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VSVLATALSEAMTASTRDLVLLDRASGQWVRHPWQELHTRAENIAEHILNDRDGAVGLVGEPTAELVSAI QGTWLAGRALAILPGPIRGADEREWAAATAQRFAGIGVGQILTYGEHLELLRPNVFGITVHDLAVVGHAQ RSTTLVSAPAAPGTPAVLQGTAGSTGTPRTALLSQDAVKHNVAGMLRHTDVDPGRDRGLTWLPLYHDMGL TFLLTGFMSGSEMWLAPTASFAASPFRWLAWLSESRAGLTAAPNFAYSVIGKYARRVPDVDLSNLRFALN GGEPVDCDGFELFLRELSRFGLDPGVAAPSYGLAESTCAVTSPRPGTGLLVDDITDPDTGTPRRHAVLGE PIPGMELRIAPSEGRRSGEREIGEVEIRGTSMMSGYLGEEPLAPGQWFPTGDLGYLTDAGLVVCGRVKEL ITIAGRNIFPTEVERVAAEVRGVREGAVVAVGTDSGSARQGLVIAAEFRGADESGAKSEVVQRVASQCGV VPSEVVFLKPGSLPRTSSGKLRRLAVKNDLDGLRAPVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4411 | - | - | 100% (528) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_5217 | - | 2e-74 | 34.56% (518) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1935 | - | 3e-74 | 35.01% (517) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1380 | fadD33 | 0.0 | 60.50% (524) | long-chain-fatty-acid-- |
| M. tuberculosis H37Rv | Rv1345 | fadD33 | 0.0 | 60.50% (524) | long-chain-fatty-acid-- |
| M. leprae Br4923 | MLBr_00243 | - | 1e-66 | 33.72% (522) | long-chain-fatty-acid--CoA ligase |
| M. abscessus ATCC 19977 | MAB_1692 | - | 1e-71 | 33.98% (515) | acyl-CoA synthetase |
| M. marinum M | MMAR_0174 | pks16_1 | 2e-74 | 33.53% (510) | polyketide synthase Pks16_1 |
| M. avium 104 | MAV_2874 | - | 1e-177 | 60.94% (530) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_2131 | - | 0.0 | 63.43% (525) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3540 | - | 0.0 | 61.21% (531) | PUTATIVE acyl-CoA synthase |
| M. ulcerans Agy99 | MUL_4922 | pks16_1 | 2e-73 | 33.33% (510) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1945 | - | 0.0 | 75.62% (525) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4411|M.gilvum_PYR-GCK ----------MSVLATALSEAMTASTRDLVLLD------RASGQWVRHPW
Mvan_1945|M.vanbaalenii_PYR-1 ----------MSVLATAVSHAMTASLRELVLLD------RASGQWSRHPW
MSMEG_2131|M.smegmatis_MC2_155 ----------MNVLSAALTEAMTTSSADLVVFE------PETRTWHRHPW
TH_3540|M.thermoresistible__bu ----------VTVLAQALADALTTAGADLVVLD------QETRSWSRHPW
Mb1380|M.bovis_AF2122/97 ----------MSELAAVLTRSMQASAGDLMVLD------RETSLWCRHPW
