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MTMEDTRTRGEHDGAAPAAYPLDPLSGAEIESAAAVVTASEYATPTLKFVMIQLAEPAKTASLTFVGEQD VPRRAFLTMYDAAAKLICEAVVDLGARVIESWTPVPGRFPSYLVEHMTGVEEKVREDPRWQEAMRKRGVT DFSLAMIDPWPAGYYGAQDHYDNSPLICRPLTFVRAAPSENGYARPVEGLIVTFDLDTMTVLDVEDHGAV RLPAKGGNYSEQFMFSPDNRPAFSGFRDDVKTIEITQPDGPSFTVDGWNVQWQKWSLRVGFNPREGLVLH EVTYNDRGAVRPIMYRAALSEMVVPYGDSSPTHWNKNVFDMGEVGMGFSANPLTLGCDCLGEIFYFDGTV NDSDGNAVTIPNAICMHEEDYGISWKHTDFRTGEVEVRRSRRLVISMICTVGNYEYGFFWYLYNDASIEM EVKLTGVLTTGAIADGETPRWGKMVAPGMYGPNHQHFFNFRMDMSIDGPGNSVYEVDSIPEPDPALNPHH NAWITKDTLVASEAEGARDWEYSTGRYWKVVNPSKLNEFGAPVGYKLMPKDIVPVMVQEGSVIYDRARFV QHNLWVTKFDAKELYAAGDYMYQSADAQGLPEYVADDAPLEDTDVVLWYTVGAHHVVCPEDWPVMPCHYT GFKLKPVGFFDGNPALDLPPSPPKACHMA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2218 | tynA | - | 100% (659) | tyramine oxidase |
| M. vanbaalenii PYR-1 | Mvan_3407 | tynA | e-139 | 41.27% (659) | tyramine oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_4125 | tynA | 0.0 | 84.07% (659) | tyramine oxidase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4204 | tynA | 1e-143 | 40.41% (641) | tyramine oxidase |
| M. marinum M | MMAR_2608 | tynA | 1e-134 | 39.91% (639) | copper methylamine oxidase precursor, MaoX |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2526 | tynA | 0.0 | 89.97% (658) | tyramine oxidase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2218|M.vanbaalenii_PYR-1 MTMEDTRTRGEHDGAAPAAYPLDPLSGAEIESAAAVVTASEYATPTLKFV
MSMEG_2526|M.smegmatis_MC2_155 MTMDSTITN-VEGAATAAPYPLDPLTGAEIEAAAAVITGSDYATPTLKFV
Mflv_4125|M.gilvum_PYR-GCK MTMEDTRIG-ADPAAGLAPYPLDPLTVAEIESAAAVVRASDYATPTLKFV
MAB_4204|M.abscessus_ATCC_1997 --------------MNDTFHPLDPLSAEEFTTVAKILAQTHDVGASWRYT
MMAR_2608|M.marinum_M ----------MTETIVQTFHPLDPLTESEFQQAVSVVRRDRNITERWRFA
: :*****: *: .. :: ::.
Mvan_2218|M.vanbaalenii_PYR-1 MIQLAEPAKTASLTFVGEQDVP-RRAFLTMYDAAAKLICEAVVDLGARVI
MSMEG_2526|M.smegmatis_MC2_155 MIQLAEPEKNEKLTFVG-MDVP-RRAFVTMYDAAAKLIYEAIVDLGARVI
Mflv_4125|M.gilvum_PYR-GCK MIQLAEPAKTPALTFADAPDTP-RCAFLTMYDAAAKMIYEAVVDLRAGLI
MAB_4204|M.abscessus_ATCC_1997 SVELSEPSKAEVAAFDNNGTRPDRRALATCLDTTQNATYKAVISLTSGEV
MMAR_2608|M.marinum_M SMELAEPGKREIADFENNAVVPDRRAVIVCFDRDTNGTYKALVSLSGDRI
::*:** * * . * * *. . * : :*::.* . :
