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TELADRLATVLRPMLGTEVAIDKLRALTGGASRTTWAFDAVTGHRRRSLILRTGPPDDVHAGMELEARVQ AAAAAAGAPVPHVLVADDSPAALGNPFLICDEVGGETIVRRIQRQLDDAGRQRLLGECAQALAAIHRADA GDAGLVHEDPVAHWRERLDAMGESTATFEWAFRWLDAHRPAGSAPVLVHGDYRMGNLIVEGSRLAAVLDW ELVHVGAGYEDLAWFCVRAWRFGAPASYGAGGLGSIEDFLRAYERAGGTAVDRGAFHWWLVLATLRWGVI CQYQAWRHLSGQARSVELATIGRRVCENEWDLLDLLEGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1490 | - | - | 100% (320) | hypothetical protein MMAR_1490 |
| M. marinum M | MMAR_5325 | - | 1e-18 | 27.95% (297) | hypothetical protein MMAR_5325 |
| M. marinum M | MMAR_5309 | - | 1e-15 | 26.33% (281) | hypothetical protein MMAR_5309 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3193 | - | 3e-13 | 30.30% (231) | hypothetical protein Mb3193 |
| M. gilvum PYR-GCK | Mflv_4469 | - | 1e-119 | 65.93% (317) | aminoglycoside phosphotransferase |
| M. tuberculosis H37Rv | Rv3168 | - | 3e-13 | 30.30% (231) | hypothetical protein Rv3168 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3637c | - | 2e-39 | 33.64% (330) | putative aminoglycoside phosphotransferase |
| M. avium 104 | MAV_4028 | - | 1e-140 | 75.08% (325) | aminoglycoside phosphotransferase |
| M. smegmatis MC2 155 | MSMEG_2069 | - | 1e-134 | 72.33% (318) | phosphotransferase enzyme family protein |
| M. thermoresistible (build 8) | TH_0640 | - | 1e-127 | 72.08% (308) | phosphotransferase enzyme family protein |
| M. ulcerans Agy99 | MUL_2450 | - | 0.0 | 98.75% (320) | hypothetical protein MUL_2450 |
| M. vanbaalenii PYR-1 | Mvan_1891 | - | 1e-116 | 61.92% (344) | aminoglycoside phosphotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1490|M.marinum_M -----------------------MTELADRLATVLRPMLGTEVAIDKLRA
MUL_2450|M.ulcerans_Agy99 -----------------------MTELADRLATVLRPMLGTEVAIDKLRA
MAV_4028|M.avium_104 -------------------MDSDAAELRPKLEGVLATALGAGTAVEQLRT
Mflv_4469|M.gilvum_PYR-GCK ----------------------MSDDLARALEDVLRPVLGD-TTVEDLQR
Mvan_1891|M.vanbaalenii_PYR-1 ----------------------MSVELAPALEEVLRPVLGD-VTVENLQR
TH_0640|M.thermoresistible__bu ---------------------------------VLAPVLGEGVTVDGLTR
MSMEG_2069|M.smegmatis_MC2_155 -----------------MTETRDPASLTGGLVDVLAPVVGAGVSVENLRE
MAB_3637c|M.abscessus_ATCC_199 -----------------------MSDLTEGLTRYLRDEFGKDFTVSGVVG
Mb3193|M.bovis_AF2122/97 MANEPAIGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAPEVTVESGVD
Rv3168|M.tuberculosis_H37Rv MANEPAIGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAPEVTVESGVD
* . ::.
