For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TMEDTRIGADPAAGLAPYPLDPLTVAEIESAAAVVRASDYATPTLKFVMIQLAEPAKTPALTFADAPDTP RCAFLTMYDAAAKMIYEAVVDLRAGLIESWTPIPGRFPSYLVEHMTGVEEKVREDPRWQEAMRRRGVTDF SLAMIDPWPAGYYGAQDHYDNSPLVCRPLTFMRAAPSEHGYARPVEGLIVTFDLDAMAVIDVEDHGVVPL PPTAGNYSEAFMFDPNNRPAFTAFRDDVKPIEITQPDGPSFTVDGWNVKWQKWSLRIGFNPREGITLHEV TYTDRGETRPVLYRASLSEMVVPYGDSAPTHWNKNVFDMGEVGMGFSANPLTLGCDCLGEIHYFDGTVND SAGNAVTIPNAICMHEEDFGISWKHTDFRTEEVEVRRSRRLVISMICTVGNYEYGFFWYFYNDASIEVEV KLSGVLTTGAVEMAPGEQPRWGKMVAPGIYGPNHQHFFNFRLDMSVDGPGNSVYEVDSIPEPDPARNPHR NAWITRDTLVASESDGARDWNWSTGRYWKIANPSRRNELGIPVAYKLVPKDVVPVMVQEGSYIYDRARFL QHNLWVTRYDPAEKFAAGDYMYQSADTQGLPEFVAGDEPLEDSDVVLWYTLGAHHVVRPEDWPVMPCAYT GFHLKPIGFFDGNPALDLPPSPPKACHATRAGLPVAERALES*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4125 | tynA | - | 100% (673) | tyramine oxidase |
| M. gilvum PYR-GCK | Mflv_3126 | tynA | e-142 | 41.72% (664) | tyramine oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4204 | tynA | 1e-147 | 40.87% (641) | tyramine oxidase |
| M. marinum M | MMAR_2608 | tynA | 1e-135 | 39.16% (641) | copper methylamine oxidase precursor, MaoX |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2526 | tynA | 0.0 | 82.67% (658) | tyramine oxidase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2218 | tynA | 0.0 | 84.07% (659) | tyramine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2526|M.smegmatis_MC2_155 MTMDSTITN-VEGAATAAPYPLDPLTGAEIEAAAAVITGSDYATPTLKFV
Mvan_2218|M.vanbaalenii_PYR-1 MTMEDTRTRGEHDGAAPAAYPLDPLSGAEIESAAAVVTASEYATPTLKFV
Mflv_4125|M.gilvum_PYR-GCK MTMEDTRIG-ADPAAGLAPYPLDPLTVAEIESAAAVVRASDYATPTLKFV
MAB_4204|M.abscessus_ATCC_1997 --------------MNDTFHPLDPLSAEEFTTVAKILAQTHDVGASWRYT
MMAR_2608|M.marinum_M ----------MTETIVQTFHPLDPLTESEFQQAVSVVRRDRNITERWRFA
: :*****: *: .. :: ::.
MSMEG_2526|M.smegmatis_MC2_155 MIQLAEPEKNEKLTFVG-MDVP-RRAFVTMYDAAAKLIYEAIVDLGARVI
Mvan_2218|M.vanbaalenii_PYR-1 MIQLAEPAKTASLTFVGEQDVP-RRAFLTMYDAAAKLICEAVVDLGARVI
Mflv_4125|M.gilvum_PYR-GCK MIQLAEPAKTPALTFADAPDTP-RCAFLTMYDAAAKMIYEAVVDLRAGLI
MAB_4204|M.abscessus_ATCC_1997 SVELSEPSKAEVAAFDNNGTRPDRRALATCLDTTQNATYKAVISLTSGEV
MMAR_2608|M.marinum_M SMELAEPGKREIADFENNAVVPDRRAVIVCFDRDTNGTYKALVSLSGDRI
::*:** * * . * * *. . * : :*::.* . :
