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SVELAPALEEVLRPVLGDVTVENLQRLTGGASRTTWAFSAHARSRSGTAHARSESDTAHARSESDTAQTG GAGRPLILRTGARDDIHASMELEAKVQQRAAAAGAPVPHIVNADNSPAAVGAPYLICDAIAGETIVRRIF RGLDDGGRARLLEQCATALAAIHRADPAGIGLTSPDDLAGWRSRLDEIGDTTATFEWTFRRLADARPEPS PMRLVHGDFRMGNLIVDESGLAAVLDWELTHIGEIYEDLAWFCIRAWRFGAPETLGAGGLGSVETFLQAY ESAADTSLDRNTFRWWLTVATLRWGVICRHQAERHLSGESPSVELAAIGRRVSETEWDLLELLSGGGPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1891 | - | - | 100% (350) | aminoglycoside phosphotransferase |
| M. vanbaalenii PYR-1 | Mvan_5603 | - | 1e-13 | 30.43% (184) | aminoglycoside phosphotransferase |
| M. vanbaalenii PYR-1 | Mvan_2028 | - | 1e-09 | 22.59% (301) | aminoglycoside phosphotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3787c | fadE36 | 3e-12 | 27.17% (184) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4469 | - | 1e-159 | 80.00% (350) | aminoglycoside phosphotransferase |
| M. tuberculosis H37Rv | Rv3761c | fadE36 | 3e-12 | 27.17% (184) | acyl-CoA dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3637c | - | 4e-38 | 37.02% (262) | putative aminoglycoside phosphotransferase |
| M. marinum M | MMAR_1490 | - | 1e-116 | 61.92% (344) | hypothetical protein MMAR_1490 |
| M. avium 104 | MAV_4028 | - | 1e-118 | 64.31% (353) | aminoglycoside phosphotransferase |
| M. smegmatis MC2 155 | MSMEG_2069 | - | 1e-119 | 63.95% (344) | phosphotransferase enzyme family protein |
| M. thermoresistible (build 8) | TH_0640 | - | 1e-128 | 69.32% (339) | phosphotransferase enzyme family protein |
| M. ulcerans Agy99 | MUL_2450 | - | 1e-114 | 61.05% (344) | hypothetical protein MUL_2450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1891|M.vanbaalenii_PYR-1 -----MSVELAPALEEVLRPVLGD-VTVENLQRLTGGASRTTWAFSAHAR
Mflv_4469|M.gilvum_PYR-GCK -----MSDDLARALEDVLRPVLGD-TTVEDLQRLTGGASRTTWAFTSRSD
TH_0640|M.thermoresistible__bu ----------------VLAPVLGEGVTVDGLTRLTGGASRTTWAFDAVAG
MMAR_1490|M.marinum_M ------MTELADRLATVLRPMLGTEVAIDKLRALTGGASRTTWAFDAVTG
MUL_2450|M.ulcerans_Agy99 ------MTELADRLATVLRPMLGTEVAIDKLRALTGGASRTTWAFDAVTG
MAV_4028|M.avium_104 --MDSDAAELRPKLEGVLATALGAGTAVEQLRTLTGGASRTTWAFDAVTG
MSMEG_2069|M.smegmatis_MC2_155 MTETRDPASLTGGLVDVLAPVVGAGVSVENLRELTGGASRTTWSFEAVTA
MAB_3637c|M.abscessus_ATCC_199 ------MSDLTEGLTRYLRDEFGKDFTVSGVVGVSAGARRRNVLLDATFG
Mb3787c|M.bovis_AF2122/97 MTSVDRLDGLDLGALDRYLRSLGIGRDGELRGELISGG-RSNLTFRVYDD
Rv3761c|M.tuberculosis_H37Rv MTSVDRLDGLDLGALDRYLRSLGIGRDGELRGELISGG-RSNLTFRVYDD
.* . : .*. * . :
Mvan_1891|M.vanbaalenii_PYR-1 SRSGTAHARSESDTAHARSESDTAQTGGAGRPLILRTGARDDIHASMELE
Mflv_4469|M.gilvum_PYR-GCK GRS---------------------------RHLILRTGARDDIHASMELE
TH_0640|M.thermoresistible__bu ETR---------------------------TPLILRMGPPDEVHAGMELE
MMAR_1490|M.marinum_M HRR---------------------------RSLILRTGPPDDVHAGMELE
MUL_2450|M.ulcerans_Agy99 HRR---------------------------RSLILRTGPPDDVHAGMELE
MAV_4028|M.avium_104 GRR---------------------------RPLILRTGPPDDVHAGMELE
MSMEG_2069|M.smegmatis_MC2_155 SQR---------------------------RALILRTGPPDEVHAGMELE
MAB_3637c|M.abscessus_ATCC_199 SET---------------------------LELVATIVPAAVQQIPVSGE
Mb3787c|M.bovis_AF2122/97 ASS-----------------------------WLVRRPPLHGLTPSAHDM
Rv3761c|M.tuberculosis_H37Rv ASS-----------------------------WLVRRPPLHGLTPSAHDM
: .
