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VPVDVTLTEAETDALRDWVRRTGIGSTVTGVEPLTGGSQNIVVRLQVDGRPMVLRRPPPHPRPTSDNTMR REIAVLQTLKGTAVPHPELIAGCEDLDVLGVVFYLMQAIDGFNPGTEIDEAYIRDAGMRHRAGLSYAASL AELGKVPWEGSPLAALKRPGSFLARQVPQFMRLLESYRHERYAPESFPSVHLLAEWLESHRPEDTEPGIM HGDCHLSNVLLRRDVPEVAAFVDWEMCTVGDPLLDLGWMLICWPDGPNPIDVGSELAALGGLATRPELVE AYLAAGGRRTSALDWYVAMACFKLAIVIEGTWSRYLAGQASAEAGERLHASAENLIELGTRVSKGDNPFA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2028 | - | - | 100% (350) | aminoglycoside phosphotransferase |
| M. vanbaalenii PYR-1 | Mvan_4201 | - | 5e-51 | 37.70% (313) | aminoglycoside phosphotransferase |
| M. vanbaalenii PYR-1 | Mvan_5603 | - | 2e-22 | 29.64% (280) | aminoglycoside phosphotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3787c | fadE36 | 4e-24 | 28.48% (316) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4318 | - | 1e-178 | 83.67% (349) | aminoglycoside phosphotransferase |
| M. tuberculosis H37Rv | Rv3761c | fadE36 | 5e-24 | 28.48% (316) | acyl-CoA dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4910c | - | 8e-81 | 43.19% (345) | putative aminoglycoside phosphotransferase |
| M. marinum M | MMAR_5325 | - | 6e-78 | 45.76% (330) | hypothetical protein MMAR_5325 |
| M. avium 104 | MAV_0300 | - | 2e-79 | 45.35% (344) | phosphotransferase enzyme family protein, putative |
| M. smegmatis MC2 155 | MSMEG_2286 | - | 1e-150 | 73.84% (344) | aminoglycoside phosphotransferase |
| M. thermoresistible (build 8) | TH_3571 | - | 1e-152 | 75.29% (344) | PUTATIVE aminoglycoside phosphotransferase |
| M. ulcerans Agy99 | MUL_4404 | - | 7e-75 | 46.41% (306) | hypothetical protein MUL_4404 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2028|M.vanbaalenii_PYR-1 MPVDV----TLTEAETDALRDWVRRTGIG-STVTGVEPLTGGSQNIVVRL
Mflv_4318|M.gilvum_PYR-GCK MPVDV----TLTDDAVAALQEWVRRTGLG-SVVSDVEPLTGGSQNIVVRV
MSMEG_2286|M.smegmatis_MC2_155 MPGDVQQLPTLSEHDQQALQAWVRSEKIG-STVSDVEPLTGGTQNIVVRV
TH_3571|M.thermoresistible__bu MLDHAGALPTLSADDQAALQRWVRDQGIG-TTVSDVQPLTGGSQNVVVRV
MMAR_5325|M.marinum_M ----------MHPVDPDAVAEWMSGQGLGEGPLYDVCAVTGGTQNVMLRF
MUL_4404|M.ulcerans_Agy99 ----------------------MSGQGLGEGPLYDVCAVTGGTQNVMLRF
MAV_0300|M.avium_104 MTPTSPEGMTVDAVDLPAVADWMSAQGLGEGPLHDVATLTGGTQNVMLRF
MAB_4910c|M.abscessus_ATCC_199 --MAAPHHIDPKSVDFDVVSHWMDEQGLPGGQLTDISAITGGTQNIMVRF
Mb3787c|M.bovis_AF2122/97 ----MTSVDRLDGLDLGALDRYLRSLGIGRDGELRGELISGGRSNLTFRV
Rv3761c|M.tuberculosis_H37Rv ----MTSVDRLDGLDLGALDRYLRSLGIGRDGELRGELISGGRSNLTFRV
: : ::** .*: .*.
