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SVLATAVSHAMTASLRELVLLDRASGQWSRHPWQEVHARAENIAERVLDGPDGAVGLVGEPTVEFVAAIQ GAWLAGRAVSILPGPVRGADDRQWAMSTVERFAGIGVSQALSYGNHLELLGANGSRLQVHDVTAVGHTRR STTLSPQAAPAGAPAVLQGTAGSTGTPRTALLSPEAVLNNVSALWQHTSTDPDRDVGMTWLPLYHDMGLT FLLTGFLTGAEMWLAPTAAFAASPFRWLTWLSDSRASLTAAPNFAYSVIGRYARRVSDVDLGRLRFAING GEPVDCEGFQLFLDELARFGLDPRAAAPSYGLAESTCAVTTPEPGTGLVVESITDPATDAVQRHAVLGRP IPGMDVRISESEHSRKVGDHTIGELEIRGTSMMSGYLGQDPLEPGEWFRTGDLGYLTDDGLVVCGRVKEL ITVAGRNIFPSEVERVAAQVRGVREGAVVAVGTDGNSARQGLIVAAEFRGPDEAGARSEVVQRVASQCGV VPADVVFLAPGSLPRTSSGKLRRLEVKQNLEAARV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1945 | - | - | 100% (526) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1051 | - | 2e-73 | 34.82% (517) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4798 | - | 4e-72 | 34.56% (515) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1380 | fadD33 | 0.0 | 62.36% (526) | long-chain-fatty-acid-- |
| M. gilvum PYR-GCK | Mflv_4411 | - | 0.0 | 75.62% (525) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1345 | fadD33 | 0.0 | 62.36% (526) | long-chain-fatty-acid-- |
| M. leprae Br4923 | MLBr_00243 | - | 1e-66 | 33.59% (518) | long-chain-fatty-acid--CoA ligase |
| M. abscessus ATCC 19977 | MAB_1140 | - | 7e-73 | 34.87% (519) | acyl-CoA synthetase |
| M. marinum M | MMAR_0174 | pks16_1 | 1e-75 | 35.26% (519) | polyketide synthase Pks16_1 |
| M. avium 104 | MAV_2874 | - | 1e-179 | 62.12% (528) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_2131 | - | 0.0 | 63.57% (527) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3540 | - | 0.0 | 63.96% (530) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_4922 | pks16_1 | 1e-75 | 35.26% (519) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1945|M.vanbaalenii_PYR-1 ----MSVLATAVSHAMTASLRELVLLDRAS--GQWSRHPWQEVHARAENI
Mflv_4411|M.gilvum_PYR-GCK ----MSVLATALSEAMTASTRDLVLLDRAS--GQWVRHPWQELHTRAENI
MSMEG_2131|M.smegmatis_MC2_155 ----MNVLSAALTEAMTTSSADLVVFEPET--RTWHRHPWGQVHLRAQNV
TH_3540|M.thermoresistible__bu ----VTVLAQALADALTTAGADLVVLDQET--RSWSRHPWPEVYVRAENV
Mb1380|M.bovis_AF2122/97 ----MSELAAVLTRSMQASAGDLMVLDRET--SLWCRHPWPEVHGLAESV
Rv1345|M.tuberculosis_H37Rv ----MSELAAVLTRSMQASAGDLMVLDRET--SLWCRHPWPEVHGLAESV
MAV_2874|M.avium_104 ----MSELAAALTAAMRTGGSDLVVFDRES--AAWRRHRWPEVHGLAEGI
MLBr_00243|M.leprae_Br4923 ----MSKFTEKMFRNARESSKGIVTGEP----HNPVRHTWGQVHERASRI
MAB_1140|M.abscessus_ATCC_1997 ----MSRFTDELYANALSSSKGMVTGEP----DTPVRHTWKQVHERAKQV
MMAR_0174|M.marinum_M ----MRRLCDSQGATQHGLTTAPVGADGRSHLDQLTNTPWSDIHHLGRRA
MUL_4922|M.ulcerans_Agy99 MNTIMRRLCDSQGATQHGLTTAPVGADGRSHLDQLTNTPWSDIHHLGRRA
: : : : . * ::: .