MSMEG_2526|M.smegmatis_MC2_155 DSWTPIPGRFPSYLVEHMTGVEEKVREDPRWQEAMRRRGVTDFSLAMIDP
Mvan_2218|M.vanbaalenii_PYR-1 ESWTPVPGRFPSYLVEHMTGVEEKVREDPRWQEAMRKRGVTDFSLAMIDP
Mflv_4125|M.gilvum_PYR-GCK ESWTPIPGRFPSYLVEHMTGVEEKVREDPRWQEAMRRRGVTDFSLAMIDP
MAB_4204|M.abscessus_ATCC_1997 LSWNHIPGVQPNFTVDEWEEADAVLRGHPDVIAALARRGITDMDLVFMDT
MMAR_2608|M.marinum_M LSWTCLPGVQPNITHDEWLEAGEVLRSHPAVIAALCRRGITDLENMLVDV
**. :** *. :. . :* .* *: :**:**:. ::*
MSMEG_2526|M.smegmatis_MC2_155 WPAGYYGAQDHYDNSPLVCRPLTFVRAAPSENGYARPVEGLIVTFDLDKM
Mvan_2218|M.vanbaalenii_PYR-1 WPAGYYGAQDHYDNSPLICRPLTFVRAAPSENGYARPVEGLIVTFDLDTM
Mflv_4125|M.gilvum_PYR-GCK WPAGYYGAQDHYDNSPLVCRPLTFMRAAPSEHGYARPVEGLIVTFDLDAM
MAB_4204|M.abscessus_ATCC_1997 WTYGDAVMPEKYRGRRLGWS-DTWVRAADGANPYAGPVNGFHCVIDMNSM
MMAR_2608|M.marinum_M WAYGDALIPEAYRGRRLAWS-DSWLTSPGGGNLYARHIKGFHCVIDLNTM
*. * : * . * ::: :. . : ** ::*: .:*:: *
MSMEG_2526|M.smegmatis_MC2_155 EVLDIEDHGVVPLPPKAGNYTEQFMFDADNRPAFTEFRQDVKKIEITQPD
Mvan_2218|M.vanbaalenii_PYR-1 TVLDVEDHGAVRLPAKGGNYSEQFMFSPDNRPAFSGFRDDVKTIEITQPD
Mflv_4125|M.gilvum_PYR-GCK AVIDVEDHGVVPLPPTAGNYSEAFMFDPNNRPAFTAFRDDVKPIEITQPD
MAB_4204|M.abscessus_ATCC_1997 ELLDIEDTFTVERPTMMGEYVPRHVPERLRK---QSTRESLQPLHITQPD
MMAR_2608|M.marinum_M ELLDIEEGSPLEFPAVMAEYVPRHIPENLRD---SSVRGALRPLEIIQPD
::*:*: : *. .:* .: . . * :: :.* ***
MSMEG_2526|M.smegmatis_MC2_155 GPSFTVDGWNVTWQKWSLRVGFNAREGLTLHEITYNDRGTVRPIMYRAAL
Mvan_2218|M.vanbaalenii_PYR-1 GPSFTVDGWNVQWQKWSLRVGFNPREGLVLHEVTYNDRGAVRPIMYRAAL
Mflv_4125|M.gilvum_PYR-GCK GPSFTVDGWNVKWQKWSLRIGFNPREGITLHEVTYTDRGETRPVLYRASL
MAB_4204|M.abscessus_ATCC_1997 GPSFTIEGNKLQWQNWSLRVGFNYREGMTLHAVTYNDNGRVRSVANRMSF
MMAR_2608|M.marinum_M GPSFTLRGNHLEWQNWSLRVGFNYREGMTLHTVTYNDHGRVRPIAYRMSF
*****: * :: **:****:*** ***:.** :**.*.* .*.: * ::
MSMEG_2526|M.smegmatis_MC2_155 SEMVVPYGDSSPTHWNKNVFDMGEVGMGFSANPLTLGCDCLGEIHYFDGT
Mvan_2218|M.vanbaalenii_PYR-1 SEMVVPYGDSSPTHWNKNVFDMGEVGMGFSANPLTLGCDCLGEIFYFDGT
Mflv_4125|M.gilvum_PYR-GCK SEMVVPYGDSAPTHWNKNVFDMGEVGMGFSANPLTLGCDCLGEIHYFDGT
MAB_4204|M.abscessus_ATCC_1997 AEMMVPYRDHCEDHYRRTAFDIGEWGIGFMTTSLELGCDCLGEIRYLDAV
MMAR_2608|M.marinum_M AEMAVPYRDHCADHYRRTAFDIGEWGLGFMTTSLEKGCDCLGEIRYLDAV
:** *** * . *:.:..**:** *:** :..* ******** *:*..