Rv1345|M.tuberculosis_H37Rv ----------MSELAAVLTRSMQASAGDLMVLD------RETSLWCRHPW
MAV_2874|M.avium_104 ----------MSELAAALTAAMRTGGSDLVVFD------RESAAWRRHRW
MMAR_0174|M.marinum_M --------------MRRLCDSQGATQHGLTTAPVGADGRSHLDQLTNTPW
MUL_4922|M.ulcerans_Agy99 ----------MNTIMRRLCDSQGATQHGLTTAPVGADGRSHLDQLTNTPW
MAB_1692|M.abscessus_ATCC_1997 MSRLREDRPGSNPVIDRLLAGAGITGRGLTSAPIGPDGASQLDELSTTAW
MLBr_00243|M.leprae_Br4923 ----------MSKFTEKMFRNARESSKGIVTG--------EPHNPVRHTW
: : *
Mflv_4411|M.gilvum_PYR-GCK QELHTRAENIAEHIL---NDRDGAVGLVGEPTAELVSAIQGTWLAGRALA
Mvan_1945|M.vanbaalenii_PYR-1 QEVHARAENIAERVL---DGPDGAVGLVGEPTVEFVAAIQGAWLAGRAVS
MSMEG_2131|M.smegmatis_MC2_155 GQVHLRAQNVAERIG---QDGSSAVGIVGEPTVEGVAAILGALLAGSAVS
TH_3540|M.thermoresistible__bu PEVYVRAENVADRVL---ADEATAVGLVGEPTVELISAIIGALLAGAAVS
Mb1380|M.bovis_AF2122/97 PEVHGLAESVAAWLLD--HDRPAAVGLVGEPTVELVAAIQGAWLAGAAVS
Rv1345|M.tuberculosis_H37Rv PEVHGLAESVAAWLLD--HDRPAAVGLVGEPTVELVAAIQGAWLAGAAVS
MAV_2874|M.avium_104 PEVHGLAEGIAAWLLD--RDRPAALGLVGEPTLEFVAAIVGAWLAGAGVS
MMAR_0174|M.marinum_M SDIHHLGRRAAGALQRDGVTPGDVVAVLAGAPGEIAPLVQGAWMCGAAVT
MUL_4922|M.ulcerans_Agy99 SDIHHLGRRAAGALQRDGVTPGDVVAVLAGAPGEIAPLVQGAWMCGAAVT
MAB_1692|M.abscessus_ATCC_1997 ADVHRTGLRIAGALQAAGVRPGDAVAVLAGAPGEIAPLVQGIWFSGASVT
MLBr_00243|M.leprae_Br4923 GQVHERASRIAGGLAGVGVGHGDAVGVLVGVPVEIAPTAQGLWMRGASLT
::: . * : .:.:: . * . * : * .::
Mflv_4411|M.gilvum_PYR-GCK ILPGPIRGADEREWAAATAQRFAGIGVGQILTYGEHLELLR-PNVFG---
Mvan_1945|M.vanbaalenii_PYR-1 ILPGPVRGADDRQWAMSTVERFAGIGVSQALSYGNHLELLG-ANGSR---
MSMEG_2131|M.smegmatis_MC2_155 ILPGLVRGADPDQWADSTLNRFANIGVTTVFSHGSYLEQLR-TRDSS---
TH_3540|M.thermoresistible__bu VLPGPVRGADPRQWAQGTLKRFTGIGVRTVFSHGAQLELLRGVDDASG-A
Mb1380|M.bovis_AF2122/97 ILPGPVRGANDQRWADATLTRFLGIGVRTVLSQGSYLARLRSVDTAG---
Rv1345|M.tuberculosis_H37Rv ILPGPVRGANDQRWADATLTRFLGIGVRTVLSQGSYLARLRSVDTAG---
MAV_2874|M.avium_104 ILPGPVRGAEGRRWADTTLTRFAGIGVRTVLSHGSHLDALQALDPSRPDE
MMAR_0174|M.marinum_M MLHQPTHRSDLQAWAADTKKTLSMVGASTVVVGSPFQSAAQEFAKVG---
MUL_4922|M.ulcerans_Agy99 MLHQPTHRSDLQAWAADTKKTLSMVGASTAVVGSPFQSAAQEFAKVG---
MAB_1692|M.abscessus_ATCC_1997 MLHQPTHRSDMRLWVEDTGRALAAVGSSTVVVGDPFMAAASQFGAVA---
MLBr_00243|M.leprae_Br4923 MLHQPTPRTDLAVWEEDTTTVIDMIEAKAVIISDPFMAVAPILEARG---
:* :: * * : : . .
