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NTIMRRLCDSQGATQHGLTTAPVGADGRSHLDQLTNTPWSDIHHLGRRAAGALQRDGVTPGDVVAVLAGA PGEIAPLVQGAWMCGAAVTMLHQPTHRSDLQAWAADTKKTLSMVGASTAVVGSPFQSAAQEFAKVGLRGL ELSELLTADEGRIVVAEEDSPAFLQLTSGSTGHPKAVSITYRNIEANGRALMAAASADVASDVVVSWLPL FHDMGMMGLLIIPMYEGMDAVHITPADFLNDPLLWAELITKHRGSITAAPNFAYSLLARRLRRAQDHAFD LSSLRFALNGAEGIDVATLERLATEGARFGLRRDAIVPAYGMAEATLAISVVRPGEGFRVCPPHPDLVAA QGEAAAPRVMLGPPVPGCDVRVVSEDRTVLAPSEIGELEIRGDNVTAGYRTEAGFEPAVDAGGWLATGDV GYLAENGQPVICGRKKDILIISGRNVHPEDIERSVVGIAGIRSGGVAAVRLATASASEGFVMVAESALHA DDAESNRIRTEVADRVFVNLGVSPRAVHVVPAGWLPKTSSGKLRRRQTSERLRLFDDAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4922 | pks16_1 | - | 100% (550) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4648 | pks16 | e-131 | 49.31% (505) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_4044 | - | e-109 | 42.27% (511) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1041 | pks16 | 1e-128 | 47.26% (529) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_5217 | - | 1e-134 | 50.10% (505) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1013 | pks16 | 1e-128 | 47.26% (529) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_00243 | - | 1e-127 | 47.13% (505) | long-chain-fatty-acid--CoA ligase |
| M. abscessus ATCC 19977 | MAB_1692 | - | 0.0 | 71.17% (548) | acyl-CoA synthetase |
| M. marinum M | MMAR_0174 | pks16_1 | 0.0 | 99.63% (546) | polyketide synthase Pks16_1 |
| M. avium 104 | MAV_1150 | - | 1e-131 | 49.11% (505) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_5435 | - | 1e-130 | 49.11% (505) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3958 | - | 1e-134 | 49.15% (529) | PUTATIVE AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_1051 | - | 1e-133 | 49.70% (505) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1041|M.bovis_AF2122/97 ----------MSRFTEKMFHNARTATTGMVTG--------EPHMPVRHTW
Rv1013|M.tuberculosis_H37Rv ----------MSRFTEKMFHNARTATTGMVTG--------EPHMPVRHTW
MAV_1150|M.avium_104 ----------MSRFTEKMYRNARTAKTGMVTG--------EPHNPVRHTW