MMAR_1490|M.marinum_M LTGGASRTTWAFDAVTGHRR---------------------------RSL
MUL_2450|M.ulcerans_Agy99 LTGGASRTTWAFDAVTGHRR---------------------------RSL
MAV_4028|M.avium_104 LTGGASRTTWAFDAVTGGRR---------------------------RPL
Mflv_4469|M.gilvum_PYR-GCK LTGGASRTTWAFTSRSDGRS---------------------------RHL
Mvan_1891|M.vanbaalenii_PYR-1 LTGGASRTTWAFSAHARSRSGTAHARSESDTAHARSESDTAQTGGAGRPL
TH_0640|M.thermoresistible__bu LTGGASRTTWAFDAVAGETR---------------------------TPL
MSMEG_2069|M.smegmatis_MC2_155 LTGGASRTTWSFEAVTASQR---------------------------RAL
MAB_3637c|M.abscessus_ATCC_199 VSAGARRRNVLLDATFGSET---------------------------LEL
Mb3193|M.bovis_AF2122/97 STGMSSETIILTARRQQDGRS------------------------IQQKL
Rv3168|M.tuberculosis_H37Rv STGMSSETIILTARWQQDGRS------------------------IQQKL
:. : . *
MMAR_1490|M.marinum_M ILRTGPPDD---VHAGMELEARVQAAAAA---AGAPVPHVLVADDSPAAL
MUL_2450|M.ulcerans_Agy99 ILRTGPPDD---VHAGMELEARVQAAAAA---AGAPVPHVLVADDSPAAL
MAV_4028|M.avium_104 ILRTGPPDD---VHAGMELEAQAQAAAAA---AGAPVPHILVADNSPAAL
Mflv_4469|M.gilvum_PYR-GCK ILRTGARDD---IHASMELEAKVQQRAAA---AGAPVPHILAADNSPDAV
Mvan_1891|M.vanbaalenii_PYR-1 ILRTGARDD---IHASMELEAKVQQRAAA---AGAPVPHIVNADNSPAAV
TH_0640|M.thermoresistible__bu ILRMGPPDE---VHAGMELEAEVQRRAAA---AGAPVPRILTADDSTAAL
MSMEG_2069|M.smegmatis_MC2_155 ILRTGPPDE---VHAGMELEAGAQRAAAA---AGAPVPHVLVADNSTAAL
MAB_3637c|M.abscessus_ATCC_199 VATIVPAAV---QQIPVSGEAGVRELARS---NGVPVPRVRGICPDAAYV
Mb3193|M.bovis_AF2122/97 VARVAPAAEDVPVFPTYRLDHQFEVIRLVGELTDVPVPRVRWIETTGDVL
Rv3168|M.tuberculosis_H37Rv VARVAPAAEDVPVFPTYRLDHQFEVIRLVGELTDVPVPRVRWIETTGDVL
: . : . ..***:: :
MMAR_1490|M.marinum_M GNPFLICDEVGGETIVRRIQRQLDD----AGRQR----LLGECAQALAAI
MUL_2450|M.ulcerans_Agy99 GNPFLICDEVGGETIVRRIQRQLDD----AGRQR----LLGECAQALAAI
MAV_4028|M.avium_104 GNPFLICDEIKGETIARRIQRRLDATDGHAARAH----LLGQCAHAVAAI
Mflv_4469|M.gilvum_PYR-GCK GEPYLICDAIAGETIVRKIFRMLDD----TGRAR----LLTQCATALAAI
Mvan_1891|M.vanbaalenii_PYR-1 GAPYLICDAIAGETIVRRIFRGLDD----GGRAR----LLEQCATALAAI
TH_0640|M.thermoresistible__bu GNPYLICAAVPGETIVRRIQRSLDD----TGRAV----LLRQCAQALAAI
MSMEG_2069|M.smegmatis_MC2_155 GNPYLVCDFIPGETIVRRIQRQLDA----AGRAK----LLTQCAQALAAI
MAB_3637c|M.abscessus_ATCC_199 GAPFMISERIAGETVPRKVLRLVEARGIGDLVAG----QLGSAMGRLHGI
Mb3193|M.bovis_AF2122/97 GTPFFLMDYVEGVVPPDVMPYTFGDNWFADAPAERQRQLQDATVAALATL
Rv3168|M.tuberculosis_H37Rv GTPFFLMDYVEGVVPPDVMPYTFGDNWFADAPAERQRQLQDATVAALATL
* *::: : * . : . : :
MMAR_1490|M.marinum_M HRADAG-----------DAGLVHE---DPVAHWRERLDAMGESTATFEWA
MUL_2450|M.ulcerans_Agy99 HRADAG-----------DAGLVHE---DPVAHWRERPDAMGESTATFEWA
MAV_4028|M.avium_104 HRAEIDR--------IEDPGLRRQ---DQLAEWRQRLDDMGDTTATFEWA