Mvan_1945|M.vanbaalenii_PYR-1 AERVL---DGPDGAVGLVGEPTVEFVAAIQGAWLAGRAVSILPGPVRGAD
Mflv_4411|M.gilvum_PYR-GCK AEHIL---NDRDGAVGLVGEPTAELVSAIQGTWLAGRALAILPGPIRGAD
MSMEG_2131|M.smegmatis_MC2_155 AERIG---QDGSSAVGIVGEPTVEGVAAILGALLAGSAVSILPGLVRGAD
TH_3540|M.thermoresistible__bu ADRVL---ADEATAVGLVGEPTVELISAIIGALLAGAAVSVLPGPVRGAD
Mb1380|M.bovis_AF2122/97 AAWLLD--HDRPAAVGLVGEPTVELVAAIQGAWLAGAAVSILPGPVRGAN
Rv1345|M.tuberculosis_H37Rv AAWLLD--HDRPAAVGLVGEPTVELVAAIQGAWLAGAAVSILPGPVRGAN
MAV_2874|M.avium_104 AAWLLD--RDRPAALGLVGEPTLEFVAAIVGAWLAGAGVSILPGPVRGAE
MLBr_00243|M.leprae_Br4923 AGGLAGVGVGHGDAVGVLVGVPVEIAPTAQGLWMRGASLTMLHQPTPRTD
MAB_1140|M.abscessus_ATCC_1997 AGGLAGAGLGPDDAIGMLVGMPVEIAPAIQAVWMRGASLTMLHQPTPRTD
MMAR_0174|M.marinum_M AGALQRDGVTPGDVVAVLAGAPGEIAPLVQGAWMCGAAVTMLHQPTHRSD
MUL_4922|M.ulcerans_Agy99 AGALQRDGVTPGDVVAVLAGAPGEIAPLVQGAWMCGAAVTMLHQPTHRSD
* : .:.:: . * . . : * .:::* ::
Mvan_1945|M.vanbaalenii_PYR-1 DRQWAMSTVERFAGIGVSQALSYGNHLELLG-ANGSR---LQVHDVTAVG
Mflv_4411|M.gilvum_PYR-GCK EREWAAATAQRFAGIGVGQILTYGEHLELLR-PNVFG---ITVHDLAVVG
MSMEG_2131|M.smegmatis_MC2_155 PDQWADSTLNRFANIGVTTVFSHGSYLEQLR-TRDSS---LVIHDDAEVA
TH_3540|M.thermoresistible__bu PRQWAQGTLKRFTGIGVRTVFSHGAQLELLRGVDDASG-APAIHDVSTVA
Mb1380|M.bovis_AF2122/97 DQRWADATLTRFLGIGVRTVLSQGSYLARLRSVDTAG---VTIGDLSTAA
Rv1345|M.tuberculosis_H37Rv DQRWADATLTRFLGIGVRTVLSQGSYLARLRSVDTAG---VTIGDLSTAA
MAV_2874|M.avium_104 GRRWADTTLTRFAGIGVRTVLSHGSHLDALQALDPSRPDEMVVEDLAVAA
MLBr_00243|M.leprae_Br4923 LAVWEEDTTTVIDMIEAKAVIISDPFMAVAPILEARGVKVVTVEQLLAAD
MAB_1140|M.abscessus_ATCC_1997 LAVWAEDTLKVVDMIGAKAVIVSAPFDAAAPVLEEKGVIVVHIKDLWDAD
MMAR_0174|M.marinum_M LQAWAADTKKTLSMVGASTVVVGSPFQSAAQEFAKVGLRGLELSELLTAD
MUL_4922|M.ulcerans_Agy99 LQAWAADTKKTLSMVGASTAVVGSPFQSAAQEFAKVGLRGLELSELLTAD
* * . : . . : : .
