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PSAIVTALAAPIRRVQALVGPGWSADPAADPAAALTGVRDTLTEVADAAGRAWRDAEAGWSGSGGDAAAR FAAATSAAIDGAAARAGQLGVTAGDAAAAVAGAHRRLQSIVDEFEARAGALEPHLDSPGVARELLAEARD ALRRAVAVVEELLAELDGHTAAAGAVAPAGSPAVAPAGSPAVTAPAGWSGAGGAGPGPGGAPAGWAGPGA VNGGFGELAGFTPVEATGTPDAATFGDGVAVRLPDGTVVMAPNAVAASAVRHALTQLGVPYQWGGTTPGV GLDCSGLTQWAYREAGLSLPRLAQEQDLGAAVGAGSLLPGDLAVWDGHVAMIVGDGTMIEAGDPVKLSPI RTANAGQGFQGFWRPTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1599 | - | - | 100% (368) | NLP/P60 protein |
| M. vanbaalenii PYR-1 | Mvan_3713 | - | 8e-20 | 28.05% (385) | NLP/P60 protein |
| M. vanbaalenii PYR-1 | Mvan_3552 | - | 3e-19 | 26.11% (383) | NLP/P60 protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2213c | - | 2e-20 | 31.14% (289) | hypothetical protein Mb2213c |
| M. gilvum PYR-GCK | Mflv_4838 | - | 1e-147 | 71.66% (367) | NLP/P60 protein |
| M. tuberculosis H37Rv | Rv2190c | - | 2e-20 | 31.14% (289) | hypothetical protein Rv2190c |
| M. leprae Br4923 | MLBr_00885 | - | 7e-20 | 29.48% (363) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_3664 | - | 2e-71 | 39.34% (427) | hypothetical protein MAB_3664 |
| M. marinum M | MMAR_3234 | - | 1e-22 | 29.17% (336) | hypothetical protein MMAR_3234 |
| M. avium 104 | MAV_2304 | - | 2e-21 | 30.14% (292) | NLP/P60 family protein |
| M. smegmatis MC2 155 | MSMEG_1686 | - | 1e-119 | 61.76% (374) | NPL/P60-family protein secreted protein |
| M. thermoresistible (build 8) | TH_1643 | - | 4e-96 | 59.51% (326) | NPL/P60-family protein secreted protein |
| M. ulcerans Agy99 | MUL_3545 | - | 7e-23 | 28.57% (336) | hypothetical protein MUL_3545 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2213c|M.bovis_AF2122/97 -------------------MRLDQRWLIARVIMRSAIGFFASFTVSSGVL
Rv2190c|M.tuberculosis_H37Rv -------------------MRLDQRWLIARVIMRSAIGFFASFTVSSGVL
MMAR_3234|M.marinum_M -------------------MRLDCRQLTARVIRRSAIGSLASFTALSGFV
MUL_3545|M.ulcerans_Agy99 -------------------MRLDCRQLTARVIRRSAIGSLASFTALSGFV
MAV_2304|M.avium_104 --------------------------------------------------
MLBr_00885|M.leprae_Br4923 -------------------MRLGCKHPVVRLIAHFVVGTLVGFAVLSRFF
Mvan_1599|M.vanbaalenii_PYR-1 -----------------------MPSAIVTALAAPIRRVQALVGPGWSAD
Mflv_4838|M.gilvum_PYR-GCK -----------------------MPSATVEALAAPIRRVQGLVGPGWSGD
MSMEG_1686|M.smegmatis_MC2_155 -----------------------MPGALVHALAAPLHDLRTLVGPGWVAT
TH_1643|M.thermoresistible__bu --------------------------------------VRRWVWP-----
MAB_3664|M.abscessus_ATCC_1997 MVETSPISPSRLSEAVNTNYPDFSNNPFSSGLIGPAMDMAGTVGPGQFKE