Mflv_4411|M.gilvum_PYR-GCK ITVHDLAVVGHAQRSTTLVSAPAAPGTPAVLQGTAGSTGTPRTALLSQDA
Mvan_1945|M.vanbaalenii_PYR-1 LQVHDVTAVGHTRRSTTLSPQAAPAGAPAVLQGTAGSTGTPRTALLSPEA
MSMEG_2131|M.smegmatis_MC2_155 LVIHDDAEVAHAQRSTTLELGAPLGE-FAVLQGTAGSTGTPRTAQLRPDA
TH_3540|M.thermoresistible__bu PAIHDVSTVAHDRRSTTLLPPSEPNG-IAILQGTAGSTGTPRTAALPAEA
Mb1380|M.bovis_AF2122/97 VTIGDLSTAAHTNR---SATPVASEG-PAVLQGTAGSTGAPRTAILSPGA
Rv1345|M.tuberculosis_H37Rv VTIGDLSTAAHTNR---SATPVASEG-PAVLQGTAGSTGAPRTAILSPGA
MAV_2874|M.avium_104 MVVEDLAVAANTGRRC-PEPPAPHAN-PAILQGTAGSTGTPKTAALSPDA
MMAR_0174|M.marinum_M ---LRGLELSELLTADEGRIVVAEEDSPAFLQLTSGSTGHPKAVSITYRN
MUL_4922|M.ulcerans_Agy99 ---LRGLELSELLTADEGRIVVAEEDSPAFLQLTSGSTGHPKAVSITYRN
MAB_1692|M.abscessus_ATCC_1997 ---AQVLEMSALLDGPPGEIVQSDQDAIAFLQLTSGSTGTPKAVSISYRN
MLBr_00243|M.leprae_Br4923 ---VKVVTVEQLLAADPVDPIETDEDDLALMQLTSGSTGSPKAVQITHRN
*.:* *:**** *::. :
Mflv_4411|M.gilvum_PYR-GCK VKHNVAGMLRHTDVDPGRDRGLTWLPLYHDMGLT-FLLTGFMSGSEMWLA
Mvan_1945|M.vanbaalenii_PYR-1 VLNNVSALWQHTSTDPDRDVGMTWLPLYHDMGLT-FLLTGFLTGAEMWLA
MSMEG_2131|M.smegmatis_MC2_155 VLANLRGLAERVGLAGS-DIGCSWLPLYHDMGLT-FLLSAAVGGTETWQA
TH_3540|M.thermoresistible__bu VLANLRGLTTRTSVTTD-DVGCSWLPLYHDMGLS-FLLSGALVGAELWQA
Mb1380|M.bovis_AF2122/97 VLSNLRGLNQRVGTDAATDVGCSWLPLYHDMGLA-FVLSAALAGAPLWLA
Rv1345|M.tuberculosis_H37Rv VLSNLRGLNQRVGTDAATDVGCSWLPLYHDMGLA-FVLSAALAGAPLWLA
MAV_2874|M.avium_104 VLANLRGLNARLGVTPA-DVGCSWLPLYHDMGLS-FLLASALGGMSLWLA
MMAR_0174|M.marinum_M IEANGRALMAAASADVASDVVVSWLPLFHDMGMMGLLIIPMYEGMDAVHI
MUL_4922|M.ulcerans_Agy99 IEANGRALMAAASADVASDVVVSWLPLFHDMGMMGLLIIPMYEGMDAVHI
MAB_1692|M.abscessus_ATCC_1997 IEANLRAMVSASGADPETDVVVSWLPLFHDMGMMGFLIVPMCRAMSTVSV
MLBr_00243|M.leprae_Br4923 VYSNVEAMFIGVRYNVEKDVMISWLPCFHDMGMIGFLTVPMYFGAELVKV
: * .: * :*** :****: :: .