Mvan_1945|M.vanbaalenii_PYR-1 HTRRSTTLSPQAAPAGAPAVLQGTAGSTGTPRTALLSPEAVLNNVSALWQ
Mflv_4411|M.gilvum_PYR-GCK HAQRSTTLVSAPAAPGTPAVLQGTAGSTGTPRTALLSQDAVKHNVAGMLR
MSMEG_2131|M.smegmatis_MC2_155 HAQRSTTLELGAPLGE-FAVLQGTAGSTGTPRTAQLRPDAVLANLRGLAE
TH_3540|M.thermoresistible__bu HDRRSTTLLPPSEPNG-IAILQGTAGSTGTPRTAALPAEAVLANLRGLTT
Mb1380|M.bovis_AF2122/97 HTNR---SATPVASEG-PAVLQGTAGSTGAPRTAILSPGAVLSNLRGLNQ
Rv1345|M.tuberculosis_H37Rv HTNR---SATPVASEG-PAVLQGTAGSTGAPRTAILSPGAVLSNLRGLNQ
MAV_2874|M.avium_104 NTGRRC-PEPPAPHAN-PAILQGTAGSTGTPKTAALSPDAVLANLRGLNA
MLBr_00243|M.leprae_Br4923 ------PVDPIETDEDDLALMQLTSGSTGSPKAVQITHRNVYSNVEAMFI
MAB_1140|M.abscessus_ATCC_1997 ------PIEPLEADEDSVALMQLTSGSTGSPKAVKITHRNLYANAHGMYV
MMAR_0174|M.marinum_M ------EGRIVVAEEDSPAFLQLTSGSTGHPKAVSITYRNIEANGRALMA
MUL_4922|M.ulcerans_Agy99 ------EGRIVVAEEDSPAFLQLTSGSTGHPKAVSITYRNIEANGRALMA
*.:* *:**** *::. : : * .:
Mvan_1945|M.vanbaalenii_PYR-1 HTSTDPDRDVGMTWLPLYHDMGLT-FLLTGFLTGAEMWLAPTAAFAASPF
Mflv_4411|M.gilvum_PYR-GCK HTDVDPGRDRGLTWLPLYHDMGLT-FLLTGFMSGSEMWLAPTASFAASPF
MSMEG_2131|M.smegmatis_MC2_155 RVGLAGS-DIGCSWLPLYHDMGLT-FLLSAAVGGTETWQAPTTAFASAPF
TH_3540|M.thermoresistible__bu RTSVTTD-DVGCSWLPLYHDMGLS-FLLSGALVGAELWQAPTTAFAASPF
Mb1380|M.bovis_AF2122/97 RVGTDAATDVGCSWLPLYHDMGLA-FVLSAALAGAPLWLAPTTAFTASPF
Rv1345|M.tuberculosis_H37Rv RVGTDAATDVGCSWLPLYHDMGLA-FVLSAALAGAPLWLAPTTAFTASPF
MAV_2874|M.avium_104 RLGVTPA-DVGCSWLPLYHDMGLS-FLLASALGGMSLWLAPTSAFTASPF
MLBr_00243|M.leprae_Br4923 GVRYNVEKDVMISWLPCFHDMGMIGFLTVPMYFGAELVKVTPIDFLRDTL
MAB_1140|M.abscessus_ATCC_1997 ASKYKPEIDVMVSWLPLFHDMGMVGFLTVPMFFGAELVKITPMDFMRDVL
MMAR_0174|M.marinum_M AASADVASDVVVSWLPLFHDMGMMGLLIIPMYEGMDAVHITPADFLNDPL
MUL_4922|M.ulcerans_Agy99 AASADVASDVVVSWLPLFHDMGMMGLLIIPMYEGMDAVHITPADFLNDPL
* :*** :****: :: * .. * :
Mvan_1945|M.vanbaalenii_PYR-1 RWLTWLSDSRASLTAAPNFAYSVIGRYAR---RVSDVDLGRLRFAINGGE
Mflv_4411|M.gilvum_PYR-GCK RWLAWLSESRAGLTAAPNFAYSVIGKYAR---RVPDVDLSNLRFALNGGE