Mb2213c|M.bovis_AF2122/97 AANVLADPADDALAKLNELSRQAEQTTEALHSAQLDLNEKLAAQRAADQK
Rv2190c|M.tuberculosis_H37Rv AANVLADPADDALAKLNELSRQAEQTTEALHSAQLDLNEKLAAQRAADQK
MMAR_3234|M.marinum_M AAGAMADPAEDALAKLNELSRQAEQTTEAMHSAELDLGAKLAAQQAAENK
MUL_3545|M.ulcerans_Agy99 AAGAMADQAEDALAKLNELSRQAEQTTEAMHSAELELGAKLAAQQAAENK
MAV_2304|M.avium_104 ------------MAKLNELSRQAEQTTEAMHSAQLDLNEKLAAQRAAEKK
MLBr_00885|M.leprae_Br4923 VATAMADPAEDALAKLNELSRQAEQTTEAVHSAQLDLTEKLAAQRAADKK
Mvan_1599|M.vanbaalenii_PYR-1 PAADPAAALTGVRDTLTEVADAAGRAWRDAEAGWSGSGGDAAARFAAATS
Mflv_4838|M.gilvum_PYR-GCK PAADPSGALAGVRQMLSDVAGSAGHAWRTVDDRWSGAGADAAASFASATT
MSMEG_1686|M.smegmatis_MC2_155 --DPPVAALSSVRSALTDLAAAAEASWARVSDGWAGTASDAAGEFSAVTA
TH_1643|M.thermoresistible__bu -----------------------GIGSRPATDRRRRSSVXXXGRIAVA--
MAB_3664|M.abscessus_ATCC_1997 -GQDPSKMLESGMQVMQQVMQQGLQAGSSLIGSFAGAAAQALGQFAGMAG
. :
Mb2213c|M.bovis_AF2122/97 LADNRTALDAARARLATFQTAVNKVAAATYMGGRTHGMDAILTAESPQLL
Rv2190c|M.tuberculosis_H37Rv LADNRTALDAARARLATFQTAVNKVAAATYMGGRTHGMDAILTAESPQLL
MMAR_3234|M.marinum_M LTDDQAALDAAKGQLASFQTAVNKVAAAAYMGGRANGMDTILTAPSPQLL
MUL_3545|M.ulcerans_Agy99 LTDDQAALDATKGQLASFQTAVNKVAAAAYMGGRANGMDTILTAPSPQLL
MAV_2304|M.avium_104 HDDDQAAVDAAKAHLASYQNAVNNLAAATYMGGRVDGMEAILTAGSPQGL
MLBr_00885|M.leprae_Br4923 YTDDQAALADAQVRLATFQAAVNKLAAATYMSGRINGMTALLTAYSPQQL
Mvan_1599|M.vanbaalenii_PYR-1 AAIDGAAARAGQLGVTAGDAAAAVAGAHRRLQSIVDEFEARAGALEPHLD
Mflv_4838|M.gilvum_PYR-GCK AAIDDAADRAGRLGVAAEDAAAAVGHAHRRLQQIVDEFESKARALEQRLD
MSMEG_1686|M.smegmatis_MC2_155 ATARALADRAGMLSGVAREAGTAVARAQARLDAVIEAFEQRAAALEPRLD
TH_1643|M.thermoresistible__bu -----LADAAARLAATTDTAAVAISDAAARLRVIIERFEARAGALEAHLD
MAB_3664|M.abscessus_ATCC_1997 QALSSMATRSGAMGANVGQASESTARATSLITEALQEFQHTSEALTPLLW
* . * : . : *
Mb2213c|M.bovis_AF2122/97 IDRLSVQRVMAHQMSTQMARFKAAGEQAVKAEQAAAKSAADARSAAEQAA
Rv2190c|M.tuberculosis_H37Rv IDRLSVQRVMAHQMSTQMARFKAAGEQAVKAEQAAAKSAADARSAAEQAA
MMAR_3234|M.marinum_M IDGLSMQRVMAHQMATQMSGFRTAREQAAKAEQASEKSAADAKSAAEQAA
MUL_3545|M.ulcerans_Agy99 IDGLSMQRVMVHQMATQMSGFRTAREQTAKAEQASEKSAADAKSAAEQAA
MAV_2304|M.avium_104 IDKLAVQRLMATQMASQMKSYRIAGEQAAKAERESAKSAADAKSAAEQAA
MLBr_00885|M.leprae_Br4923 INKLALQRVLGVQMATQMAGYRDAGEQAVKAEQTSAKSAADAKHAADQAA
Mvan_1599|M.vanbaalenii_PYR-1 SPGVARELLAEARDALRRAVAVVEELLAELDGHTAAAGAVAPAGS-----
Mflv_4838|M.gilvum_PYR-GCK DPGVARELLTAARDALGEAIAVVEELQTELDRQARIVDSAAPAGS-----
MSMEG_1686|M.smegmatis_MC2_155 EPGVAEELVAEAQRALREALAVIEELRAELDGHAGTVTSAPVA-------
TH_1643|M.thermoresistible__bu EPGVAAELIAEARQALAEALGVVDDLHTDLARHATALTDPAGTPP-----