MSMEG_5435|M.smegmatis_MC2_155 ----------MSRFTEKMYRNARTVTTGMVTG--------EPHEPVRHTW
TH_3958|M.thermoresistible__bu -----------------MFHNARTATTGMVTG--------EPHAPVRHTW
MLBr_00243|M.leprae_Br4923 ----------MSKFTEKMFRNARESSKGIVTG--------EPHNPVRHTW
Mflv_5217|M.gilvum_PYR-GCK ----------MSQFTETMYANAHRSSKGLNTG--------EPHSPVRHTW
Mvan_1051|M.vanbaalenii_PYR-1 ----------MSRFTETMFANAHLSTKGFNTG--------EPHSPVRHSW
MUL_4922|M.ulcerans_Agy99 ----------MNTIMRRLCDSQGATQHGLTTAPVGADGRSHLDQLTNTPW
MMAR_0174|M.marinum_M --------------MRRLCDSQGATQHGLTTAPVGADGRSHLDQLTNTPW
MAB_1692|M.abscessus_ATCC_1997 MSRLREDRPGSNPVIDRLLAGAGITGRGLTSAPIGPDGASQLDELSTTAW
: . *: :. . . .*
Mb1041|M.bovis_AF2122/97 GEVHERARCIAGGLAAAGVGLGDVVGVLAGFPVEIAPTAQALWMRGASLT
Rv1013|M.tuberculosis_H37Rv GEVHERARCIAGGLAAAGVGLGDVVGVLAGFPVEIAPTAQALWMRGASLT
MAV_1150|M.avium_104 GEVHERARRIAGGLAAAGIGPGDAVGVLAGFPVEIAPTAQGLWMRGASLT
MSMEG_5435|M.smegmatis_MC2_155 GEVHERARRIAGGLAAAGIGHGDAVGVLAGFPVEIAPTAQGVWMRGASLT
TH_3958|M.thermoresistible__bu GEVHERARRIAGGLAAAGVGHGDAVGVLAGWPVEIAPTAQALWIRGASLT
MLBr_00243|M.leprae_Br4923 GQVHERASRIAGGLAGVGVGHGDAVGVLVGVPVEIAPTAQGLWMRGASLT
Mflv_5217|M.gilvum_PYR-GCK EEVHQRARRIAGGLAAAGVGHGDAVAMLAGAPVEIAPAAQGVWMRGASVT
Mvan_1051|M.vanbaalenii_PYR-1 EEVHQRARRVAGGLAAAGVGPGDAVAMLAGAPVEIAPAAQGVWMRGASVT
MUL_4922|M.ulcerans_Agy99 SDIHHLGRRAAGALQRDGVTPGDVVAVLAGAPGEIAPLVQGAWMCGAAVT
MMAR_0174|M.marinum_M SDIHHLGRRAAGALQRDGVTPGDVVAVLAGAPGEIAPLVQGAWMCGAAVT
MAB_1692|M.abscessus_ATCC_1997 ADVHRTGLRIAGALQAAGVRPGDAVAVLAGAPGEIAPLVQGIWFSGASVT
::*. . **.* *: **.*.:*.* * **** .*. *: **::*
Mb1041|M.bovis_AF2122/97 MLHQPTPRTDLAVWAEDTMTVIGMIEAKAVIVSEPFLVAIPILEQKGMQV
Rv1013|M.tuberculosis_H37Rv MLHQPTPRTDLAVWAEDTMTVIGMIEAKAVIVSEPFLVAIPILEQKGMQV
MAV_1150|M.avium_104 MLHQPTPRTDLAVWADDTMNVIGMIEAKAVVVSEPFLVAIPVLQEKDIKV
MSMEG_5435|M.smegmatis_MC2_155 MLHQPTPRTDLAVWAEDTMNVIGMIELKAVIISEPFLVATPVLEEKGILV
TH_3958|M.thermoresistible__bu MLHQPTPRTDLMMWAEDTMNVIGMIAAKVVVVSDPFTAAIPVLEERGIKV
MLBr_00243|M.leprae_Br4923 MLHQPTPRTDLAVWEEDTTTVIDMIEAKAVIISDPFMAVAPILEARGVKV
Mflv_5217|M.gilvum_PYR-GCK MVHQPTPRTDLIRWADETTSVIDMISASAVVISDPFMAAAPLLSGMGMTV