Mvan_1891|M.vanbaalenii_PYR-1 AKVQQRAAAAG---APVPHIVNADNSPAAVGAPYLICDAIAGETIVR-RI
Mflv_4469|M.gilvum_PYR-GCK AKVQQRAAAAG---APVPHILAADNSPDAVGEPYLICDAIAGETIVR-KI
TH_0640|M.thermoresistible__bu AEVQRRAAAAG---APVPRILTADDSTAALGNPYLICAAVPGETIVR-RI
MMAR_1490|M.marinum_M ARVQAAAAAAG---APVPHVLVADDSPAALGNPFLICDEVGGETIVR-RI
MUL_2450|M.ulcerans_Agy99 ARVQAAAAAAG---APVPHVLVADDSPAALGNPFLICDEVGGETIVR-RI
MAV_4028|M.avium_104 AQAQAAAAAAG---APVPHILVADNSPAALGNPFLICDEIKGETIAR-RI
MSMEG_2069|M.smegmatis_MC2_155 AGAQRAAAAAG---APVPHVLVADNSTAALGNPYLVCDFIPGETIVR-RI
MAB_3637c|M.abscessus_ATCC_199 AGVRELARSNG---VPVPRVRGICPDAAYVGAPFMISERIAGETVPR-KV
Mb3787c|M.bovis_AF2122/97 AREYRVVAALGDTPVPVARTISLCQDDSVLGAPFQVVEFVAGQVVRRRAE
Rv3761c|M.tuberculosis_H37Rv AREYRVVAALGDTPVPVARTISLCQDDSVLGAPFQVVEFVAGQVVRRRAE
* . : * .**.: . :* *: : : *:.: *
Mvan_1891|M.vanbaalenii_PYR-1 FRGLDD----GGRARLLEQCATALAAIHRADPA---GIGLTSP---DDLA
Mflv_4469|M.gilvum_PYR-GCK FRMLDD----TGRARLLTQCATALAAIHRADPD---GVGLAAP---DELA
TH_0640|M.thermoresistible__bu QRSLDD----TGRAVLLRQCAQALAAIHRADPT---GAGLTVG---DQLT
MMAR_1490|M.marinum_M QRQLDD----AGRQRLLGECAQALAAIHRADAG---DAGLVHE---DPVA
MUL_2450|M.ulcerans_Agy99 QRQLDD----AGRQRLLGECAQALAAIHRADAG---DAGLVHE---DPVA
MAV_4028|M.avium_104 QRRLDATDGHAARAHLLGQCAHAVAAIHRAEIDRIEDPGLRRQ---DQLA
MSMEG_2069|M.smegmatis_MC2_155 QRQLDA----AGRAKLLTQCAQALAAIHRAEPP--TDIGLTEL---DQVG
MAB_3637c|M.abscessus_ATCC_199 LRLVEARGIGDLVAGQLGSAMGRLHGIDPAMAPPDLPGDLESEPAVVMLE
Mb3787c|M.bovis_AF2122/97 LEALGSRSVIEGCVDALIRVLVDLHSIDPKAVG-LSDFGKPDGYLERQVR
Rv3761c|M.tuberculosis_H37Rv LEALGSRSVIEGCVDALIRVLVDLHSIDPKAVG-LSDFGKPDGYLERQVR
. : * : .*. . :