MAB_3664|M.abscessus_ATCC_1997 VPGVAAELAEAASRCTARVAEHTAQLEGELAGQAGELTGMAGADMGNPAT
:: : . :
Mb2213c|M.bovis_AF2122/97 AVRANLQHKQSQLQVQIAVVKSQYVALTPEERTALAD-------------
Rv2190c|M.tuberculosis_H37Rv AVRANLQHKQSQLQVQIAVVKSQYVALTPEERTALAD-------------
MMAR_3234|M.marinum_M AVRANLQHKQSQLQVQIAVVKSQYLALTPDQRTALAD-------------
MUL_3545|M.ulcerans_Agy99 AVRANLQHKQSQLQVQIAVVKSQYLALTPDQRTALVD-------------
MAV_2304|M.avium_104 AVRASLQSKQSQLQVQIAVVKSQYMSLTADQRTALAN-------------
MLBr_00885|M.leprae_Br4923 VVRAGLQSKQSKLQLQIAVVKSHYLSLSPRQRTTLAE-------------
Mvan_1599|M.vanbaalenii_PYR-1 PAVAPAGSPAVTAPAGWSGAGGAGP-------------------------
Mflv_4838|M.gilvum_PYR-GCK PP---------TTPAEWQSASGTGG-------------------------
MSMEG_1686|M.smegmatis_MC2_155 ------------VPAGFSGAVPAMR-------------------------
TH_1643|M.thermoresistible__bu SAR--------TVPSGFTGGSPPLGGMGSGLGGLPS--------------
MAB_3664|M.abscessus_ATCC_1997 PASGSVQPAMSAMQGGLQAGTQAMSGVASGVTQTMSSMGQGLGQIPQALT
Mb2213c|M.bovis_AF2122/97 -----PGPVPAVAAIAPG-APPAALPPG-APPGDGPAP------------
Rv2190c|M.tuberculosis_H37Rv -----PGPVPAVAAIAPG-APPAALPPG-APPGDGPAP------------
MMAR_3234|M.marinum_M -----PGQVPAGLPGAPG-PAPEGTPPGGPPPAGAPVP------------
MUL_3545|M.ulcerans_Agy99 -----PGQVPAGLPGAPG-PAPEGTPPGGPPPAGAPVP------------
MAV_2304|M.avium_104 -----PGPAVPAAATAPGAPAPEAAPPG--TPPGGPGP------------
MLBr_00885|M.leprae_Br4923 -----PGPVPAVAT-LPG-----AASAGVSPPPD----------------
Mvan_1599|M.vanbaalenii_PYR-1 ----GPGGAPAGWAGPGAVNGGFGELA-GFTPVEAT--------------
Mflv_4838|M.gilvum_PYR-GCK ----GPGGGFAPGSGGFGNSGATGEMA-AFTRPDGT--------------
MSMEG_1686|M.smegmatis_MC2_155 ----ASG---FSGLGPNLGSGSPSAFAPAFSAPEAAPG------------
TH_1643|M.thermoresistible__bu ---VSPGGAAGSGLGGGAARGLAELVGLATDRPDSAA-------------
MAB_3664|M.abscessus_ATCC_1997 GLLSGAGGGSGSASALAGGSGLNGIAAGALANPFGAGGGHASSTAGGTSS
.*
Mb2213c|M.bovis_AF2122/97 -----------GVAPPP--GGMPGLPFVQPDGAGGD---RTAVVQAALTQ
Rv2190c|M.tuberculosis_H37Rv -----------GVAPPP--GGMPGLPFVQPDGAGGD---RTAVVQAALTQ
MMAR_3234|M.marinum_M -----------GEAPPP--GGVSAMPFTPPDGAGGD---RAAVVQAALTQ
MUL_3545|M.ulcerans_Agy99 -----------GEAPPPGAGGVSAMPFTPPDGAGGD---RAAVVQAALTQ
MAV_2304|M.avium_104 -----------GEAPPP--GGAPGMAPGGGGVGGGD---RATVVQAALTQ
MLBr_00885|M.leprae_Br4923 -------------AAPP--GGLLGVAP-APFAGGGD---RAAVVQAALTQ
Mvan_1599|M.vanbaalenii_PYR-1 -----------GTPDAATFGDGVAVRLPDGTVVMAPNAVAASAVRHALTQ
Mflv_4838|M.gilvum_PYR-GCK -----------DTPDAAEFGEGVAVRLPDGTVVVAPNAVAANAVRHALTQ