Mvan_1051|M.vanbaalenii_PYR-1 MVHQPTPRTDLVRWAEETTAVITMIDAKAVVISDPFMAAAPVLEGLGMTV
MUL_4922|M.ulcerans_Agy99 MLHQPTHRSDLQAWAADTKKTLSMVGASTAVVGSPFQSAAQEFAKVGLRG
MMAR_0174|M.marinum_M MLHQPTHRSDLQAWAADTKKTLSMVGASTVVVGSPFQSAAQEFAKVGLRG
MAB_1692|M.abscessus_ATCC_1997 MLHQPTHRSDMRLWVEDTGRALAAVGSSTVVVGDPFMAAASQFGAVAAQV
*:**** *:*: * :* .: : ...::..** . :
Mb1041|M.bovis_AF2122/97 LTVADLLASDPIGPIEVGEDDLALMQLTSGSTGSPKAVQITHRNIYSNAE
Rv1013|M.tuberculosis_H37Rv LTVADLLASDPIGPIEVGEDDLALMQLTSGSTGSPKAVQITHRNIYSNAE
MAV_1150|M.avium_104 LTVADLLASDPIDPVEVGEDDLALMQLTSGSTGSPKAVQITHRNIYSNAE
MSMEG_5435|M.smegmatis_MC2_155 LKVADLLAADPIDPVETGEDDLALMQLTSGSTGSPKAVQITHRNIHSNAE
TH_3958|M.thermoresistible__bu LTVEQLLAADPIDPVDTSEDDVALMQLTSGSTGSPKAVVITHRNIYSNAE
MLBr_00243|M.leprae_Br4923 VTVEQLLAADPVDPIETDEDDLALMQLTSGSTGSPKAVQITHRNVYSNVE
Mflv_5217|M.gilvum_PYR-GCK LSIADLLTAEPIDPVDTCDDDIALMQLTSGSTGSPKAVQITHANIVANAD
Mvan_1051|M.vanbaalenii_PYR-1 LTIADLLAADRVDPVETSDDDIALMQLTSGSTGSPKAVQITHANIVANAD
MUL_4922|M.ulcerans_Agy99 LELSELLTADEGRIVVAEEDSPAFLQLTSGSTGHPKAVSITYRNIEANGR
MMAR_0174|M.marinum_M LELSELLTADEGRIVVAEEDSPAFLQLTSGSTGHPKAVSITYRNIEANGR
MAB_1692|M.abscessus_ATCC_1997 LEMSALLDGPPGEIVQSDQDAIAFLQLTSGSTGTPKAVSISYRNIEANLR
: : ** . : :* *::******** **** *:: *: :*
Mb1041|M.bovis_AF2122/97 AMFVGAQYDVDKDVMVSWLPCFHDMGMVGFLTIPMFFGAELVKVTPMDFL
Rv1013|M.tuberculosis_H37Rv AMFVGAQYDVDKDVMVSWLPCFHDMGMVGFLTIPMFFGAELVKVTPMDFL
MAV_1150|M.avium_104 AMFIGAQYDVDKDVMVSWLPCFHDMGMVGFLTIPMYFGAELVKVTPMDFL
MSMEG_5435|M.smegmatis_MC2_155 AMFVGAKYDVEKDVMVSWLPCFHDMGMVGFLTIPMYFGAELVKVTPMDFL
TH_3958|M.thermoresistible__bu AMFVGAQYDVDNDVMVSWLPCFHDMGMIGFLTVPMYFGAELVKVTPMDFL
MLBr_00243|M.leprae_Br4923 AMFIGVRYNVEKDVMISWLPCFHDMGMIGFLTVPMYFGAELVKVTPIDFL
Mflv_5217|M.gilvum_PYR-GCK AMTAGCDFDIDTDVIVSWLPCFHDMGMTGYLTVPMYFGAELVKITPMDFL
Mvan_1051|M.vanbaalenii_PYR-1 AMTAGCNFDIDTDVIVSWLPCFHDMGMTGYLTVPMYFGAELVKVTPMDFL
MUL_4922|M.ulcerans_Agy99 ALMAAASADVASDVVVSWLPLFHDMGMMGLLIIPMYEGMDAVHITPADFL
MMAR_0174|M.marinum_M ALMAAASADVASDVVVSWLPLFHDMGMMGLLIIPMYEGMDAVHITPADFL
