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IEFDVSTPSLPGDLSILAGSRPTAPFLIRPAENADDLASYRRLRRDSFVVDQGMFSGSDHDDIDDDPRVV VLIAAAADGSVLGGVRLAPVGGVDLGWWTGSRLVVDRSTRITGIGAALVRAACAYAESAGVLRFEATVQR RYQPMFTALGWDPLGDVEIAARPHVWMRRQINPFDALAAATKSFLGAALNPLRAVDGALGPAGFVGDDGS PVPGTDLVAACDAIIPSLVERDPEWAGWCSVLVNINDLSAMGATPTGLLDAVAAPTRAVLDRIIGGIAAA SSAWAVPVLGGHTQLGVPAALSVTALGHTVSPVPAGGGVAGDRVRLTADTTGRWRRGYTGRQWDSTTSRN SAELASMAGLVARMAPRAAKDVSMAGVVGTVGMLAEASGTGAELDVATIPRPASAGMAPWLTCFPGFGML TVGGALGSAAVPAGVASSECGSLTAEPGVRLRWPDGVTTTALTSPVTGLGKA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0567 | - | - | 100% (473) | selenophosphate synthetase |
| M. smegmatis MC2 155 | MSMEG_2398 | thiL | 1e-05 | 26.21% (248) | thiamine monophosphate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_4216 | - | 7e-05 | 25.66% (226) | thiamine monophosphate kinase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | MLBr_01676 | thiL | 6e-06 | 27.27% (231) | thiamine monophosphate kinase |
| M. abscessus ATCC 19977 | MAB_3284c | - | 2e-08 | 28.33% (293) | thiamine monophosphate kinase |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_3829 | thiL | 5e-07 | 27.02% (285) | thiamine monophosphate kinase |
| M. thermoresistible (build 8) | TH_2051 | thiL | 3e-07 | 28.24% (216) | PROBABLE THIAMINE-MONOPHOSPHATE KINASE THIL |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1220 | - | 0.0 | 69.33% (463) | GCN5-related N-acetyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4216|M.gilvum_PYR-GCK --------------------------------------------------
TH_2051|M.thermoresistible__bu --------------------------------------------------
MLBr_01676|M.leprae_Br4923 --------------------------------------------------
MAV_3829|M.avium_104 --------------------------------------------------
MAB_3284c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0567|M.smegmatis_MC2_155 MIEFDVSTPSLPGDLSILAGSRPTAP--FLIRPAENADDLASYRRLRRDS
Mvan_1220|M.vanbaalenii_PYR-1 -MLFQAISPHR-GELSILAGSRPATGGQFLIRLAG-APELRAYHRLRQES
Mflv_4216|M.gilvum_PYR-GCK --------------------------------------------------
TH_2051|M.thermoresistible__bu --------------------------------------------------
MLBr_01676|M.leprae_Br4923 --------------------------------------------------
MAV_3829|M.avium_104 --------------------------------------------------
MAB_3284c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0567|M.smegmatis_MC2_155 FVVDQGMFSGSDHDDIDDDPRVVVLIAAAADGSVLGGVRLAPVGGVDLGW
