLHGFATF MAB_3155c|M.abscessus_ATCC_199 DGRVG-----DAKGSTAEIAALLGAPVVLVVDAKGYSQSLSALLHGFVAH *:*****:* *:*::****** :. MUL_2113|M.ulcerans_Agy99 DSKT--RIAGVILNRVGSARHEHVLRQACEQAGVPVVGAIPRSAELELPT MMAR_1885|M.marinum_M DSKT--RIAGVILNRVGSARHEHVLRQACEQAGVPVVGAIPRSAELELPT Mb2873c|M.bovis_AF2122/97 DTAT--RIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPT Rv2848c|M.tuberculosis_H37Rv DTAT--RIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPT MAV_3704|M.avium_104 DAAT--RVAGVILNRVGSARHEQVLRQACEQAGVPVLGAIPRSAELELPT MSMEG_2617|M.smegmatis_MC2_155 DSAV--HVAGVILNRVGSPRHEAVLRQACEHAGVAVLGAIPRADELSVPS TH_1982|M.thermoresistible__bu DPAT--RLAGVILNRVGSARHEQALRTACDQAGVPVLGAVPRTDELAVPS Mflv_4048|M.gilvum_PYR-GCK DQTV--RLAGVILNRVGSSRHDEVLRQACDHAGVAVLGSIPRADELAVPS Mvan_2304|M.vanbaalenii_PYR-1 DSSV--RLAGVILNRVGSARHEQVLRQACEQAGAVVLGSIPRADELAVPS MAB_3155c|M.abscessus_ATCC_199 AAEAGIRIAGVILNRVGSARHRDILTAAADRAGLRVFGALPRTDELSVPS . ::**********.** * *.::** *.*::**: ** :*: MUL_2113|M.ulcerans_Agy99 RYLGLVTAVEYGRRARLAVEAMTALIARHVDVEAVLAAAGSSVGDAPWDP MMAR_1885|M.marinum_M RYLGLVTAVEYGRRARLAVEAMTALIARHVDVEAVLAAAGSSVGDAPWDP Mb2873c|M.bovis_AF2122/97 RYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDP Rv2848c|M.tuberculosis_H37Rv RYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDP MAV_3704|M.avium_104 RYLGLVTAVEYGRRARLAVEAMTALVARHLDLAAVAAVAAARPVATPWDP MSMEG_2617|M.smegmatis_MC2_155 RHLGLITAVEHGRQARDAVAAMTELVGRHVDLAAVMACASARVSAQPWSP TH_1982|M.thermoresistible__bu RHLGLITAVEHGWHARAAVAAMTDLVGRHVDLAAVVAIAGARVTAEPWTP Mflv_4048|M.gilvum_PYR-GCK RHLGLVTAEEHGRHATAAVAAMTELVARHVDLAAVTAVAGGDVADAPWTP Mvan_2304|M.vanbaalenii_PYR-1 RHLGLVTAVEHGRRATAAVQAMTELVARHVDLAAVASVASSRVDDAPWTP MAB_3155c|M.abscessus_ATCC_199 RHLGLVTAVEHGQAALGAISAMAQLVATHVNVGAIAAAAHSDVTSPIWEP *:***:** *:* * *: **: ::. *::: *: : * . * * MUL_2113|M.ulcerans_Agy99 VTAIG---GAPAGHATIAMAAGKAFSFAYAEHAELLRAAGADVVEFDPLG MMAR_1885|M.marinum_M VTAIG---GAPAGHATIAMAAGKAFSFAYAEHAELLRAAGADVVEFDPLG Mb2873c|M.bovis_AF2122/97 VIAVG---NTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLS Rv2848c|M.tuberculosis_H37Rv VIAVG---NTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLS MAV_3704|M.avium_104 AAAVGDPGGRGGERATVAVATGKAFSFGYAEHAELLAAAGARVAEFDPLV MSMEG_2617|M.smegmatis_MC2_155 CVETS-FPVADVAGVTVALASGKAFSFGYAEHAELLRGTGATVAEFDPLV TH_1982|M.thermoresistible__bu --HQV-APTG--AGARVALAAGKAFSFGYPEYAELLRATGAEVVEFDPLT Mflv_4048|M.gilvum_PYR-GCK ------AQFAAGPTATVALAAGKAFTFGYAEHREILCAAGADVVTFDPLC Mvan_2304|M.vanbaalenii_PYR-1 ------PPRTSPARVTVALAAGRAFSFGYAEHRELLCASGADVVEFDPLC MAB_3155c|M.abscessus_ATCC_199 AEAVG---APTDREPVVALAAGQAFTFGYAEHRELLAAAGALVAEFDPRS :*:*:*:**:*.*.