MAB_1692|M.abscessus_ATCC_1997 AMVSASGADPETDVVVSWLPLFHDMGMMGFLIVPMCRAMSTVSVTPMDFL
*: . : .**::**** ****** * * :** . . * :** ***
Mb1041|M.bovis_AF2122/97 RDTLLWAKLIDKYQGTMTAAPNFAYALLAKRLRRQAKPGDFDLSTLRFAL
Rv1013|M.tuberculosis_H37Rv RDTLLWAKLIDKYQGTMTAAPNFAYALLAKRLRRQAKPGDFDLSTLRFAL
MAV_1150|M.avium_104 RDTLLWAKLIDKYKGTMTAAPNFAYALLAKRLRRQAKPGDFDLSTLRFAL
MSMEG_5435|M.smegmatis_MC2_155 RDTLLWAKLIDKYKGTMTAAPNFAYALLAKRLRRQAKPGDFDLSTLRFAL
TH_3958|M.thermoresistible__bu RDTLLWARLIDKYKGTMTAAPNFAYALLAKRLRRQAKPGEFDLSTLRFAL
MLBr_00243|M.leprae_Br4923 RDTLLWAKLIDKYKGTVICGPNFAYSLFTKRLRKQAKPGQFDLSTLRIAM
Mflv_5217|M.gilvum_PYR-GCK GDILLWPRLIHKYRGTMTAAPNFAYNLLARRLRRQATPGEFDLSSLRWAL
Mvan_1051|M.vanbaalenii_PYR-1 SDILLWPRLIDKYRGTMTAAPNFAYNLLARRLRRQADPGEFDLSSLRWAL
MUL_4922|M.ulcerans_Agy99 NDPLLWAELITKHRGSITAAPNFAYSLLARRLR-RAQDHAFDLSSLRFAL
MMAR_0174|M.marinum_M NDPLLWAELITKHRGSITAAPNFAYSLLARRLR-RAQDHAFDLSSLRFAL
MAB_1692|M.abscessus_ATCC_1997 GDPLLWAKLISTYRGSMTAGPNFAYSLLARRLR-KAPDGAYDLSSLQFAL
* ***..** .::*:: ..***** *:::*** :* :***:*: *:
Mb1041|M.bovis_AF2122/97 SGAEPVEPADVEDLLDAGKPFGLRPSAILPAYGMAETTLAVSFSECNAGL
Rv1013|M.tuberculosis_H37Rv SGAEPVEPADVEDLLDAGKPFGLRPSAILPAYGMAETTLAVSFSECNAGL
MAV_1150|M.avium_104 SGAEPVEPADVEDLLDAGKPFGLKPSAILPAYGMAETTLAVSFSECNAGL
MSMEG_5435|M.smegmatis_MC2_155 SGAEPVEPADVEDFLDAGKPFGLRPEAILPAYGMAETTLAVSFSPCGEGL
TH_3958|M.thermoresistible__bu SGAEPVEPADVEDLIDAGKPFGLRPEAILPAYGMAETTLAVSFSECGAGL
MLBr_00243|M.leprae_Br4923 SGAEPVDPADVEDLIDAGRPFGFRPEAILPAYGMAETTLAVSFSPVGEGL
Mflv_5217|M.gilvum_PYR-GCK SGAEQVDPDDVEDLCAAGAPFGLRPEAVIPAYGMAETTVAVSFSECGGGM
Mvan_1051|M.vanbaalenii_PYR-1 SGAEQVDPLDVEDLCDAGAPFGLKPEAIVPAYGMAETTVAVSFSECGGGM
MUL_4922|M.ulcerans_Agy99 NGAEGIDVATLERLATEGARFGLRRDAIVPAYGMAEATLAISVVRPGEGF
MMAR_0174|M.marinum_M NGAEGIDVATLERLATEGARFGLRRDAIVPAYGMAEATLAISVVRPGEGF
MAB_1692|M.abscessus_ATCC_1997 SGAEAIDVATLERFVAEGARFGMRADAVVPAYGMAEATLAVSFVRRGEGY
.*** :: :* : * **:: .*::*******:*:*:*. . *
Mb1041|M.bovis_AF2122/97 VVDEVDADLLAALRRAVPATKGNTRRLATLGPLLQDLEARIIDEQGDVMP
Rv1013|M.tuberculosis_H37Rv VVDEVDADLLAALRRAVPATKGNTRRLATLGPLLQDLEARIIDEQGDVMP