Mflv_4469|M.gilvum_PYR-GCK HRADP-----------DGVGLAAP---DELAGWRTRLDEIGDTTATFEWT
Mvan_1891|M.vanbaalenii_PYR-1 HRADP-----------AGIGLTSP---DDLAGWRSRLDEIGDTTATFEWT
TH_0640|M.thermoresistible__bu HRADP-----------TGAGLTVG---DQLTEWHRQLDEIGDTTATFEWT
MSMEG_2069|M.smegmatis_MC2_155 HRAEPP----------TDIGLTEL---DQVGQWRDQLDEMGDTTATFEWA
MAB_3637c|M.abscessus_ATCC_199 DPAMAPP--------DLPGDLESEPAVVMLEQMREGVAALLPDRPVFQRA
Mb3193|M.bovis_AF2122/97 HSIPNAQNTFSFLTQGRTSDTTLHRHFNWVRSWYDFAVEGIGRSPLLERT
Rv3168|M.tuberculosis_H37Rv HSIPNAQNTFSFLTQGRTSDTTLHRHFNWVRSWYDFAVEGIGRSPLLERT
. . : . :: :
MMAR_1490|M.marinum_M FRWLDAHRP---AGSAPVLVHGDYRMGNLIVEGSRLAAVLDWE-LVHVGA
MUL_2450|M.ulcerans_Agy99 FRWLDAHRP---AESAPVLVHGDYRMGNLIVEGSRLAAVLDWE-LVHVGA
MAV_4028|M.avium_104 FRWLAARRP---RAAPAVLVHGDFRMGNLIVDGAQLAAVLDWE-LVHVGQ
Mflv_4469|M.gilvum_PYR-GCK FRRLADERP---DPSPMRLVHGDFRMGNLIVDDSGLAAVLDWE-LTHIGE
Mvan_1891|M.vanbaalenii_PYR-1 FRRLADARP---EPSPMRLVHGDFRMGNLIVDESGLAAVLDWE-LTHIGE
TH_0640|M.thermoresistible__bu FRRLAADRP---PPSEPVLVHGDFRMGNLIVDGGRLAAVLDWE-LTHLGE
MSMEG_2069|M.smegmatis_MC2_155 FRWLAANRP---PASPPRLIHGDFRMGNLIVDGSDLAAVLDWE-LVHIGE
MAB_3637c|M.abscessus_ATCC_199 LSWLTERMPG--PPVRRSLVHTDIRNGNVIVGEDGLRAVLDWEGTTRFGD
Mb3193|M.bovis_AF2122/97 FEWLQSHWPDDAAAREPVLLWGDARVGNVLYRDFQPVAVLDWE-MVALGP
Rv3168|M.tuberculosis_H37Rv FEWLQSHWPDDAAAREPVLLWGDARVGNVLYRDFQPVAVLDWE-MVALGP
: * * *: * * **:: ****** . .*
MMAR_1490|M.marinum_M GYEDLAWFCVRAWRFGAPASYGAGGLGSIEDFLRAYER----AGGTAVDR
MUL_2450|M.ulcerans_Agy99 GYEDLAWFCVRAWRFGAPASYGAGGLGSIEDFLRAYER----AGGTAVDR
MAV_4028|M.avium_104 AYEDLAWFCIRAWRFGAPAGLGAGGLGSIESFLRAYEQ----ASATTVDR
Mflv_4469|M.gilvum_PYR-GCK IYEDLSWFCIRAWRFGAAESLGAGGLGSVETFLQAYES----AAQIVLDR
Mvan_1891|M.vanbaalenii_PYR-1 IYEDLAWFCIRAWRFGAPETLGAGGLGSVETFLQAYES----AADTSLDR
TH_0640|M.thermoresistible__bu VYEDLAWFCIRAWRFGAPRHLGAGGLGSVADFLTAYEE----AGGRPVDR
MSMEG_2069|M.smegmatis_MC2_155 VYEDLAWFCIRAWRFGATESHAAGGLGSIENFLTAYED----AGGMTLDR
MAB_3637c|M.abscessus_ATCC_199 PMRDVGWTALRMWRFGLDDRE-FGGFAGRDVFVRSYEE----SGG-TFDP
Mb3193|M.bovis_AF2122/97 RELDVAWMIFAHRVF--QELAGLATLPGLPEVMREDDVRATYQALTGVEL
Rv3168|M.tuberculosis_H37Rv RELDVAWMIFAHRVF--QELAGLATLPGLPEVMREDDVRATYQALTGVEL
*:.* . * . : . .: : . .:
MMAR_1490|M.marinum_M GAFHWWLVLATLRWGVICQYQAWRHLSGQARSVELATIGRRVCENEWDLL
MUL_2450|M.ulcerans_Agy99 GAFHWWLVLATLRWGVICQYQAWRHLSGQARSVELATTGRRVCENEWDLP
MAV_4028|M.avium_104 AAFHWWLVLATLRWGVICRYQAERHLSGLHRSVELATIGRRVCETEWDLL
Mflv_4469|M.gilvum_PYR-GCK STFRWWLTVATLRWGVICRHQAERHLSGEARSVELAAIGRRVSETEWDLL
Mvan_1891|M.vanbaalenii_PYR-1 NTFRWWLTVATLRWGVICRHQAERHLSGESPSVELAAIGRRVSETEWDLL