MSMEG_2131|M.smegmatis_MC2_155 SWVHWLTESRATLTAAPNMAYGLIGKYSR---RLTDVDLSAMRFALNGGE
TH_3540|M.thermoresistible__bu SWLHWLTASRATMTAAPNMAYGLIGKYSR---RVTDVDLGRLRFALNGGE
Mb1380|M.bovis_AF2122/97 RWLSWLSDSGATMTAAPNFAYNLIGKYAR---RVSEVDLGALRVTLNGGE
Rv1345|M.tuberculosis_H37Rv RWLSWLSDSGATMTAAPNFAYNLIGKYAR---RVSEVDLGALRVTLNGGE
MAV_2874|M.avium_104 RWLAWLSESRATITAAPNFAYNLVGKYAR---RVSGVDLGALRVAINGGE
MLBr_00243|M.leprae_Br4923 LWAKLIDKYKGTVICGPNFAYSLFTKRLRKQAKPGQFDLSTLRIAMSGAE
MAB_1140|M.abscessus_ATCC_1997 LWGRLIDKYKGTMTAAPNFAYSLFAKRLRNQAKPGDFDLSTLRFVLSGAE
MMAR_0174|M.marinum_M LWAELITKHRGSITAAPNFAYSLLARRLR-RAQDHAFDLSSLRFALNGAE
MUL_4922|M.ulcerans_Agy99 LWAELITKHRGSITAAPNFAYSLLARRLR-RAQDHAFDLSSLRFALNGAE
* : . : ..**:**.:. : * : .**. :*..:.*.*
Mvan_1945|M.vanbaalenii_PYR-1 PVDCEGFQLFLDELARFGLDPRAAAPSYGLAESTCAVTTPEPG-------
Mflv_4411|M.gilvum_PYR-GCK PVDCDGFELFLRELSRFGLDPGVAAPSYGLAESTCAVTSPRPG-------
MSMEG_2131|M.smegmatis_MC2_155 PVDIDGTARFGTELSRFGFDPGALSPSYGLAESSCAVTVPVPG-------
TH_3540|M.thermoresistible__bu PVDCDATTRFATEMARFGFDAAALCPSYGLAESTCAVTVPIPG-------
Mb1380|M.bovis_AF2122/97 PVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVPVPG-------
Rv1345|M.tuberculosis_H37Rv PVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVPVPG-------
MAV_2874|M.avium_104 PVDCAGFERFATAMAPFGFDAGAATPSYGLAESTCAVSVPAPG-------
MLBr_00243|M.leprae_Br4923 PVDPADVEDLIDAGRPFGFRPEAILPAYGMAETTLAVSFSPVG-EGLLVD
MAB_1140|M.abscessus_ATCC_1997 PVDPAVVEDLCDAGKPFGFKPSAMVPAYGMAETALAVSFSEVEASGLVVD
MMAR_0174|M.marinum_M GIDVATLERLATEGARFGLRRDAIVPAYGMAEATLAISVVRPG-EGFRVC
MUL_4922|M.ulcerans_Agy99 GIDVATLERLATEGARFGLRRDAIVPAYGMAEATLAISVVRPG-EGFRVC
:* : **: . *:**:**:: *::
Mvan_1945|M.vanbaalenii_PYR-1 ---TGLVVESITDP--ATDAVQRHAVLGRPIPGMDVRISES-EHSRKVGD
Mflv_4411|M.gilvum_PYR-GCK ---TGLLVDDITDP--DTGTPRRHAVLGEPIPGMELRIAPS-EG-RRSGE
MSMEG_2131|M.smegmatis_MC2_155 ---VGLKVDEITVTTEAGSSTQKLAVLGHAIAGMEVRLQPG-DEDAGVVD