MAV_1150|M.avium_104 VVDEVDADLLAALRRAVPATKGNTRRLATLGPLLQDLEARIVDENGDVMP
MSMEG_5435|M.smegmatis_MC2_155 VVDEVDADLLAALRRAVPATKGNTKRLASLGPLLNDLEARVVDENGEVMP
TH_3958|M.thermoresistible__bu IVDEVDADLLAALRRAVPASKGNTRRLASLGPLLPDLEARVVDEDGNILP
MLBr_00243|M.leprae_Br4923 LVDEVDADLLAALRRAVPATKGNIRRLVSLGPLLDGLEVRIVDEDGNVLP
Mflv_5217|M.gilvum_PYR-GCK VVDEVDADLLAVLHRAVPAAKGHTRRLVALGRPLAGLEMRIVDEDGAALQ
Mvan_1051|M.vanbaalenii_PYR-1 VVDEVDADLLAVLHRAVPATKGHTRRLVTLGRPLQGLELRVVDEDGAELP
MUL_4922|M.ulcerans_Agy99 RVCPPHPDLVAAQGEAAAPR-------VMLGPPVPGCDVRVVSEDRTVLA
MMAR_0174|M.marinum_M RVCPPHPDLVAAQGEAAAPR-------VMLGPPVPGCDVRVVSEDRTVLA
MAB_1692|M.abscessus_ATCC_1997 RVCPPHPDLVAAQGTQASAR-------VPLGLPLPGCEVRVVTEDRQVLA
* ..**:*. ... . ** : . : *:: *: :
Mb1041|M.bovis_AF2122/97 ARGVGVIELRGESLTPGYLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVV
Rv1013|M.tuberculosis_H37Rv ARGVGVIELRGESLTPGYLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVV
MAV_1150|M.avium_104 PRGVGVIELRGESVTPGYLTMGGFIPAQDENGWYDTGDLGYLTEEGHVVV
MSMEG_5435|M.smegmatis_MC2_155 ARGVGVIELRGEPVTPGYITMGGFVPAQDEYGWYDTGDLGYITEEGNIVV
TH_3958|M.thermoresistible__bu PRGVGIIELRGEPVTPGYVTMGGFVPAQDEHGWYDTGDLGYLTEEGHVVV
MLBr_00243|M.leprae_Br4923 SRGVGVIELRGESLTPGYITMGGFISAQDEHGWYDTGDLGYQMENGHIVV
Mflv_5217|M.gilvum_PYR-GCK PRGVGVIEVRGQSVTRGYTTAAGFIAAQDDRGWYDTGDIGYLTEDGDVVV
Mvan_1051|M.vanbaalenii_PYR-1 ARGVGVIEVRGEPVTKGYTTVAGFIGAQDDRGWYDTGDIGYLTEVGDVVV
MUL_4922|M.ulcerans_Agy99 PSEIGELEIRGDNVTAGYRTEAGFEPAVDAGGWLATGDVGYLAENGQPVI
MMAR_0174|M.marinum_M PSEIGELEIRGDNVTAGYRTEAGFEPAVDAGGWLATGDVGYLTENGQPVI
MAB_1692|M.abscessus_ATCC_1997 PESIGELEIRGDNVTAGYRTASGFESMLDAQGWLSTGDIGYLTADGQPVI
. :* :*:**: :* ** * .** * ** ***:** *. *:
Mb1041|M.bovis_AF2122/97 CGRVKDVIIMAGRNIYPTDIERAAGRVDGVRPGCAVAVRLDAGHSRESFA
Rv1013|M.tuberculosis_H37Rv CGRVKDVIIMAGRNIYPTDIERAAGRVDGVRPGCAVAVRLDAGHSRESFA
MAV_1150|M.avium_104 CGRVKDVIIMAGRNIYPTDIERAACRVEGVRPGCAVAVRLDAGHSRETFA
MSMEG_5435|M.smegmatis_MC2_155 CGRVKDVIIMAGRNIYPTDIERAAGRVEGVRPGCAVAVRLDAGHSRETFA