Mflv_4411|M.gilvum_PYR-GCK PTASFAASPFRWLAWLSESRAGLTAAPNFAYSVIGKYARR---VPDVDLS
Mvan_1945|M.vanbaalenii_PYR-1 PTAAFAASPFRWLTWLSDSRASLTAAPNFAYSVIGRYARR---VSDVDLG
MSMEG_2131|M.smegmatis_MC2_155 PTTAFASAPFSWVHWLTESRATLTAAPNMAYGLIGKYSRR---LTDVDLS
TH_3540|M.thermoresistible__bu PTTAFAASPFSWLHWLTASRATMTAAPNMAYGLIGKYSRR---VTDVDLG
Mb1380|M.bovis_AF2122/97 PTTAFTASPFRWLSWLSDSGATMTAAPNFAYNLIGKYARR---VSEVDLG
Rv1345|M.tuberculosis_H37Rv PTTAFTASPFRWLSWLSDSGATMTAAPNFAYNLIGKYARR---VSEVDLG
MAV_2874|M.avium_104 PTSAFTASPFRWLAWLSESRATITAAPNFAYNLVGKYARR---VSGVDLG
MMAR_0174|M.marinum_M TPADFLNDPLLWAELITKHRGSITAAPNFAYSLLARRLRR-AQDHAFDLS
MUL_4922|M.ulcerans_Agy99 TPADFLNDPLLWAELITKHRGSITAAPNFAYSLLARRLRR-AQDHAFDLS
MAB_1692|M.abscessus_ATCC_1997 TPMDFLGDPLLWAKLISTYRGSMTAGPNFAYSLLARRLRK-APDGAYDLS
MLBr_00243|M.leprae_Br4923 TPIDFLRDTLLWAKLIDKYKGTVICGPNFAYSLFTKRLRKQAKPGQFDLS
.. * .: * : . : ..**:**.:. : *: **.
Mflv_4411|M.gilvum_PYR-GCK NLRFALNGGEPVDCDGFELFLRELSRFGLDPGVAAPSYGLAESTCAVTSP
Mvan_1945|M.vanbaalenii_PYR-1 RLRFAINGGEPVDCEGFQLFLDELARFGLDPRAAAPSYGLAESTCAVTTP
MSMEG_2131|M.smegmatis_MC2_155 AMRFALNGGEPVDIDGTARFGTELSRFGFDPGALSPSYGLAESSCAVTVP
TH_3540|M.thermoresistible__bu RLRFALNGGEPVDCDATTRFATEMARFGFDAAALCPSYGLAESTCAVTVP
Mb1380|M.bovis_AF2122/97 ALRVTLNGGEPVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVP
Rv1345|M.tuberculosis_H37Rv ALRVTLNGGEPVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVP
MAV_2874|M.avium_104 ALRVAINGGEPVDCAGFERFATAMAPFGFDAGAATPSYGLAESTCAVSVP
MMAR_0174|M.marinum_M SLRFALNGAEGIDVATLERLATEGARFGLRRDAIVPAYGMAEATLAISVV
MUL_4922|M.ulcerans_Agy99 SLRFALNGAEGIDVATLERLATEGARFGLRRDAIVPAYGMAEATLAISVV
MAB_1692|M.abscessus_ATCC_1997 SLQFALSGAEAIDVATLERFVAEGARFGMRADAVVPAYGMAEATLAVSFV
MLBr_00243|M.leprae_Br4923 TLRIAMSGAEPVDPADVEDLIDAGRPFGFRPEAILPAYGMAETTLAVSFS
::.::.*.* :* : **: . *:**:**:: *::
Mflv_4411|M.gilvum_PYR-GCK RPGTGLLVDDITDP--DTGTPRRHAV---------LGEPIPGMELRIAPS
Mvan_1945|M.vanbaalenii_PYR-1 EPGTGLVVESITDP--ATDAVQRHAV---------LGRPIPGMDVRISES