Mvan_2028|M.vanbaalenii_PYR-1 QVDGRPMVLRRPPPHPRPTSDNTMRREIAVLQTLKGTAVPHPELIAGCED
Mflv_4318|M.gilvum_PYR-GCK RLDGSDVVLRRPPQHPRPTSNDTMRREIAVLQTLRGTDAPHPEFVAGCED
MSMEG_2286|M.smegmatis_MC2_155 HVDGRPMVLRRPPAHPRPTSDKTMLREIAVLRTLAGSGVPHPGFIAGCAD
TH_3571|M.thermoresistible__bu HVDGQPMVLRRPPVHPRPNSNQTMQREIAVLRTLAGTSVPHPGFIAGCED
MMAR_5325|M.marinum_M TRSGRTYVLRRGPRHLRPRSNSVILRETKVLAALAGTDVPHPRLIAACPD
MUL_4404|M.ulcerans_Agy99 TRSGRTYVLRRGPRHLRPRSNSVILRETKVLAALAGTDVPHPRLIAACPD
MAV_0300|M.avium_104 SRAGRSYVLRRGPRHLRPRSNNVILRETKVLAALAGSDVPHPHLIAVCDD
MAB_4910c|M.abscessus_ATCC_199 SRGGREYVLRRPPKHLREASNNVIRREARLLGALRGQGVPAPELIAACTD
Mb3787c|M.bovis_AF2122/97 YDDASSWLVRRPPLHGLTPSAHDMAREYRVVAALGDTPVPVARTISLCQD
Rv3761c|M.tuberculosis_H37Rv YDDASSWLVRRPPLHGLTPSAHDMAREYRVVAALGDTPVPVARTISLCQD
. ::** * * * : ** :: :* . .* . :: * *
Mvan_2028|M.vanbaalenii_PYR-1 LDVLG-VVFYLMQAIDGFNPGTEIDEAYIRDAGMRHRAGLSYAASLAELG
Mflv_4318|M.gilvum_PYR-GCK LDVLG-VVFYLMQAVDGFNPGTEIDEAYVRDAGMRHRVGLSYAASLARLG
MSMEG_2286|M.smegmatis_MC2_155 LDVLG-VVFYLMEEVVGFNPGNEVAPAYQR-ADMRHAVGLSYAASLAGLG
TH_3571|M.thermoresistible__bu LDVLG-VVFYLMEEVDGFNPGNEIAEGYVRDATWRHDVGPAYAASLAELG
MMAR_5325|M.marinum_M PTVLGDAVFYLMEPVEGFNAGEGLPPLHAGDASIRFQMGLSMADALAKLG
MUL_4404|M.ulcerans_Agy99 PTVLDDAVFYLMEPVEGFNAGEGLPPLHAGDASIRFQMGLSMADALAKLG
MAV_0300|M.avium_104 PGVLGDAVFYLMEPVDGFNAGEGLPPLHAGNPQVRHQMGLSMADALAKLG
MAB_4910c|M.abscessus_ATCC_199 ETVLGGAVFYLMEPVDGFNASVGLPELHAGNAEIRHQMGLEAVSGIAALG
Mb3787c|M.bovis_AF2122/97 DSVLG-APFQVVEFVAGQVVRRRAELEALGSRSVIEGCVDALIRVLVDLH
Rv3761c|M.tuberculosis_H37Rv DSVLG-APFQVVEFVAGQVVRRRAELEALGSRSVIEGCVDALIRVLVDLH
**. . * ::: : * :. *
Mvan_2028|M.vanbaalenii_PYR-1 KVPWEGSPLAALKRPGSFLARQVPQFMRLLESYR-HERYAPESFPSVHLL
Mflv_4318|M.gilvum_PYR-GCK AVPWEGSPLAALKRPGSFLARQVPQFLRLLESYR-HENYAPESFPSVHVL
MSMEG_2286|M.smegmatis_MC2_155 NAGWENSELAALRRPGSFLARQVPQFLKLLESYR-HDNYQPESMAGAQPL
TH_3571|M.thermoresistible__bu NAPWEDRPLAALKRPGSFLQRQVPQFLRLLESYR-HDNYPADSLPDVAGL
MMAR_5325|M.marinum_M AVDHAAVGLADFGKPAGFLERQVPRWLAELESYQQYDGYPGPDIPGIGEV
MUL_4404|M.ulcerans_Agy99 AVDHAAVGLADFGKPAGFLERQVPRWLAELESYQQYDGYPGPDIPGIGEV
MAV_0300|M.avium_104 AVDHVAVGLADFGKPEGFLERQVPRWLSELESYSQYDGYPGPQIPGIDQV
MAB_4910c|M.abscessus_ATCC_199 ALDYQELGLDGYGNPDGFLERQVPRWLKELDSYAKHDGYPGPDIPGLQSV
Mb3787c|M.bovis_AF2122/97 SIDPKAVGLSDFGKPDGYLERQVRRWGSQWELVRLPDDHRDADIS---RL
Rv3761c|M.tuberculosis_H37Rv SIDPKAVGLSDFGKPDGYLERQVRRWGSQWELVRLPDDHRDADIS---RL
* .* .:* *** :: : : : .:. :
Mvan_2028|M.vanbaalenii_PYR-1 AEWLESHRPEDTEPGIMHGDCHLSNVLLRRDVP-EVAAFVDWEMCTVGDP
Mflv_4318|M.gilvum_PYR-GCK AEWLEAHRPPDSEPGIMHGDCHLNNVLLRRDVP-ELAAFIDWEMCTVGDP
MSMEG_2286|M.smegmatis_MC2_155 AQWLDEHRPPDGEPGIMHGDAHLNNVLLRREVP-ELAAFIDWEMCTIGDP