*: *:* .:** *. *** MUL_2113|M.ulcerans_Agy99 EPLPADSTGVLLPGGFPEQFTAELSANDLVRRQIKDLAHAGAPLHAECAG MMAR_1885|M.marinum_M EPLPADSTGVLLPGGFPEQFTAELSANDLVRRQIKDLAHAGAPLHAECAG Mb2873c|M.bovis_AF2122/97 ETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAG Rv2848c|M.tuberculosis_H37Rv ETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAG MAV_3704|M.avium_104 DALPDGTNALLLPGGFPEQFTAELSANEVVRRQINELAAAGAPVHAECAG MSMEG_2617|M.smegmatis_MC2_155 DPLPDGADALVLPGGFPEQFTAELSANDLVRQQISELARRGAPIHAECAG TH_1982|M.thermoresistible__bu DELPERTAALVLPGGFPEQFTTELAANTAAREQIRAAAAAGIPIHAECAG Mflv_4048|M.gilvum_PYR-GCK DPLPAHTSALVLPGGFPEEFVTELSANEPVRSQIRALAAAGAPIHAECAG Mvan_2304|M.vanbaalenii_PYR-1 DPLPPDAAALVLPGGFPEEFGTELSANEVVREQIRALAAGGAPVQAECAG MAB_3155c|M.abscessus_ATCC_199 DSLPAETAALVIPGGFPEQFATDLSANATLRQQVGEMVG---PIHAECAG : ** : .:::******:* ::*:** * *: . *::***** MUL_2113|M.ulcerans_Agy99 LIYLASELDGYPMCDVLAGSARFTPHLTLGYRDAVAVADSALYAAGHRVV MMAR_1885|M.marinum_M LIYLASELDGYPMCDVLAGSARFTPHLTLGYRDAVAVADSALYAAGHRVV Mb2873c|M.bovis_AF2122/97 LLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVV Rv2848c|M.tuberculosis_H37Rv LLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVV MAV_3704|M.avium_104 LLYLVSELDGHPMCGVLAGQARFTPQLTLAYRDAVAVVDSPLYAAGQRAV MSMEG_2617|M.smegmatis_MC2_155 LTYLVDDLDGAPMCGVLRGSAKFTERLTLGYRDAVAVVDSSMHAAGERVV TH_1982|M.thermoresistible__bu LLYLLDELDGHPMCGVLAGSARFTERLVLGYRDAVAVTDSPLHRAGERVV Mflv_4048|M.gilvum_PYR-GCK LTYLVDELDGHPMCGVLAGSASFTPSLTLGYRDAVAVAESSLHAVGERVT Mvan_2304|M.vanbaalenii_PYR-1 LTYLVDDLDGHPMCGVLSGSASFTESLTLGYRDAVAVADSPLHNIGDRVV MAB_3155c|M.abscessus_ATCC_199 LTYLCRDLDGVPMCGVLDARARFTDSLTLGYREAVALTGSVLFEEGERLS * ** :*** ***.*: . * ** * *.**:***:. * :. *.* MUL_2113|M.ulcerans_Agy99 GHEFHRTTVTFSDRYEP-AWVYRGNDAAAVRDGVVHAG-VHVSYLHTHPA MMAR_1885|M.marinum_M GHEFHRTTVTFSDRYEP-AWVYRGNDAAAVRDGVVHAG-VHASYLHTHPA Mb2873c|M.bovis_AF2122/97 GHEFHRTAVTFADSYQP-AWVYQGQDVDDVRDGAVHSG-VHASYLHTHPA Rv2848c|M.tuberculosis_H37Rv GHEFHRTAVTFADSYQP-AWVYQGQDVDDVRDGAVHSG-VHASYLHTHPA MAV_3704|M.avium_104 GHEFHRTTVTFSDDYLP-AWMYRTQ-ESGHRDGAVRAG-VHASYLHTHPA MSMEG_2617|M.smegmatis_MC2_155 GHEFHRTTVTFDDDLPP-AWAFAGRGGAPARDGAVLRG-VHAGYLHTHPA TH_1982|M.thermoresistible__bu GHEFHRTAVTFAERYPP-VWAFRGADGSAGHDGAVHRG-VQAGYLHVHPA Mflv_4048|M.gilvum_PYR-GCK GHEFHRTAVQFASDRQA-AWQYRGRGGAAVEDGAVLGG-VHAGYLHTHAA Mvan_2304|M.vanbaalenii_PYR-1 GHEFHRTTVHFVDARQP-AWRYSGRGAKMVEDGAVLGG-VHAGYLHTHPA MAB_3155c|M.abscessus_ATCC_199 GHEFHRTTVDYPEDGAPRAWAWRTADGVRREGTVVGEGRIHASYLHTHPA *******:* : . . .* : .. .* * ::..***.*.* MUL_2113|M.ulcerans_Agy99 STPDAVARFV--AHAARAGHGI-------- MMAR_1885|M.marinum_M STPDAVARFV--AHAARAGHGI-------- Mb2873c|M.bovis_AF2122/97 ATPGAVARFV--AHAACNTPRA-------- Rv2848c|M.tuberculosis_H37Rv ATPGAVARFV--AHAACNTPRA-------- MAV_3704|M.avium_104 AAPAAVARFVGCALAARADPGRTRAHPGNH MSMEG_2617|M.smegmatis_MC2_155 AHPQAIARFVASAVPTN------------- TH_1982|M.thermoresistible__bu AHPHAVSRFVAAGTAGRA------------ Mflv_4048|M.gilvum_PYR-GCK AHPQAIARFVAAAATTKLAG---------- Mvan_2304|M.vanbaalenii_PYR-1 AHPRAIARFVAAAATTRLAG---------- MAB_3155c|M.abscessus_ATCC_199 AHPSATARFVARAAATGLSNDARSG----- : * * :*** . .