TH_3958|M.thermoresistible__bu CGRVKDVIIMAGRNIYPTDIERAAQRVEGVRPGGAVAVRLDAGHSRETFA
MLBr_00243|M.leprae_Br4923 CGRVKDVIIMAGRNVYPTDIERAAGRVDGVRPGCAVAVRLDAGHSRETFA
Mflv_5217|M.gilvum_PYR-GCK CGRLKDVIIMAGRNIFPADIERAASRVEGVRPGCAVAVRLDAGRSRESFA
Mvan_1051|M.vanbaalenii_PYR-1 CGRLKDVIIMAGRNIYPTDIERAAGRVDGVRPGCAVAVRLEAGRSRETFA
MUL_4922|M.ulcerans_Agy99 CGRKKDILIISGRNVHPEDIERSVVGIAGIRSGGVAAVRLATASASEGFV
MMAR_0174|M.marinum_M CGRKKDILIISGRNVHPEDIERSVVGIAGIRSGGVAAVRLATASASEGFV
MAB_1692|M.abscessus_ATCC_1997 CGRKKDILIISGRNVHPEDIERSVAGISGVRSGGVAAVRLHTASAGEGFA
*** **::*::***:.* ****:. : *:*.* ..**** :. : * *.
Mb1041|M.bovis_AF2122/97 VAVESNAFEDPAEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSG
Rv1013|M.tuberculosis_H37Rv VAVESNAFEDPAEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSG
MAV_1150|M.avium_104 VAVESNAFQDPAEVRRIEHQVAREVVAEVDMRPRNVVVLGPGTIPKTPSG
MSMEG_5435|M.smegmatis_MC2_155 VAVESNAWQDPAEVRRIEHQVAHEVVSEVDVRPRNVVVLGPGSIPKTPSG
TH_3958|M.thermoresistible__bu VAVESNAWQDPEEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGSIPKTSSG
MLBr_00243|M.leprae_Br4923 VAVESNAFEDTAEVRRIEHQVAHEVLKEVDVRPRNVVVLGPGTIPKTPSG
Mflv_5217|M.gilvum_PYR-GCK VAVESKHFDDEVEVRRVERQVAHEVFAEVDVRPRNVVVLEPGTIPKTPSG
Mvan_1051|M.vanbaalenii_PYR-1 VAVECKDFGDETQVRRVERQVAHEVFAEVDVRPRNVVVLAPGTIPKTPSG
MUL_4922|M.ulcerans_Agy99 MVAESALHADDAESNRIRTEVADRVFVNLGVSPRAVHVVPAGWLPKTSSG
MMAR_0174|M.marinum_M MVAESALHADDAESNRIRTEVADRVFVNLGVSPRAVHVVPAGWLPKTSSG
MAB_1692|M.abscessus_ATCC_1997 MVAESALHADIAESERIRAEVADRVYRTLGVSPRDVHVVPAGWIPKTSSG
:..*. * : .*:. :** .* :.: ** * *: .* :***.**
Mb1041|M.bovis_AF2122/97 KLRRANSVTLVT------
Rv1013|M.tuberculosis_H37Rv KLRRANSVTLVT------
MAV_1150|M.avium_104 KLRRSNSVTLVT------
MSMEG_5435|M.smegmatis_MC2_155 KLRRANSVSLVTQ-----
TH_3958|M.thermoresistible__bu KLRRSTSVSLVT------
MLBr_00243|M.leprae_Br4923 KLRRASSVTLVT------
Mflv_5217|M.gilvum_PYR-GCK KLRRAHALSLVS------
Mvan_1051|M.vanbaalenii_PYR-1 KLRRAHALSLVS------
MUL_4922|M.ulcerans_Agy99 KLRRRQTSERLRLFDDAL
MMAR_0174|M.marinum_M KLRRRQTSERLRLFDDAL
MAB_1692|M.abscessus_ATCC_1997 KLRRRATSERLKRCEPAR
**** : :