Mvan_2218|M.vanbaalenii_PYR-1 ESWTPVPGRFPSYLVEHMTGVEEKVREDPRWQEAMRKRGVTDFSLAMIDP
MSMEG_2526|M.smegmatis_MC2_155 DSWTPIPGRFPSYLVEHMTGVEEKVREDPRWQEAMRRRGVTDFSLAMIDP
Mflv_4125|M.gilvum_PYR-GCK ESWTPIPGRFPSYLVEHMTGVEEKVREDPRWQEAMRRRGVTDFSLAMIDP
MAB_4204|M.abscessus_ATCC_1997 LSWNHIPGVQPNFTVDEWEEADAVLRGHPDVIAALARRGITDMDLVFMDT
MMAR_2608|M.marinum_M LSWTCLPGVQPNITHDEWLEAGEVLRSHPAVIAALCRRGITDLENMLVDV
**. :** *. :. . :* .* *: :**:**:. ::*
Mvan_2218|M.vanbaalenii_PYR-1 WPAGYYGAQDHYDNSPLICRPLTFVRAAPSENGYARPVEGLIVTFDLDTM
MSMEG_2526|M.smegmatis_MC2_155 WPAGYYGAQDHYDNSPLVCRPLTFVRAAPSENGYARPVEGLIVTFDLDKM
Mflv_4125|M.gilvum_PYR-GCK WPAGYYGAQDHYDNSPLVCRPLTFMRAAPSEHGYARPVEGLIVTFDLDAM
MAB_4204|M.abscessus_ATCC_1997 WTYGDAVMPEKYRGRRLGWS-DTWVRAADGANPYAGPVNGFHCVIDMNSM
MMAR_2608|M.marinum_M WAYGDALIPEAYRGRRLAWS-DSWLTSPGGGNLYARHIKGFHCVIDLNTM
*. * : * . * ::: :. . : ** ::*: .:*:: *
Mvan_2218|M.vanbaalenii_PYR-1 TVLDVEDHGAVRLPAKGGNYSEQFMFSPDNRPAFSGFRDDVKTIEITQPD
MSMEG_2526|M.smegmatis_MC2_155 EVLDIEDHGVVPLPPKAGNYTEQFMFDADNRPAFTEFRQDVKKIEITQPD
Mflv_4125|M.gilvum_PYR-GCK AVIDVEDHGVVPLPPTAGNYSEAFMFDPNNRPAFTAFRDDVKPIEITQPD
MAB_4204|M.abscessus_ATCC_1997 ELLDIEDTFTVERPTMMGEYVPRHVPERLRK---QSTRESLQPLHITQPD
MMAR_2608|M.marinum_M ELLDIEEGSPLEFPAVMAEYVPRHIPENLRD---SSVRGALRPLEIIQPD
::*:*: : *. .:* .: . . * :: :.* ***
Mvan_2218|M.vanbaalenii_PYR-1 GPSFTVDGWNVQWQKWSLRVGFNPREGLVLHEVTYNDRGAVRPIMYRAAL
MSMEG_2526|M.smegmatis_MC2_155 GPSFTVDGWNVTWQKWSLRVGFNAREGLTLHEITYNDRGTVRPIMYRAAL
Mflv_4125|M.gilvum_PYR-GCK GPSFTVDGWNVKWQKWSLRIGFNPREGITLHEVTYTDRGETRPVLYRASL
MAB_4204|M.abscessus_ATCC_1997 GPSFTIEGNKLQWQNWSLRVGFNYREGMTLHAVTYNDNGRVRSVANRMSF
MMAR_2608|M.marinum_M GPSFTLRGNHLEWQNWSLRVGFNYREGMTLHTVTYNDHGRVRPIAYRMSF
*****: * :: **:****:*** ***:.** :**.*.* .*.: * ::
Mvan_2218|M.vanbaalenii_PYR-1 SEMVVPYGDSSPTHWNKNVFDMGEVGMGFSANPLTLGCDCLGEIFYFDGT
MSMEG_2526|M.smegmatis_MC2_155 SEMVVPYGDSSPTHWNKNVFDMGEVGMGFSANPLTLGCDCLGEIHYFDGT
Mflv_4125|M.gilvum_PYR-GCK SEMVVPYGDSAPTHWNKNVFDMGEVGMGFSANPLTLGCDCLGEIHYFDGT
MAB_4204|M.abscessus_ATCC_1997 AEMMVPYRDHCEDHYRRTAFDIGEWGIGFMTTSLELGCDCLGEIRYLDAV
MMAR_2608|M.marinum_M AEMAVPYRDHCADHYRRTAFDIGEWGLGFMTTSLEKGCDCLGEIRYLDAV
:** *** * . *:.:..**:** *:** :..* ******** *:*..