Mvan_1220|M.vanbaalenii_PYR-1 FVVEQGMFSGTDRDDLDDDPRTVVLVAVAADGTVLGGVRLAPACAPDIGW
Mflv_4216|M.gilvum_PYR-GCK --------------------------------------------------
TH_2051|M.thermoresistible__bu --------------------------------------------------
MLBr_01676|M.leprae_Br4923 --------------------------------------------------
MAV_3829|M.avium_104 --------------------------------------------------
MAB_3284c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_0567|M.smegmatis_MC2_155 WTGSRLVVDRSTRITGIGAALVRAACAYAESAGVLRFEATVQRRYQPMFT
Mvan_1220|M.vanbaalenii_PYR-1 WTGSRLVADPAARAAGLGPALVRAACAHAESVGALRFEATVQHRYAPMFV
Mflv_4216|M.gilvum_PYR-GCK -----------MAAEDAD---AKLSELGEFAVIDRLVADRRQPPAVSLGP
TH_2051|M.thermoresistible__bu ---MAGDQPRDMAGDEAGGRAETLAAVGEFAVIDRLVAGRRQPGAVALGP
MLBr_01676|M.leprae_Br4923 ----MCNHECGALGESVT-----LEQLGEFAVIDRLVRGRRQPAVVALGP
MAV_3829|M.avium_104 ------------MRDEST-----LRQLGEFGVIDRLVAGRRQPAAVTLGP
MAB_3284c|M.abscessus_ATCC_199 -----------MPN---------LGDTGEFGVISRLTAGRDLGADVLLGP
MSMEG_0567|M.smegmatis_MC2_155 ALGWDPLGDVEIAARPHVWMRRQINPFDALAAATKSFLGAALNPLRAVDG
Mvan_1220|M.vanbaalenii_PYR-1 GLGWTDEGGCVVAGRPHVVMRWPLDPVQRVAAATKSFLGEVLDPLRRVPN
: ... : . :
Mflv_4216|M.gilvum_PYR-GCK GDDAAVVFAADGRTVVCTDMLVEGRHFRLDWS--TPHDIGRKAIAQNAAD
TH_2051|M.thermoresistible__bu GDDAAVVHAADGRTVVCTDMLVQDRHFRLDWS--TPHQVGRKAIAQNAAD
MLBr_01676|M.leprae_Br4923 GDDAAVVTASDGRIVVSTDVLVQDRHFRLDWS--TPHDVGRKAIAQNAAD
MAV_3829|M.avium_104 GDDAALVTTGDGRVVVSTDMLVQDRHFRLDWS--TPHDIGRKAIAQNAAD
MAB_3284c|M.abscessus_ATCC_199 GDDAAVVTVPDGRVVVSTDMLVQDRHFRLEWS--SPSDIGRKAVAQNAAD
MSMEG_0567|M.smegmatis_MC2_155 ALGPAGFVGDDGSPVPGTDLVAACDAIIPSLVERDPEWAGWCSVLVNIND
Mvan_1220|M.vanbaalenii_PYR-1 GLGPKGFVGDDGVPVPGGDVVAACDAIIPSMVERDPEWAGWCSVLVNVND
. .. . ** * *::. : . * * :: * *
Mflv_4216|M.gilvum_PYR-GCK IEAMGARATAFVVAFGAPGDTPTAAAVQVADGMWHEAALLGAGIVGGDTV
TH_2051|M.thermoresistible__bu IAAMGARSTAFVVAFGAPADTPAAAALALADGLWAEAQSLGAGIVGGDLV
MLBr_01676|M.leprae_Br4923 IEAMGARATTFVVGLGAPGDTPVAQVDALVDGLWDEAGRIGAGIVGGDLV
MAV_3829|M.avium_104 IEAMGARPTAFVVGFGAPGQTAAAQVDALVDGMWDEAQRVGAGIAGGDLV
MAB_3284c|M.abscessus_ATCC_199 IEAMGGRVTAFVVAVGAPAQTDIAFLDQLNEGVWAEAALVQAPIVGGDLV
MSMEG_0567|M.smegmatis_MC2_155 LSAMGATPTGLLDAVAAPTR---AVLDRIIGGIAAASSAWAVPVLGGHTQ
Mvan_1220|M.vanbaalenii_PYR-1 LSAMGATPTGLLDAVGAPNR---SLLTRIVRGVANASQAWRVPVLGGHTQ
: ***. * :: ...** : : *: : . : **.