Mvan_1891|M.vanbaalenii_PYR-1 GWRSRLDEIGD----TTATFEWTFRRLADARP-EPSPMRLVHGDFRMGNL
Mflv_4469|M.gilvum_PYR-GCK GWRTRLDEIGD----TTATFEWTFRRLADERP-DPSPMRLVHGDFRMGNL
TH_0640|M.thermoresistible__bu EWHRQLDEIGD----TTATFEWTFRRLAADRP-PPSEPVLVHGDFRMGNL
MMAR_1490|M.marinum_M HWRERLDAMGE----STATFEWAFRWLDAHRP-AGSAPVLVHGDYRMGNL
MUL_2450|M.ulcerans_Agy99 HWRERPDAMGE----STATFEWAFRWLDAHRP-AESAPVLVHGDYRMGNL
MAV_4028|M.avium_104 EWRQRLDDMGD----TTATFEWAFRWLAARRP-RAAPAVLVHGDFRMGNL
MSMEG_2069|M.smegmatis_MC2_155 QWRDQLDEMGD----TTATFEWAFRWLAANRP-PASPPRLIHGDFRMGNL
MAB_3637c|M.abscessus_ATCC_199 QMREGVAALLP----DRPVFQRALSWLTERMPGPPVRRSLVHTDIRNGNV
Mb3787c|M.bovis_AF2122/97 RWGSQWELVRLPDDHRDADISRLHLALQQAIP-QQSRTSIVHGDYRIDNT
Rv3761c|M.tuberculosis_H37Rv RWGSQWELVRLPDDHRDADISRLHLALQQAIP-QQSRTSIVHGDYRIDNT
: . :. * * ::* * * .*
Mvan_1891|M.vanbaalenii_PYR-1 IVDESG---LAAVLDWE-LTHIGEIYEDLAWFCIR-----AWRFGAPETL
Mflv_4469|M.gilvum_PYR-GCK IVDDSG---LAAVLDWE-LTHIGEIYEDLSWFCIR-----AWRFGAAESL
TH_0640|M.thermoresistible__bu IVDGGR---LAAVLDWE-LTHLGEVYEDLAWFCIR-----AWRFGAPRHL
MMAR_1490|M.marinum_M IVEGSR---LAAVLDWE-LVHVGAGYEDLAWFCVR-----AWRFGAPASY
MUL_2450|M.ulcerans_Agy99 IVEGSR---LAAVLDWE-LVHVGAGYEDLAWFCVR-----AWRFGAPASY
MAV_4028|M.avium_104 IVDGAQ---LAAVLDWE-LVHVGQAYEDLAWFCIR-----AWRFGAPAGL
MSMEG_2069|M.smegmatis_MC2_155 IVDGSD---LAAVLDWE-LVHIGEVYEDLAWFCIR-----AWRFGATESH
MAB_3637c|M.abscessus_ATCC_199 IVGEDG---LRAVLDWEGTTRFGDPMRDVGWTALR-----MWRFGLDDRE
Mb3787c|M.bovis_AF2122/97 ILDTDDPCHVRAVVDWE-LSTLGDPLSDAALMCVYRDPALDLIVHAQAAW
Rv3761c|M.tuberculosis_H37Rv ILDTDDPCHVRAVVDWE-LSTLGDPLSDAALMCVYRDPALDLIVHAQAAW
*: : **:*** .* * . .: .