TH_3540|M.thermoresistible__bu ---AGLQIDEVEVVTEAGTATRRHAVLGEAIPGMQVRIAPRPDQQVGITG
Mb1380|M.bovis_AF2122/97 ---IGLLADRVID----GSGAHKHAVLGNPIPGMEVRISCG-DQAAGNAS
Rv1345|M.tuberculosis_H37Rv ---IGLLADRVID----GSGAHKHAVLGNPIPGMEVRISCG-DQAAGNAS
MAV_2874|M.avium_104 ---TGLRFADVSD----ETGTRRHAVLGAPIPGTEIRISP-----RHDVP
MLBr_00243|M.leprae_Br4923 EVDADLLAALRRAVPATKGNIRRLVSLGPLLDGLEVRIVDE--DGNVLPS
MAB_1140|M.abscessus_ATCC_1997 EVDADLLAALRRAVPATRGNLRHLATLGPLLPGIEARVVDE--DLNVLPA
MMAR_0174|M.marinum_M PPHPDLVAAQGEAAAPR-------VMLGPPVPGCDVRVVSE--DRTVLAP
MUL_4922|M.ulcerans_Agy99 PPHPDLVAAQGEAAAPR-------VMLGPPVPGCDVRVVSE--DRTVLAP
.* . ** : * : *:
Mvan_1945|M.vanbaalenii_PYR-1 HTIGELEIRGTSMMSGYLGQD----PLEPGEWFRTGDLGYLTDDG-LVVC
Mflv_4411|M.gilvum_PYR-GCK REIGEVEIRGTSMMSGYLGEE----PLAPGQWFPTGDLGYLTDAG-LVVC
MSMEG_2131|M.smegmatis_MC2_155 REVGEVEIRGTSMMSGYRGEA----PLDPGEWFPTGDLGYLTDDG-LVIC
TH_3540|M.thermoresistible__bu REVGEVQIRGSSMMSGYLGEP----PIDREAWFPTGDLGYFVDGG-LVVC
Mb1380|M.bovis_AF2122/97 REIGEIEIRGASMMAGYLGQQ----PIDPDDWFATGDLGYLGAGG-LVVC
Rv1345|M.tuberculosis_H37Rv REIGEIEIRGASMMAGYLGQQ----PIDPDDWFATGDLGYLGAGG-LVVC
MAV_2874|M.avium_104 DGIGEIEIRGASMMDGYLGHA----PIDHQNWFPTGDLGFFSDGG-LVVC
MLBr_00243|M.leprae_Br4923 RGVGVIELRGESLTPGYITMGGFISAQDEHGWYDTGDLGYQMENGHIVVC
MAB_1140|M.abscessus_ATCC_1997 RGVGVIELRGESVTPGYVTMGGFLAAQDENGWYNTGDLGYLTEKGHVVVC
MMAR_0174|M.marinum_M SEIGELEIRGDNVTAGYRTEAGFEPAVDAGGWLATGDVGYLTENGQPVIC
MUL_4922|M.ulcerans_Agy99 SEIGELEIRGDNVTAGYRTEAGFEPAVDAGGWLATGDVGYLAENGQPVIC
:* :::** .: ** . * ***:*: * *:*
Mvan_1945|M.vanbaalenii_PYR-1 GRVKELITVAGRNIFPSEVERVAAQVRGVREGAVVAVGTDGN----SARQ
Mflv_4411|M.gilvum_PYR-GCK GRVKELITIAGRNIFPTEVERVAAEVRGVREGAVVAVGTDSG----SARQ
MSMEG_2131|M.smegmatis_MC2_155 GRKKELITVAGRNIFPTEIERIAARVKGVREGAVVAVGTNER----AVRP
TH_3540|M.thermoresistible__bu GRAKEMITVAGRNVFPTEIEQVAGQVPGVREGAVVAVGTNEN----SVRP
Mb1380|M.bovis_AF2122/97 GRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGDR----STRP