Mflv_4216|M.gilvum_PYR-GCK AAPQWVISVAALGDLGGREPVRRDGARPGDTVAVTGVLGRSAAGYELLRN
TH_2051|M.thermoresistible__bu RAPNWVVSVTALGDLEGRPPVPRGGARAGDVVAAVGQLGRSAAGYALWRN
MLBr_01676|M.leprae_Br4923 SCPQWVLSVTVLGDLDGRAPVLRSGAKNGSMVAVAGALGRSAAGYALWHK
MAV_3829|M.avium_104 SCPQWVISVTALGELDGRSPVCRAGAEPGALIAVAGDLGRSAAGFDLWRN
MAB_3284c|M.abscessus_ATCC_199 SARELVVSVTVLGDLQGRAPVTRSGAVVGDTVAICGALGTSAAGYRLWQE
MSMEG_0567|M.smegmatis_MC2_155 LGVPAALSVTALGHT--VSPVPAGGGVAGDRVRLTADTTG------RWRR
Mvan_1220|M.vanbaalenii_PYR-1 LGVPASLAVTALGRT--ADPVPAAGGAAGDALRLTVDLSG------RWRP
::*:.** ** *. * : :
Mflv_4216|M.gilvum_PYR-GCK GIDGFDELRRQHRVPSPPYGQGAIAAQAGATAMTDVSDG-LLADLAHIAS
TH_2051|M.thermoresistible__bu GIKDFPALRERHLVPAPPYRQGPVAASSGATSMIDVSDG-LVADLGHVAE
MLBr_01676|M.leprae_Br4923 GIDGFDDLRRRHLVPEPPYGKGVAAAACGAQAMIDVSDG-LIADLRHVAR
MAV_3829|M.avium_104 QIGGFDELRRRHAVPQPPYGQGAVAAAGGAQAMIDVSDG-LIADLRHVAE
MAB_3284c|M.abscessus_ATCC_199 QIDEFPDLRRVHLVPAPPYGQGPAAARAGATAMTDVSDG-LLADLAHIAE
MSMEG_0567|M.smegmatis_MC2_155 GYTGRQWDSTTSRNSAELASMAGLVARMAPRAAKDVSMAGVVGTVGMLAE
Mvan_1220|M.vanbaalenii_PYR-1 GYHGRQWDSTSARCPDDLARMGSYVAAARPRAAKDVSMAGIAGTAGMLAE
. . .* . : *** . : . :*
Mflv_4216|M.gilvum_PYR-GCK ASGVSIDITLDTLTSDEAAVADAAGATGVDARQWVLGGGEDHALVATFPG
TH_2051|M.thermoresistible__bu SSAVGIDVFTDALAGDHAAVAPAAEVTGADAWSWVLGGGEDHALVATFPG
MLBr_01676|M.leprae_Br4923 ASGVSIDLSTAALAADHAALIAAATAVGGDPWPWVLGGGEDHALVACFAG
MAV_3829|M.avium_104 ASGVGMDVSTAALAADRDAVAAAAAAVGVDAWPWVLTGGEDHALVACFPG
MAB_3284c|M.abscessus_ATCC_199 LSAVHIDLSSPSLEPYLQPVAGAAGLLGADPWEWVLTGGEDHALVGMFPG
MSMEG_0567|M.smegmatis_MC2_155 ASGTGAELDVATIPRPASAGMAPWLTCFPGFGMLTVGGALGSAAVPAGVA
Mvan_1220|M.vanbaalenii_PYR-1 AGGVGAEIDVAAVPRPRDADMGSWMTCFPGFGMLTAGG-VGAAPLPDGVA
... :: :: . . . . * . * : .
Mflv_4216|M.gilvum_PYR-GCK AVPPNWRVLGTVAATAADGAPAVTVDGSPWIGNAGWQSF---
TH_2051|M.thermoresistible__bu EPPPGWRVIG----RVVDGPARVLVDGVAWSGSAGWESFGD-
MLBr_01676|M.leprae_Br4923 TALSGWRIIG----RVFDGPARVLVDGQEWRGHAGWQSFGG-
MAV_3829|M.avium_104 PAPAGWRIIG----RVLDGPARVLVDEREWSGPAGWQSY---
MAB_3284c|M.abscessus_ATCC_199 VVPTGWVPIG----RVTVGEPGVTVDGAAWTRATGWDSFRLS
MSMEG_0567|M.smegmatis_MC2_155 SSECGSLTAEP---GVRLRWPDGVTTTALTSPVTGLGKA---
Mvan_1220|M.vanbaalenii_PYR-1 SRVCGRLTAQP---GVRLRWPDGVVTTALPAGVTGLGRA---
. . . . :*