MSMEG_2526|M.smegmatis_MC2_155 VNDSDGNAVTIPNAICMHEEDYGISWKHTDFRTGEVEVRRSRRLVISMIC
Mvan_2218|M.vanbaalenii_PYR-1 VNDSDGNAVTIPNAICMHEEDYGISWKHTDFRTGEVEVRRSRRLVISMIC
Mflv_4125|M.gilvum_PYR-GCK VNDSAGNAVTIPNAICMHEEDFGISWKHTDFRTEEVEVRRSRRLVISMIC
MAB_4204|M.abscessus_ATCC_1997 LHNSKGEPYTIKNAICIHEEDNAVLWKHVDH-DHGAQVRRMRRLTVSFHV
MMAR_2608|M.marinum_M LHNSKGEPYTIKNAICIHEEDNAVLWKHVVC-DGSAEVRRMRRLTVSFHV
:::* *:. ** ****:**** .: ***. .:*** ***.:*:
MSMEG_2526|M.smegmatis_MC2_155 TVGNYEYGFFWYLYNDAGIEMEVKLTGVLTTG--SIPEGETPRWGKMVAP
Mvan_2218|M.vanbaalenii_PYR-1 TVGNYEYGFFWYLYNDASIEMEVKLTGVLTTG--AIADGETPRWGKMVAP
Mflv_4125|M.gilvum_PYR-GCK TVGNYEYGFFWYFYNDASIEVEVKLSGVLTTGAVEMAPGEQPRWGKMVAP
MAB_4204|M.abscessus_ATCC_1997 TVANYEYLTYWRFYQDGNIECEVRATGIMVVS--NFTEGAAHPHGTLVDN
MMAR_2608|M.marinum_M TVANYEYLVYWRFYQDGNIECEIRATGLMVTT--NFDNGQAHASGTLVDE
**.**** :* :*:*..** *:: :*::.. : * *.:*
MSMEG_2526|M.smegmatis_MC2_155 GMYGPNHQHFFNFRMDMSIDGPGNSVYEVDSIPEPDPELNPHHNAWITKD
Mvan_2218|M.vanbaalenii_PYR-1 GMYGPNHQHFFNFRMDMSIDGPGNSVYEVDSIPEPDPALNPHHNAWITKD
Mflv_4125|M.gilvum_PYR-GCK GIYGPNHQHFFNFRLDMSVDGPGNSVYEVDSIPEPDPARNPHRNAWITRD
MAB_4204|M.abscessus_ATCC_1997 RTYAPYHQHFLVARLDLDVDGTENTVYATETEIEPVGPENPYGLSLRQRN
MMAR_2608|M.marinum_M RTYAPYHQHFLTARLDLDIDGTDNTVYTSETEMVPTGPDNPYGLSLRQRN
*.* ****: *:*:.:**. *:** :: * **: : ::
MSMEG_2526|M.smegmatis_MC2_155 TLVASESEGARDWEFSTGRYWKVVNPSKLNEFGAPVGYKIMPKDVIPVMV
Mvan_2218|M.vanbaalenii_PYR-1 TLVASEAEGARDWEYSTGRYWKVVNPSKLNEFGAPVGYKLMPKDIVPVMV
Mflv_4125|M.gilvum_PYR-GCK TLVASESDGARDWNWSTGRYWKIANPSRRNELGIPVAYKLVPKDVVPVMV
MAB_4204|M.abscessus_ATCC_1997 TPLRTESEGKQDFCWETQRAWKVVNDNTRNGIGTAPAYKLVPGAAIPSMF
MMAR_2608|M.marinum_M IPLRTEEEGKQDYCWETQRAWRVVNENVTNGLGTHPSYKLVGGAAIPPMF
: :* :* :*: :.* * *::.* . * :* .**:: :* *.
MSMEG_2526|M.smegmatis_MC2_155 QEGSVIYDRARFVQHNLWVTKYDPRELYAAGDYMYQCAEAQGLPQYVADD
Mvan_2218|M.vanbaalenii_PYR-1 QEGSVIYDRARFVQHNLWVTKFDAKELYAAGDYMYQSADAQGLPEYVADD
Mflv_4125|M.gilvum_PYR-GCK QEGSYIYDRARFLQHNLWVTRYDPAEKFAAGDYMYQSADTQGLPEFVAGD
MAB_4204|M.abscessus_ATCC_1997 DPSSPVLARCRAIEHTLWVTPNSPDERWPAGEFVTQSKEDHGLPAWTEGN
MMAR_2608|M.marinum_M DLRSPVLRRAEAITHTVWVTPNHPDERWPAGEFVNQSGPGLGLPAWTAAN
: * : *.. : *.:*** . * :.**::: *. *** :. :
MSMEG_2526|M.smegmatis_MC2_155 APLENTDVVLWYTVGAHHVVCPEDWPVMPCHYTGFKLKPVGFFDGNPALD
Mvan_2218|M.vanbaalenii_PYR-1 APLEDTDVVLWYTVGAHHVVCPEDWPVMPCHYTGFKLKPVGFFDGNPALD
Mflv_4125|M.gilvum_PYR-GCK EPLEDSDVVLWYTLGAHHVVRPEDWPVMPCAYTGFHLKPIGFFDGNPALD
MAB_4204|M.abscessus_ATCC_1997 RSIENTDVVLWYVFGIHHITRPEDWPIMPVDTVNFWLKPVGFFDRNPSLD
MMAR_2608|M.marinum_M RSIENTDVVVWYTFGIHHITRPEDWPVMPADTVSFWLKPVGFFDRNPSLD
.:*::***:**..* **:. *****:** ..* ***:**** **:**
MSMEG_2526|M.smegmatis_MC2_155 VPPSPPAACHNH-------------
Mvan_2218|M.vanbaalenii_PYR-1 LPPSPPKACHMA-------------
Mflv_4125|M.gilvum_PYR-GCK LPPSPPKACHATRAGLPVAERALES
MAB_4204|M.abscessus_ATCC_1997 VAPTPPKSCHMSGHQED--------
MMAR_2608|M.marinum_M VAPTAAATCHGEGGC----------
:.*:.. :**