Rv1345|M.tuberculosis_H37Rv GRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGDR----STRP
MAV_2874|M.avium_104 GRAKELITLAGRNIFPTEIETVAAQVPGVREGAVVALGTGEN----SARP
MLBr_00243|M.leprae_Br4923 GRVKDVIIMAGRNVYPTDIERAAGRVDGVRPGCAVAVRLDAG----HSRE
MAB_1140|M.abscessus_ATCC_1997 GRVKDVIIMAGRNIYPTDIERAAGRVDGVRPGCAVAVRLEAGVDPKNQRE
MMAR_0174|M.marinum_M GRKKDILIISGRNVHPEDIERSVVGIAGIRSGGVAAVRLATA----SASE
MUL_4922|M.ulcerans_Agy99 GRKKDILIISGRNVHPEDIERSVVGIAGIRSGGVAAVRLATA----SASE
** *::: ::***:.* ::* . : *:* * ..*:
Mvan_1945|M.vanbaalenii_PYR-1 GLIVAAEFRGPDEAG----ARSEVVQRVASQCGVVPADVVFLAPGSLPRT
Mflv_4411|M.gilvum_PYR-GCK GLVIAAEFRGADESG----AKSEVVQRVASQCGVVPSEVVFLKPGSLPRT
MSMEG_2131|M.smegmatis_MC2_155 GLVIAAEFRGPDEAG----ARSEVVQRVASECGVVPADVVFLAPGSLPRT
TH_3540|M.thermoresistible__bu GLVIVAEYRGRDEAG----ARSQVVQRVASECGVVPTDVLLRPPGSLPRT
Mb1380|M.bovis_AF2122/97 GLVVAAEFRGPDEAN----ARAELIQRVASECGIVPSDVVFVSPGSLPRT
Rv1345|M.tuberculosis_H37Rv GLVVAAEFRGPDEAN----ARAELIQRVASECGIVPSDVVFVSPGSLPRT
MAV_2874|M.avium_104 GLIIAAEFAGRDRAG----ARAEVIQRVASVCGVVPSDVIFMAPGSLPRT
MLBr_00243|M.leprae_Br4923 TFAVAVESNAFEDTAEVRRIEHQVAHEVLKEVDVRPRNVVVLGPGTIPKT
MAB_1140|M.abscessus_ATCC_1997 TFAVVVESNAFENPDEVRRIEQQVAHEVVAEVDVRPRNVVVLGPGSIPKT
MMAR_0174|M.marinum_M GFVMVAESALHADDAESNRIRTEVADRVFVNLGVSPRAVHVVPAGWLPKT
MUL_4922|M.ulcerans_Agy99 GFVMVAESALHADDAESNRIRTEVADRVFVNLGVSPRAVHVVPAGWLPKT
: :..* . :: ..* .: * * . .* :*:*
Mvan_1945|M.vanbaalenii_PYR-1 SSGKLRRLEVKQNLEAARV---
Mflv_4411|M.gilvum_PYR-GCK SSGKLRRLAVKNDLDGLRAPVS
MSMEG_2131|M.smegmatis_MC2_155 SSGKLRRLEVKRQLEESKG---
TH_3540|M.thermoresistible__bu SSGKLRRLEVKRNLEGVGR---
Mb1380|M.bovis_AF2122/97 SSGKLRRLAVRRSLEMAD----
Rv1345|M.tuberculosis_H37Rv SSGKLRRLAVRRSLEMAD----
MAV_2874|M.avium_104 SSGKLRRLDVRRSLEAVD----
MLBr_00243|M.leprae_Br4923 PSGKLRR-ASSVTLVT------
MAB_1140|M.abscessus_ATCC_1997 PSGKLRR-STSVALVI------
MMAR_0174|M.marinum_M SSGKLRRRQTSERLRLFDDAL-
MUL_4922|M.ulcerans_Agy99 SSGKLRRRQTSERLRLFDDAL-
.****** *