Mvan_2218|M.vanbaalenii_PYR-1 VNDSDGNAVTIPNAICMHEEDYGISWKHTDFRTGEVEVRRSRRLVISMIC
MSMEG_2526|M.smegmatis_MC2_155 VNDSDGNAVTIPNAICMHEEDYGISWKHTDFRTGEVEVRRSRRLVISMIC
Mflv_4125|M.gilvum_PYR-GCK VNDSAGNAVTIPNAICMHEEDFGISWKHTDFRTEEVEVRRSRRLVISMIC
MAB_4204|M.abscessus_ATCC_1997 LHNSKGEPYTIKNAICIHEEDNAVLWKHVDH-DHGAQVRRMRRLTVSFHV
MMAR_2608|M.marinum_M LHNSKGEPYTIKNAICIHEEDNAVLWKHVVC-DGSAEVRRMRRLTVSFHV
:::* *:. ** ****:**** .: ***. .:*** ***.:*:
Mvan_2218|M.vanbaalenii_PYR-1 TVGNYEYGFFWYLYNDASIEMEVKLTGVLTTG--AIADGETPRWGKMVAP
MSMEG_2526|M.smegmatis_MC2_155 TVGNYEYGFFWYLYNDAGIEMEVKLTGVLTTG--SIPEGETPRWGKMVAP
Mflv_4125|M.gilvum_PYR-GCK TVGNYEYGFFWYFYNDASIEVEVKLSGVLTTGAVEMAPGEQPRWGKMVAP
MAB_4204|M.abscessus_ATCC_1997 TVANYEYLTYWRFYQDGNIECEVRATGIMVVS--NFTEGAAHPHGTLVDN
MMAR_2608|M.marinum_M TVANYEYLVYWRFYQDGNIECEIRATGLMVTT--NFDNGQAHASGTLVDE
**.**** :* :*:*..** *:: :*::.. : * *.:*
Mvan_2218|M.vanbaalenii_PYR-1 GMYGPNHQHFFNFRMDMSIDGPGNSVYEVDSIPEPDPALNPHHNAWITKD
MSMEG_2526|M.smegmatis_MC2_155 GMYGPNHQHFFNFRMDMSIDGPGNSVYEVDSIPEPDPELNPHHNAWITKD
Mflv_4125|M.gilvum_PYR-GCK GIYGPNHQHFFNFRLDMSVDGPGNSVYEVDSIPEPDPARNPHRNAWITRD
MAB_4204|M.abscessus_ATCC_1997 RTYAPYHQHFLVARLDLDVDGTENTVYATETEIEPVGPENPYGLSLRQRN
MMAR_2608|M.marinum_M RTYAPYHQHFLTARLDLDIDGTDNTVYTSETEMVPTGPDNPYGLSLRQRN
*.* ****: *:*:.:**. *:** :: * **: : ::
Mvan_2218|M.vanbaalenii_PYR-1 TLVASEAEGARDWEYSTGRYWKVVNPSKLNEFGAPVGYKLMPKDIVPVMV
MSMEG_2526|M.smegmatis_MC2_155 TLVASESEGARDWEFSTGRYWKVVNPSKLNEFGAPVGYKIMPKDVIPVMV
Mflv_4125|M.gilvum_PYR-GCK TLVASESDGARDWNWSTGRYWKIANPSRRNELGIPVAYKLVPKDVVPVMV
MAB_4204|M.abscessus_ATCC_1997 TPLRTESEGKQDFCWETQRAWKVVNDNTRNGIGTAPAYKLVPGAAIPSMF
MMAR_2608|M.marinum_M IPLRTEEEGKQDYCWETQRAWRVVNENVTNGLGTHPSYKLVGGAAIPPMF
: :* :* :*: :.* * *::.* . * :* .**:: :* *.
Mvan_2218|M.vanbaalenii_PYR-1 QEGSVIYDRARFVQHNLWVTKFDAKELYAAGDYMYQSADAQGLPEYVADD
MSMEG_2526|M.smegmatis_MC2_155 QEGSVIYDRARFVQHNLWVTKYDPRELYAAGDYMYQCAEAQGLPQYVADD
Mflv_4125|M.gilvum_PYR-GCK QEGSYIYDRARFLQHNLWVTRYDPAEKFAAGDYMYQSADTQGLPEFVAGD
MAB_4204|M.abscessus_ATCC_1997 DPSSPVLARCRAIEHTLWVTPNSPDERWPAGEFVTQSKEDHGLPAWTEGN
MMAR_2608|M.marinum_M DLRSPVLRRAEAITHTVWVTPNHPDERWPAGEFVNQSGPGLGLPAWTAAN
: * : *.. : *.:*** . * :.**::: *. *** :. :
Mvan_2218|M.vanbaalenii_PYR-1 APLEDTDVVLWYTVGAHHVVCPEDWPVMPCHYTGFKLKPVGFFDGNPALD
MSMEG_2526|M.smegmatis_MC2_155 APLENTDVVLWYTVGAHHVVCPEDWPVMPCHYTGFKLKPVGFFDGNPALD
Mflv_4125|M.gilvum_PYR-GCK EPLEDSDVVLWYTLGAHHVVRPEDWPVMPCAYTGFHLKPIGFFDGNPALD
MAB_4204|M.abscessus_ATCC_1997 RSIENTDVVLWYVFGIHHITRPEDWPIMPVDTVNFWLKPVGFFDRNPSLD
MMAR_2608|M.marinum_M RSIENTDVVVWYTFGIHHITRPEDWPVMPADTVSFWLKPVGFFDRNPSLD
.:*::***:**..* **:. *****:** ..* ***:**** **:**
Mvan_2218|M.vanbaalenii_PYR-1 LPPSPPKACHMA-------------
MSMEG_2526|M.smegmatis_MC2_155 VPPSPPAACHNH-------------
Mflv_4125|M.gilvum_PYR-GCK LPPSPPKACHATRAGLPVAERALES
MAB_4204|M.abscessus_ATCC_1997 VAPTPPKSCHMSGHQED--------
MMAR_2608|M.marinum_M VAPTAAATCHGEGGC----------
:.*:.. :**