MSMEG_2131|M.smegmatis_MC2_155 VPGVGLKVDEITVTTEAGSSTQKLAV---------LGHAIAGMEVRLQPG
TH_3540|M.thermoresistible__bu IPGAGLQIDEVEVVTEAGTATRRHAV---------LGEAIPGMQVRIAPR
Mb1380|M.bovis_AF2122/97 VPGIGLLADRVID----GSGAHKHAV---------LGNPIPGMEVRISCG
Rv1345|M.tuberculosis_H37Rv VPGIGLLADRVID----GSGAHKHAV---------LGNPIPGMEVRISCG
MAV_2874|M.avium_104 APGTGLRFADVSD----ETGTRRHAV---------LGAPIPGTEIRISP-
MMAR_0174|M.marinum_M RPGEGFRVCPPHPDLVAAQGEAAAPR-------VMLGPPVPGCDVRVVSE
MUL_4922|M.ulcerans_Agy99 RPGEGFRVCPPHPDLVAAQGEAAAPR-------VMLGPPVPGCDVRVVSE
MAB_1692|M.abscessus_ATCC_1997 RRGEGYRVCPPHPDLVAAQGTQASAR-------VPLGLPLPGCEVRVVTE
MLBr_00243|M.leprae_Br4923 PVGEGLLVDEVDADLLAALRRAVPATKGNIRRLVSLGPLLDGLEVRIVDE
* * . ** : * ::*:
Mflv_4411|M.gilvum_PYR-GCK -EG-RRSGEREIGEVEIRGTSMMSGYLGEE----PLAPGQWFPTGDLGYL
Mvan_1945|M.vanbaalenii_PYR-1 -EHSRKVGDHTIGELEIRGTSMMSGYLGQD----PLEPGEWFRTGDLGYL
MSMEG_2131|M.smegmatis_MC2_155 -DEDAGVVDREVGEVEIRGTSMMSGYRGEA----PLDPGEWFPTGDLGYL
TH_3540|M.thermoresistible__bu PDQQVGITGREVGEVQIRGSSMMSGYLGEP----PIDREAWFPTGDLGYF
Mb1380|M.bovis_AF2122/97 -DQAAGNASREIGEIEIRGASMMAGYLGQQ----PIDPDDWFATGDLGYL
Rv1345|M.tuberculosis_H37Rv -DQAAGNASREIGEIEIRGASMMAGYLGQQ----PIDPDDWFATGDLGYL
MAV_2874|M.avium_104 ----RHDVPDGIGEIEIRGASMMDGYLGHA----PIDHQNWFPTGDLGFF
MMAR_0174|M.marinum_M --DRTVLAPSEIGELEIRGDNVTAGYRTEAGFEPAVDAGGWLATGDVGYL
MUL_4922|M.ulcerans_Agy99 --DRTVLAPSEIGELEIRGDNVTAGYRTEAGFEPAVDAGGWLATGDVGYL
MAB_1692|M.abscessus_ATCC_1997 --DRQVLAPESIGELEIRGDNVTAGYRTASGFESMLDAQGWLSTGDIGYL
MLBr_00243|M.leprae_Br4923 --DGNVLPSRGVGVIELRGESLTPGYITMGGFISAQDEHGWYDTGDLGYQ
:* :::** .: ** * ***:*:
Mflv_4411|M.gilvum_PYR-GCK TDAG-LVVCGRVKELITIAGRNIFPTEVERVAAEVRGVREGAVVAVGTDS
Mvan_1945|M.vanbaalenii_PYR-1 TDDG-LVVCGRVKELITVAGRNIFPSEVERVAAQVRGVREGAVVAVGTDG
MSMEG_2131|M.smegmatis_MC2_155 TDDG-LVICGRKKELITVAGRNIFPTEIERIAARVKGVREGAVVAVGTNE
TH_3540|M.thermoresistible__bu VDGG-LVVCGRAKEMITVAGRNVFPTEIEQVAGQVPGVREGAVVAVGTNE
Mb1380|M.bovis_AF2122/97 GAGG-LVVCGRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGD
Rv1345|M.tuberculosis_H37Rv GAGG-LVVCGRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGD
MAV_2874|M.avium_104 SDGG-LVVCGRAKELITLAGRNIFPTEIETVAAQVPGVREGAVVALGTGE
MMAR_0174|M.marinum_M TENGQPVICGRKKDILIISGRNVHPEDIERSVVGIAGIRSGGVAAVRLAT
MUL_4922|M.ulcerans_Agy99 AENGQPVICGRKKDILIISGRNVHPEDIERSVVGIAGIRSGGVAAVRLAT
MAB_1692|M.abscessus_ATCC_1997 TADGQPVICGRKKDILIISGRNVHPEDIERSVAGISGVRSGGVAAVRLHT
MLBr_00243|M.leprae_Br4923 MENGHIVVCGRVKDVIIMAGRNVYPTDIERAAGRVDGVRPGCAVAVRLDA
* *:*** *::: ::***:.* ::* . : *:* * ..*:
Mflv_4411|M.gilvum_PYR-GCK GSARQGLVIAAEFRGADESG----AKSEVVQRVASQCGVVPSEVVFLKPG
Mvan_1945|M.vanbaalenii_PYR-1 NSARQGLIVAAEFRGPDEAG----ARSEVVQRVASQCGVVPADVVFLAPG
MSMEG_2131|M.smegmatis_MC2_155 RAVRPGLVIAAEFRGPDEAG----ARSEVVQRVASECGVVPADVVFLAPG
TH_3540|M.thermoresistible__bu NSVRPGLVIVAEYRGRDEAG----ARSQVVQRVASECGVVPTDVLLRPPG
Mb1380|M.bovis_AF2122/97 RSTRPGLVVAAEFRGPDEAN----ARAELIQRVASECGIVPSDVVFVSPG
Rv1345|M.tuberculosis_H37Rv RSTRPGLVVAAEFRGPDEAN----ARAELIQRVASECGIVPSDVVFVSPG
MAV_2874|M.avium_104 NSARPGLIIAAEFAGRDRAG----ARAEVIQRVASVCGVVPSDVIFMAPG
MMAR_0174|M.marinum_M ASASEGFVMVAESALHADDAESNRIRTEVADRVFVNLGVSPRAVHVVPAG
MUL_4922|M.ulcerans_Agy99 ASASEGFVMVAESALHADDAESNRIRTEVADRVFVNLGVSPRAVHVVPAG
MAB_1692|M.abscessus_ATCC_1997 ASAGEGFAMVAESALHADIAESERIRAEVADRVYRTLGVSPRDVHVVPAG
MLBr_00243|M.leprae_Br4923 GHSRETFAVAVESNAFEDTAEVRRIEHQVAHEVLKEVDVRPRNVVVLGPG
: :..* . :: ..* .: * * . .*
Mflv_4411|M.gilvum_PYR-GCK SLPRTSSGKLRRLAVKNDLDGLRAPVS
Mvan_1945|M.vanbaalenii_PYR-1 SLPRTSSGKLRRLEVKQNLEAARV---
MSMEG_2131|M.smegmatis_MC2_155 SLPRTSSGKLRRLEVKRQLEESKG---
TH_3540|M.thermoresistible__bu SLPRTSSGKLRRLEVKRNLEGVGR---
Mb1380|M.bovis_AF2122/97 SLPRTSSGKLRRLAVRRSLEMAD----
Rv1345|M.tuberculosis_H37Rv SLPRTSSGKLRRLAVRRSLEMAD----
MAV_2874|M.avium_104 SLPRTSSGKLRRLDVRRSLEAVD----
MMAR_0174|M.marinum_M WLPKTSSGKLRRRQTSERLRLFDDAL-
MUL_4922|M.ulcerans_Agy99 WLPKTSSGKLRRRQTSERLRLFDDAL-
MAB_1692|M.abscessus_ATCC_1997 WIPKTSSGKLRRRATSERLKRCEPAR-
MLBr_00243|M.leprae_Br4923 TIPKTPSGKLRR-ASSVTLVT------
:*:*.****** *