TH_0640|M.thermoresistible__bu QTFRWWLTVATLRWGVICRYQAERHLSGQTRSVELAAIGRRVAETEWDLL
MSMEG_2069|M.smegmatis_MC2_155 DAIRWWLVLATLRWGVICLYQAERHLSGQTRSVELATIGRRVCETEWDIL
MAB_3637c|M.abscessus_ATCC_199 ERFQWWKVLGTLWWGVGLAAQAKSYLDGSVRDIVMAASGRRIPEIEWDLL
Mb3193|M.bovis_AF2122/97 GDLHWFYVYSGVMWACVFMRTGARRVHFG--EIEKPDDVESLFYHAGLMK
Rv3168|M.tuberculosis_H37Rv GDLHWFYVYSGVMWACVFMRTGARRVHFG--EIEKPDDVESLFYHAGLMK
::*: . . : *. . : .: . . : :
MMAR_1490|M.marinum_M DLLEGA--------------------------------------------
MUL_2450|M.ulcerans_Agy99 DLLEGA--------------------------------------------
MAV_4028|M.avium_104 NLLEGAA-------------------------------------------
Mflv_4469|M.gilvum_PYR-GCK DLLSGKGPQ-----------------------------------------
Mvan_1891|M.vanbaalenii_PYR-1 ELLSGGGPR-----------------------------------------
TH_0640|M.thermoresistible__bu DLLDRGGPAESRQTPMSARAKSRQTPMSARAKSRSGGIHGRPTAAELVAA
MSMEG_2069|M.smegmatis_MC2_155 TLLDGSTA------------------------------------------
MAB_3637c|M.abscessus_ATCC_199 MLTKPSEREGTR--------------------------------------
Mb3193|M.bovis_AF2122/97 HLLGEEH-------------------------------------------
Rv3168|M.tuberculosis_H37Rv HLLGEEH-------------------------------------------
*
MMAR_1490|M.marinum_M --------------------------------------------------
MUL_2450|M.ulcerans_Agy99 --------------------------------------------------
MAV_4028|M.avium_104 --------------------------------------------------
Mflv_4469|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1891|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0640|M.thermoresistible__bu VAEFLETDVREACTGSVNFHARVAANVLRIVERELLDESVAADEALTALG
MSMEG_2069|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3637c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3193|M.bovis_AF2122/97 --------------------------------------------------
Rv3168|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1490|M.marinum_M ---------------------------------------------
MUL_2450|M.ulcerans_Agy99 ---------------------------------------------
MAV_4028|M.avium_104 ---------------------------------------------
Mflv_4469|M.gilvum_PYR-GCK ---------------------------------------------
Mvan_1891|M.vanbaalenii_PYR-1 ---------------------------------------------
TH_0640|M.thermoresistible__bu FSDEAQLAAAIRAGDLDDRADELTACLRTLVRQRLAVAHPGYEDQ
MSMEG_2069|M.smegmatis_MC2_155 ---------------------------------------------
MAB_3637c|M.abscessus_ATCC_199 ---------------------------------------------
Mb3193|M.bovis_AF2122/97 ---------------------------------------------
Rv3168|M.tuberculosis_H37Rv ---------------------------------------------