TH_3571|M.thermoresistible__bu AAWLEDNRPPDTEPGIMHGDAHLNNVLLRRDRP-EVAAFVDWEMCTVGDP
MMAR_5325|M.marinum_M SCWLDSHRPTAWTPGILHGDYHMANVMFSRTGP-EVVAICDWEMCTIGDP
MUL_4404|M.ulcerans_Agy99 SCWLDSHRPTAWTPGILHGDYHMANVMFSRTGP-EVVAICDWEMCTIGDP
MAV_0300|M.avium_104 SAWLEQHRPAHWTPGIMHGDYHAANVMFSRTGP-EVVAIVDWEMCTIGDP
MAB_4910c|M.abscessus_ATCC_199 ANWLERHRPSQWKPGIMHGDFHLANMMFRNDGP-QLAAIVDWEMSTIGDP
Mb3787c|M.bovis_AF2122/97 HLALQQAIPQQSRTSIVHGDYRIDNTILDTDDPCHVRAVVDWELSTLGDP
Rv3761c|M.tuberculosis_H37Rv HLALQQAIPQQSRTSIVHGDYRIDNTILDTDDPCHVRAVVDWELSTLGDP
*: * ..*:*** : * :: * .: *. ***:.*:***
Mvan_2028|M.vanbaalenii_PYR-1 LLDLGWMLICWPDGPNPIDVGSELAALGGLATRPELVEAYLAAGGRRTSA
Mflv_4318|M.gilvum_PYR-GCK LLDLGWLLVCWPDGPNPIDAGSALGALGGLASRAELIDAYRDAGGRPTTH
MSMEG_2286|M.smegmatis_MC2_155 LLDLGWMLVCWPDDPNPINAGSALAALGGLATRAELLDAYRAAGGRQTDH
TH_3571|M.thermoresistible__bu LLDLGWLLVCWPLDPNPIDVGTELAALGGLAGRGELLEAYRAAGGRDTSH
MMAR_5325|M.marinum_M LLDLGWLLATWRQSDGASVFGHALGAQDGLASTDDLLQRYAANTTRDLSH
MUL_4404|M.ulcerans_Agy99 LLDLGWLLATWRQSDGASVFGHALGAQDGLASTDDLLQRYAANTTRDLSH
MAV_0300|M.avium_104 LLDLGWLLATWRQPDGSAVFSHALGGQEGLASTDELFRRYAANTSRDLSH
MAB_4910c|M.abscessus_ATCC_199 LLDLGWMLATWPSETDDASLGGALVQAGGLPTPQELVAHYAERTDRDLGA
Mb3787c|M.bovis_AF2122/97 LSDAALMCVYRDPALDLIVHAQAAWTSPLLPAADELADRYSLVSGQPLGH
Rv3761c|M.tuberculosis_H37Rv LSDAALMCVYRDPALDLIVHAQAAWTSPLLPAADELADRYSLVSGQPLGH
* * . : . . *. :* * :
Mvan_2028|M.vanbaalenii_PYR-1 LDWYVAMACFKLAIVIEGTWSR---YLAGQASAEAGERLHASAENLIELG
Mflv_4318|M.gilvum_PYR-GCK LDWYIAMACFKLAIVIEGTWSR---YLAGRASAEAGERLHASAENLIALG
MSMEG_2286|M.smegmatis_MC2_155 LDWYVALACFKLGIVIEGTWSR---YLAGQANREAGEQLHASAENLMTLG
TH_3571|M.thermoresistible__bu LDWYVALACFKLGIVIEGTWSR---HLAGLAPKEAGERLHASAVDLIELG
MMAR_5325|M.marinum_M ITWYTVLACFKLGIVIEGTLAR---ACAGQAEKEVGDQLHAATVHLFERA
MUL_4404|M.ulcerans_Agy99 ITWYTVLACFKLGIIVEGTLAR---ACAGQAEKEVGDQLHAATVHLFERA
MAV_0300|M.avium_104 IAWYTVLACFKLGIVIEGTLAR---ACAGQAEKEVGDQLHAATVHLFERA
MAB_4910c|M.abscessus_ATCC_199 MDWYTVLACFKLGIILEGTHAR---ACAGKAPVAVGDYLHGLTLQLFKRA
Mb3787c|M.bovis_AF2122/97 WEFYMALAYFKLAIIAAGIDYRRRMSEQAEGKDTAAESVPDVVAPLIARG
Rv3761c|M.tuberculosis_H37Rv WEFYMALAYFKLAIIAAGIDYRRRMSEQAEGKDTAAESVPDVVAPLIARG
:* .:* ***.*: * * . . ..: : . *: .
Mvan_2028|M.vanbaalenii_PYR-1 TRVSKGDNPFA
Mflv_4318|M.gilvum_PYR-GCK TRVSTGDNPFV
MSMEG_2286|M.smegmatis_MC2_155 LQVTKGDSPFR
TH_3571|M.thermoresistible__bu NRVAKGANPFE
MMAR_5325|M.marinum_M LGLIGA-----
MUL_4404|M.ulcerans_Agy99 LGLIGA-----
MAV_0300|M.avium_104 LRLIDEQG---
MAB_4910c|M.abscessus_ATCC_199 VAITG------
Mb3787c|M.bovis_AF2122/97 LAEIAKKSG--
Rv3761c|M.tuberculosis_H37Rv LAEIAKKSG--