MSMEG_1686|M.smegmatis_MC2_155 --------GLLDTPDAAMFGDGVAVRLPDGSTTMAPNAVAASAVRHALTQ
TH_1643|M.thermoresistible__bu -----------RPADPAAFGVGVAVRLPDGSTVTAPNAVAADAVRHALTQ
MAB_3664|M.abscessus_ATCC_1997 GLGSANASAAKMLLDPRSMGKGVQLFLPDGSTSQAPNAAAAEAVRKALSQ
. * : . : .*: **:*
Mb2213c|M.bovis_AF2122/97 VGAPYAWGGAAPG-GFDCSGLVMWAFQQAGIALPHSSQALAHGGQPVALS
Rv2190c|M.tuberculosis_H37Rv VGAPYAWGGAAPG-GFDCSGLVMWAFQQAGIALPHSSQALAHGGQPVALS
MMAR_3234|M.marinum_M VGTPYAWGGAAPG-GFDCSGLVMWAFQQAGIALPHSSQALAHGGQPVSLS
MUL_3545|M.ulcerans_Agy99 VGTPYAWGGAAPG-GFDCSGLVMWAFQQAGIALPHSSQALAHEGQPVSLS
MAV_2304|M.avium_104 VGSPYVWGGAAPG-GFDCSGLVMWAFQQAGISLPHSSQALAHGGQPVSLS
MLBr_00885|M.leprae_Br4923 IGSPYAWGGAAPG-GFDCSGLVMWAYQQAGIALPHSSQALARGGQPVSLS
Mvan_1599|M.vanbaalenii_PYR-1 LGVPYQWGGTTPGVGLDCSGLTQWAYREAGLSLPRLAQEQDLG-AAVGAG
Mflv_4838|M.gilvum_PYR-GCK LGVPYQWGGTTPGVGLDCSGLTQWAYREAGLDIPRLAQEQDIG-GAVSGG
MSMEG_1686|M.smegmatis_MC2_155 LGVPYHWGGTTPGVGLDCSGLTQWAYREAGLNIPRLAQEQDIG-AAVAAN
TH_1643|M.thermoresistible__bu LGVPYQWGGTTPGVGLDCSGLTQWAYQQAGLQLPRLAQEQDVG-AAVDAG
MAB_3664|M.abscessus_ATCC_1997 VGVPYEWGGTKPGVGLDCSGLTQWAYGQSGVDIPRLAQEQGVG-VKVDQG
:* ** ***: ** *:*****. **: ::*: :*: :* * .
Mb2213c|M.bovis_AF2122/97 DLQPGDVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSSGPIYDA
Rv2190c|M.tuberculosis_H37Rv DLQPGDVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSSGPIYDA
MMAR_3234|M.marinum_M DLQPGDVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMNSSGPIYDA
MUL_3545|M.ulcerans_Agy99 DLQPGDVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMNSSGPIYDA
MAV_2304|M.avium_104 DLQPGDVLTFYSDASHAGIYIGDGMMIHSSTYGVPVRVVPMNSSGPIYDA
MLBr_00885|M.leprae_Br4923 ELQPGDVLTFYSDASHAGIYVGDGMMIHSSTYGVPVRVVPMNSSGPIYDA
Mvan_1599|M.vanbaalenii_PYR-1 SLLPGDLAVWDG---HVAMIVGDGTMIEA---GDPVKLSPIRTANAGQGF
Mflv_4838|M.gilvum_PYR-GCK SLLPGDLAVWDG---HVAMVVGDGLMVEA---GDPVQLSPIRTANAGQGF
MSMEG_1686|M.smegmatis_MC2_155 ALRPGDLAVWDG---HVAMIVGPNTMIEA---GDPVQLSPIRTTNAGQGF
TH_1643|M.thermoresistible__bu ALLPGDLAVWDG---HVAMVVGNGMMIEA---GDPVKLSPIRTTNAGQGF
MAB_3664|M.abscessus_ATCC_1997 SVMPGDLAVWDG---HVAMVIGNGMMVEA---GDPVQISPIRTTNAGQGF
: ***: .: . *..: :* . *:.: * **:: *: ::.. .
Mb2213c|M.bovis_AF2122/97 RRY-----
Rv2190c|M.tuberculosis_H37Rv RRY-----
MMAR_3234|M.marinum_M RRY-----
MUL_3545|M.ulcerans_Agy99 RRY-----
MAV_2304|M.avium_104 RRY-----
MLBr_00885|M.leprae_Br4923 RRY-----
Mvan_1599|M.vanbaalenii_PYR-1 QGFWRPTA
Mflv_4838|M.gilvum_PYR-GCK QGFWRPTV
MSMEG_1686|M.smegmatis_MC2_155 QGFWRPTA
TH_1643|M.thermoresistible__bu QGFWRPTG
MAB_3664|M.abscessus_ATCC_1997 HGFYRPTS
: :