Mvan_1891|M.vanbaalenii_PYR-1 GAGGLGSVETFLQAYESAADTSLDRNTFRWWLTVATLRWGVICR-HQAER
Mflv_4469|M.gilvum_PYR-GCK GAGGLGSVETFLQAYESAAQIVLDRSTFRWWLTVATLRWGVICR-HQAER
TH_0640|M.thermoresistible__bu GAGGLGSVADFLTAYEEAGGRPVDRQTFRWWLTVATLRWGVICR-YQAER
MMAR_1490|M.marinum_M GAGGLGSIEDFLRAYERAGGTAVDRGAFHWWLVLATLRWGVICQ-YQAWR
MUL_2450|M.ulcerans_Agy99 GAGGLGSIEDFLRAYERAGGTAVDRGAFHWWLVLATLRWGVICQ-YQAWR
MAV_4028|M.avium_104 GAGGLGSIESFLRAYEQASATTVDRAAFHWWLVLATLRWGVICR-YQAER
MSMEG_2069|M.smegmatis_MC2_155 AAGGLGSIENFLTAYEDAGGMTLDRDAIRWWLVLATLRWGVICL-YQAER
MAB_3637c|M.abscessus_ATCC_199 -FGGFAGRDVFVRSYEESGG-TFDPERFQWWKVLGTLWWGVGLA-AQAKS
Mb3787c|M.bovis_AF2122/97 TSPLLPAADELADRYSLVSGQPLGH--WEFYMALAYFKLAIIAAGIDYRR
Rv3761c|M.tuberculosis_H37Rv TSPLLPAADELADRYSLVSGQPLGH--WEFYMALAYFKLAIIAAGIDYRR
: . : *. . .. .:: .:. : .: :
Mvan_1891|M.vanbaalenii_PYR-1 HLSGESPSVELAAIGRRVSETEWDLLELLSGGGPR---------------
Mflv_4469|M.gilvum_PYR-GCK HLSGEARSVELAAIGRRVSETEWDLLDLLSGKGPQ---------------
TH_0640|M.thermoresistible__bu HLSGQTRSVELAAIGRRVAETEWDLLDLLDRGGPAESRQTPMSARAKSRQ
MMAR_1490|M.marinum_M HLSGQARSVELATIGRRVCENEWDLLDLLEGA------------------
MUL_2450|M.ulcerans_Agy99 HLSGQARSVELATTGRRVCENEWDLPDLLEGA------------------
MAV_4028|M.avium_104 HLSGLHRSVELATIGRRVCETEWDLLNLLEGAA-----------------
MSMEG_2069|M.smegmatis_MC2_155 HLSGQTRSVELATIGRRVCETEWDILTLLDGSTA----------------
MAB_3637c|M.abscessus_ATCC_199 YLDGSVRDIVMAASGRRIPEIEWDLLMLTKPSEREGTR------------
Mb3787c|M.bovis_AF2122/97 RMSEQAEGKDTAAESVPDVVAPLIARGLAEIAKKSG--------------
Rv3761c|M.tuberculosis_H37Rv RMSEQAEGKDTAAESVPDVVAPLIARGLAEIAKKSG--------------
:. . *: . * .
Mvan_1891|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4469|M.gilvum_PYR-GCK --------------------------------------------------
TH_0640|M.thermoresistible__bu TPMSARAKSRSGGIHGRPTAAELVAAVAEFLETDVREACTGSVNFHARVA
MMAR_1490|M.marinum_M --------------------------------------------------
MUL_2450|M.ulcerans_Agy99 --------------------------------------------------
MAV_4028|M.avium_104 --------------------------------------------------
MSMEG_2069|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3637c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3787c|M.bovis_AF2122/97 --------------------------------------------------
Rv3761c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1891|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4469|M.gilvum_PYR-GCK --------------------------------------------------
TH_0640|M.thermoresistible__bu ANVLRIVERELLDESVAADEALTALGFSDEAQLAAAIRAGDLDDRADELT
MMAR_1490|M.marinum_M --------------------------------------------------
MUL_2450|M.ulcerans_Agy99 --------------------------------------------------
MAV_4028|M.avium_104 --------------------------------------------------
MSMEG_2069|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3637c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3787c|M.bovis_AF2122/97 --------------------------------------------------
Rv3761c|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1891|M.vanbaalenii_PYR-1 ---------------------
Mflv_4469|M.gilvum_PYR-GCK ---------------------
TH_0640|M.thermoresistible__bu ACLRTLVRQRLAVAHPGYEDQ
MMAR_1490|M.marinum_M ---------------------
MUL_2450|M.ulcerans_Agy99 ---------------------
MAV_4028|M.avium_104 ---------------------
MSMEG_2069|M.smegmatis_MC2_155 ---------------------
MAB_3637c|M.abscessus_ATCC_199 ---------------------
Mb3787c|M.bovis_AF2122/97 ---------------------
Rv3761c|M.tuberculosis_H37Rv ---------------------